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81. 发明授权

US07596408B2 Implantable medical device with anti-infection agent 失效
标题翻译：具有抗感染剂的植入式医疗器械
公开(公告)号：US07596408B2
公开(公告)日：2009-09-29
申请号：US10837319
申请日：2004-04-30
申请人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson , Erik R. Scott , James E. Randall
发明人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson , Erik R. Scott , James E. Randall
IPC分类号： A61N1/02
CPC分类号： A61N1/3754 , A61B5/076 , A61B2560/04 , A61L31/16 , A61L2300/404 , A61N1/3605 , A61N1/375
摘要： An implantable medical device with anti-infection agent. The implantable medical device may be configured for placement in the head of a patient and for monitoring or treatment of the brain. The implantable medical device may have a housing or it may have a housing and a member for providing a smooth interface between the device and the adjacent tissue. The anti-infection agent may be provided on or impregnated in the housing or the member. In some embodiments, the device includes a single module while in other embodiments a plurality of modules are coupled to provide a smaller profile. In some embodiments the implantable medical device may include both anti-infection and lubricious materials.
摘要翻译：具有抗感染剂的可植入医疗器械。可植入医疗装置可被配置用于放置在患者的头部并用于监测或治疗大脑。可植入医疗装置可以具有壳体，或者其可以具有壳体和用于在装置和相邻组织之间提供平滑界面的构件。抗感染剂可以设置在或浸渍在壳体或构件中。在一些实施例中，设备包括单个模块，而在其它实施例中，多个模块被耦合以提供较小的轮廓。在一些实施例中，可植入医疗装置可以包括抗感染和光滑材料。

82. 发明授权

US07596399B2 Implantation of implantable medical device 有权
标题翻译：植入式植入式医疗器械
公开(公告)号：US07596399B2
公开(公告)日：2009-09-29
申请号：US10835527
申请日：2004-04-29
申请人： Ruchika Singhal , Carl D. Wahlstrand , Robert M. Skime , Steven J. Urquhart
发明人： Ruchika Singhal , Carl D. Wahlstrand , Robert M. Skime , Steven J. Urquhart
IPC分类号： A61B5/04 , A61B8/00
CPC分类号： A61B5/6864 , A61B5/107 , A61B5/686 , A61B5/6868
摘要： In general, the invention is directed to strategies pertaining to implantation of an implantable medical device between a scalp and a skull of the patient. The invention pertains to collection of data such as data pertaining to the skull of the patient, the scalp of the patient, the vascular structure or neurological structures in the head of the patient, and the like. The data may be in the form of images, such as images generated by X-ray, magnetic resonance imaging, CT-scan and fluoroscopy. A surgeon can use the collected data to determine, for example, whether the patient is a candidate for a cranial implantation, whether the patient's skull and scalp can support the implantation, what configuration of device should be implanted, where the device should be implanted, and how the surgical incisions should be made.
摘要翻译：通常，本发明涉及关于在头皮和患者头骨之间植入可植入医疗装置的策略。本发明涉及诸如患者头骨，患者头皮，患者头部的血管结构或神经结构等数据的收集等。数据可以是图像的形式，例如通过X射线产生的图像，磁共振成像，CT扫描和荧光透视。外科医生可以使用收集的数据来确定例如患者是颅骨植入的候选者，患者的颅骨和头皮是否能够支撑植入，应植入装置的哪些配置，植入装置的位置，以及如何做外科切口。

83. 发明授权

US07392089B2 Reducing relative intermodule motion in a modular implantable medical device 失效
标题翻译：在模块化可植入医疗设备中减少相对模块间运动
公开(公告)号：US07392089B2
公开(公告)日：2008-06-24
申请号：US10731881
申请日：2003-12-09
申请人： Carl D. Wahlstrand , Darren A. Janzig , Robert M. Skime
发明人： Carl D. Wahlstrand , Darren A. Janzig , Robert M. Skime
IPC分类号： A61N1/36
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/3754 , A61N1/3758
摘要： A modular implantable medical device includes a plurality of modules that are at least partially encapsulated by an overmold. The modules may be connected by coupling modules, which may be flexible to provide for one or more degrees of relative intermodular motion. The overmold may also be flexible. In order to reduce relative intermodule motion to acceptable direction and/or ranges, the overmold may include one or more motion reduction elements.
摘要翻译：模块化可植入医疗装置包括至少部分地由包覆成型包封的多个模块。模块可以通过耦合模块连接，耦合模块可以是柔性的，以提供一个或多个相对的模块间运动程度。包覆成型也可以是柔性的。为了将相对模块间运动减小到可接受的方向和/或范围，包覆模具可以包括一个或多个运动减少元件。

84. 发明申请

US20070203542A1 Stimulation templates for programming a stimulation lead with complex electrode array geometry 有权
标题翻译：用于用复杂电极阵列几何编程刺激引线的刺激模板
公开(公告)号：US20070203542A1
公开(公告)日：2007-08-30
申请号：US11591189
申请日：2006-10-31
申请人： Steven M. Goetz , Richard T. Stone , Warren W. Ball , Carl D. Wahlstrand
发明人： Steven M. Goetz , Richard T. Stone , Warren W. Ball , Carl D. Wahlstrand
IPC分类号： A61N1/00
CPC分类号： A61N1/37247 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0553 , A61N1/36082 , A61N1/36185
摘要： The disclosure is directed to programming implantable stimulators to deliver stimulation energy via one or more implantable leads having complex electrode array geometries. A user interface of a programmer allows a user to define stimulation therapy by interacting with one or more representations of the lead that delivers the therapy. The disclosure also contemplates selecting stimulation parameters to satisfy a user defined stimulation field by selecting one or more volumetric stimulation templates that best fit the stimulation field. The user interface may display the stimulation templates in relation to different perspectives of a lead and the stimulation field. Use of stimulation templates may simplify the determination of stimulation parameters in response to any of a variety of types of user definition of a stimulation field.
摘要翻译：本公开涉及编程可植入刺激器以通过具有复杂电极阵列几何形状的一个或多个可植入引线输送刺激能量。程序员的用户界面允许用户通过与递送治疗的引线的一个或多个表示相互作用来定义刺激治疗。本公开还考虑通过选择最适合刺激场的一个或多个体积刺激模板来选择刺激参数以满足用户定义的刺激场。用户界面可以显示与铅和刺激场的不同观点相关的刺激模板。刺激模板的使用可以响应于刺激场的各种类型的用户定义中的任一种来简化刺激参数的确定。

85. 发明申请

US20070203541A1 Programming interface with a cross-sectional view of a stimulation lead with complex electrode array geometry 有权
标题翻译：具有复杂电极阵列几何形状的刺激引线横截面视图的编程界面
公开(公告)号：US20070203541A1
公开(公告)日：2007-08-30
申请号：US11591188
申请日：2006-10-31
申请人： Steven M. Goetz , Richard T. Stone , Warren W. Ball , Carl D. Wahlstrand
发明人： Steven M. Goetz , Richard T. Stone , Warren W. Ball , Carl D. Wahlstrand
IPC分类号： A61N1/00
CPC分类号： A61N1/0534 , A61N1/36071 , A61N1/36157 , A61N1/36185 , A61N1/37247
摘要： The disclosure is directed to programming implantable stimulators to deliver stimulation energy via one or more implantable leads having complex electrode array geometries. The disclosure also contemplates guided programming to select electrode combinations and parameter values to support efficacy. The techniques may be applied to a programming interface associated with a clinician programmer, a patient programmer, or both. A user interface permits a user to view electrodes from different perspectives relative to the lead. For example, the user interface provides a side view of a lead and a cross-sectional view of the lead. The user interface may include an axial control medium to select and/or view electrodes at different axial positions along the length of a lead, and a rotational control medium to select and/or view electrodes at different angular positions around a circumference of the lead.
摘要翻译：本公开涉及编程可植入刺激器以通过具有复杂电极阵列几何形状的一个或多个可植入引线输送刺激能量。本公开还考虑了引导编程以选择电极组合和参数值以支持功效。这些技术可以应用于与临床医生程序员，患者程序员或两者相关联的编程接口。用户界面允许用户从相对于铅的不同角度来观察电极。例如，用户界面提供引线的侧视图和引线的横截面图。用户界面可以包括轴向控制介质，用于选择和/或查看沿引线长度的不同轴向位置处的电极;以及旋转控制介质，用于选择和/或查看围绕引线圆周的不同角位置处的电极。

86. 发明授权

US07263401B2 Implantable medical device with a nonhermetic battery 有权
标题翻译：具有非密封电池的可植入医疗器械
公开(公告)号：US07263401B2
公开(公告)日：2007-08-28
申请号：US10835233
申请日：2004-04-29
申请人： Erik R. Scott , Carl D. Wahlstrand , Robert M. Skime , Craig L. Schmidt
发明人： Erik R. Scott , Carl D. Wahlstrand , Robert M. Skime , Craig L. Schmidt
IPC分类号： A61N1/00 , H01J5/00
CPC分类号： A61N1/375 , A61N1/378
摘要： An implantable medical device (IMD) including a nonhermetic battery is described. The IMD includes components and a power source module that includes the nonhermetic battery. The IMD also includes a barrier to substantially impede movement of substances from the nonhermetic battery to the components. The barrier may include a hermetic feedthrough, a gel, a polymer, or a solid electrolyte within the nonhermetic battery, and a seal member. The barrier may also be a material that encapsulates the nonhermetic battery and a getter within the IMD. In some embodiments, the IMD comprises a modular IMD including an interconnect member. In that case, the barrier may include a material that fills at least a portion of a void defined by the interconnect member. A length and a cross-sectional area of the interconnect member may also act as a barrier.
摘要翻译：描述了包括非密封电池的可植入医疗装置（IMD）。 IMD包括组件和包含非密封电池的电源模块。 IMD还包括阻止物质从非密封电池移动到部件的屏障。阻挡层可以包括非密封电池内的密封馈通，凝胶，聚合物或固体电解质，以及密封构件。屏障还可以是在IMD内封装非密封电池和吸气剂的材料。在一些实施例中，IMD包括包括互连构件的模块化IMD。在这种情况下，阻挡层可以包括填充由互连构件限定的空隙的至少一部分的材料。互连构件的长度和横截面积也可以用作屏障。

87. 发明授权

US07242982B2 Overmold for a modular implantable medical device 有权
标题翻译：用于模块化可植入医疗设备的包覆模型
公开(公告)号：US07242982B2
公开(公告)日：2007-07-10
申请号：US10730873
申请日：2003-12-09
申请人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson
发明人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson
IPC分类号： A61N1/36
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/3754 , A61N1/3758
摘要： A modular implantable medical device permits implantable medical devices to have a smaller profile in order to better fit into locations within the human body. A modular implantable medical device separates various functional components of the implantable medical device into a set of interconnected modules. This distributed architecture of a modular implantable medical device may permit the device footprint to be distributed over a larger area while making the profile smaller, and may permit the overall shape of the implantable medical device to better match the body location into which it is to be implanted. An overmold integrates the modules of a modular implantable medical device into a single structure. In some embodiments the overmold is flexible and provides a biocompatible interface from the component modules and the patient, while restraining potentially harmful intermodule motion.
摘要翻译：模块化可植入医疗装置允许植入式医疗装置具有更小的外形，以便更好地适应人体内的位置。模块化可植入医疗装置将可植入医疗装置的各种功能部件分离成一组互连的模块。模块化可植入医疗设备的这种分布式架构可以允许设备占地面积分布在更大的区域上，同时使轮廓更小，并且可以允许可植入医疗设备的整体形状更好地匹配要被植入的医疗设备的身体位置植入。包覆模具将模块化可植入医疗设备的模块集成到单个结构中。在一些实施方案中，包覆成型是柔性的并且提供来自组件模块和患者的生物相容性界面，同时限制潜在有害的模块间运动。

88. 发明授权

US07231256B2 Neurostimulation site screening 有权
标题翻译：神经刺激部位筛查
公开(公告)号：US07231256B2
公开(公告)日：2007-06-12
申请号：US11078467
申请日：2005-03-11
申请人： Carl D. Wahlstrand , Robert M. Skime
发明人： Carl D. Wahlstrand , Robert M. Skime
IPC分类号： A61N1/00
CPC分类号： A61N1/0551 , A61N1/0502 , A61N1/36017 , A61N1/36021 , A61N1/36071
摘要： The disclosure describes a process for non-invasively screening a patient to select a stimulation site for treatment of head, neck or facial pain and tension symptoms caused by disorders such as occipital neuralgia. The screening process involves application of a transcutaneous stimulation screening device, a percutaneous micro-electrode screening device, and a temporary implantable screening device to the patient to select a site for chronic implantation.
摘要翻译：本公开描述了非侵入式筛选患者以选择用于治疗头部，颈部或面部疼痛的刺激部位和由诸如枕骨神经痛等疾病引起的紧张症状的方法。筛选过程包括将经皮刺激筛选装置，经皮微电极筛选装置和临时植入式筛选装置应用于患者以选择用于慢性植入的部位。

89. 发明授权

US09162072B2 Implantable medical device with lubricious material 有权
标题翻译：具有光滑材料的植入式医疗器械
公开(公告)号：US09162072B2
公开(公告)日：2015-10-20
申请号：US11526514
申请日：2006-09-25
申请人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson , Erik R. Scott , James E. Randall
发明人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson , Erik R. Scott , James E. Randall
IPC分类号： A61N1/375 , A61N1/36 , A61N1/05
CPC分类号： A61N1/375 , A61B2560/0443 , A61N1/0526 , A61N1/3605
摘要： An implantable medical device with lubricious material permits implantable medical devices to have a reduced friction between the device and at least a portion of the surrounding tissue. The implantable medical device may have a housing or it may have a housing and a member for providing a smooth interface between the device and the tissue. The lubricious material may be provided on or impregnated in the housing or the member. In some embodiments, the device is configured for implantation in the head of a human body. In other embodiments, the device is configured for implantation between the cranium and the scalp. In some embodiments, the device includes a single module while in other embodiments a plurality of modules are coupled together to provide a smaller profile.
摘要翻译：具有润滑材料的可植入医疗装置允许植入式医疗装置在装置与周围组织的至少一部分之间具有减小的摩擦。可植入医疗装置可以具有壳体，或者可以具有壳体和用于在装置和组织之间提供平滑界面的构件。润滑材料可以设置在或浸渍在壳体或构件中。在一些实施例中，该装置被配置用于植入人体的头部。在其他实施例中，该装置被配置用于在颅骨和头皮之间植入。在一些实施例中，设备包括单个模块，而在其他实施例中，多个模块耦合在一起以提供较小的轮廓。

90. 发明授权

US08880188B2 Implantable medical leads and systems that utilize reflection points to control induced radio frequency energy 有权
标题翻译：可植入的医疗引线和系统，利用反射点来控制感应射频能量
公开(公告)号：US08880188B2
公开(公告)日：2014-11-04
申请号：US13981577
申请日：2012-01-27
申请人： Carl D. Wahlstrand , Thomas B. Hoegh
发明人： Carl D. Wahlstrand , Thomas B. Hoegh
IPC分类号： A61N1/00 , A61N1/05 , A61N1/08
CPC分类号： A61N1/08 , A61N1/05 , A61N1/086
摘要： Implantable medical leads and systems that include lead utilize reflection points within the lead to control radio frequency current that has been induced onto one or more filars within the lead. The radio frequency current may be controlled by the reflection points to block at least some of the radio frequency current from reaching an electrode of the lead and to dissipate at least some of the radio frequency current as heat on the filar. Controlling the radio frequency current thereby reduces the amount that is dissipated into bodily tissue through one or more electrodes of the lead and reduces the likelihood of tissue damage. The reflection points may be created by physical changes such as to material or size in the filar and/or in insulation layers that may be present such as an inner jacket about the filar and an outer jacket formed by the body of the lead.
摘要翻译：包括铅的植入式医疗引线和系统利用引线内的反射点来控制引导到引线内的一个或多个丝状体上的射频电流。射频电流可以由反射点控制，以阻止射频电流中的至少一些到达引线的电极，并将至少一些射频电流作为热丝散布在丝状体上。控制射频电流从而减少通过引线的一个或多个电极消散到身体组织中的量，并减少了组织损伤的可能性。反射点可以通过物理变化产生，例如在丝状物和/或可能存在的绝缘层中的材料或尺寸，例如围绕丝状物的内护套和由引线主体形成的外护套。

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