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81. 发明申请

US20110182812A1 Imaging Agents for Detecting Neurological Disorders 有权
标题翻译：用于检测神经障碍的成像剂
公开(公告)号：US20110182812A1
公开(公告)日：2011-07-28
申请号：US13035405
申请日：2011-02-25
申请人： Anna Katrin Szardenings , Wei Zhang , Hartmuth C. Kolb , Daniel Kurt Cashion , Gang Chen , Dhanalakshmi Kasi , Changhui Liu , Anjana Sinha , Eric Wang , Chul Yu , Umesh B. Gangadharmath , Joseph C. Walsh
发明人： Anna Katrin Szardenings , Wei Zhang , Hartmuth C. Kolb , Daniel Kurt Cashion , Gang Chen , Dhanalakshmi Kasi , Changhui Liu , Anjana Sinha , Eric Wang , Chul Yu , Umesh B. Gangadharmath , Joseph C. Walsh
IPC分类号： A61K51/04 , C07D513/04 , C07D231/56 , C07D487/04 , C07D471/04 , C07D413/14 , C07D401/10 , C07D401/04 , A61K49/00 , A61P43/00 , A61P25/28
CPC分类号： C07D235/04 , A61K51/04 , C07B59/002 , C07D215/06 , C07D235/14 , C07D277/62 , C07D401/02 , C07D401/04 , C07D403/06 , C07D413/10 , C07D413/14 , C07D471/04 , C07D487/04
摘要： Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formulas (I)-(V) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.
摘要翻译：式（I） - （V）的成像剂和用于检测神经障碍的方法包括向需要的患者施用能够结合tau蛋白和＆amp;淀粉样蛋白肽的式（I） - （V）化合物。本发明还涉及成像A＆bgr的方法; 和tau聚集体，其包括引入可检测量的包含放射性标记的式（I） - （V）化合物的药物制剂，并检测患者中与淀粉样蛋白沉积物和/或tau蛋白相关的标记化合物。这些方法和组合使得临床前诊断和监测AD和其他神经障碍的进展。

82. 发明申请

US20110148324A1 METHODS AND SYSTEMS FOR LED DRIVER HAVING CONSTANT OUTPUT CURRENT 有权
标题翻译：具有恒定输出电流的LED驱动器的方法和系统
公开(公告)号：US20110148324A1
公开(公告)日：2011-06-23
申请号：US12698829
申请日：2010-02-02
申请人： Hongyue Du , Xinfeng Liu , Wei Zhang , Jiusheng Zhang , Hongbo Zhang
发明人： Hongyue Du , Xinfeng Liu , Wei Zhang , Jiusheng Zhang , Hongbo Zhang
IPC分类号： H05B41/36
CPC分类号： H05B33/0812 , Y02B20/345
摘要： A control circuit for a switched mode power supply includes a transconductance amplifier circuit for receiving a voltage signal related to a current from an input of the power supply and producing a first signal, an analog signal processor coupled to the amplifier circuit for receiving the first signal and a second signal from the input of the power supply and a third signal from an output of the power supply. The analog signal processor is configured to produce a fourth signal as a function of the first, the second, and the third signals. An adder circuit is coupled to the fourth signal and a dimmer control signal, and the adder circuit is configured to output a fifth signal. A comparator circuit is coupled to the adder circuit for providing a control signal to a power transistor that controls current flow in the power supply based on comparison of the fifth signal and a reference signal.
摘要翻译：用于开关模式电源的控制电路包括跨导放大器电路，用于从电源的输入端接收与电流相关的电压信号并产生第一信号;耦合到放大器电路的模拟信号处理器，用于接收第一信号以及来自电源的输入的第二信号和来自电源的输出的第三信号。模拟信号处理器被配置为产生作为第一信号，第二信号和第三信号的函数的第四信号。加法器电路耦合到第四信号和调光控制信号，并且加法器电路被配置为输出第五信号。比较器电路耦合到加法器电路，用于根据第五信号和参考信号的比较，向控制电源中的电流的功率晶体管提供控制信号。

83. 发明申请

US20110091382A1 NOVEL IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION 有权
标题翻译：用于检测神经功能障碍的新型成像剂
公开(公告)号：US20110091382A1
公开(公告)日：2011-04-21
申请号：US12372717
申请日：2009-02-17
申请人： Hartmuth C. Kolb , Joseph C. Walsh , Qianwa Liang , Brian A. Duclos , Wei Zhang , Peter J.H. Scott , Kai Chen , Zhiyong Gao , Tieming Zhao , Vani P. Mocharla , Dhanalakshmi Kasi , Gang Chen , Eric Wang , Anjana Sinha , Chunfang Xia , Henry Clifton Padgett , Farhad Karimi
发明人： Hartmuth C. Kolb , Joseph C. Walsh , Qianwa Liang , Brian A. Duclos , Wei Zhang , Peter J.H. Scott , Kai Chen , Zhiyong Gao , Tieming Zhao , Vani P. Mocharla , Dhanalakshmi Kasi , Gang Chen , Eric Wang , Anjana Sinha , Chunfang Xia , Henry Clifton Padgett , Farhad Karimi
IPC分类号： A61K51/04 , C07D209/82 , C07D311/20 , C07D403/12 , C07D405/12 , C07D471/04 , A61P25/28 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/18
CPC分类号： C07B59/002
摘要： Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.
摘要翻译：本文公开了在哺乳动物中诊断阿尔茨海默病或其倾向的化合物和方法，所述方法包括向哺乳动物施用诊断有效量的放射性标记的化合物，其中所述化合物选自放射性标记的黄酮，香豆素，咔唑，喹啉酮，色烯酮，咪唑和三唑衍生物，使化合物分布到脑组织中，并使脑组织成像，其中与正常对照结合水平相比，化合物与脑组织的结合增加指示哺乳动物患有或有发生阿尔茨海默病的风险。

84. 发明申请

US20110085741A1 METHODS AND APPARATUS FOR EDITING IMAGES 失效
标题翻译：用于编辑图像的方法和装置
公开(公告)号：US20110085741A1
公开(公告)日：2011-04-14
申请号：US12896546
申请日：2010-10-01
申请人： Wei Zhang , Wai Kuen Cham
发明人： Wei Zhang , Wai Kuen Cham
IPC分类号： G06K9/40
CPC分类号： G06T5/003 , G06T5/50 , G06T2200/21 , G06T2207/10016 , G06T2207/20221
摘要： Methods and apparatus for editing an image having focused and defocused objects are provided in the present application. According to an embodiment, the method comprises: determining blurriness of edge pixels in the image; propagating the determined blurriness to non-edge pixels adjacent to each of the edge pixels so as to determine blurriness of the non-edge pixels; estimating a focus map based on the blurriness of the edge pixels and the non-edge pixels to identify the defocused objects and the focused objects; and refocusing the defocused objects based on the focus map or defocusing at least one of the defocused objects and the focused objects.
摘要翻译：在本申请中提供了用于编辑具有聚焦和散焦对象的图像的方法和装置。根据实施例，该方法包括：确定图像中的边缘像素的模糊度; 将确定的模糊度传播到与每个边缘像素相邻的非边缘像素，以便确定非边缘像素的模糊度; 基于边缘像素和非边缘像素的模糊度来估计焦点图，以识别散焦对象和聚焦对象; 并且基于焦点图重新聚焦散焦对象，或者使至少一个散焦对象和聚焦对象散焦。

85. 发明申请

US20110042861A1 METHODS AND APPARATUS OF FIELD-INDUCED PRESSURE IMPRINT LITHOGRAPHY 审中-公开
标题翻译：现场感应压印版图的方法与装置
公开(公告)号：US20110042861A1
公开(公告)日：2011-02-24
申请号：US12940302
申请日：2010-11-05
申请人： Stephen Y. Chou , Wei Zhang
发明人： Stephen Y. Chou , Wei Zhang
IPC分类号： B29C59/02 , B28B1/10
CPC分类号： B29C43/003 , B29C33/62 , B29C43/021 , B29C43/36 , B29C43/52 , B29C43/56 , B29C59/022 , B29C59/026 , B29C2043/025 , B29C2043/3211 , B29C2043/568 , B29C2059/023 , B82Y10/00 , B82Y40/00 , G03F7/0002 , G03F9/7053
摘要： An improved method of imprint lithography involves using field-induced pressure from electric or magnetic fields to press a mold onto a substrate having a moldable surface. In essence, the method comprises the steps of providing a substrate having a moldable surface, providing a mold having a molding surface and pressing the molding surface and the moldable surface together by field-induced pressure from electric or magnetic fields to imprint the molding surface onto the moldable surface. The molding surface advantageously comprises a plurality of projecting features of nanoscale extent or separation, but the molding surface can also be a smooth planar surface, as for planarization. The improved method can be practiced without mechanical presses and without sealing the region between the mold and the substrate.
摘要翻译：改进的压印光刻方法涉及使用来自电场或磁场的场致压来将模具压到具有可模制表面的基底上。实质上，该方法包括以下步骤：提供具有可模制表面的基底，提供具有模制表面的模具，并且通过来自电场或磁场的场诱导压力将成型表面和可模塑表面压在一起，以将模制表面压印到可模制表面。模制表面有利地包括多个纳米尺度或分离的突出特征，但是成型表面也可以是平滑的平坦表面。可以在没有机械压力机的情况下实施改进的方法，并且不密封模具和基板之间的区域。

86. 发明申请

US20110021915A1 Detection of Structure in Ultrasound M-Mode Imaging 有权
标题翻译：超声M模式成像检测结构
公开(公告)号：US20110021915A1
公开(公告)日：2011-01-27
申请号：US12839547
申请日：2010-07-20
申请人： Shaolei Feng , Wei Zhang , Shaohua Kevin Zhou , Jin-hyeong Park
发明人： Shaolei Feng , Wei Zhang , Shaohua Kevin Zhou , Jin-hyeong Park
IPC分类号： A61B8/14
CPC分类号： A61B8/08 , A61B5/107 , A61B5/7267 , A61B8/0883 , A61B8/461 , A61B8/463 , A61B8/465 , A61B8/486 , G06T7/73 , G06T2207/10132 , G06T2207/30048
摘要： Automated detection of structure is provided in ultrasound M-mode imaging. A coarse and fine search for structure is used. For example, a less noise susceptible initial position or range of positions for a given structure is determined. This position is then refined. The coarse positioning and/or the refined position may use machine-trained classifiers. The positions of other structure may be used in either coarse or fine positioning, such as using a Markov Random Field. The structure or structures may be identified in the M-mode image without user input of a location in the M-mode image or along the line.
摘要翻译：在超声M模式成像中提供了结构的自动检测。使用粗略和精细的结构搜索。例如，确定给定结构的较小噪声敏感的初始位置或位置范围。然后改善这一立场。粗略定位和/或精细位置可以使用机器训练的分类器。其他结构的位置可以用于粗略或精细定位，例如使用马尔可夫随机场。可以在M模式图像中识别结构或结构，而无需用户输入M模式图像中的位置或沿着线。

87. 发明申请

US20110004141A1 METHOD AND ARRANGEMENT FOR DETERMINING THE RECIRCULATION IN A FISTULA OR THE CARDIOPULMONARY RECIRCULATION, AND A BLOOD TREATMENT DEVICE COMPRISING A DEVICE FOR DETERMINING THE FISTULA RECIRCULATION OR THE CARDIOPULMONARY RECIRCULATION PART 有权
标题翻译：用于确定模型或心脏重建中的再循环的方法和装置，以及包含用于确定模块再循环或心脏重建部分的装置的血液处理装置
公开(公告)号：US20110004141A1
公开(公告)日：2011-01-06
申请号：US12744281
申请日：2007-11-22
申请人： Wei Zhang , Elke Schulte , Christoph Bardorz
发明人： Wei Zhang , Elke Schulte , Christoph Bardorz
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61M1/16 , A61M1/1617 , A61M1/3658 , A61M2205/13
摘要： A method for determining the recirculation in a fistula and/or the cardiopulmonary recirculation part during an extracorporeal blood treatment is disclosed, where the blood to be treated flows in an extracorporeal blood circuit through a blood chamber of a dialyzer split by a semi-permeable membrane into the blood chamber and a liquid chamber, and dialysis liquid flows in a dialysis liquid path through the dialysis liquid chamber of the dialyzer. A device for determining the recirculation in a fistula and/or the cardio-pulmonary recirculation part, and a blood treatment device including such a device are also disclosed. The method and device are based on the fact that the sum of the fistula recirculation and the cardiopulmonary recirculation part, i.e. the total recirculation, is determined for two blood flow rates which differ from each other. The fistula recirculation and/or the cardiopulmonary recirculation part are then determined from the recirculation for the two blood flow rates.
摘要翻译：公开了一种用于在体外血液处理期间确定瘘管和/或心肺再循环部分中的再循环的方法，其中待治疗的血液通过半透膜分离的透析器的血室在体外血液回路中流动进入血液室和液体室，并且透析液体在透析液体路径中流过透析器的透析液体室。还公开了一种用于确定瘘管和/或心肺再循环部分中的再循环的装置，以及包括这种装置的血液处理装置。该方法和装置基于以下事实：对于彼此不同的两个血液流速，确定瘘再循环和心肺再循环部分的总和，即总再循环。然后从两次血流速率的再循环中确定瘘再循环和/或心肺再循环部分。

88. 发明申请

US20100317949A1 OPTICAL COUPLER FOR NON-INVASIVE SPECTROPHOTOMETRIC PATIENT MONITORING 审中-公开
标题翻译：光纤耦合器用于非入门光谱测量患者监测
公开(公告)号：US20100317949A1
公开(公告)日：2010-12-16
申请号：US12483610
申请日：2009-06-12
申请人： Eric V. CHAMNESS , Wei Zhang
发明人： Eric V. CHAMNESS , Wei Zhang
IPC分类号： A61B5/1455
CPC分类号： A61B5/14552 , A61B5/14553
摘要： Flexible, low-cost, physically robust optical coupling patches for use in spectrophotometric patient monitoring, and methods of fabrication thereof, are described. The optical coupling patch comprises a flexible base layer having a skin-contacting surface and a first aperture formed therethrough that establishes an optical interface with a skin surface when the base layer is placed against the skin surface. The optical coupling patch further comprises an elastomeric waveguiding member laterally disposed on a surface of the base layer opposite the skin-contacting surface. The optical coupling patch guides optical radiation between a laterally propagating state at a first location laterally distal from the first aperture and a generally vertically propagating state at the first aperture.
摘要翻译：描述了用于分光光度患者监测的柔性，低成本，物理上坚固的光耦合贴片及其制造方法。光学耦合贴片包括具有皮肤接触表面的柔性基底层和穿过其形成的第一孔，当基底层抵靠皮肤表面放置时，其与皮肤表面建立光学界面。光学耦合贴片还包括横向设置在与皮肤接触表面相对的基底层的表面上的弹性体波导构件。光耦合贴片在第一位置处的横向传播状态之间引导光辐射，并且在第一孔处大致垂直传播状态。

89. 发明授权

US07850856B2 Method and device for monitoring the supply of substitution fluid during an extracorporeal blood treatment 有权
标题翻译：用于在体外血液处理期间监测替代液供应的方法和装置
公开(公告)号：US07850856B2
公开(公告)日：2010-12-14
申请号：US10498034
申请日：2002-11-22
申请人： Wei Zhang , Ralf Wamsiedler
发明人： Wei Zhang , Ralf Wamsiedler
IPC分类号： B01D61/30 , B01D61/24 , B01D61/28 , B01D61/26 , B01D61/00 , A61M1/14 , A61M1/34
CPC分类号： A61M1/3639 , A61M1/342 , A61M1/3434 , A61M1/3437 , A61M1/3465 , A61M1/3656 , A61M5/16859 , Y10S210/929
摘要： The invention relates to a method for monitoring the supply of substitution liquid during an extracorporeal blood treatment and to an extracorporeal blood treatment unit equipped with a device for monitoring the supply of substitution liquid. The monitoring of the supply of substitution liquid is based on the measurement of pressure waves, which are generated by the substitution liquid pump, in the extracorporeal blood circulation system. A disturbance in the supply of substitution liquid is inferred when the amplitude of the pressure waves exceeds a predetermined limit value. The amplitude of the pressure waves is preferably monitored in the venous blood line.
摘要翻译：本发明涉及一种用于在体外血液处理期间监测置换液体供应的方法以及配备有用于监测替代液体供应的装置的体外血液处理单元。对替代液体供应的监测是基于在体外血液循环系统中由替代液体泵产生的压力波的测量。当压力波的幅度超过预定的极限值时，推断供给替代液体的干扰。优选在静脉血管中监测压力波的振幅。

90. 发明申请

US20100293603A1 METHOD, DEVICE, AND SYSTEM FOR AUTHENTICATION 有权
标题翻译：用于认证的方法，设备和系统
公开(公告)号：US20100293603A1
公开(公告)日：2010-11-18
申请号：US12846190
申请日：2010-07-29
申请人： Wei Zhang , Liang Gu , Wenliang Liang , Yuhua Chen
发明人： Wei Zhang , Liang Gu , Wenliang Liang , Yuhua Chen
IPC分类号： G06F21/00 , H04W4/00
CPC分类号： H04L63/08 , H04L63/0892 , H04L63/162 , H04W12/06 , H04W84/12
摘要： A method for authentication includes: a Gateway Mobile Station (G-MS) receives an authentication trigger message from a host, and sends the authentication trigger message to an authentication server through an Ethernet Convergence Sublayer (Eth-CS) to trigger authentication. A network system includes a G-MS, which is connected to a host and an authentication server in communicable mode. The G-MS is configured to: receive an authentication trigger message from the host and send the authentication trigger message to the authentication server through the Eth-CS. The authentication server is configured to: receive the authentication trigger message that the G-MS sends through the Eth-CS, and authenticate the host. A G-MS includes: a receiving unit, configured to receive an authentication trigger message from the host; and a sending unit, configured to send the authentication trigger message received by the receiving unit to the authentication server through the Eth-CS.
摘要翻译：一种认证方法包括：网关移动台（G-MS）从主机接收认证触发消息，并通过以太网收敛子层（Eth-CS）将认证触发消息发送给认证服务器，以触发认证。网络系统包括连接到主机的G-MS和可通信模式的认证服务器。 G-MS配置为：从主机接收认证触发消息，并通过Eth-CS向认证服务器发送认证触发消息。认证服务器配置为：接收G-MS通过Eth-CS发送的认证触发消息，并对主机进行认证。 G-MS包括：接收单元，被配置为从主机接收认证触发消息; 以及发送单元，被配置为通过所述Eth-CS将由所述接收单元接收到的所述认证触发消息发送到所述认证服务器。

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