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81. 发明申请

US20090299420A1 METHOD AND APPARATUS FOR CRYOTHERAPY AND PACING PRECONDITIONING 审中-公开
标题翻译：方法和装置用于结冰和皮肤预处理
公开(公告)号：US20090299420A1
公开(公告)日：2009-12-03
申请号：US12474448
申请日：2009-05-29
申请人： Allan C. Shuros , Craig Stolen , Shantha Arcot-Krishnamurthy , Eric A. Mokelke
发明人： Allan C. Shuros , Craig Stolen , Shantha Arcot-Krishnamurthy , Eric A. Mokelke
IPC分类号： A61B18/02 , A61N1/362
CPC分类号： A61N1/06 , A61B18/02 , A61B2017/22002 , A61B2018/0022 , A61B2018/0212 , A61B2018/0243 , A61F2/958 , A61N1/362
摘要： A method and apparatus are described for delivering myocardial pacing and cryotherapy in conjunction with a coronary revascularization procedure using one catheter/stent system. In one embodiment, a balloon-stent delivery platform incorporates pacing electrode(s) on or near the distal tip for myocardial pacing.
摘要翻译：描述了一种用于使用一个导管/支架系统与冠状动脉血运重建术一起递送心肌起搏和冷冻治疗的方法和装置。在一个实施例中，球囊支架递送平台包括用于心肌起搏的远侧末端上或附近的起搏电极。

82. 发明申请

US20090270935A1 SYSTEMS AND METHODS FOR SELECTIVELY STIMULATING NERVE ROOTS 有权
标题翻译：用于选择性刺激神经病变的系统和方法
公开(公告)号：US20090270935A1
公开(公告)日：2009-10-29
申请号：US12431621
申请日：2009-04-28
申请人： Weiying Zhao , Stephen Ruble , Allan C. Shuros , Jason J. Hamann
发明人： Weiying Zhao , Stephen Ruble , Allan C. Shuros , Jason J. Hamann
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/0551 , A61N1/0553 , A61N1/0556 , A61N1/36057 , A61N1/36071 , A61N1/36114 , A61N1/36139 , A61N1/3627 , A61N1/365 , A61N1/37241
摘要： Various system embodiments comprise an implantable lead, an implantable housing, a neural stimulation circuit in the housing, and a controller in the housing and connected to the neural stimulation circuit. The lead has a proximal end and a distal end. The distal end is adapted to deliver neural stimulation pulses to the ventral nerve root and the dorsal nerve root. The proximal end of the lead is adapted to connect to the housing. The neural stimulation circuit is adapted to generate neural stimulation pulses to stimulate the ventral nerve root or the dorsal nerve root using the implantable lead. The controller is adapted to control the neural stimulation circuit to deliver a neural stimulation treatment.
摘要翻译：各种系统实施例包括可植入引线，可植入壳体，壳体中的神经刺激电路以及壳体中的控制器并连接到神经刺激电路。引线具有近端和远端。远端适于将神经刺激脉冲输送到腹侧神经根和背神经根。引线的近端适于连接到外壳。神经刺激电路适于产生神经刺激脉冲，以使用可植入引线刺激腹侧神经根或背神经根。控制器适于控制神经刺激电路以递送神经刺激治疗。

83. 发明申请

US20090157090A1 Cardiac Lead Placement Using Multiple Spatially Distributed Sensors 有权
标题翻译：使用多个空间分布式传感器的心脏导联放置
公开(公告)号：US20090157090A1
公开(公告)日：2009-06-18
申请号：US12236838
申请日：2008-09-24
申请人： Shantha Arcot-Krishnamurthy , Quan Ni , Michael Stucky , Allan C. Shuros
发明人： Shantha Arcot-Krishnamurthy , Quan Ni , Michael Stucky , Allan C. Shuros
IPC分类号： A61N1/05 , A61B17/00
CPC分类号： A61N1/056 , A61N1/36514
摘要： Systems and methods facilitate placement of a lead in or on a patient's heart. At least one reference sensor is positioned at a right heart location of a patient's heart and a cardiac lead apparatus comprising at least one lead apparatus sensor is advanced to a plurality of left heart locations. Using the reference sensor and the lead apparatus sensor, a distance parameter indicative of a distance between the reference and lead apparatus sensors is measured for each of the plurality of left heart locations. Strain or stress estimates are determined for the plurality of left heart locations derived from the distance parameter measurements. Using the strain or stress estimates, a physician perceivable output is produced indicating suitability of the left heart locations as pacing sites.
摘要翻译：系统和方法有利于将铅放置在患者心脏中或患者的心脏上。至少一个参考传感器位于患者心脏的右心脏位置，并且将包括至少一个引导装置传感器的心脏引导装置提前到多个左心脏位置。使用参考传感器和引导装置传感器，针对多个左心脏位置中的每一个测量指示参考和引导装置传感器之间的距离的距离参数。对于从距离参数测量导出的多个左心脏位置确定应变或应力估计。使用应变或压力估计，产生医生可感知的输出，指示左心脏位置作为起搏部位的适合性。

84. 发明申请

US20090082825A1 CLOSED-LOOP CONTROL OF INTERMITTENT EXCITATORY CARDIAC STIMULATION FOR THERAPEUTIC EFFECT 有权
标题翻译：间歇性激素治疗效果的闭环控制
公开(公告)号：US20090082825A1
公开(公告)日：2009-03-26
申请号：US11860957
申请日：2007-09-25
申请人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Christopher Hartemink
发明人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Christopher Hartemink
IPC分类号： A61N1/365
CPC分类号： A61N1/3627
摘要： A device and method for delivering electrical stimulation to the heart in order to improve cardiac function in heart failure patients. The stimulation is delivered as high-output pacing in which the stimulation is excitatory and also of sufficient energy to augment myocardial contractility. In order to provide a consistent hemodynamic response, the high-output pacing is optimized by delivering it using different parameter sets, evaluating the hemodynamic response thereto as reflected by one or more measured physiological variables, and selecting the parameter set with the best hemodynamic response.
摘要翻译：用于向心脏递送电刺激以改善心力衰竭患者的心脏功能的装置和方法。刺激作为高产出起搏，其中刺激是兴奋性的，并且具有足够的能量以增加心肌收缩力。为了提供一致的血流动力学响应，通过使用不同的参数组递送高输出起搏，通过一个或多个测量的生理变量反映的血液动力学响应进行评估，并且选择具有最佳血液动力学响应的参数集来优化高输出起搏。

85. 发明申请

US20080234772A1 METHOD AND DEVICE FOR MYOCARDIAL STRESS REDISTRIBUTION 有权
标题翻译：用于心肌应激再分配的方法和装置
公开(公告)号：US20080234772A1
公开(公告)日：2008-09-25
申请号：US11689032
申请日：2007-03-21
申请人： Allan C. Shuros , Rodney W. Salo , Shantha Arcot-Krishnamurthy
发明人： Allan C. Shuros , Rodney W. Salo , Shantha Arcot-Krishnamurthy
IPC分类号： A61N1/362
CPC分类号： A61N1/3627
摘要： Methods and devices are described for delivering electrical stimulation to the heart in a manner that advantageously redistributes myocardial stress during systole for therapeutic purposes in the treatment of, for example, post-MI and HF patients. Pre-excitation pacing may be applied to deliberately de-stress a particular myocardial region that may be expected to undergo deleterious remodeling, such an the area around a myocardial infarct or a hypertrophying region or to deliberately stress a region remote from the pre-excitation pacing site in order to exert a cardioprotective conditioning effect, similar to the beneficial effects of exercise. Pre-excitation pacing may be advantageously combined with inotropic electrical stimulation applied to the stressed region.
摘要翻译：描述了将方法和装置以有效地将收缩期内的心肌应力重新分配到治疗目的的治疗目的的心脏和心脏病和心脏病患者的方式，以向心脏递送电刺激。预激发起搏可用于故意减压可能预期会发生有害重塑的特定心肌区域，例如心肌梗塞或肥大区域周围的区域，或故意压迫远离预激励起搏的区域为了发挥心脏保护性调理作用，类似于运动的有益效果。预激发起搏可以有利地与施加到应激区域的变力电刺激组合。

86. 发明申请

US20080132972A1 METHOD AND DEVICE FOR CARDIAC VASOACTIVE THERAPY 失效
标题翻译： CARDIAC VASOACTIVE治疗的方法和装置
公开(公告)号：US20080132972A1
公开(公告)日：2008-06-05
申请号：US11566896
申请日：2006-12-05
申请人： Allan C. Shuros , Shantha Arcot-Krishnamurthy , Joseph Walker
发明人： Allan C. Shuros , Shantha Arcot-Krishnamurthy , Joseph Walker
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61F2/82 , A61N1/3688
摘要： A method and device for treating myocardial ischemia in which an implantable pulse generator delivers electrical stimulation to electrodes disposed near a coronary artery. The stimulation parameters may be adjusted to produce vasodilation and/or vasoconstriction of the artery. The device may be configured to operate in a vasodilation and/or vasoconstriction mode in accordance with specified entry and exit conditions.
摘要翻译：一种用于治疗心肌缺血的方法和装置，其中植入式脉冲发生器将电刺激递送到设置在冠状动脉附近的电极。可以调节刺激参数以产生动脉的血管舒张和/或血管收缩。该装置可以被配置为根据指定的入口和出口条件在血管舒张和/或血管收缩模式中操作。

87. 发明申请

US20080082135A1 Method and apparatus for identification of ischemic/infarcted regions and therapy optimization 有权
标题翻译：用于鉴别缺血/梗死区域的方法和装置以及治疗优化
公开(公告)号：US20080082135A1
公开(公告)日：2008-04-03
申请号：US11541837
申请日：2006-10-02
申请人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Chris Hartemink
发明人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Chris Hartemink
IPC分类号： A61N1/00
CPC分类号： A61N1/36585 , A61B5/02028 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3702 , G06F19/00
摘要： A method and apparatus is described for detecting and localizing areas of myocardial infarction or ischemia. By pacing sites in proximity to the infarcted or ischemic region with appropriately timed pacing pulses, the region is pre-excited in a manner that lessens the mechanical stress to which it is subjected, thus reducing the metabolic demand of the region and the stimulus for remodeling.
摘要翻译：描述了用于检测和定位心肌梗死或缺血区域的方法和装置。通过以适当的定时起搏脉冲对位于梗塞或缺血区域附近的部位进行起搏，该区域以减轻其受到的机械应力的方式预激发，从而降低该区域的代谢需求和重塑刺激。

88. 发明申请

US20070282386A1 METHOD AND APPARATUS FOR GASTROINTESTINAL STIMULATION VIA THE LYMPHATIC SYSTEM 有权
标题翻译：通过淋巴系统进行气道刺激的方法和装置
公开(公告)号：US20070282386A1
公开(公告)日：2007-12-06
申请号：US11422418
申请日：2006-06-06
申请人： Allan C. Shuros
发明人： Allan C. Shuros
IPC分类号： A61N1/00
CPC分类号： A61N1/36007
摘要： An implantable gastrointestinal (GI) stimulation system includes an implantable medical device and at least one stimulus delivery device configured to be placed in one or more lymphatic vessels of a patient, such as the patient's thoracic duct and/or vessels branching from the thoracic duct. In one embodiment, the implantable medical device includes a GI stimulation circuit to deliver electrical stimulation pulses to one or more target regions adjacent to a lymphatic vessel through the stimulus delivery device. In one embodiment, to control obesity, the electrical stimulation pulses are delivered to the organs and/or nerves of the GI tract to create a sensation of satiety and/or to expedite food movement through the GI tract.
摘要翻译：植入式胃肠（GI）刺激系统包括可植入医疗装置和至少一个刺激递送装置，其被配置为放置在患者的一个或多个淋巴管中，例如患者的胸导管和/或从胸导管分支的血管。在一个实施例中，可植入医疗装置包括GI刺激电路，以通过刺激输送装置将电刺激脉冲输送到与淋巴管相邻的一个或多个目标区域。在一个实施方案中，为了控制肥胖，将电刺激脉冲输送到胃肠道的器官和/或神经以产生饱腹感和/或加速通过胃肠道的食物运动。

89. 发明授权

US09149631B2 Cardiac lead placement using multiple spatially distributed sensors 有权
标题翻译：使用多个空间分布传感器的心脏导联放置
公开(公告)号：US09149631B2
公开(公告)日：2015-10-06
申请号：US12236838
申请日：2008-09-24
申请人： Shantha Arcot-Krishnamurthy , Quan Ni , Michael Stucky , Allan C. Shuros
发明人： Shantha Arcot-Krishnamurthy , Quan Ni , Michael Stucky , Allan C. Shuros
IPC分类号： A61N1/05 , A61N1/365
CPC分类号： A61N1/056 , A61N1/36514
摘要： Systems and methods facilitate placement of a lead in or on a patient's heart. At least one reference sensor is positioned at a right heart location of a patient's heart and a cardiac lead apparatus comprising at least one lead apparatus sensor is advanced to a plurality of left heart locations. Using the reference sensor and the lead apparatus sensor, a distance parameter indicative of a distance between the reference and lead apparatus sensors is measured for each of the plurality of left heart locations. Strain or stress estimates are determined for the plurality of left heart locations derived from the distance parameter measurements. Using the strain or stress estimates, a physician perceivable output is produced indicating suitability of the left heart locations as pacing sites.
摘要翻译：系统和方法有利于将铅放置在患者心脏中或患者的心脏上。至少一个参考传感器位于患者心脏的右心脏位置，并且包括至少一个引导装置传感器的心脏引导装置前进到多个左心脏位置。使用参考传感器和引导装置传感器，针对多个左心脏位置中的每一个测量指示参考和引导装置传感器之间的距离的距离参数。对于从距离参数测量导出的多个左心脏位置确定应变或应力估计。使用应变或压力估计，产生医生可感知的输出，指示左心脏位置作为起搏部位的适合性。

90. 发明授权

US08983600B2 Method and apparatus for safety control during cardiac pacing mode transition 有权
标题翻译：心脏起搏模式转换期间的安全控制方法和装置
公开(公告)号：US08983600B2
公开(公告)日：2015-03-17
申请号：US12768925
申请日：2010-04-28
申请人： Allan C. Shuros , Eric A. Mokelke
发明人： Allan C. Shuros , Eric A. Mokelke
IPC分类号： A61N1/00 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3688
摘要： A cardiac pacing system introduces a transitional period when pacing mode changes, such as when pacing starts and stops, or when one or more pacing parameter values change substantially. For each pacing parameter that changes substantially when the pacing mode changes, its value is adjusted incrementally over the transitional period to protect the heart from potentially harmful conditions associated with an abrupt change in the value of that pacing parameter.
摘要翻译：心脏起搏系统引入起搏模式改变的过渡时期，例如起搏开始和停止时，或当一个或多个起搏参数值发生显着变化时。对于每个起搏参数，当起搏模式发生变化时，其参数会发生显着变化，其过渡期间会逐渐调整其值，以保护心脏免受与该起搏参数值突然变化相关的潜在有害状况。

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