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1. 发明授权

US07098286B2 Functionalized silicon compounds and methods for their synthesis and use 有权
公开(公告)号：US07098286B2
公开(公告)日：2006-08-29
申请号：US10857283
申请日：2004-05-28
申请人： Glenn McGall , Jonathan Eric Forman
发明人： Glenn McGall , Jonathan Eric Forman
IPC分类号： C08G77/00 , C08G77/04
CPC分类号： C08G73/0206 , C03C17/30 , C03C2218/113 , C07F7/1804 , C09D179/02 , C09D183/08 , C09D183/14 , Y10T428/31663
摘要： Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino, carboxyl and thiol, as well as modified forms thereof, such as activated or protected forms. The functionalized silicon compounds may be covalently attached to surfaces to form functionalized surfaces which may be used in a wide range of different applications. In one embodiment, the silicon compounds are attached to the surface of a substrate comprising silica, such as a glass substrate, to provide a functionalized surface on the substrate, to which molecules, including polypeptides and nucleic acids, may be attached. In one embodiment, after covalent attachment of a functionalized silicon compound to the surface of a solid silica substrate to form a functionalized coating on the substrate, an array of nucleic acids may be covalently attached to the substrate. Thus, the method permits the formation of high density arrays of nucleic acids immobilized on a substrate, which may be used, for example, in conducting high volume nucleic acid hybridization assays.

2. 发明授权

US06486286B1 Use of hexahydrolupulones as antibacterial agents 有权
标题翻译：官能化硅化合物及其合成和使用方法
公开(公告)号：US06486286B1
公开(公告)日：2002-11-26
申请号：US09418044
申请日：1999-10-13
申请人： Glenn McGall , Jonathan Eric Forman
发明人： Glenn McGall , Jonathan Eric Forman
IPC分类号： C08G7700
CPC分类号： C08G73/0206 , C03C17/30 , C03C2218/113 , C07F7/1804 , C09D179/02 , C09D183/08 , C09D183/14 , Y10T428/31663
摘要： Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino, carboxyl and thiol, as well as modified forms thereof, such as activated or protected forms. The functionalized silicon compounds may be covalently attached to surfaces to form functionalized surfaces which may be used in a wide range of different applications. In one embodiment, the silicon compounds are attached to the surface of a substrate comprising silica, such as a glass substrate, to provide a functionalized surface on the substrate, to which molecules, including polypeptides and nucleic acids, may be attached. In one embodiment, after covalent attachment of a functionalized silicon compound to the surface of a solid silica substrate to form a functionalized coating on the substrate, an array of nucleic acids may be covalently attached to the substrate. Thus, the method permits the formation of high density arrays of nucleic acids immobilized on a substrate, which may be used, for example, in conducting high volume nucleic acid hybridization assays.
摘要翻译：提供了官能化硅化合物及其合成和使用的方法。官能化的硅化合物包括至少一个活化的硅基团和至少一个可衍生的官能团。示例性的可衍生的官能团包括羟基，氨基，羧基和硫醇，以及其修饰形式，例如活化或受保护的形式。官能化的硅化合物可以共价连接到表面以形成可用于广泛的不同应用的官能化表面。在一个实施方案中，将硅化合物连接到包含二氧化硅（例如玻璃底物）的底物的表面上，以在基底上提供功能化的表面，分子（包括多肽和核酸）可以附着于该功能化表面。在一个实施方案中，在官能化硅化合物共价连接到固体二氧化硅底物的表面上以在基底上形成官能化涂层之后，核酸阵列可以共价连接到基底上。因此，该方法允许形成固定在底物上的高密度核酸阵列，其可用于例如进行高体积核酸杂交测定。

3. 发明授权

US07129307B2 Functionalized silicon compounds and methods for their synthesis and use 有权
公开(公告)号：US07129307B2
公开(公告)日：2006-10-31
申请号：US10853378
申请日：2004-05-25
申请人： Glenn McGall , Jonathan Eric Forman
发明人： Glenn McGall , Jonathan Eric Forman
IPC分类号： C08G77/00 , C08G77/04
CPC分类号： C08G73/0206 , C03C17/30 , C03C2218/113 , C07F7/1804 , C09D179/02 , C09D183/08 , C09D183/14 , Y10T428/31663
摘要： Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino, carboxyl and thiol, as well as modified forms thereof, such as activated or protected forms. The functionalized silicon compounds may be covalently attached to surfaces to form functionalized surfaces which may be used in a wide range of different applications. In one embodiment, the silicon compounds are attached to the surface of a substrate comprising silica, such as a glass substrate, to provide a functionalized surface on the substrate, to which molecules, including polypeptides and nucleic acids, may be attached. In one embodiment, after covalent attachment of a functionalized silicon compound to the surface of a solid silica substrate to form a functionalized coating on the substrate, an array of nucleic acids may be covalently attached to the substrate. Thus, the method permits the formation of high density arrays of nucleic acids immobilized on a substrate, which may be used, for example, in conducting high volume nucleic acid hybridization assays.

4. 发明授权

US06743882B2 Functionalized silicon compounds and methods for their synthesis and use 有权
标题翻译：官能化硅化合物及其合成和使用方法
公开(公告)号：US06743882B2
公开(公告)日：2004-06-01
申请号：US10282979
申请日：2002-10-29
申请人： Glenn McGall , Jonathan Eric Forman
发明人： Glenn McGall , Jonathan Eric Forman
IPC分类号： C08G7700
CPC分类号： C08G73/0206 , C03C17/30 , C03C2218/113 , C07F7/1804 , C09D179/02 , C09D183/08 , C09D183/14 , Y10T428/31663
摘要： Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino, carboxyl and thio, as well as modified forms thereof, such as activated or protected forms. The functionalized silicon compounds may be covalently attached to surfaces to form functionalized surfaces which may be used in a wide range of different applications. In one embodiment, the silicon compounds are attached to the surface of a substrate comprising silica, such as a glass substrate, to provide a functionalized surface on the substrate, to which molecules, including polypeptides and nucleic acids, may be attached. In one embodiment, after covalent attachment of a functionalized silicon compound to the surface of a solid silica substrate to form a functionalized coating on the substrate, an array of nucleic acids may be covalently attached to the substrate. Thus, the method permits the formation of high density arrays of nucleic acids immobilized on a substrate, which may be used, for example, in conducting high volume nucleic acid hybridization assays.
摘要翻译：提供了官能化硅化合物及其合成和使用的方法。官能化的硅化合物包括至少一个活化的硅基团和至少一个可衍生的官能团。示例性的可衍生官能团包括羟基，氨基，羧基和硫基，以及其修饰形式，例如活化或受保护的形式。官能化的硅化合物可以共价连接到表面以形成可用于广泛的不同应用的官能化表面。在一个实施方案中，将硅化合物连接到包含二氧化硅（例如玻璃底物）的底物的表面上，以在基底上提供功能化的表面，分子（包括多肽和核酸）可以附着于该功能化表面。在一个实施方案中，在官能化硅化合物共价连接到固体二氧化硅底物的表面上以在基底上形成官能化涂层之后，核酸阵列可以共价连接到基底上。因此，该方法允许形成固定在底物上的高密度核酸阵列，其可用于例如进行高体积核酸杂交测定。

5. 发明授权

US06486287B2 Functionalized silicon compounds and methods for their synthesis and use 有权
公开(公告)号：US06486287B2
公开(公告)日：2002-11-26
申请号：US09832489
申请日：2001-04-11
申请人： Glenn McGall , Jonathan Eric Forman
发明人： Glenn McGall , Jonathan Eric Forman
IPC分类号： C08G7700
CPC分类号： C08G73/0206 , C03C17/30 , C03C2218/113 , C07F7/1804 , C09D179/02 , C09D183/08 , C09D183/14 , Y10T428/31663
摘要： Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino, carboxyl and thiol, as well as modified forms thereof, such as activated or protected forms. The functionalized silicon compounds may be covalently attached to surfaces to form functionalized surfaces which may be used in a wide range of different applications. In one embodiment, the silicon compounds are attached to the surface of a substrate comprising silica, such as a glass substrate, to provide a functionalized surface on the substrate, to which molecules, including polypeptides and nucleic acids, may be attached. In one embodiment, after covalent attachment of a functionalized silicon compound to the surface of a solid silica substrate to form a functionalized coating on the substrate, an array of nucleic acids may be covalently attached to the substrate. Thus, the method permits the formation of high density arrays of nucleic acids immobilized on a substrate, which may be used, for example, in conducting high volume nucleic acid hybridization assays.

6. 发明授权

US06410675B1 Functionalized silicon compounds and methods for their synthesis and use 有权
公开(公告)号：US06410675B1
公开(公告)日：2002-06-25
申请号：US09832490
申请日：2001-04-11
申请人： Glenn McGall , Jonathan Eric Forman
发明人： Glenn McGall , Jonathan Eric Forman
IPC分类号： C08G7700
摘要： Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino, carboxyl and thiol, as well as modified forms thereof, such as activated or protected forms. The functionalized silicon compounds may be covalently attached to surfaces to form functionalized surfaces which may be used in a wide range of different applications. In one embodiment, the silicon compounds are attached to the surface of a substrate comprising silica, such as a glass substrate, to provide a functionalized surface on the substrate, to which molecules, including polypeptides and nucleic acids, may be attached. In one embodiment, after covalent attachment of a functionalized silicon compound to the surface of a solid silica substrate to form a functionalized coating on the substrate, an array of nucleic acids may be covalently attached to the substrate. Thus, the method permits the formation of high density arrays of nucleic acids immobilized on a substrate, which may be used, for example, in conducting high volume nucleic acid hybridization assays.

7. 发明授权

US07129308B2 Functionalized silicon compounds and methods for their synthesis and use 有权
公开(公告)号：US07129308B2
公开(公告)日：2006-10-31
申请号：US10857247
申请日：2004-05-28
申请人： Glenn McGall , Jonathan Eric Forman
发明人： Glenn McGall , Jonathan Eric Forman
IPC分类号： C08G77/00 , C08G77/04
CPC分类号： C08G73/0206 , C03C17/30 , C03C2218/113 , C07F7/1804 , C09D179/02 , C09D183/08 , C09D183/14 , Y10T428/31663
摘要： Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino, carboxyl and thiol, as well as modified forms thereof, such as activated or protected forms. The functionalized silicon compounds may be covalently attached to surfaces to form functionalized surfaces which may be used in a wide range of different applications. In one embodiment, the silicon compounds are attached to the surface of a substrate comprising silica, such as a glass substrate, to provide a functionalized surface on the substrate, to which molecules, including polypeptides and nucleic acids, may be attached. In one embodiment, after covalent attachment of a functionalized silicon compound to the surface of a solid silica substrate to form a functionalized coating on the substrate, an array of nucleic acids may be covalently attached to the substrate. Thus, the method permits the formation of high density arrays of nucleic acids immobilized on a substrate, which may be used, for example, in conducting high volume nucleic acid hybridization assays.

8. 发明授权

US07125947B2 Functionalized silicon compounds and methods for their synthesis and use 有权
公开(公告)号：US07125947B2
公开(公告)日：2006-10-24
申请号：US10857329
申请日：2004-05-28
申请人： Glenn McGall , Jonathan Eric Forman
发明人： Glenn McGall , Jonathan Eric Forman
IPC分类号： C08G77/00 , C08G77/04
CPC分类号： C08G73/0206 , C03C17/30 , C03C2218/113 , C07F7/1804 , C09D179/02 , C09D183/08 , C09D183/14 , Y10T428/31663
摘要： Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino, carboxyl and thiol, as well as modified forms thereof, such as activated or protected forms. The functionalized silicon compounds may be covalently attached to surfaces to form functionalized surfaces which may be used in a wide range of different applications. In one embodiment, the silicon compounds are attached to the surface of a substrate comprising silica, such as a glass substrate, to provide a functionalized surface on the substrate, to which molecules, including polypeptides and nucleic acids, may be attached. In one embodiment, after covalent attachment of a functionalized silicon compound to the surface of a solid silica substrate to form a functionalized coating on the substrate, an array of nucleic acids may be covalently attached to the substrate. Thus, the method permits the formation of high density arrays of nucleic acids immobilized on a substrate, which may be used, for example, in conducting high volume nucleic acid hybridization assays.

9. 发明授权

US06429275B2 Functionalized silicon compounds and methods for their synthesis and use 有权
公开(公告)号：US06429275B2
公开(公告)日：2002-08-06
申请号：US09832656
申请日：2001-04-11
申请人： Glenn McGall , Jonathan Eric Forman
发明人： Glenn McGall , Jonathan Eric Forman
IPC分类号： C08G7700
CPC分类号： C08G73/0206 , C03C17/30 , C03C2218/113 , C07F7/1804 , C09D179/02 , C09D183/08 , C09D183/14 , Y10T428/31663
摘要： Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino, carboxyl and thiol, as well as modified forms thereof, such as activated or protected forms. The functionalized silicon compounds may be covalently attached to surfaces to form functionalized surfaces which may be used in a wide range of different applications. In one embodiment, the silicon compounds are attached to the surface of a substrate comprising silica, such as a glass substrate, to provide a functionalized surface on the substrate, to which molecules, including polypeptides and nucleic acids, may be attached. In one embodiment, after covalent attachment of a functionalized silicon compound to the surface of a solid silica substrate to form a functionalized coating on the substrate, an array of nucleic acids may be covalently attached to the substrate. Thus, the method permits the formation of high density arrays of nucleic acids immobilized on a substrate, which may be used, for example, in conducting high volume nucleic acid hybridization assays.

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