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81. 发明授权

US5129890A Hydrophilically coated flexible wire guide 失效
标题翻译：水性涂层柔性电线指南
公开(公告)号：US5129890A
公开(公告)日：1992-07-14
申请号：US648923
申请日：1991-02-01
申请人： Brian L. Bates , Thomas A. Osborne
发明人： Brian L. Bates , Thomas A. Osborne
IPC分类号： A61M25/01 , A61L29/00 , A61M25/00 , A61M25/09
CPC分类号： A61M25/09 , A61M2025/09091 , A61M2025/09166
摘要： A wire guide comprising an elongate central core and a coil formed of radiopaque material which is positioned substantially concentrically with the elongate central core. The wire guide also comprises a polymer sleeve which encloses the elongated central core. The guide wire further comprises a hydrophilic coating which substantially encloses the polymer sleeve.

82. 发明授权

US4306562A Tear apart cannula 失效
标题翻译：撕开插管
公开(公告)号：US4306562A
公开(公告)日：1981-12-22
申请号：US173960
申请日：1980-07-31
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61M25/06 , A61M25/00
CPC分类号： A61M25/0668
摘要： This invention relates to a flexible cannula comprising material which tears readily in a longitudinal direction and can thus be easily removed by pulling tabs on opposite sides of the cannula apart after the catheter or other device has been inserted into the body.
摘要翻译：本发明涉及一种柔性插管，其包括在纵向方向上容易撕裂的材料，并且因此可以在导管或其它装置已经插入体内之后通过拉动导管的相对侧上的突片来容易地移除。

83. 发明授权

US08808352B2 Cast bioremodelable graft 有权
标题翻译：铸造生物可重复移植
公开(公告)号：US08808352B2
公开(公告)日：2014-08-19
申请号：US11054043
申请日：2005-02-09
申请人： Scott E. Eells , Michael C. Hiles , Thomas A. Osborne
发明人： Scott E. Eells , Michael C. Hiles , Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61L27/507 , A61L27/3629 , A61L27/3633 , A61L27/58
摘要： A cast bioremodelable graft (22) including a cast tubular construct (33) of a bioremodelable substance (34). The bioremodelable substance is cast on or applied to a form and then vacuum pressed to dry or harden the substance. Expandable members (18) are disposed on, in, under or about the cast tubular construct to expand the graft when released from an endoluminal delivery system. A second layer (39) can be applied over the first layer (38) and the expandable stents to contain the stents there between without the need for any separate attachment. The graft is dehydrated and preferably vacuum pressed to harden the bioremodelable substance. The form is removed to form one or more lumens (23-25) in the graft, which is then loaded on an endoluminal delivery system.
摘要翻译：包括生物可重塑物质（34）的铸造管状构造物（33）的铸塑生物可重塑移植物（22）。将生物可重塑物质浇铸或施加到形式上，然后真空压制以干燥或硬化物质。可膨胀构件（18）设置在铸造管状结构的内部，下面或周围，以在从内腔输送系统释放时膨胀移植物。第二层（39）可以施加在第一层（38）上，并且可扩展支架在其间包含支架，而不需要任何单独的附接。将移植物脱水并优选真空压制以使生物可重塑物质硬化。去除形式以在移植物中形成一个或多个腔（23-25），然后将其装载在腔内递送系统上。

84. 发明授权

US08753317B2 Hemostasis cannula 有权
标题翻译：止血套管
公开(公告)号：US08753317B2
公开(公告)日：2014-06-17
申请号：US11055211
申请日：2005-02-10
申请人： Thomas A. Osborne , Ram H. Paul
发明人： Thomas A. Osborne , Ram H. Paul
IPC分类号： A61M5/178
CPC分类号： A61M39/0606 , A61M39/0693 , A61M2039/0072 , A61M2039/062 , A61M2039/0633 , A61M2039/064
摘要： A medical instrument includes a housing with a passage through which a catheter is received. A valve body is mounted in the passage, and, as the catheter penetrates through the valve body, the valve body conforms to the outer wall of the catheter to maintain a fluid tight seal between the valve body and the catheter. When the valve body is unstressed before being mounted in the passage, the valve body has a first planar dimension and a second planar dimension that is less than the first planar dimension.
摘要翻译：医疗器械包括具有通过导管接收的通道的壳体。阀体安装在通道中，并且当导管穿过阀体时，阀体与导管的外壁相符，以保持阀体和导管之间的流体密封。当阀体在安装在通道中之前不受应力时，阀体具有第一平面尺寸和小于第一平面尺寸的第二平面尺寸。

85. 发明授权

US08696646B2 Treatment fluid delivery method, and turbulator for promoting uptake of a treatment agent 有权
标题翻译：处理液输送方法和用于促进处理剂吸收的湍流器
公开(公告)号：US08696646B2
公开(公告)日：2014-04-15
申请号：US13101380
申请日：2011-05-05
申请人： James R. Randolph , Thomas A. Osborne
发明人： James R. Randolph , Thomas A. Osborne
IPC分类号： A61M25/00
CPC分类号： A61M25/0023 , A61B17/22 , A61M25/0021 , A61M25/0043 , A61M25/0067 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0102 , A61M2025/0057 , A61M2025/0063 , A61M2025/0073
摘要： A turbulator for promoting mixing of fluids passing through a body lumen includes an elongate flow perturbing component and an elongate shape controlling component freely slidable within the flow perturbing component. The turbulator is adjustable from a low profile, lumen access configuration to a deployed configuration via sliding the shape controlling component within the flow perturbing component. Adjusting the turbulator within a body lumen of a patient induces turbulence within a flow of fluid passing through the body lumen to increase mixing of a treatment fluid with the body fluid by way of the induced turbulence.
摘要翻译：用于促进通过体腔的流体的混合的湍流器包括细长的流动扰动部件和在流动扰动部件内可自由滑动的细长形状控制部件。通过在流动扰动部件内滑动形状控制部件，可以将紊流器从低轮廓，内腔存取配置调整到展开配置。调节患者体腔内的湍流器在通过体腔的流体流中引起湍流，以通过诱导的湍流增加治疗流体与体液的混合。

86. 发明授权

US08348988B2 Endoluminal prosthetic device 有权
标题翻译：腔内假体装置
公开(公告)号：US08348988B2
公开(公告)日：2013-01-08
申请号：US11037792
申请日：2005-01-18
申请人： Ashvin Lad , Michael P. DeBruyne , Thomas A. Osborne
发明人： Ashvin Lad , Michael P. DeBruyne , Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/848 , A61F2/89 , A61F2002/067 , A61F2002/075 , A61F2220/0016 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0067
摘要： An endoluminal prosthetic device for placement in a body lumen is formed by stitching stents to a graft. A first or anchoring stent is used for securing a graft made of biocompatible material that forms at least one lumen. There is also a second stent. The first and second stents each include a plurality of struts and apices between the struts. At least two of the apices in each of the first and second stents are secured to the graft by stitches. A running suture links at least one stitch of the first stent and one stitch of the second stent. The running suture linking the first stent and the second stent adds strength to the stitches and better secures the first stent to the device. The endoluminal prosthetic device may be used in an aortic vessel to treat stenoses or aneurysms.
摘要翻译：通过将支架缝合到移植物上而形成用于放置在体腔内的腔内假体装置。第一或锚固支架用于固定由形成至少一个腔的生物相容性材料制成的移植物。还有第二支架。第一和第二支架各自包括支柱之间的多个支柱和顶点。第一和第二支架中的每一个中的至少两个顶点通过针迹固定到移植物上。运行缝合线连接第一支架的至少一个线圈和第二支架的一个线圈。连接第一支架和第二支架的运行缝合线为线圈增加了强度，并且将第一支架更好地固定到装置。腔内修复装置可用于主动脉血管以治疗狭窄或动脉瘤。

87. 发明授权

US08337545B2 Woven implantable device 有权
标题翻译：编织植入式装置
公开(公告)号：US08337545B2
公开(公告)日：2012-12-25
申请号：US11403463
申请日：2006-04-12
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61F2/24 , A61F2/02 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2475 , A61F2/88 , A61F2220/0008 , A61F2220/0016 , A61F2230/0026 , A61F2230/0054 , A61F2230/0095
摘要： A prosthetic valve device, a method for making a valve device, and a method for implanting a valve device into a recipient are provided. The valve device includes at least one flexible member formed at least partially from a woven layer. The woven layer includes a first material and a second material being at least partially woven together. The at least one flexible member is movable between a first position that permits fluid flow in a first direction and a second position that substantially prevents fluid flow in a second direction. The valve has a first, unexpanded configuration and a second, expanded configuration.
摘要翻译：提供了一种人造瓣膜装置，制造阀装置的方法以及将阀装置植入接受器中的方法。阀装置包括至少部分地由编织层形成的至少一个柔性构件。编织层包括至少部分编织在一起的第一材料和第二材料。所述至少一个柔性构件可在允许流体沿第一方向流动的第一位置和基本上防止流体沿第二方向流动的第二位置之间移动。阀具有第一，未膨胀的构型和第二扩展构型。

88. 发明授权

US08303627B2 Patent foramen ovale closure device and method 有权
标题翻译：卵圆孔闭合装置及方法
公开(公告)号：US08303627B2
公开(公告)日：2012-11-06
申请号：US12159829
申请日：2007-01-09
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61B17/068
CPC分类号： A61B17/0057 , A61B17/0644 , A61B17/0684 , A61B2017/00349 , A61B2017/00353 , A61B2017/00575
摘要： A device for closure of a patent foramen ovale. The device includes at least one elongated tissue anchor at the distal end of the device. A distal end portion of the tissue anchor is selectively deployable between a closed position in which the distal end portion of the tissue anchor is capable of penetrating the septum and the flap, and a radially extensible position in which the distal end portion of the tissue anchor is capable of engaging the septum or flap so that the septum and flap may be urged into registry. A deployment member is associated with the tissue anchor for selectively deploying the distal end portion of the tissue anchor between the closed position and the radially extensible position. A closure element is disposed at the distal end of the device. The closure element is engageable with the septum and the flap when the septum and flap are in registry, for maintaining such registry. An actuator is associated with the closure element for selectively engaging the closure element with the septum and flap.
摘要翻译：用于闭合卵孔卵泡的设备。该装置包括在装置的远端处的至少一个细长的组织锚。组织锚固件的远端部分可选择性地展开在关闭位置，组合锚固件的远端部分能够穿过隔膜和瓣部之间的封闭位置以及组织锚固件的远端部分的径向可伸展位置能够接合隔膜或瓣片，使得隔膜和皮瓣可被推入注册。展开构件与组织锚固件相关联，用于选择性地将组织锚的远端部分展开在关闭位置和可径向延伸位置之间。闭合元件设置在装置的远端。当隔膜和襟翼处于注册状态时，封闭元件可与隔膜和襟翼接合，以保持这种注册。致动器与闭合元件相关联，用于选择性地将闭合元件与隔膜和瓣片接合。

89. 发明申请

US20120222969A1 STENT AND METHOD OF FORMING A STENT WITH INTEGRAL BARBS 审中-公开
标题翻译：形成具有整体棒的手柄的方法和方法
公开(公告)号：US20120222969A1
公开(公告)日：2012-09-06
申请号：US13471066
申请日：2012-05-14
申请人： Thomas A. Osborne , Jason A. Mead
发明人： Thomas A. Osborne , Jason A. Mead
IPC分类号： B21D43/28 , C25F3/16 , B23K26/00 , H02G1/12 , B24B1/00
CPC分类号： A61F2/2418 , A61F2/07 , A61F2/2475 , A61F2/848 , A61F2/89 , A61F2/90 , A61F2/915 , A61F2002/075 , A61F2002/8483 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0067 , A61F2230/0091 , A61F2230/0095 , C25F3/24
摘要： A method for manufacturing a barbed stent includes providing a sheet of stent material, cutting the sheet to form a stent wire with integral barbs extending therefrom, and forming the stent wire into a final stent shape having a longitudinal axis. A stent for deployment within the body of a patient includes integral barbs.
摘要翻译：一种用于制造有倒钩的支架的方法包括提供支架材料片材，切割片材以形成具有从其延伸的整体倒钩的支架线材，以及将支架线材形成为具有纵向轴线的最终支架形状。用于部署在患者体内的支架包括一体倒钩。

90. 发明授权

US08246651B2 Removable vena cava filter for reduced trauma in collapsed configuration 有权
标题翻译：可拆卸的腔静脉过滤器可减少塌陷形态的创伤
公开(公告)号：US08246651B2
公开(公告)日：2012-08-21
申请号：US12717637
申请日：2010-03-04
申请人： Per Hendriksen , Allan G. Hemmingsen , Arne Molgaard-Nielsen , Thomas A. Osborne , Rolf Gunther
发明人： Per Hendriksen , Allan G. Hemmingsen , Arne Molgaard-Nielsen , Thomas A. Osborne , Rolf Gunther
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2002/8483 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： The present invention provides a method of capturing thrombi in a blood vessel, which includes delivering a removable filter in a collapsed state within the blood vessel and deploying the filter to an expanded state within the blood vessel. The filter includes a plurality of primary struts and a plurality of secondary struts emanating from a hub and extending arcuately along a longitudinal axis and linearly radially. Each primary strut has an arcuate segment including first and second curved portions. Each secondary strut includes first and second arcs. The primary struts terminate with an anchoring hook. Each primary strut crosses another primary strut along the longitudinal axis in the collapsed state such that the arcuate segments occupy a first diameter and the anchoring hooks occupy a second diameter, the first diameter being greater than the second diameter for filter retrieval or delivery. In the expanded state, the secondary struts centralize the filter in the blood vessel and the anchoring hooks engage with the blood vessel.
摘要翻译：本发明提供了一种在血管中捕获血栓的方法，其包括在血管内以折叠状态递送可移除的过滤器，并将该过滤器展开至血管内的扩张状态。过滤器包括多个主支柱和从轮毂发出并沿着纵向轴线弧形延伸并且线性地径向延伸的多个辅助支柱。每个主支柱具有包括第一和第二弯曲部分的弓形段。每个辅助支柱包括第一和第二弧。主支柱终止于锚钩。每个主支柱在收缩状态下沿着纵向轴线跨越另一个主支柱，使得弓形段占据第一直径，并且锚定钩占据第二直径，第一直径大于用于过滤器取出或输送的第二直径。在扩张状态下，副支柱将过滤器集中在血管中，并且锚钩与血管接合。

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