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81. 发明申请

US20170216872A1 STICKER HALF-CUTTING APPARATUS 审中-公开
公开(公告)号：US20170216872A1
公开(公告)日：2017-08-03
申请号：US15500930
申请日：2015-07-17
申请人： Se-Jin LEE
发明人： Se-Jin LEE
IPC分类号： B05C1/08 , B65H35/02 , B05B12/08 , B26D7/08 , B26F1/38
CPC分类号： B05C1/0813 , B05B9/01 , B05B12/084 , B05C1/0873 , B05C1/12 , B05C19/00 , B05C19/008 , B26D7/088 , B26F1/384 , B65H35/02
摘要： The present invention comprises: a support roller part rotating while supporting the lower side of a transferred sticker sheet; a half-cutting roller part provided at the top of the support roller part so as to rotate by engaging with the support roller part, and having a half cutter for cutting a printed part of the sticker sheet passing the support roller part; and an anti-adhesion fluid supplying unit for applying an anti-adhesion fluid on the surface of the half cutter coming into contact with the printed part of the sticker sheet.

82. 发明授权

US08560656B2 Terminal provided with networking module and method for receiving and transmitting data using the same 有权
标题翻译：提供网络模块和接收和传输数据的终端的终端
公开(公告)号：US08560656B2
公开(公告)日：2013-10-15
申请号：US12343179
申请日：2008-12-23
申请人： Se-Jin Lee
发明人： Se-Jin Lee
IPC分类号： G06F15/173
CPC分类号： H04L65/403 , G06F3/01 , G06F3/16 , H04L12/66
摘要： The present invention relates to a terminal provided with a networking module for sharing data with a counter terminal connected to the terminal and a method for receiving and transmitting data between two terminals. The terminal according to the present invention comprises a connection port 10 connecting the terminal to a counter terminal and a networking module 20 receiving and transmitting data through the connection port 10 connected with the counter terminal. A control unit 30 of the terminal commands the networking module 20 to receive and transmit data by running an interfacing program. In the terminal according to the present invention, since two terminals can share data stored in each other without other device such as an external storage device of an adapter, it is advantageous in that users can easily move data between two terminals.
摘要翻译：本发明涉及具有与连接到终端的计数器终端共享数据的网络模块的终端以及用于在两个终端之间接收和发送数据的方法。根据本发明的终端包括将终端连接到计数器终端的连接端口10和通过与计数器终端连接的连接端口10接收和发送数据的联网模块20。终端的控制单元30命令网络模块20通过运行接口程序来接收和发送数据。在根据本发明的终端中，由于两个终端可以共享彼此存储的数据，而不需要诸如适配器的外部存储设备的其他设备，因此用户可以容易地在两个终端之间移动数据是有利的。

83. 发明申请

US20120094908A1 TRUNCATED ACTIVIN TYPE II RECEPTOR AND METHODS OF USE 审中-公开
标题翻译：交联活化剂II型受体及其使用方法
公开(公告)号：US20120094908A1
公开(公告)日：2012-04-19
申请号：US12897607
申请日：2010-10-04
申请人： Se-Jin Lee , Alexandra C. McPherron
发明人： Se-Jin Lee , Alexandra C. McPherron
IPC分类号： A61K38/17
CPC分类号： A61K38/00 , A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2227/30 , A01K2267/02 , A01K2267/03 , A01K2267/0306 , A01K2267/0362 , A61K38/1709 , C07K14/4703 , C07K14/475 , C07K14/71 , C12N15/8509 , C12N2800/30 , C12N2830/002 , C12N2830/008 , C12N2830/85 , G01N33/74 , G01N2333/495 , G01N2500/00
摘要： The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In addition, the invention provides a virtual representation of a GDF receptor or a functional peptide portion thereof. The present invention also provides a method of modulating an effect of myostatin on a cell by contacting the cell with an agent that affects myostatin signal transduction in the cell. In addition, the invention provides a method of ameliorating the severity of a pathologic condition, which is characterized, at least in part, by an abnormal amount, development or metabolic activity of muscle or adipose tissue in a subject, by modulating myostatin signal transduction in a muscle cell or an adipose tissue cell in the subject. The invention also provides a method of modulating the growth of muscle tissue or adipose tissue in a eukaryotic organism by administering an agent that affects myostatin signal transduction to the organism.
摘要翻译：本发明提供了基本上纯化的生长分化因子（GDF）受体，包括GDF-8（肌生成抑制素）受体，以及其功能肽部分。此外，本发明提供了GDF受体或其功能肽部分的虚拟表示。本发明还提供了通过使细胞与影响细胞中肌生成抑制素信号转导的试剂接触来调节肌生长抑制素对细胞的作用的方法。此外，本发明提供了一种改善病理状况的严重性的方法，该方法至少部分地由受试者的肌肉或脂肪组织的异常量，发育或代谢活性表征，通过调节肌生成抑制素信号转导受试者中的肌肉细胞或脂肪组织细胞。本发明还提供了通过施用影响生物体的肌生成抑制素信号转导的试剂来调节真核生物体中肌肉组织或脂肪组织生长的方法。

84. 发明授权

US08124830B2 Transgenic non-human animals expressing a truncated activin type II receptor 有权
标题翻译：表达截短的激活素II型受体的转基因非人动物
公开(公告)号：US08124830B2
公开(公告)日：2012-02-28
申请号：US12361512
申请日：2009-01-28
申请人： Se-Jin Lee , Alexandra C. McPherron
发明人： Se-Jin Lee , Alexandra C. McPherron
IPC分类号： A01K67/00 , A01K67/033 , C12N15/00
CPC分类号： A61K38/00 , A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2227/30 , A01K2267/02 , A01K2267/03 , A01K2267/0306 , A01K2267/0362 , A61K38/1709 , C07K14/4703 , C07K14/475 , C07K14/71 , C12N15/8509 , C12N2800/30 , C12N2830/002 , C12N2830/008 , C12N2830/85 , G01N33/74 , G01N2333/495 , G01N2500/00
摘要： The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In addition, the invention provides a virtual representation of a GDF receptor or a functional peptide portion thereof. The present invention also provides a method of modulating an effect of myostatin on a cell by contacting the cell with an agent that affects myostatin signal transduction in the cell. In addition, the invention provides a method of ameliorating the severity of a pathologic condition, which is characterized, at least in part, by an abnormal amount, development or metabolic activity of muscle or adipose tissue in a subject, by modulating myostatin signal transduction in a muscle cell or an adipose tissue cell in the subject. The invention also provides a method of modulating the growth of muscle tissue or adipose tissue in a eukaryotic organism by administering an agent that affects myostatin signal transduction to the organism.
摘要翻译：本发明提供了基本上纯化的生长分化因子（GDF）受体，包括GDF-8（肌生成抑制素）受体，以及其功能肽部分。此外，本发明提供了GDF受体或其功能肽部分的虚拟表示。本发明还提供了通过使细胞与影响细胞中肌生成抑制素信号转导的试剂接触来调节肌生长抑制素对细胞的作用的方法。此外，本发明提供了一种改善病理状况的严重性的方法，该方法至少部分地由受试者的肌肉或脂肪组织的异常量，发育或代谢活性表征，通过调节肌生成抑制素信号转导受试者中的肌肉细胞或脂肪组织细胞。本发明还提供了通过施用影响生物体的肌生成抑制素信号转导的试剂来调节真核生物体中肌肉组织或脂肪组织生长的方法。

85. 发明授权

US07976839B2 Growth differentiation factor-11 有权
标题翻译：生长分化因子-11
公开(公告)号：US07976839B2
公开(公告)日：2011-07-12
申请号：US12133302
申请日：2008-06-04
申请人： Se-Jin Lee , Alexandra C. McPherron
发明人： Se-Jin Lee , Alexandra C. McPherron
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2207/05 , A01K2217/075 , A01K2227/105 , A01K2267/02 , C07K14/475 , C07K14/51 , C07K2319/00 , C12N15/1136 , C12N2310/11 , C12N2310/111
摘要： A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-11 (GDF-11) chromosomally integrated into the germ cells of the animal is provided. Also provided are methods for making such animals, and methods of treating animals, including humans, with antibodies or antisense directed to GDF-11. The animals so treated are characterized by increased muscle tissue and bone tissue.
摘要翻译：选自鸟，牛，羊和猪的转基因非转基因动物，其具有导致染色体整合的生长分化因子-11（GDF-11）的生成和/或活性的转基因提供动物的生殖细胞。还提供了制备这种动物的方法，以及用针对GDF-11的抗体或反义治疗动物（包括人）的方法。如此治疗的动物的特征在于肌肉组织和骨组织增加。

86. 发明授权

US07399848B2 Polynucleotides encoding growth differentiation factor-8 有权
标题翻译：编码生长分化因子-8的多核苷酸
公开(公告)号：US07399848B2
公开(公告)日：2008-07-15
申请号：US10997809
申请日：2004-11-23
申请人： Se-Jin Lee , Alexandra C. McPherron
发明人： Se-Jin Lee , Alexandra C. McPherron
IPC分类号： C12N1/13 , C12N1/15 , C12N1/21 , C12N15/12 , C12N15/63
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2227/10 , A01K2227/105 , A01K2227/30 , A01K2267/02 , A01K2267/03 , A01K2267/0331 , A01K2267/035 , A01K2267/0362 , A61K38/00 , C07K14/475 , C07K14/495 , C07K2319/00
摘要： Disclosed are polynucleotides encoding growth differentiation factor-8 (GDF-8) useful for increasing the muscle mass in chickens.
摘要翻译：公开了编码可用于增加鸡的肌肉质量的生长分化因子-8（GDF-8）的多核苷酸。

87. 发明申请

US20070215510A1 Vacuum Vessel Having Improved Airtightness 审中-公开
标题翻译：具有改善气密性的真空容器
公开(公告)号：US20070215510A1
公开(公告)日：2007-09-20
申请号：US11632713
申请日：2005-01-28
申请人： Yi-Je Sung , Doo-Whan Kang , Se-Jin Lee , Hyun-Ki Lee
发明人： Yi-Je Sung , Doo-Whan Kang , Se-Jin Lee , Hyun-Ki Lee
IPC分类号： B65D81/20
CPC分类号： A47J47/10 , B65D79/005 , B65D81/2015
摘要： Disclosed herein is a vacuum vessel, capable of maintaining the freshness of food contained in the vessel for a lengthy period of time by creating a vacuum in the vessel. The vacuum vessel includes a main body (10) having along an edge thereof an annular protrusion. A seat (15) is disposed in the main body to seat an exterior receptacle containing food therein. A cover (20) covers the main body, and includes a valve mount part and a packing groove defined between inner and outer rings at a position corresponding to the annular protrusion of the main body. A packing (25) is fitted into the packing groove, and has an insert groove to engage with the annular protrusion of the main body, and an extension part to enhance a seal. A check valve (30)(130)(230) is mounted to the valve mount part of the cover.
摘要翻译：本文公开了一种真空容器，其能够通过在容器中产生真空来长时间地保持容纳在容器中的食物的新鲜度。真空容器包括沿其边缘具有环形突起的主体（10）。座体（15）设置在主体中，以将容纳食物的外部容器安放在其中。盖（20）覆盖主体，并且在对应于主体的环形突起的位置处包括阀安装部分和限定在内环和外环之间的填充槽。填料（25）装配到填料槽中，并具有与主体的环形突起接合的插入槽和用于增强密封的延伸部分。止回阀（30）（130）（230）安装到盖的阀安装部分。

88. 发明授权

US06891082B2 Transgenic non-human animals expressing a truncated activintype II receptor 失效
标题翻译：表达截短的活化素II型受体的转基因非人动物
公开(公告)号：US06891082B2
公开(公告)日：2005-05-10
申请号：US09841730
申请日：2001-04-24
申请人： Se-Jin Lee , Alexandra C. McPherron
发明人： Se-Jin Lee , Alexandra C. McPherron
IPC分类号： A01K67/027 , A61P3/04 , A61P3/06 , C07K14/47 , C07K14/475 , C07K14/71 , C12N5/02 , C12N5/10 , C12N5/22 , C12N15/09 , C12N15/18 , C12N15/85 , G01N33/74 , C12N5/00 , C07H21/02 , C12N15/00 , G01N33/00
CPC分类号： A61K38/00 , A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2227/30 , A01K2267/02 , A01K2267/03 , A01K2267/0306 , A01K2267/0362 , A61K38/1709 , C07K14/4703 , C07K14/475 , C07K14/71 , C12N15/8509 , C12N2800/30 , C12N2830/002 , C12N2830/008 , C12N2830/85 , G01N33/74 , G01N2333/495 , G01N2500/00
摘要： The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In addition, the invention provides a virtual representation of a GDF receptor or a functional peptide portion thereof. The present invention also provides a method of modulating an effect of myostatin on a cell by contacting the cell with an agent that affects myostatin signal transduction in the cell. In addition, the invention provides a method of ameliorating the severity of a pathologic condition, which is characterized, at least in part, by an abnormal amount, development or metabolic activity of muscle or adipose tissue in a subject, by modulating myostatin signal transduction in a muscle cell or an adipose tissue cell in the subject. The invention also provides a method of modulating the growth of muscle tissue or adipose tissue in a eukaryotic organism by administering an agent that affects myostatin signal transduction to the organism.
摘要翻译：本发明提供了基本上纯化的生长分化因子（GDF）受体，包括GDF-8（肌生成抑制素）受体，以及其功能肽部分。此外，本发明提供了GDF受体或其功能肽部分的虚拟表示。本发明还提供了通过使细胞与影响细胞中肌生成抑制素信号转导的试剂接触来调节肌生长抑制素对细胞的作用的方法。此外，本发明提供了一种改善病理状况的严重性的方法，该方法至少部分地由受试者的肌肉或脂肪组织的异常量，发育或代谢活性表征，通过调节肌生成抑制素信号转导受试者中的肌肉细胞或脂肪组织细胞。本发明还提供了通过施用影响生物体的肌生成抑制素信号转导的试剂来调节真核生物体中肌肉组织或脂肪组织生长的方法。

89. 发明授权

US06680372B1 Antibodies specific for growth differentiation factor-7 失效
标题翻译：特异于生长分化因子-7的抗体
公开(公告)号：US06680372B1
公开(公告)日：2004-01-20
申请号：US09412791
申请日：1999-10-05
申请人： Se-Jin Lee , Thanh Huynh
发明人： Se-Jin Lee , Thanh Huynh
IPC分类号： C07K1624
CPC分类号： C07K14/475 , A61K38/00 , C07K14/51
摘要： The present invention provides antibodies that bind to the growth differentiation factor-7.
摘要翻译：本发明提供了结合生长分化因子-7的抗体。

90. 发明授权

US06673534B1 Methods for detection of mutations in myostatin variants 失效
公开(公告)号：US06673534B1
公开(公告)日：2004-01-06
申请号：US08967089
申请日：1997-11-10
申请人： Se-Jin Lee , Alexander C. McPherron
发明人： Se-Jin Lee , Alexander C. McPherron
IPC分类号： C12Q168
CPC分类号： C12Q1/6876 , A01K2217/075 , A01K2267/02 , A01K2267/03 , A61K38/00 , C07K14/475 , C07K14/495 , C07K16/22 , C07K2319/00 , C12N15/8509 , C12Q1/6883 , C12Q2600/156
摘要： Methods for detecting allelic variants of the myostatin (growth and differentiation factor-8) gene are provided. Specifically provided are methods of identifying subjects having or having a predisposition for increased muscle mass as compared to subjects having wild-type myostatin. Increased muscle mass is particularly desirable for identification of animals used to produce food products, including bovine, porcine, ovine, avian and piscine species.

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