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81. 发明授权

US06410675B1 Functionalized silicon compounds and methods for their synthesis and use 有权
公开(公告)号：US06410675B1
公开(公告)日：2002-06-25
申请号：US09832490
申请日：2001-04-11
申请人： Glenn McGall , Jonathan Eric Forman
发明人： Glenn McGall , Jonathan Eric Forman
IPC分类号： C08G7700
摘要： Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino, carboxyl and thiol, as well as modified forms thereof, such as activated or protected forms. The functionalized silicon compounds may be covalently attached to surfaces to form functionalized surfaces which may be used in a wide range of different applications. In one embodiment, the silicon compounds are attached to the surface of a substrate comprising silica, such as a glass substrate, to provide a functionalized surface on the substrate, to which molecules, including polypeptides and nucleic acids, may be attached. In one embodiment, after covalent attachment of a functionalized silicon compound to the surface of a solid silica substrate to form a functionalized coating on the substrate, an array of nucleic acids may be covalently attached to the substrate. Thus, the method permits the formation of high density arrays of nucleic acids immobilized on a substrate, which may be used, for example, in conducting high volume nucleic acid hybridization assays.

82. 发明授权

US06238862B1 Methods for testing oligonucleotide arrays 失效
标题翻译：测试寡核苷酸阵列的方法
公开(公告)号：US06238862B1
公开(公告)日：2001-05-29
申请号：US08995265
申请日：1997-12-19
申请人： Glenn McGall , Anthony D. Barone , Martin Diggelmann , David J. Lockhart , Ann Maria Caviani Pease , Mark Chee
发明人： Glenn McGall , Anthony D. Barone , Martin Diggelmann , David J. Lockhart , Ann Maria Caviani Pease , Mark Chee
IPC分类号： C12Q168
CPC分类号： B82Y30/00 , B01J2219/00432 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00693 , B01J2219/00711 , B01J2219/00722 , C12Q1/6837 , C40B40/06 , C40B60/14 , Y10S435/807
摘要： Methods for testing oligonucleotide arrays are disclosed including methods for testing the efficiency of nucleotide coupling; methods for testing amounts of deprotected oligonucleotides; methods for determining amounts of depurinated oligonucleotides; and methods of detecting the presence of cleavable structural features, such as double-stranded nucleic acids.
摘要翻译：公开了测试寡核苷酸阵列的方法，包括测试核苷酸偶联效率的方法; 检测去保护的寡核苷酸的量的方法; 用于测定去酰基化寡核苷酸量的方法; 以及检测可切割结构特征如双链核酸的存在的方法。

83. 发明授权

US5959098A Substrate preparation process 失效
公开(公告)号：US5959098A
公开(公告)日：1999-09-28
申请号：US634053
申请日：1996-04-17
申请人： Martin Goldberg , Martin Diggelman , Earl Hubbell , Glenn McGall , Nam Quoc Ngo , Macdonald Morris , Mel Yamamoto , Jennifer Tan , Richard P. Rava
发明人： Martin Goldberg , Martin Diggelman , Earl Hubbell , Glenn McGall , Nam Quoc Ngo , Macdonald Morris , Mel Yamamoto , Jennifer Tan , Richard P. Rava
IPC分类号： C12N15/09 , B01J19/00 , C07B61/00 , C07H21/00 , C07K1/00 , C07K1/04 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/53 , G01N37/00 , C08G63/48 , G01N33/543
CPC分类号： C07K1/047 , B01J19/0046 , B82Y30/00 , C07H21/00 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B60/14 , Y02P20/55 , Y10S436/809
摘要： The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention combine high throughput process steps with high resolution photolithographic techniques in the manufacture of polymer arrays.

84. 发明授权

US5658734A Process for synthesizing chemical compounds 失效
标题翻译：合成化合物的方法
公开(公告)号：US5658734A
公开(公告)日：1997-08-19
申请号：US544376
申请日：1995-10-17
申请人： Phillip Joe Brock , William Dinan Hinsberg , Jeffrey William Labadie , Glenn McGall , Gregory Michael Wallraff
发明人： Phillip Joe Brock , William Dinan Hinsberg , Jeffrey William Labadie , Glenn McGall , Gregory Michael Wallraff
IPC分类号： B01J19/00 , C07H21/00 , C40B40/06 , C40B40/10 , C40B60/14 , C12Q1/68 , G01N33/543
CPC分类号： B82Y30/00 , B01J19/0046 , C07H21/00 , B01J2219/00432 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , Y10S435/969 , Y10S436/809 , Y10S530/81
摘要： The present invention relates to a process for synthesizing on a single substrate a plurality of chemical compounds having diverse structures. The process involves the use of a bilayer photoresist to build up selected regions of the array in a step wise fashion.
摘要翻译：本发明涉及在单个基板上合成多种具有不同结构的化合物的方法。该方法涉及使用双层光致抗蚀剂以逐步的方式建立阵列的选定区域。

85. 发明授权

US5599695A Printing molecular library arrays using deprotection agents solely in the vapor phase 失效
标题翻译：使用去保护剂仅在气相中印刷分子库阵列
公开(公告)号：US5599695A
公开(公告)日：1997-02-04
申请号：US395604
申请日：1995-02-27
申请人： R. Fabian Pease , Glenn McGall , Martin J. Goldberg , Richard P. Rava , Stephen P. A. Fodor , Virginia Goss , Lubert Stryer , James L. Winkler
发明人： R. Fabian Pease , Glenn McGall , Martin J. Goldberg , Richard P. Rava , Stephen P. A. Fodor , Virginia Goss , Lubert Stryer , James L. Winkler
IPC分类号： B01J19/00 , B41M3/00 , C07H21/00 , C40B40/06 , C40B50/14 , C40B60/14 , G03F7/00 , C12P19/34 , C07H21/02 , C07K5/00 , G01N33/543
CPC分类号： C07H21/00 , B01J19/0046 , G03F7/00 , B01J2219/00378 , B01J2219/00382 , B01J2219/00385 , B01J2219/00427 , B01J2219/00454 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00722 , B41M3/00 , C40B40/06 , C40B50/14 , C40B60/14
摘要： A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier material, among other materials. The method and apparatus also relies upon standard DMT based chemistry, and a vapor phase deprotection agent such as solid TCA and the like.
摘要翻译：一种用于选择性地将印刷材料施加到基底上以在基底的选定区域合成寡核苷酸阵列的方法和装置。印刷材料包括阻挡材料，单体序列，核苷，去保护剂，载体材料等。该方法和装置还依赖于基于标准的基于DMT的化学，以及气相脱保护剂如固体TCA等。

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