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81. 发明授权

US6077543A Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients 失效
公开(公告)号：US6077543A
公开(公告)日：2000-06-20
申请号：US999097
申请日：1997-12-29
申请人： Marc S. Gordon , Andrew Clark , Thomas K. Brewer
发明人： Marc S. Gordon , Andrew Clark , Thomas K. Brewer
IPC分类号： A61K9/12 , A61K9/00 , A61K9/14 , A61K9/16 , A61K31/07 , A61K31/12 , A61K31/122 , A61K31/353 , A61K31/355 , A61K31/557 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/59 , A61K31/7012 , A61K31/715 , A61K38/00 , A61K45/00 , A61K47/00 , B01D1/18 , B01J2/04 , A61K9/72
CPC分类号： A61K9/0075 , A61K31/353 , A61K31/355 , A61K31/557 , A61K31/56 , A61K31/573 , A61K31/59 , A61K31/7012 , A61K31/715 , A61K9/1611 , A61K9/1623 , A61K9/1694 , B01D1/18 , B01J2/04 , Y10S514/938 , Y10S514/951 , Y10S514/958 , Y10S977/775 , Y10S977/783 , Y10S977/829 , Y10S977/884 , Y10S977/89 , Y10S977/906 , Y10S977/915 , Y10S977/926
摘要： Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions of the components and spray drying them simultaneously in a spray dryer. The hydrophilic and hydrophobic component are separately dissolved in separate solvents and directed simultaneously through a nozzle, usually a coaxial nozzle, into the spray dryer. The method provides dry powders having relatively uniform characteristics.

82. 发明授权

US09710857B2 Detecting anomalous user activity 有权
公开(公告)号：US09710857B2
公开(公告)日：2017-07-18
申请号：US12950884
申请日：2010-11-19
申请人： Ulrich Flegel , Shane Bracher , Pascal Hochwarth , Hermann Resch , Paola Sala , Stephan Wollny , Hua Wang , Andrew Clark , George Mohay , Roheena Khan , Malcolm Corney
发明人： Ulrich Flegel , Shane Bracher , Pascal Hochwarth , Hermann Resch , Paola Sala , Stephan Wollny , Hua Wang , Andrew Clark , George Mohay , Roheena Khan , Malcolm Corney
IPC分类号： G06Q10/00 , G06Q99/00 , G06F11/00 , G06Q40/06
CPC分类号： G06Q40/06
摘要： Systems, methods and articles for determining anomalous user activity are disclosed. Data representing a transaction activity corresponding to a plurality of user transactions can be received and user transactions can be grouped according to types of user transactions. The transaction activity can be determined to be anomalous in relation to the grouped user transactions based on a predetermined parameter.

83. 发明授权

US08845568B2 Distractor straps for use with distractor apparatuses 有权
标题翻译：牵引器带用于牵引器装置
公开(公告)号：US08845568B2
公开(公告)日：2014-09-30
申请号：US13435040
申请日：2012-03-30
申请人： Andrew Clark , David Chella , Jesse Drake
发明人： Andrew Clark , David Chella , Jesse Drake
IPC分类号： A61F5/04 , A61F5/37
CPC分类号： A61F5/3776 , A61F5/04
摘要： Distractor straps for use with distractor apparatuses are disclosed. In one embodiment, a distractor strap includes a cinch strap having a free end and a second end. The second end of the cinch strap includes an adjustment mechanism receiving the free end of the cinch strap such that the cinch strap forms a closed loop. A diameter of the closed loop is adjustable with the adjustment mechanism. The distractor strap further includes a cross strap comprising a first loop, a second loop, and strapping connecting the first loop and the second loop. The cinch strap is positioned in the first loop and the second loop such that the cross strap extends across the diameter of the closed loop formed by the cinch strap and the cross strap and the cinch strap are slidable with respect to one another.
摘要翻译：公开了用于牵引器装置的牵引带。在一个实施例中，牵引带包括具有自由端和第二端的束带。束带的第二端包括接收束带的自由端的调节机构，使得束带形成闭环。闭环的直径可用调节机构调节。牵引带还包括交叉带，其包括第一回路，第二回路和连接第一回路和第二回路的捆扎带。系带位于第一环和第二环中，使得交叉带横跨由带束带形成的闭环的直径延伸，并且交叉带和带束带可相对于彼此滑动。

84. 发明授权

US08777011B2 Capsule package with moisture barrier 有权
标题翻译：胶囊包装防潮
公开(公告)号：US08777011B2
公开(公告)日：2014-07-15
申请号：US10313419
申请日：2002-12-06
申请人： Scot Cheu , William Leung , Mei-Chang Kuo , Andrew Clark
发明人： Scot Cheu , William Leung , Mei-Chang Kuo , Andrew Clark
IPC分类号： B65D83/04
CPC分类号： B65D81/24 , B65D81/2015 , B65D81/2038
摘要： A package for storing an aerosolizable pharmaceutical formulation comprises a capsule adapted to contain the aerosolizable pharmaceutical formulation, and a moisture barrier around the capsule. The moisture barrier comprises a material that is resistant to moisture passage, whereby the moisture barrier reduces the amount of moisture in contact with the aerosolizable pharmaceutical formulation so that the aerosolizable pharmaceutical formulation may be aerosolized when the capsule is opened. In one version, the moisture barrier comprises a metal.
摘要翻译：用于储存可雾化药物制剂的包装包括适于容纳可雾化药物制剂的胶囊和胶囊周围的防潮屏障。防潮层包括耐潮湿通道的材料，由此防潮剂减少与可雾化药物制剂接触的水分量，使得当胶囊打开时可雾化的药物制剂可以雾化。在一个版本中，防潮层包括金属。

85. 发明申请

US20140093541A1 TREATMENT FOR PEANUT ALLERGY 有权
标题翻译： PEANUT过敏症治疗
公开(公告)号：US20140093541A1
公开(公告)日：2014-04-03
申请号：US14005789
申请日：2012-03-16
申请人： Andrew Clark , Pamela Ewan
发明人： Andrew Clark , Pamela Ewan
IPC分类号： C07K14/415
CPC分类号： C07K14/415 , A61K39/35 , A61K2039/542 , A61K2039/545
摘要： The present invention relates to oral immunotherapy for the desensitisation of patients who are hypersensitive to peanut allergen. The immunotherapy comprises increasing the oral dose daily dose of peanut protein administered to the patient at intervals of at least 2 weeks in a series of increments from an initial dose to a maximum dose, the series of dose increments including 2 mg, 5 mg, 12.5 mg, 25 mg, 50 mg, 100 mg, 200 mg, 400 mg and 800 mg; administering a daily oral dose of the maximum dose of peanut protein for at least 2 years and then administering a weekly oral dose of the maximum dose of peanut protein for at least 2 years.
摘要翻译：本发明涉及对花生过敏原过敏的患者的脱敏的口服免疫治疗。免疫疗法包括以从初始剂量到最大剂量的一系列增量，以至少2周的间隔增加施用于患者的花生蛋白的口服剂量日剂量，所述剂量增量包括2mg，5mg，12.5 mg，25mg，50mg，100mg，200mg，400mg和800mg; 每日口服剂量的最大剂量的花生蛋白至少2年，然后每周口服剂量的最大剂量的花生蛋白质至少2年。

86. 发明授权

US08515850B2 System and method for forecasting realized volatility via wavelets and non-linear dynamics 有权
标题翻译：通过小波和非线性动力学预测实现波动率的系统和方法
公开(公告)号：US08515850B2
公开(公告)日：2013-08-20
申请号：US13220115
申请日：2011-08-29
申请人： Andrew Clark , Jeff Kenyon
发明人： Andrew Clark , Jeff Kenyon
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04 , G06Q40/06
摘要： The system and method described herein may be used to forecast realized volatility via wavelets and non-linear dynamics. In particular, a volatility time series that includes daily volatility values associated with a security may be decomposed into wavelets via multi-resolution analysis and dynamical properties associated with the individual wavelets may be analyzed to identify deterministic and non-deterministic wavelets and produce a volatility forecast derived from a fit computed on the deterministic wavelets. For example, the wavelets may be analyzed to discover time delay, Theiler, and embedding dimension values associated therewith, which may be used to project volatility values associated with each wavelet. The projected volatility values associated with each wavelet may then be summed to produce a volatility forecast associated with the security.
摘要翻译：本文描述的系统和方法可用于通过小波和非线性动力学预测实现的波动性。特别地，包括与安全性相关联的每日波动值的波动性时间序列可以通过多分辨率分析被分解为小波，并且可以分析与各个小波相关联的动力特性以识别确定性和非确定性小波并产生波动性预测从确定性小波计算的拟合得出。例如，可以分析小波以发现与之相关的时间延迟，Theiler和嵌入维度值，其可用于投影与每个小波相关联的波动率值。然后可以将与每个小波相关联的预测波动率相加以产生与安全性相关联的波动性预测。

87. 发明授权

US08408200B2 Flow resistance modulated aerosolized active agent delivery 失效
标题翻译：阻流调制气雾剂活性剂输送
公开(公告)号：US08408200B2
公开(公告)日：2013-04-02
申请号：US09414384
申请日：1999-10-07
申请人： Andrew Clark , Carlos Schuler , Steve Paboojian
发明人： Andrew Clark , Carlos Schuler , Steve Paboojian
IPC分类号： A61M16/00 , A61M15/00 , A62B9/02
CPC分类号： A61M15/00 , A61M2016/0021 , A61M2202/064
摘要： The present invention is directed to methods and devices for delivering an active agent formulation to the lung of a human patient. The active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant. The active agent formulation is delivered to a patient at a low inspiratory flow rate for an initial period of time to increase bioavailability of the active agent.
摘要翻译：本发明涉及用于将活性剂制剂递送到人类患者的肺的方法和装置。活性剂制剂可以是干粉形式，它可以是雾化的，或者它可以与推进剂混合。活性剂制剂以低吸入流速在初始时期递送给患者，以提高活性剂的生物利用度。

88. 发明申请

US20130024395A1 SYSTEM AND METHOD FOR CONSTRUCTING OUTPERFORMING PORTFOLIOS RELATIVE TO TARGET BENCHMARKS 审中-公开
标题翻译：与目标基准相关的构建成形组合物的系统和方法
公开(公告)号：US20130024395A1
公开(公告)日：2013-01-24
申请号：US13189128
申请日：2011-07-22
申请人： Andrew Clark , Jeff Kenyon
发明人： Andrew Clark , Jeff Kenyon
IPC分类号： G06Q40/00 , G06N3/12
CPC分类号： G06Q40/06
摘要： The system and method described herein may be used to construct outperforming portfolios relative to target benchmarks. In particular, the system and method described herein may use multi-factor models that employ multi-objective evolutionary algorithms and mean variance optimization calculations to select constituents from a target benchmark index to include in a portfolio. The selected constituents may then be weighed to construct or rebalance the portfolio in a manner that can consistently outperform the target benchmark index while satisfying real-world constraints that relate to turnover limits, minimum and maximum stock positions, cardinalities, target market capitalizations, investment strategies, and other characteristics associated with the portfolio.
摘要翻译：本文描述的系统和方法可用于构建相对于目标基准的表现优于投资组合。特别地，本文描述的系统和方法可以使用采用多目标进化算法和均值方差优化计算的多因子模型，以从目标基准指数中选择要包括在投资组合中的成分。所选择的成分可能被称重，以便能够持续优于目标基准指数的方式构建或重新平衡投资组合，同时满足与周转限制，最小和最大库存头寸，基数，目标市值，投资策略相关的现实世界约束，以及与投资组合相关的其他特征。

89. 发明申请

US20120090672A1 REO-Ge Multi-Junction Solar Cell 审中-公开
公开(公告)号：US20120090672A1
公开(公告)日：2012-04-19
申请号：US13020766
申请日：2011-02-03
申请人： MICHAEL S. LEBBY , Andrew Clark , Robin Smith
发明人： MICHAEL S. LEBBY , Andrew Clark , Robin Smith
IPC分类号： H01L31/0352
CPC分类号： H01L31/0725 , H01L31/072 , H01L31/0735 , H01L31/0745 , H01L31/1812 , H01L31/1836 , H01L31/1852 , Y02E10/544
摘要： The invention relates to a semiconductor based structure for a device for converting radiation to electrical energy comprising various combinations of rare-earths and Group IV, III-V, and II-VI semiconductors and alloys thereof enabling enhanced performance including high radiation conversion efficiency.

90. 发明申请

US20080028850A1 Apparatus for Measuring Properties of Gases Supplied To a Patient 有权
标题翻译：用于测量向患者提供的气体性质的装置
公开(公告)号：US20080028850A1
公开(公告)日：2008-02-07
申请号：US11572822
申请日：2005-08-19
申请人： Matthew Payton , Kevin O'Donnell , Andrew Clark , Christopher Quill , Peter Hawkins
发明人： Matthew Payton , Kevin O'Donnell , Andrew Clark , Christopher Quill , Peter Hawkins
IPC分类号： G01F1/68 , A61M16/16
CPC分类号： A61M16/1005 , A61M16/00 , A61M16/0066 , A61M16/024 , A61M16/06 , A61M16/0666 , A61M16/0875 , A61M16/1075 , A61M16/109 , A61M16/1095 , A61M16/16 , A61M16/161 , A61M2016/0027 , A61M2016/102 , A61M2205/3368 , A61M2205/502 , Y10S261/65
摘要： The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature (thermister 23), of gases flowing through a heated tube (3), supplying gases to a patient, which utilises the heating wire (21, 28) within the tube.
摘要翻译：经常对患者进行治疗的气体温度（例如氧疗法或正压治疗，如阻塞性睡眠呼吸暂停（OSA）或慢性阻塞性肺疾病（COPD））进行测量，以确保安全性湿度传递给患者。所公开的本发明涉及流过加热管（3）的气体的特性，特别是温度（thermister 23）的测量，向使用该管内的加热线（21,28）供应气体的患者。

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