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81. 发明授权

US07988294B2 Tear film measurement 有权
标题翻译：撕裂膜测量
公开(公告)号：US07988294B2
公开(公告)日：2011-08-02
申请号：US12633057
申请日：2009-12-08
申请人： Donald R. Korb , Benjamin T. Gravely
发明人： Donald R. Korb , Benjamin T. Gravely
IPC分类号： A61B3/10
CPC分类号： G01B11/0675 , A61B3/101
摘要： The invention comprises an apparatus for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking is disclosed. An illuminator directs light to the lipid layer of a patient's eye. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. A collector collects and focuses the specularly reflected light such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer. In order to facilitate ease of measurement, the patient's head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the patient's eye.
摘要翻译：本发明包括一种用于测量在眨眼之后脂质层分布之后眼前表面上的预角膜撕裂膜的脂质层组分的相对厚度的装置。照明器将光引导到患者眼睛的脂质层。照明器是覆盖可见光区域的广谱光源，是一个薄片光发射器，使得光源从脂质层镜面反射并在脂质层中发生建设性和破坏性干扰。收集器收集并聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。收集器还产生表示镜面反射光的输出信号，其适用于进一步分析，例如投影到高分辨率视频监视器上，或由计算机分析或存储在计算机中。为了便于测量，当照明器将光引导到患者眼睛的脂质层时，患者的头部可以位于观察平台上。

82. 发明授权

US07981147B2 Outer eyelid heat and pressure treatment for treating meibomian gland dysfunction 有权
标题翻译：外眼睑热压治疗睑板腺功能障碍
公开(公告)号：US07981147B2
公开(公告)日：2011-07-19
申请号：US12015576
申请日：2008-01-17
申请人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
发明人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
IPC分类号： A61M35/00 , A61F7/02 , A61F7/08
CPC分类号： A61F7/12 , A61B18/12 , A61B2017/00084 , A61B2018/046 , A61B2018/048 , A61F7/007 , A61F9/00718 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61K31/65 , A61K38/1841 , A61N7/00
摘要： A method of treating meibomian gland dysfunction. Heat is applied to the outside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force may also be applied to the outside of the patient's eyelid to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions or occlusions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands while reducing the amount of time to reach desired temperature levels and/or aid in reducing discomfort to the patient during treatment.
摘要翻译：治疗睑板腺功能障碍的方法。将热量施加到眼睑的外侧，以向睑板腺提供导电热传递。热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。也可以将力施加到患者眼睑的外侧，以改善导电传热并减少引起对流热损失的眼睑中的血流。因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物或闭塞的时间。达到增加的温度水平可以改善睑板腺中的阻塞物或闭塞的熔化，松动或软化，同时减少达到期望温度水平的时间量和/或有助于减轻治疗期间对患者的不适。

83. 发明授权

US07981145B2 Treatment of meibomian glands 有权
标题翻译：治疗睑板腺
公开(公告)号：US07981145B2
公开(公告)日：2011-07-19
申请号：US11541418
申请日：2006-09-29
申请人： Donald R. Korb , Timothy R. Willis , Stephen M. Grenon
发明人： Donald R. Korb , Timothy R. Willis , Stephen M. Grenon
IPC分类号： A61M35/00 , A61F7/02 , A61F7/08
CPC分类号： A61B17/22004 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61F7/02 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N7/00
摘要： In one embodiment consistent with the present invention a method of treating mammalian meibomian glands involves clearing the glands by applying a regulated heat to an eyelid containing the meibomian glands to a temperature adequate to melt obstructions in the meibomian glands to put the obstructions in a fluid or suspension (melted) state and maintaining the heat for a time period adequate to melt the obstructions. The glands can then be mechanically treated to express fluid from the glands, wherein the treating is carried out either during the time period or after the time period but while the obstruction remains in a fluid state. Subsequent pharmacological treatment of the glands by use a pharmacological agent (topical or systemic) can then be used to assist in maintaining proper flow of lipids from the glands. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.
摘要翻译：在与本发明一致的一个实施方案中，治疗哺乳动物睑板腺的方法涉及通过将含有睑板腺的眼睑施加调节的热量至足以融化睑板腺中的阻塞物以将阻塞物置于流体中的方式来清除腺体，或悬浮（熔化）状态并将热量保持足够的时间以融化障碍物。然后可以对腺体进行机械处理以从腺体表达流体，其中治疗在时间段期间或在时间段之后进行，但是当阻塞物保持在流体状态时。然后通过使用药物（局部或全身）对腺体进行的后续药理学治疗可用于帮助保持来自腺体的适当的脂质流动。该摘要不被认为是限制性的，因为其他实施例可能偏离本摘要中描述的特征。

84. 发明申请

US20100256552A1 METHOD AND APPARATUS FOR TREATING MEIBOMIAN GLAND DYSFUNCTION 有权
标题翻译：用于治疗脑血管性功能障碍的方法和装置
公开(公告)号：US20100256552A1
公开(公告)日：2010-10-07
申请号：US12821183
申请日：2010-06-23
申请人： Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
发明人： Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
IPC分类号： A61F7/00
CPC分类号： A61N5/0625 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N1/403 , A61N5/025 , A61N7/00 , A61N2005/0643 , A61N2005/0659 , A61N2005/067
摘要： A method and apparatus for treating gland dysfunction caused by gland obstruction in order to restore the natural flow of secretion from the gland comprises the application of a combination of energy, suction, vibration, heat, aspiration, chemical agents and pharmacological agents to loosen and thereafter remove the obstructive material.
摘要翻译：用于治疗由腺体阻塞引起的腺体功能障碍以便恢复从腺体分泌的天然流动的方法和装置包括施加能量，吸力，振动，热，吸入，化学药剂和药理学物质的组合以松动其后清除阻塞物。

85. 发明申请

US20100085540A1 TEAR FILM MEASUREMENT 有权
标题翻译：眼膜测量
公开(公告)号：US20100085540A1
公开(公告)日：2010-04-08
申请号：US12633057
申请日：2009-12-08
申请人： Donald R. Korb , Benjamin T. Gravely
发明人： Donald R. Korb , Benjamin T. Gravely
IPC分类号： A61B3/10
CPC分类号： G01B11/0675 , A61B3/101
摘要： The invention comprises an apparatus for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking is disclosed. An illuminator directs light to the lipid layer of a patient's eye. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. A collector collects and focuses the specularly reflected light such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer. In order to facilitate ease of measurement, the patient's head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the patient's eye.
摘要翻译：本发明包括一种用于测量在眨眼之后脂质层分布之后眼前表面上的预角膜撕裂膜的脂质层组分的相对厚度的装置。照明器将光引导到患者眼睛的脂质层。照明器是覆盖可见光区域的广谱光源，是一个薄片光发射器，使得光源从脂质层镜面反射并在脂质层中发生建设性和相消干涉。收集器收集并聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。收集器还产生代表镜面反射光的输出信号，其适用于进一步分析，例如投影到高分辨率视频监视器上，或由计算机分析或存储在计算机中。为了便于测量，当照明器将光引导到患者眼睛的脂质层时，患者的头部可以位于观察平台上。

86. 发明申请

US20080319323A1 Tear film measurement 有权
标题翻译：撕裂膜测量
公开(公告)号：US20080319323A1
公开(公告)日：2008-12-25
申请号：US11900314
申请日：2007-09-11
申请人： Benjamin T. Gravely , Donald R. Korb
发明人： Benjamin T. Gravely , Donald R. Korb
IPC分类号： A61B6/00
CPC分类号： A61B3/101
摘要： The invention comprises a method for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking. Light is directed to the lipid layer of a patient's eye with an illuminator. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. The specularly reflected light is collected and focused using a collector such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer. In order to facilitate ease of measurement, the patient's head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the patient's eye.
摘要翻译：本发明包括一种用于在眨眼之后脂质层分布后测量眼表面上的眼前膜泪膜的脂质层组分的相对厚度的方法。光照射器被引导到患者眼睛的脂质层。照明器是覆盖可见光区域的广谱光源，是一个薄片光发射器，使得光源从脂质层镜面反射并在脂质层中发生建设性和破坏性干扰。使用收集器收集和聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。收集器还产生表示镜面反射光的输出信号，其适用于进一步分析，例如投影到高分辨率视频监视器上，或由计算机分析或存储在计算机中。为了便于测量，当照明器将光引导到患者眼睛的脂质层时，患者的头部可以位于观察平台上。

87. 发明授权

US5942558A Hydrogel lens pre-coated with lipid layer 失效
标题翻译：水凝胶镜片预先涂上脂质层
公开(公告)号：US5942558A
公开(公告)日：1999-08-24
申请号：US942244
申请日：1997-10-01
申请人： Donald R. Korb
发明人： Donald R. Korb
IPC分类号： G02C7/04 , B29D11/00 , B65D85/34 , C08J7/04 , G02B1/04 , G02B1/10 , G02C13/00
CPC分类号： G02B1/043 , Y10S524/916
摘要： A storage solution for a hydrogel contact lens comprising a material having polar groups at one end and non-polar groups at the other end. The storage solution desirably further contains an oil. The material comprising polar and non-polar groups modifies the surface properties of the lens and facilitating the formation of a lipid layer over the lens.
摘要翻译：一种用于水凝胶隐形眼镜的储存溶液，其包含在一端具有极性基团的材料，另一端具有非极性基团。储存溶液理想地还含有油。包含极性和非极性基团的材料改变了晶状体的表面性质并且有助于在晶状体上形成脂质层。

88. 发明授权

US5738856A Skin care preparation and method 失效
标题翻译：皮肤护理准备和方法
公开(公告)号：US5738856A
公开(公告)日：1998-04-14
申请号：US552426
申请日：1995-11-03
申请人： Donald R. Korb , Thomas Glonek , Jack V. Greiner
发明人： Donald R. Korb , Thomas Glonek , Jack V. Greiner
IPC分类号： A61K9/06 , A61K8/37 , A61K8/55 , A61K9/08 , A61K9/107 , A61K9/12 , A61K31/23 , A61K31/661 , A61K47/44 , A61Q19/00 , A61K7/48
CPC分类号： A61Q19/00 , A61K8/375 , A61K8/553 , A61Q19/007 , Y10S514/844 , Y10S514/861 , Y10S514/863 , Y10S514/864 , Y10S514/937
摘要： A composition and method for treatment of skin. The composition comprises a pharmaceutically acceptable carrier containing a bilayer component having one or more polar terminus groups and one or more non-polar terminus groups separated from said polar terminus groups capable of penetrating the outer surface of the skin to form an aligned bilayer within the stratum corneum. The bilayer assists in the formation of bilayer lamellae that is believed to replicate the bilayer lamellae present in healthy skin. The composition is topically applied to the skin as often as is required.
摘要翻译：用于治疗皮肤的组合物和方法。该组合物包含药学上可接受的载体，其含有具有一个或多个极性末端基团和一个或多个非极性末端基团的双层组分，所述非极性末端基团能从所述极性末端基团分离，所述极性末端基团能够穿透皮肤的外表面，以在层内形成排列的双层角质层双层帮助形成双层薄片，据信它可以复制存在于健康皮肤中的双层薄片。该组合物经常按需要局部施用于皮肤。

89. 发明授权

US5578586A Dry eye treatment process and solution 失效
标题翻译：干眼治疗过程和解决方案
公开(公告)号：US5578586A
公开(公告)日：1996-11-26
申请号：US192051
申请日：1994-02-04
申请人： Thomas Glonek , Jack V. Greiner , Donald R. Korb
发明人： Thomas Glonek , Jack V. Greiner , Donald R. Korb
IPC分类号： A61K20060101 , A61K9/00 , A61K31/685 , A61K31/20 , A61K31/66
CPC分类号： A61K9/0048 , A61K31/685 , Y10S514/912
摘要： A method and composition for reducing evaporation of an aqueous layer from the surface of the eye. The method comprises applying an admixture of a charged phospholipid and a non-polar oil over the eye, preferably in the form of a meta-stable oil in water emulsion in a dosage not exceeding 100 microliters.
摘要翻译：一种用于减少水层从眼表的蒸发的方法和组合物。该方法包括在眼睛上施用带电荷的磷脂和非极性油的混合物，优选以不超过100微升的剂量的元稳定的水包油乳液的形式。

90. 发明授权

US5371108A Dry eye treatment process and solution 失效
标题翻译：干眼治疗过程和解决方案
公开(公告)号：US5371108A
公开(公告)日：1994-12-06
申请号：US31645
申请日：1993-03-15
申请人： Donald R. Korb , Thomas Glonek
发明人： Donald R. Korb , Thomas Glonek
IPC分类号： A61F9/007 , A61K9/00 , A61K9/107 , A61K31/23 , A61K35/06 , A61P27/02 , A61P43/00 , A61K31/01 , A61K47/00
CPC分类号： A61K9/0048 , Y10S514/912
摘要： A method and composition for reducing evaporation of an aqueous layer from the surface of the eye. The method comprises applying a gel of oil and wax over the eye, preferably in the form of a meta-stable oil in water emulsion in a dosage not exceeding 100 microliters. The gel is formed by gelling a hydrocarbon oil with a wax, preferably dispersed in aqueous medium at a pH of at least about 8.0.
摘要翻译：一种用于减少水层从眼表的蒸发的方法和组合物。该方法包括在眼睛上施用油和蜡的凝胶，优选以不超过100微升的剂量的元稳定的水包油乳液形式。凝胶通过用蜡凝胶化烃油而形成，优选在至少约8.0的pH下分散在水性介质中。

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