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81. 发明授权

US5796972A Method and apparatus for performing microcode paging during instruction execution in an instruction processor 失效
标题翻译：在指令处理器中的指令执行期间执行微代码寻呼的方法和装置
公开(公告)号：US5796972A
公开(公告)日：1998-08-18
申请号：US783614
申请日：1997-01-14
申请人： David C. Johnson , Douglas A. Fuller , Kenneth L. Engelbrecht , Gregory A. Marlan , Ronald G. Arnold , Gerald G. Fagerness
发明人： David C. Johnson , Douglas A. Fuller , Kenneth L. Engelbrecht , Gregory A. Marlan , Ronald G. Arnold , Gerald G. Fagerness
IPC分类号： G06F9/24 , G06F9/26 , G06F9/318 , G06F9/445
CPC分类号： G06F9/328 , G06F8/66 , G06F9/24 , G06F9/268 , G06F9/30145
摘要： Method and apparatus for performing microcode paging during instruction execution in an instruction processor. In a preferred embodiment an instruction processor is provided that includes both a microcode ROM and a microcode RAM. The microcode ROM stores the current release of the microcode for the computer system, and the microcode RAM stores microcode patch instructions. During instruction execution, the present invention selects between the output of the microcode ROM and the microcode RAM, depending on whether the instruction requires a patch microcode instruction. If the desired microcode patch instruction is not stored in the microcode RAM, the instruction processor is temporarily interrupted and the desired microcode patch instruction or a group of microcode patch instructions are written, or paged, into the microcode RAM.
摘要翻译：在指令处理器中的指令执行期间执行微代码寻呼的方法和装置。在优选实施例中，提供了包括微码ROM和微代码RAM的指令处理器。微代码ROM存储用于计算机系统的微代码的当前版本，并且微代码RAM存储微代码补丁指令。在指令执行期间，本发明根据指令是否需要补丁微代码指令，在微代码ROM的输出和微代码RAM之间进行选择。如果期望的微代码补丁指令未被存储在微代码RAM中，则指令处理器被暂时中断，并且将期望的微代码补丁指令或一组微代码补丁指令写入或分页到微代码RAM中。

82. 发明授权

US5750398A Vector, element and method for inhibiting immune recognition 失效
标题翻译：用于抑制免疫识别的载体，元件和方法
公开(公告)号：US5750398A
公开(公告)日：1998-05-12
申请号：US159890
申请日：1993-11-30
申请人： David C. Johnson , Ian A. York
发明人： David C. Johnson , Ian A. York
IPC分类号： G01N33/569 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/16 , A61K39/395 , A61K48/00 , A61P3/08 , A61P25/00 , A61P27/02 , A61P29/00 , A61P31/12 , A61P37/00 , A61P37/06 , C07H21/04 , C07K14/035 , C07K16/08 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/38 , C12P21/02 , C12R1/92 , G01N33/15 , G01N33/50 , C12N15/85 , C12N15/86
CPC分类号： G01N33/505 , A61K38/162 , C07K14/005 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/5088 , A61K48/00 , C12N2710/16622 , G01N2333/035
摘要： This invention relates to the use of Herpes Simplex Virus (HSV) immediate early protein ICP47, nucleic acid sequences coding for ICP47, and homologous proteins and nucleic acid sequences, to inhibit presentation of viral and cellular antigens associated with major histocompatibility class I (MHC class I) proteins to CD8+ T lymphocytes; this inhibition effectively increases infective persistence, which can, for example, improve the utility of viral gene therapy vectors. This invention also pertains to a method for the treatment of herpesvirus infections, wherein expression and/or activity of the ICP47 protein or its homologue is inhibited in order to increase immune recognition of herpesvirus-infected cells and other cells. This invention also pertains to a method for identifying drugs that interfere with the expression or function of ICP47 and its homologues, and which are useful in treating herpesvirus infections, and also pertains to the drugs so identified. Furthermore, this invention pertains to methods for the treatment and prevention of autoimmune diseases, tissue and organ transplant rejection, diabetes, multiple sclerosis, arthritis, and tissue damage accompanying ocular herpesvirus infections, wherein ICP47 or its homologue, or nucleic acids encoding such proteins, are introduced into the cells of a patient. In addition, this invention pertains to vector elements, vectors, polypeptides and polypeptide fragments that can be utilized for the forgoing purposes.
摘要翻译：本发明涉及单纯疱疹病毒（HSV）立即早期蛋白ICP47，编码ICP47的核酸序列和同源蛋白质和核酸序列的用途，以抑制与主要组织相容性I类（MHC类别）相关的病毒和细胞抗原的呈递 I）蛋白对CD8 + T淋巴细胞; 这种抑制有效地增加感染持续性，其可以例如改善病毒基因治疗载体的效用。本发明还涉及治疗疱疹病毒感染的方法，其中抑制ICP47蛋白或其同系物的表达和/或活性以增加疱疹病毒感染的细胞和其他细胞的免疫识别。本发明还涉及用于鉴定干扰ICP47及其同源物的表达或功能的药物的方法，其可用于治疗疱疹病毒感染，并且还涉及所鉴定的药物。此外，本发明涉及治疗和预防伴随眼疱疹病毒感染的自身免疫疾病，组织和器官移植排斥，糖尿病，多发性硬化，关节炎和组织损伤的方法，其中ICP47或其同源物或编码这种蛋白质的核酸，被引入患者的细胞中。此外，本发明涉及可用于前述目的的载体元件，载体，多肽和多肽片段。

83. 发明授权

US5602998A Dequeue instruction in a system architecture for improved message passing and process synchronization 失效
标题翻译：系统架构中的出队指令，用于改进消息传递和进程同步
公开(公告)号：US5602998A
公开(公告)日：1997-02-11
申请号：US362638
申请日：1994-12-22
申请人： Merwin H. Alferness , Charles R. Caldarale , David C. Johnson , David R. Johnson , James R. McBreen , Wayne D. Ward
发明人： Merwin H. Alferness , Charles R. Caldarale , David C. Johnson , David R. Johnson , James R. McBreen , Wayne D. Ward
IPC分类号： G06F9/46
CPC分类号： G06F9/544 , G06F9/546
摘要： A system and method for removing a queue entry containing message data from a queue shared by communicating, sequential processes includes dequeue (DEQ) and dequeue or wait (DEQW) instructions. The dequeue instruction removes a queue entry from the head of the shared queue, thereby providing access to the message data contained in the queue entry to the dequeuing process. The dequeue or wait instruction removes a queue entry from the shared queue if there is one, otherwise it suspends the execution of the dequeuing process until an entry is enqueued to the queue. If an event is selected by the dequeuing process, the dequeuing process is suspended until notification of the event is detected in the shared queue. Execution of the dequeue and dequeue or wait instructions include blocking access to the queue by other processes, updating queue linkages, deactivating processes waiting on entries or events being made to the queue, monitoring interrupts, and validating the appropriate queue data structures.
摘要翻译：用于从通过通信的顺序进程共享的队列中去除包含消息数据的队列条目的系统和方法包括出队（DEQ）和出队或等待（DEQW）指令。出队指令从共享队列的头部移除队列条目，从而提供对包含在队列进入出队进程的消息数据的访问。如果有一个，出队或等待指令将从共享队列中移除一个队列条目，否则将暂停执行出队进程，直到一个条目排入队列。如果由出队进程选择了一个事件，则在共享队列中检测到事件的通知之前暂停出队进程。执行出队和出队或等待指令包括阻止其他进程对队列的访问，更新队列链接，停用等待队列进入的进程，监视中断和验证适当的队列数据结构。

84. 发明授权

US5486771A Burn-in socket testing apparatus 失效
标题翻译：老化插座测试仪
公开(公告)号：US5486771A
公开(公告)日：1996-01-23
申请号：US363559
申请日：1994-12-23
申请人： Keith L. Volz , Robert M. Renn , Robert D. Irlbeck , Frederick R. Deak , David C. Johnson
发明人： Keith L. Volz , Robert M. Renn , Robert D. Irlbeck , Frederick R. Deak , David C. Johnson
IPC分类号： G01R31/26 , G01R1/04 , H01R33/76 , H01R33/97 , H05K7/10 , G01R31/02 , H05K1/02
CPC分类号： H05K7/1023 , G01R1/0433
摘要： This invention is directed to a mechanical, robotically operated burn-in socket testing apparatus for integrated circuit "chips", where such chips, as known in the art, are typically planar electronic devices. The apparatus, operationally mounted to a planar electronic board, such as a mother board, comprises a first frame member for mounting to the mother board, where the first frame member includes electrical means for engaging chip leads and applying electrical current thereto during the burn-in testing. A second frame member is disposed in sliding engagement with the first frame member, where the second frame member is movable from a first position to a second position. Finally, cooperative latching and camming means are provided between the first and second frame members to effect the movement between the first and second positions, and to securely hold the chip during burn-in, where the camming means includes a pivotal member movable from a remote position free of the chip to a position engaging the chip.
摘要翻译：本发明涉及用于集成电路“芯片”的机械式机器人操作的老化插座测试装置，其中如本领域已知的这样的芯片通常是平面电子器件。该装置可操作地安装在诸如母板的平面电子板上，包括用于安装到母板的第一框架构件，其中第一框架构件包括用于接合芯片引线并在燃烧期间向其施加电流的电气装置，在测试。第二框架构件设置成与第一框架构件滑动接合，其中第二框架构件可从第一位置移动到第二位置。最后，协作锁定和凸轮装置设置在第一和第二框架构件之间以实现第一和第二位置之间的移动，并且在老化期间牢固地保持芯片，其中凸轮装置包括可从远程位置没有芯片到与芯片接合的位置。

85. 发明授权

US5302853A Land grid array package 失效
标题翻译：土地格栅阵列封装
公开(公告)号：US5302853A
公开(公告)日：1994-04-12
申请号：US7932
申请日：1993-01-25
申请人： Keith L. Volz , Robert M. Renn , Frederick R. Deak , David C. Johnson , Warren A. Bates , Robert D. Irlbeck
发明人： Keith L. Volz , Robert M. Renn , Frederick R. Deak , David C. Johnson , Warren A. Bates , Robert D. Irlbeck
IPC分类号： H01L23/34 , H01L23/40 , H01L23/02 , H01L23/12 , H01L23/42 , H01L23/44
CPC分类号： H01L23/4093 , H01L2924/0002
摘要： A combination heat sink (18, 41, 43) and circuit interface comprises a metallic wafer (15) disposed between an integrated circuit (11) and a printed circuit board (14) in a land grid array package (10). A frame (13) for the integrated circuit (11) is nested within the heat sink (18, 41, 43) and a latch (30) is pivotably mounted on the frame (13) for retaining the overall package (10). The circuit interface comprises a plurality of flexible electrical connectors (19) mounted on the wafer (15).
摘要翻译：组合散热器（18,41,43）和电路接口包括金属晶片（15），其设置在焊盘栅格阵列封装（10）中的集成电路（11）和印刷电路板（14）之间。用于集成电路（11）的框架（13）嵌套在散热器（18,41,43）内，并且闩锁（30）可枢转地安装在框架（13）上，用于保持整个封装（10）。电路接口包括安装在晶片（15）上的多个柔性电连接器（19）。

86. 发明授权

US5198043A Making amorphous and crystalline alloys by solid state interdiffusion 失效
标题翻译：通过固态相互扩散制备无定形和结晶合金
公开(公告)号：US5198043A
公开(公告)日：1993-03-30
申请号：US734186
申请日：1991-07-22
申请人： David C. Johnson
发明人： David C. Johnson
IPC分类号： C22C1/00
CPC分类号： C22C1/00
摘要： Methods for synthesizing solid-state crystalline alloys and products made therefrom are disclosed. Plural repeat units, each comprising an ordered sequence of superposed layers of preselected solid-state reactants, are formed superposedly on a surface of a solid substrate to form a modulated composite of the reactants. The layers comprising a repeat unit are controllably formed to have relative thicknesses corresponding to the stoichiometry of a preselected solid compound found on a phase diagram of the reactants. Each repeat unit also has a repeat-unit thickness no greater than a critical thickness for a diffusion couple of the reactants, where the repeat-unit thickness is preferably less than or equal to about 100 .ANG.. The modulated composite is then heated to an interdiffusion temperature lower than a nucleation temperature for the reactants for a time sufficient to form an amorphous alloy of the reactants having a stoichiometry corresponding to the preselected solid compound. The amorphous alloy is then heated to a nucleation temperature to initiate crystallization of the alloy. The methods described herein allow control of the outcome of a solid-state synthesis pathway in part by controlling which intermediate(s) are formed.
摘要翻译：公开了用于合成固态结晶合金和由其制成的产品的方法。在固体基材的表面上叠加地形成多个重复单元，每个重复单元包含预选的固态反应物的叠层的有序序列，以形成反应物的调制复合物。包含重复单元的层可控制地形成为具有对应于在反应物的相图上发现的预选的固体化合物的化学计量的相对厚度。每个重复单元还具有不大于反应物的扩散偶的临界厚度的重复单元厚度，其中重复单元厚度优选小于或等于约100埃。然后将调制的复合物加热到低于反应物的成核温度的相互扩散温度足以形成具有对应于预选固体化合物的化学计量的反应物的非晶态合金的时间。然后将非晶合金加热至成核温度以引发合金的结晶。本文描述的方法允许部分地通过控制形成中间体来控制固态合成途径的结果。

87. 发明授权

US4222820A Paper sizing agents 失效
标题翻译：造纸剂
公开(公告)号：US4222820A
公开(公告)日：1980-09-16
申请号：US917629
申请日：1978-06-21
申请人： Ian R. Hiskens , David C. Johnson , Michael J. Caudwell
发明人： Ian R. Hiskens , David C. Johnson , Michael J. Caudwell
IPC分类号： D21H17/34 , C08C19/28 , D21H17/14 , D21H17/16 , D21H19/10 , D21H3/08
CPC分类号： C08C19/28 , D21H17/16
摘要： A sizing agent for use in paper-making comprises an aqueous emulsion of at least one compound of the formulae ##STR1## wherein each R.sup.1 represents a hydrophobic group selected from alkyl, alkenyl, aralkyl or aralkenyl groups, where the R.sup.1 groups in either formula may be the same or different and together they contain from 25 to 60 carbon atoms. The sizing agent can be used for either internal or surface sizing, and is effective in the absence of, or in the presence of, a retention aid.
摘要翻译：用于造纸的施胶剂包括至少一种式（I）或图像化合物的水乳液，其中每个R 1表示选自烷基，链烯基，芳烷基或芳烯基的疏水基团，其中R 1基团在任一式中，它们可以相同或不同，一起含有25至60个碳原子。上浆剂可用于内部或表面施胶，并且在保留助剂不存在或存在的情况下是有效的。

88. 发明授权

US4102645A Sterilization apparatus 失效
标题翻译：灭菌装置
公开(公告)号：US4102645A
公开(公告)日：1978-07-25
申请号：US699026
申请日：1976-06-23
申请人： Thomas E. Meacham, Jr. , David C. Johnson
发明人： Thomas E. Meacham, Jr. , David C. Johnson
IPC分类号： A61L2/10 , C02F1/32 , A61L3/00
CPC分类号： C02F1/325 , A61L2/10 , C02F2201/3221
摘要： Liquid flowing through a housing is sterilized by being subjected to radiation which passes through a window transparent to ultraviolet rays. The liquid is prevented from contacting the window by an air pocket. The air in the pocket is maintained by introducing air into the liquid which either replenishes air absorbed from the pocket by the liquid at the air-water interface or prevents the liquid from absorbing air from said pocket.
摘要翻译：流过壳体的液体经受通过透明紫外线的窗口的辐射而灭菌。防止液体通过气穴与窗口接触。通过将空气引入到液体中来维持口袋中的空气，其中通过液体在空气 - 水界面补充从口袋吸收的空气，或者防止液体从所述口袋吸收空气。

89. 发明授权

US08706226B2 System and method for managing locally-initiated medical device interrogation 有权
标题翻译：用于管理本地发起的医疗设备询问的系统和方法
公开(公告)号：US08706226B2
公开(公告)日：2014-04-22
申请号：US12882747
申请日：2010-09-15
申请人： David C. Johnson , Howard D. Simms , Kenneth P. Hoyme , Muralidharan Srivathsa , Benjamin L. Somberg
发明人： David C. Johnson , Howard D. Simms , Kenneth P. Hoyme , Muralidharan Srivathsa , Benjamin L. Somberg
IPC分类号： A61N1/08
CPC分类号： G06Q50/24 , G06F19/00 , G16H50/70
摘要： A system and method for managing locally-initiated medical device interrogation is presented. An interface is provided over which to retrieve patient data recorded and transiently staged by a medical device monitoring physiological measures of a patient. The patient data is periodically retrieved by interfacing to and interrogating the medical device per a pre-defined schedule through the interface. Further retrieval of the patient data is permitted independent of the pre-defined schedule. The system stores remotely-specifiable criteria specified by a caregiver and controls patient-initiated patient data retrieval in accordance with the criteria.
摘要翻译：提出了一种用于管理本地发起的医疗设备询问的系统和方法。提供了一种接口，用于检测由监测患者的生理测量的医疗设备记录并暂时分期的患者数据。通过接口通过每个预定义的计划接口并询问医疗设备来周期性地检索患者数据。允许进一步检索患者数据，独立于预定义的时间表。系统存储由护理人员指定的可远程指定的标准，并根据标准控制患者发起的患者数据检索。

90. 发明授权

US08395498B2 Wireless patient communicator employing security information management 有权
公开(公告)号：US08395498B2
公开(公告)日：2013-03-12
申请号：US12151910
申请日：2008-05-09
申请人： Robert Gaskill , Mark Gryzwa , John LaLonde , Kenneth Hoyme , William Mass , David C. Johnson , Mike Barton
发明人： Robert Gaskill , Mark Gryzwa , John LaLonde , Kenneth Hoyme , William Mass , David C. Johnson , Mike Barton
IPC分类号： G08B1/08
CPC分类号： G08B21/02 , A61B5/0026 , A61B5/0452 , A61B5/747 , A61N1/37211 , A61N1/37282 , G06F19/00 , G06F19/3418 , G06Q50/24 , G08C17/02 , G16H40/20 , G16H40/40 , H04L67/12 , H04W12/04 , H04W12/06
摘要： A portable patient communicator (PPC) includes a portable housing supporting a processor, memory for storing medical and wireless radio firmware, first and second radios, a processor, an identity module, and a power source. The PPC and a patient implantable medical device (PIMD) communicate via the first radio in accordance with the medical firmware. The PPC communicates with a wireless network via the second radio in accordance with the wireless radio firmware. Data stored in the identity module is used to authenticate the PPC by the remote server prior to permitting PPC access to the remote server, and may also be used to authenticate the remote server by the PPC prior to permitting access to the PPC or the PIMD by the remote server or other device communicatively coupled to the wireless network, after which PIMD and other medical data is exchanged between the PPC and remote server.

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