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81. 发明申请

US20080233134A1 Antibodies That Specifically Bind to Chemokine Beta-4 失效
标题翻译：特异性结合趋化因子β-4的抗体
公开(公告)号：US20080233134A1
公开(公告)日：2008-09-25
申请号：US12123419
申请日：2008-05-19
申请人： Craig A. Rosen , Steven M. Ruben
发明人： Craig A. Rosen , Steven M. Ruben
IPC分类号： A61K39/395 , C07K16/18 , G01N33/566 , A61P37/00 , C07H21/00
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies and related molecules that specifically bind to CK-B4. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease. The invention also relates to nucleic acid molecules encoding anti-CK-B4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to CK-B4.
摘要翻译：本发明涉及特异性结合CK-B4的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症以及包括癌症的免疫系统疾病和病症，以及免疫系统疾病和病症，包括自身免疫性疾病，炎症性疾病，免疫缺陷，感染，HIV，关节炎，过敏，牛皮癣，皮炎和炎性肠病。本发明还涉及编码抗CK-B4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症以及免疫系统疾病和病症的方法和组合物，包括自身免疫性疾病，炎症性疾病，免疫缺陷，感染，HIV，关节炎，过敏牛皮癣，皮炎和炎性肠病，包括向动物，优选人类施用有效量的与CK-B4特异性结合的一种或多种抗体或其片段或变体或相关分子。

82. 发明申请

US20080167240A1 Albumin Fusion Proteins 审中-公开
标题翻译：白蛋白融合蛋白
公开(公告)号：US20080167240A1
公开(公告)日：2008-07-10
申请号：US11929953
申请日：2007-10-30
申请人： Craig A. Rosen , William A. Haseltine , David J. Ballance , Andrew J. Turner , Steven M. Ruben
发明人： Craig A. Rosen , William A. Haseltine , David J. Ballance , Andrew J. Turner , Steven M. Ruben
IPC分类号： A61K38/00 , C07K16/00 , C07H21/04 , C12N5/00 , A61P43/00 , C12N5/04 , C12P21/04
CPC分类号： C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

83. 发明申请

US20080167239A1 Albumin Fusion Proteins 有权
公开(公告)号：US20080167239A1
公开(公告)日：2008-07-10
申请号：US11929939
申请日：2007-10-30
申请人： Craig A. Rosen , William A. Haseltine , David J. Ballance , Andrew J. Turner , Steven M. Ruben
发明人： Craig A. Rosen , William A. Haseltine , David J. Ballance , Andrew J. Turner , Steven M. Ruben
IPC分类号： A61K38/00 , C07K16/00 , C07H21/04 , C12N5/00 , A61P43/00 , C12N5/02 , C12P21/04
CPC分类号： C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

84. 发明授权

US07393650B2 Method of producing an antibody to G-protein parathyroid hormone receptor HLTDG74 失效
标题翻译：产生G蛋白甲状旁腺激素受体HLTDG74抗体的方法
公开(公告)号：US07393650B2
公开(公告)日：2008-07-01
申请号：US10921218
申请日：2004-08-19
申请人： Daniel R. Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
发明人： Daniel R. Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
IPC分类号： G01N33/53 , C07K16/28 , C07K14/72
CPC分类号： C07K14/723 , A61K48/00 , C12N2799/026
摘要： Human G-protein parathyroid hormone (PTH) receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the PTH receptor receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the PTH receptor receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host. Disclosed embodiments of the invention also include antibodies that bind Human G-Protein parathyroid hormone (PTH) receptor polypeptides and methods for making and using such antibodies.
摘要翻译：公开了人类G蛋白甲状旁腺激素（PTH）受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及在治疗上使用激动剂和拮抗剂治疗与PTH受体受体多肽的低表达和过表达相关的病症的方法。还公开了用于检测PTH受体受体核酸序列中的突变并检测衍生自宿主的样品中受体的可溶形式水平的诊断方法。本发明的公开的实施方案还包括结合人类G蛋白甲状旁腺激素（PTH）受体多肽的抗体以及制备和使用这些抗体的方法。

85. 发明授权

US07320869B2 Antibodies to Chemokine Alpha-5 失效
标题翻译：趋化因子α-5抗体
公开(公告)号：US07320869B2
公开(公告)日：2008-01-22
申请号：US11224076
申请日：2005-09-13
申请人： Ying-Fei Wei , Yi Li , Jian Ni , Craig A. Rosen , Steven M. Ruben
发明人： Ying-Fei Wei , Yi Li , Jian Ni , Craig A. Rosen , Steven M. Ruben
IPC分类号： G01N33/53 , C12N5/12 , C07K16/24
CPC分类号： C07K14/521 , A61K38/00 , C07K14/522 , C07K2319/00 , C12N2799/026 , Y02A50/423 , Y10T436/143333
摘要： The present invention relates to a novel CKα-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-5 protein. CKα-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CKα-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CKα-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及作为α趋化因子家族成员的新型CKalpha-5蛋白。特别地，提供编码人CKalpha-5蛋白的分离的核酸分子。还提供了CKalpha-5多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。还公开了特异性结合CKalpha-5多肽的抗体及其片段，以及制备此类抗体的组合物和方法。本发明还涉及鉴定CKalpha-5活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

86. 发明授权

US07217529B2 Antibodies to chemokine Alpha-6 失效
标题翻译：趋化因子α-6抗体
公开(公告)号：US07217529B2
公开(公告)日：2007-05-15
申请号：US11081021
申请日：2005-03-16
申请人： Ying-Fei Wei , Steven M. Ruben , Craig A. Rosen
发明人： Ying-Fei Wei , Steven M. Ruben , Craig A. Rosen
IPC分类号： C07K16/24 , C12N5/12 , G01N33/53
CPC分类号： C07K16/24 , A61K38/00 , C07K14/522
摘要： The present invention relates to a novel CKα-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-6 protein. CKα-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CKα-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.
摘要翻译：本发明涉及作为α趋化因子家族成员的新型CKalpha-6蛋白。特别地，提供编码人CKalpha-6蛋白的分离的核酸分子。还提供了CKalpha-6多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及鉴定CKalpha-6活性的激动剂和拮抗剂的筛选方法。还提供了用于检测CNS和免疫系统相关疾病的诊断方法以及用于治疗CNS和免疫系统相关疾病的治疗方法。

87. 发明授权

US07091315B1 Protein HDPBQ71 失效
标题翻译：蛋白HDPBQ71
公开(公告)号：US07091315B1
公开(公告)日：2006-08-15
申请号：US10103295
申请日：2002-03-22
申请人： Steven M. Ruben , Craig A. Rosen , Henrik Olsen
发明人： Steven M. Ruben , Craig A. Rosen , Henrik Olsen
IPC分类号： A61K38/00 , A61K39/00 , C07K1/00 , C07K14/00 , C07K17/00 , C07H21/02 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/30
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

88. 发明授权

US07060261B2 Chemokine α-5 失效
公开(公告)号：US07060261B2
公开(公告)日：2006-06-13
申请号：US10114482
申请日：2002-04-03
申请人： Ying-Fei Wei , Yi Li , Jian Ni , Craig A. Rosen , Steven M. Ruben
发明人： Ying-Fei Wei , Yi Li , Jian Ni , Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K14/52 , C12N15/63 , C12N5/10 , A61K38/19
CPC分类号： C07K14/521 , A61K38/00 , C07K14/522 , C07K2319/00 , C12N2799/026 , Y02A50/423 , Y10T436/143333
摘要： The present invention relates to a novel CKα-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-5 protein. CKα-5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CKα-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

89. 发明授权

US07053190B2 Secreted protein HRGDF73 失效
公开(公告)号：US07053190B2
公开(公告)日：2006-05-30
申请号：US09981876
申请日：2001-10-19
申请人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Yanggu Shi
发明人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Yanggu Shi
IPC分类号： C07K16/28 , C07K14/705
CPC分类号： C07K16/28 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K14/4718 , C12N15/11 , G01N33/68
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

90. 发明授权

US07041460B2 Antibodies to monocyte-colony inhibitory factor (M-CIF) 失效
标题翻译：单核细胞集落抑制因子（M-CIF）的抗体
公开(公告)号：US07041460B2
公开(公告)日：2006-05-09
申请号：US10626530
申请日：2003-07-25
申请人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
发明人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
IPC分类号： C07K16/24 , C12N5/12 , G01N33/53
CPC分类号： G01N33/6863 , A61K38/00 , A61K48/00 , C07K1/113 , C07K1/36 , C07K14/50 , C07K14/521 , C07K14/523 , C07K16/24 , C07K2319/00 , C12N15/72 , C12N2799/026 , G01N2333/52
摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1 (CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
摘要翻译：公开了使用编码人骨髓祖细胞抑制因子-1（MPIF-1）多肽（以前称为MIP-3和趋化因子β8（CKbeta8或ckb-8））的分离的核酸分子的治疗组合物和方法。人单核细胞集落抑制因子（M-CIF）多肽（以前称为MIP1-γ和趋化因子β1（CKbeta1或ckb-1））和巨噬细胞抑制蛋白-4（MIP-4）以及MPIF-1 ，M-CIF和/或MIP-4多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。

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