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1. 发明申请

US20140030368A1 COMPOSITION FOR PREVENTING OR TREATING A RESPIRATORY DISEASE CONTAINING A MIXED HERBAL EXTRACT OF CNIDIUM OFFICINALE ROOT AND POLYGONI CUSPIDATI ROOT 审中-公开
标题翻译：用于预防或治疗包含CNIDIUM OFFICINALE ROOT和POLYGONI CUSPIDATI ROOT的混合的草药提取物的呼吸道疾病的组合物
公开(公告)号：US20140030368A1
公开(公告)日：2014-01-30
申请号：US13982002
申请日：2012-01-30
申请人： Yong Baik Cho , Moon Kyu Kang , In Ho Jung , Jong Hyun Hur , Soon Han Kim , Kyoung Chul Jung , Je Young Lee , Seul Ki Kim , Jee Young Lee , Byung Chul Yu , Min-Kyong Hyon
发明人： Yong Baik Cho , Moon Kyu Kang , In Ho Jung , Jong Hyun Hur , Soon Han Kim , Kyoung Chul Jung , Je Young Lee , Seul Ki Kim , Jee Young Lee , Byung Chul Yu , Min-Kyong Hyon
IPC分类号： A61K36/704 , A61K36/234
CPC分类号： A61K36/704 , A61K36/234 , A61K2300/00
摘要： The present invention relates to a composition for preventing or treating a respiratory disease containing an active ingredient in the form of a mixed herbal extract of Cnidii Rhizoma and Polygoni cuspidati Radix, and relates to a production method therefor. The mixed herbal extract of Cnidii Rhizoma and Polygoni cuspidati Radix has an outstanding 5-lipoxygenase suppressing activity, airway constriction suppressing activity, airway inflammation suppressing action, ear-swelling anti-inflammatory effect and antitussive and phlegm-loosening action, and has been confirmed to be useful in preventing or treating respiratory diseases including asthma, chronic obstructive pulmonary disease, acute and chronic bronchitis, allergic rhinitis, cough, expectoration, acute lower respiratory infections (bronchitis and bronchiolitis), and acute upper respiratory infections such an pharyngitis, tonsillitis and laryngitis.
摘要翻译：本发明涉及用于预防或治疗含有Cnidii Rhizoma和Polygoni cuspidati Radix的混合草药提取物形式的活性成分的呼吸系统疾病的组合物，涉及其生产方法。 Cnidii Rhizoma和Polygoni cuspidati Radix的混合草药提取物具有突出的5-脂氧合酶抑制活性，气道收缩抑制活性，气道炎症抑制作用，耳肿胀抗炎作用和镇咳和痰松动作用，并已被证实为可用于预防或治疗呼吸系统疾病，包括哮喘，慢性阻塞性肺病，急性和慢性支气管炎，过敏性鼻炎，咳嗽，咳痰，急性下呼吸道感染（支气管炎和细支气管炎）以及急性上呼吸道感染如咽炎，扁桃体炎和喉炎。

2. 发明申请

US20110182812A1 Imaging Agents for Detecting Neurological Disorders 有权
标题翻译：用于检测神经障碍的成像剂
公开(公告)号：US20110182812A1
公开(公告)日：2011-07-28
申请号：US13035405
申请日：2011-02-25
申请人： Anna Katrin Szardenings , Wei Zhang , Hartmuth C. Kolb , Daniel Kurt Cashion , Gang Chen , Dhanalakshmi Kasi , Changhui Liu , Anjana Sinha , Eric Wang , Chul Yu , Umesh B. Gangadharmath , Joseph C. Walsh
发明人： Anna Katrin Szardenings , Wei Zhang , Hartmuth C. Kolb , Daniel Kurt Cashion , Gang Chen , Dhanalakshmi Kasi , Changhui Liu , Anjana Sinha , Eric Wang , Chul Yu , Umesh B. Gangadharmath , Joseph C. Walsh
IPC分类号： A61K51/04 , C07D513/04 , C07D231/56 , C07D487/04 , C07D471/04 , C07D413/14 , C07D401/10 , C07D401/04 , A61K49/00 , A61P43/00 , A61P25/28
CPC分类号： C07D235/04 , A61K51/04 , C07B59/002 , C07D215/06 , C07D235/14 , C07D277/62 , C07D401/02 , C07D401/04 , C07D403/06 , C07D413/10 , C07D413/14 , C07D471/04 , C07D487/04
摘要： Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formulas (I)-(V) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.
摘要翻译：式（I） - （V）的成像剂和用于检测神经障碍的方法包括向需要的患者施用能够结合tau蛋白和＆amp;淀粉样蛋白肽的式（I） - （V）化合物。本发明还涉及成像A＆bgr的方法; 和tau聚集体，其包括引入可检测量的包含放射性标记的式（I） - （V）化合物的药物制剂，并检测患者中与淀粉样蛋白沉积物和/或tau蛋白相关的标记化合物。这些方法和组合使得临床前诊断和监测AD和其他神经障碍的进展。

3. 发明申请

US20100239496A1 Imaging agents for detecting neurological disorders 有权
标题翻译：用于检测神经系统疾病的成像剂
公开(公告)号：US20100239496A1
公开(公告)日：2010-09-23
申请号：US12661777
申请日：2010-03-23
申请人： Umesh B. Gangadharmath , Hartmuth C. Kolb , Peter J.H. Scott , Joseph C. Walsh , Wei Zhang , Anna Katrin Szardenings , Anjana Sinha , Gang Chen , Eric Wang , Vani P. Mocharia , Chul Yu , Changhui Liu , Daniel Kurt Cashion , Dhanalakshmi Kasi
发明人： Umesh B. Gangadharmath , Hartmuth C. Kolb , Peter J.H. Scott , Joseph C. Walsh , Wei Zhang , Anna Katrin Szardenings , Anjana Sinha , Gang Chen , Eric Wang , Vani P. Mocharia , Chul Yu , Changhui Liu , Daniel Kurt Cashion , Dhanalakshmi Kasi
IPC分类号： A61K51/04 , C07D401/04 , C07D215/06 , C07D413/10 , C07D235/18 , C07D405/04 , C07D409/04 , C07D413/14 , C07D497/04 , C12Q1/02
CPC分类号： A61K51/0455 , A61K51/04 , A61K51/0453 , A61K51/0459 , A61K51/0463 , C07B59/002 , C07D215/06 , C07D235/14 , C07D277/62 , C07D401/04 , C07D403/06 , C07D413/10 , C07D413/14 , C07D487/04
摘要： Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formula (I) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.
摘要翻译：式（I）的成像剂和用于检测神经障碍的方法包括向需要的患者施用能够结合tau蛋白和β-淀粉样蛋白肽的式（I）化合物。本发明还涉及成像A＆bgr的方法; 和tau聚集体，其包括引入可检测量的包含放射性标记的式（I）化合物的药物制剂，并检测患者中与淀粉样蛋白沉积物和/或tau蛋白相关的标记化合物。这些方法和组合使得临床前诊断和监测AD和其他神经障碍的进展。

4. 发明授权

US07399322B2 Method of making porous polymeric separator and lithium ion polymer battery 失效
标题翻译：制造多孔聚合物分离器和锂离子聚合物电池的方法
公开(公告)号：US07399322B2
公开(公告)日：2008-07-15
申请号：US10753633
申请日：2004-01-07
申请人： Si-chul Yu
发明人： Si-chul Yu
IPC分类号： H01M10/04 , B05D5/00
CPC分类号： H01M10/0525 , H01M2/1653 , H01M10/0565 , H01M2300/0082 , H01M2300/0085 , Y10T29/4911 , Y10T29/49115
摘要： The present invention relates to a method of making a polymeric porous separation membrane for a lithium ion polymer battery, the method comprising: providing a porous polyolefin membrane and a polymer solution of the concentration of 1–20 weight % in an organic solvent fabricated by dissolving in an organic solvent a polymer compound that is stable in an electrolyte containing a lithium salt and can be gelled in the electrolyte, at the temperature of 10–40° C.; and fabricating a polymeric porous separation membrane by coating the polymeric porous polyolefin membrane with the polymer solution. Thus, the porous separation membrane for a lithium ion polymer battery is fabricated by using the polymer solution fabricated at the low temperatures of 10–40° C., and the size of the pores of the coated is proper, so that the containing capacity of the electrolyte and the ion conductivity are good. Further gelling at low pressure is enabled and cohesive force to the electrodes is improved. In the lithium ion battery containing the porous separation membrane, the gelling is accomplished at atmospheric pressure or at low pressure for a few hours, so that problems caused by gelling for a short period at high pressure and high temperature such as the non uniform gelling of the battery, the deformation of the separation membrane and the weakened cohesion can be avoided. Moreover, the high-rate discharge, the cycle life becomes excellent.
摘要翻译：本发明涉及一种制备用于锂离子聚合物电池的聚合物多孔分离膜的方法，该方法包括：在通过溶解制备的有机溶剂中提供浓度为1-20重量％的多孔聚烯烃膜和聚合物溶液在有机溶剂中，在含有锂盐的电解质中稳定且可在电解质中凝胶化的聚合物化合物，温度为10-40℃; 以及通过用聚合物溶液涂覆聚合物多孔聚烯烃膜来制造聚合物多孔分离膜。因此，通过使用在10-40℃的低温下制造的聚合物溶液制造用于锂离子聚合物电池的多孔分离膜，并且涂覆的孔的尺寸是适当的，使得电解质和离子电导率都很好。能够进一步在低压下凝胶化，并提高对电极的内聚力。在含有多孔分离膜的锂离子电池中，胶凝在大气压或低压下进行数小时，因此在高压高温下凝胶化的问题，如非均匀胶凝可以避免电池，分离膜的变形和弱化的内聚力。此外，高倍率放电，循环寿命变得优异。

5. 发明申请

US20060010477A1 Method and system for providing VOD services in a digital cable TV network 有权
标题翻译：用于在数字有线电视网络中提供VOD服务的方法和系统
公开(公告)号：US20060010477A1
公开(公告)日：2006-01-12
申请号：US11175298
申请日：2005-07-07
申请人： In-chul Yu
发明人： In-chul Yu
IPC分类号： H04N7/173
CPC分类号： H04N21/6581 , H04N7/17318 , H04N21/25816 , H04N21/25841 , H04N21/47202 , H04N21/64322
摘要： A method and system for providing video-on-demand services are provided. The method of providing video-on-demand (VOD) services comprises transmitting service information to a set-top box via an out-of-band channel, receiving location and identification information of the set top box via the out-of-band channel, receiving a VOD service request from the set-top box via the out-of-band channel, and providing the set-top box with the requested content via an in-band channel with reference to the location and identification information of the set-top box.
摘要翻译：提供了一种用于提供视频点播服务的方法和系统。提供视频点播（VOD）服务的方法包括经由带外频道向机顶盒发送业务信息，经由频带外信道接收机顶盒的位置和识别信息经由频带外频道从机顶盒接收VOD服务请求，并且经由带内频道向机顶盒提供所请求的内容，参考设置 - 顶盒。

6. 发明授权

US08255960B2 Method and system for providing VOD services in a digital cable TV network 有权
标题翻译：用于在数字有线电视网络中提供VOD服务的方法和系统
公开(公告)号：US08255960B2
公开(公告)日：2012-08-28
申请号：US11175298
申请日：2005-07-07
申请人： In-chul Yu
发明人： In-chul Yu
IPC分类号： H04N7/173
CPC分类号： H04N21/6581 , H04N7/17318 , H04N21/25816 , H04N21/25841 , H04N21/47202 , H04N21/64322
摘要： A method and system for providing video-on-demand services are provided. The method of providing video-on-demand (VOD) services comprises transmitting service information to a set-top box via an out-of-band channel, receiving location and identification information of the set top box via the out-of-band channel, receiving a VOD service request from the set-top box via the out-of-band channel, and providing the set-top box with the requested content via an in-band channel with reference to the location and identification information of the set-top box.
摘要翻译：提供了一种用于提供视频点播服务的方法和系统。提供视频点播（VOD）服务的方法包括经由带外频道向机顶盒发送业务信息，经由频带外信道接收机顶盒的位置和识别信息经由频带外频道从机顶盒接收VOD服务请求，并且经由带内频道向机顶盒提供所请求的内容，参考设置 - 顶盒。

7. 发明授权

US07781158B2 Method of separating collagen from the various animal tissues for producing collagen solution and product using the same 失效
标题翻译：从各种动物组织分离胶原蛋白以产生胶原蛋白溶液的方法和使用其的产品的方法
公开(公告)号：US07781158B2
公开(公告)日：2010-08-24
申请号：US11885386
申请日：2006-03-09
申请人： Ji-Chul Yu , Jae-Deog Jang , Cheong-Ho Chang , Sae-Bom Lee , Se-Geun Yeo , Chang-Kwon Ko
发明人： Ji-Chul Yu , Jae-Deog Jang , Cheong-Ho Chang , Sae-Bom Lee , Se-Geun Yeo , Chang-Kwon Ko
IPC分类号： A01N1/00 , C12P21/04 , C12P21/06 , A61K38/00 , A61K38/39 , C07K14/00
CPC分类号： C07K14/78
摘要： A method for separation the collagen from the various animal tissues is disclosed for preparing collagen solution and product using the same. The porcine tissues are processed to have proper form and size for acid-treatment. The acid-treatment is repeated with pepsin to separate type I or II collagens. The separated collagen is salt-treated for fractionation and ethanol-treated for obtaining 5˜10% of collagen from the initial tissue weight. The prepared tissues are processed for separating collagen through the collagen separating process. The separated collagen is processed for preparing product. The method for preparing product is comprised: treating a collagen solution having a predetermined concentration under a neutral condition at a low temperature, followed by overnight treatment at a temperature of 30 to 35° C.; concentrating collagen by centrifugation; and dissolving the thus-concentrated collagen in refrigerated weakly-acidic solvent or phosphate buffered saline (PBS), thereby preparing collagen having a concentration of 1 to 5 mg/mL.
摘要翻译：公开了从各种动物组织分离胶原蛋白的方法，用于制备胶原蛋白溶液和使用其的产品。将猪组织加工成具有适当的形式和尺寸以进行酸处理。用胃蛋白酶重复酸处理以分离I型或II型胶原蛋白。分离的胶原蛋白进行盐分处理以进行分级和乙醇处理，从初始组织重量获得5〜10％的胶原蛋白。处理所制备的组织通过胶原分离过程分离胶原。处理分离的胶原蛋白以制备产品。制备产品的方法包括：在低温下在中性条件下处理具有预定浓度的胶原溶液，然后在30至35℃的温度下进行过夜处理; 通过离心浓缩胶原蛋白; 将如此浓缩的胶原蛋白溶解在冷冻的弱酸性溶剂或磷酸盐缓冲盐水（PBS）中，由此制备浓度为1〜5mg / mL的胶原。

8. 发明申请

US20090165290A1 METHOD OF MAKING BATTERY USING AS CASE WITH ALUMINIUM MULTILAYERED FILMS 审中-公开
标题翻译：使用铝合金薄膜制作电池的方法
公开(公告)号：US20090165290A1
公开(公告)日：2009-07-02
申请号：US12307950
申请日：2007-06-28
申请人： Si-chul Yu , Jong yong Lee
发明人： Si-chul Yu , Jong yong Lee
IPC分类号： H01M2/02
CPC分类号： H01M2/0277 , H01M2/0275 , H01M2/0285 , H01M2/0287 , H01M2/06 , H01M2/08 , H01M10/0431 , H01M10/0587 , Y10T29/4911
摘要： A method of manufacturing a cell using a pouch of aluminum multilayered film is disclosed. The pouch of an aluminum multilayered film is used as the outer case of the cell. The method includes: inserting an electrode assembly, which is composed of a negative electrode, separator, and positive electrode, in the pouch; sealing the electrode assembly; and bending the sealed portion of the cell once or twice. Therefore, the present invention can enhance the safety and energy density of the cell.
摘要翻译：公开了使用铝多层膜的袋制造电池的方法。使用铝多层膜的袋作为电池的外壳。该方法包括：在袋中插入由负极，隔膜和正电极组成的电极组件; 密封电极组件; 并将电池的密封部分弯曲一次或两次。因此，本发明可以提高电池的安全性和能量密度。

9. 发明申请

US20080118947A1 Method of Separating Collagen From the Various Animal Tissues for Producing Collagen Solution and Product Using the Same 失效
标题翻译：从各种动物组织分离胶原蛋白的方法，用于生产胶原蛋白溶液和使用其的产品
公开(公告)号：US20080118947A1
公开(公告)日：2008-05-22
申请号：US11885386
申请日：2006-03-09
申请人： Ji-Chul Yu , Jae-Deog Jang , Cheong-Ho Chang , Sae-Bom Lee , Se-Geun Yeo , Chang-Kwon Ko
发明人： Ji-Chul Yu , Jae-Deog Jang , Cheong-Ho Chang , Sae-Bom Lee , Se-Geun Yeo , Chang-Kwon Ko
IPC分类号： C12P21/06 , C07K14/78 , A61K38/40
CPC分类号： C07K14/78
摘要： A method for separation the collagen from the various animal tissues is disclosed for preparing collagen solution and product using the same. The porcine tissues are processed to have proper form and size for acid-treatment. The acid-treatment is repeated with pepsin to separate type I or II collagens. The separated collagen is salt-treated for fractionation and ethanol-treated for obtaining 5˜10% of collagen from the initial tissue weight. The prepared tissues are processed for separating collagen through the collagen separating process. The separated collagen is processed for preparing product. The method for preparing product is comprised: treating a collagen solution having a predetermined concentration under a neutral condition at a low temperature, followed by overnight treatment at a temperature of 30 to 35° C.; concentrating collagen by centrifugation; and dissolving the thus-concentrated collagen in refrigerated weakly-acidic solvent or phosphate buffered saline (PBS), thereby preparing collagen having a concentration of 1 to 5 mg/mL.
摘要翻译：公开了从各种动物组织分离胶原蛋白的方法，用于制备胶原蛋白溶液和使用其的产品。将猪组织加工成具有适当的形式和尺寸用于酸处理。用胃蛋白酶重复酸处理以分离I型或II型胶原蛋白。分离的胶原蛋白进行盐分处理以进行分级和乙醇处理，从初始组织重量获得5〜10％的胶原蛋白。处理所制备的组织以通过胶原分离过程分离胶原。处理分离的胶原蛋白以制备产品。制备产品的方法包括：在低温下在中性条件下处理具有预定浓度的胶原溶液，然后在30至35℃的温度下进行过夜处理; 通过离心浓缩胶原蛋白; 将如此浓缩的胶原蛋白溶解在冷冻的弱酸性溶剂或磷酸盐缓冲盐水（PBS）中，由此制备浓度为1〜5mg / mL的胶原。

10. 发明申请

US20160304555A1 PSMA Imaging Agents 有权
标题翻译： PSMA成像剂
公开(公告)号：US20160304555A1
公开(公告)日：2016-10-20
申请号：US14917127
申请日：2012-08-21
申请人： Eric WANG , Hartmuth C. KOLB , Anna Katrin INGS , Changhui LIU , Joseph C. WALSH , Gang CHEN , Anjana SINHA , Dhanalakshmi KASI , Chul YU , Umesh B. GANGADHARMATH , Wei ZHANG , Tieming ZHAO , Vani P. MOCHARLA
发明人： Eric Wang , Hartmuth C. Kolb , Anna Katrin Szardenings , Changhui Liu , Joseph C. Walsh , Gang Chen , Anjana Sinha , Dhanalakshmi Kasi , Chul Yu , Umesh B. Gangadharmath , Wei Zhang , Tieming Zhao , Vani P. Mocharla
IPC分类号： C07K5/02 , A61K51/04 , A61K51/08 , C07D249/06 , C07D249/04
CPC分类号： C07K5/0215 , A61K38/00 , A61K51/0453 , A61K51/088 , C07D207/16 , C07D209/48 , C07D213/81 , C07D213/82 , C07D233/78 , C07D233/96 , C07D239/60 , C07D249/04 , C07D249/06 , C07D251/30 , C07D263/34 , C07D277/56 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07K5/06026 , C07K5/06113
摘要： Compounds for targeting and agents for imaging, Prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.
摘要翻译：公开了靶向化合物和成像剂，前列腺特异性膜抗原（PSMA）。还公开了合成化合物和成像剂的方法以及PSMA成像方法。所公开的成像剂适用于PET和SPECT成像。

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