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81. 发明申请

US20170128051A1 LIQUID SAMPLE COLLECTION DEVICE 审中-公开
公开(公告)号：US20170128051A1
公开(公告)日：2017-05-11
申请号：US15321112
申请日：2015-06-15
申请人： Randox Laboratories Ltd.
发明人： Stuart Jackson , Ivan McConnell , John Lamont , Stephen Peter Fitzgerald
IPC分类号： A61B10/00 , A61F5/441
CPC分类号： A61B10/007 , A61F5/441
摘要： A liquid sample collection device is provided. The liquid sample collection device comprises a housing including a liquid collection chamber, and a liquid supply conduit extending from an inlet port and in use generally downwardly to the collection chamber, wherein the collection chamber includes an air vent port located such that in use liquid supplied to the collection chamber through the liquid supply conduit displaces air through the air vent port, and wherein the liquid supply conduit follows a meandering path including at least one air trap section defined at the junction between portions of the conduit extending with upward and downward components respectively, whereby in use once the air vent port is closed, air is displaced along the liquid supply conduit until it is trapped by the air trap section thereby preventing further liquid flow through the conduit.

82. 发明申请

US20170089900A1 DIAGNOSIS OF UROTHELIAL CANCER 审中-公开
公开(公告)号：US20170089900A1
公开(公告)日：2017-03-30
申请号：US15304473
申请日：2015-04-02
申请人： Randox Laboratories Ltd.
发明人： Mark Ruddock , Cherith Reid , John Lamont , Stephen Fitzgerald , Ricardo De Matos Simoes , Kathleen Williamson
IPC分类号： G01N33/574 , G01N33/577 , G01N33/543
CPC分类号： G01N33/57407 , G01N33/543 , G01N33/57488 , G01N33/577 , G01N33/6869 , G01N2333/485 , G01N2333/5412 , G01N2333/5421 , G01N2333/545
摘要： The present invention provides a method and a solid state device for identifying the presence of urothelial cancer in a patient comprising assigning the subject to a sub-population according to smoking habits, measuring the level of each biomarker of a panel of biomarkers in one or more samples obtained from the subject; and correlating the measured levels of the panel of biomarkers with the likelihood of the subject having urothelial cancer such that the subject can be classified as having urothelial cancer or as being a control.

83. 发明申请

US20160296930A1 ASSAY FLUID DELIVERY SYSTEM 有权
标题翻译：测定流体输送系统
公开(公告)号：US20160296930A1
公开(公告)日：2016-10-13
申请号：US15038024
申请日：2014-11-19
申请人： RANDOX LABORATORIES LTD
发明人： Jonathan Matear , Robson Pang , Stuart Jackson , David Sloan
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/527 , B01L2200/027 , B01L2200/04 , B01L2200/0605 , B01L2200/0621 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/123 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , F04B9/042 , G01N35/00029 , G01N35/1002 , G01N2035/00148 , G01N2035/0486
摘要： There is provided an assay fluid delivery system comprising an array of fluid reservoirs (62), each of which is selectively actuatable to deliver a respective fluid to a fluid channel structure; and a fluid delivery control system (50) comprising a plurality of reciprocally mounted actuators, each associated with a respective reservoir and being movable between a retracted position and an actuating position at which it causes fluid to be delivered from the corresponding reservoir, a plurality of cams (22) with different profiles mounted on a common, rotatable cam shaft (6), each cam being engaged with a respective one of the actuators whereby rotation of the cams causes movement of the corresponding actuators between the retracted and actuating positions, and a motor coupled to the cam shaft for rotating the cam shaft, wherein the cams are shaped relative to one another so as to cause the corresponding actuators to actuate the reservoirs in a predetermined sequence and for predetermined respective times.
摘要翻译：提供了一种分析流体递送系统，其包括流体储存器阵列（62），每个流体储存器可选择性地致动以将相应的流体输送到流体通道结构; 以及流体输送控制系统（50），其包括多个往复安装的致动器，每个致动器与相应的储存器相关联并且可在缩回位置和致动位置之间移动，在该致动位置处，使得流体从相应的储存器输送，具有不同轮廓的凸轮（22）安装在共同的可旋转的凸轮轴（6）上，每个凸轮与相应的一个致动器接合，由此凸轮的旋转引起相应致动器在缩回位置和致动位置之间的移动，马达耦合到凸轮轴用于旋转凸轮轴，其中凸轮相对于彼此成形，以使相应的致动器以预定顺序并且预定的各个时间致动储存器。

84. 发明申请

US20150269311A1 DIAGNOSIS AND RISK STRATIFICATION OF BLADDER CANCER 有权
标题翻译：乳腺癌的诊断和风险分析
公开(公告)号：US20150269311A1
公开(公告)日：2015-09-24
申请号：US14435991
申请日：2013-10-16
申请人： RANDOX LABORATORIES LTD.
发明人： Mark William Ruddock , Cherith N. Reid , Kate E. Williamson , Frank Emmert-Streib , John V. Lamont , Peter Fitzgerald
IPC分类号： G06F19/18 , G06F19/24 , G06F19/00 , G01N33/574
CPC分类号： G06F19/18 , G01N33/57407 , G01N33/57484 , G01N2333/4737 , G01N2333/4742 , G01N2333/475 , G01N2333/485 , G01N2333/523 , G01N2333/525 , G01N2333/5406 , G01N2333/5412 , G01N2333/5421 , G01N2333/545 , G01N2333/55 , G01N2333/70578 , G01N2333/70596 , G01N2333/7151 , G01N2333/7452 , G01N2333/928 , G01N2333/96433 , G01N2333/96494 , G01N2333/988 , G01N2400/00 , G06F19/00 , G06F19/24 , G16H50/30
摘要： The invention provides a method of defining the likelihood of a subject having bladder cancer, comprising the steps of: (A) assessing the subject's likelihood of having bladder cancer by: i. identifying at least one sub-population group appropriate to the subject; ii. determining the level of one or more biomarkers selected according to the sub-population group in a sample obtained from the subject; iii. inputting each of the biomarker values into an algorithm to produce an output value; and iv. correlating the output value with the likelihood of the subject having bladder cancer, wherein the sub-population group is selected according to smoking habits, gender, presence/absence of stone disease, history of benign prostate enlargement (BPE) or prescription of anti-hypertensive, anti-platelet and/or anti-ulcer medication, and (B) determining the subject's stratified risk level of serious disease by: v. determining the level of one or more biomarkers specific for one or more risk classifiers defined using Random Forest Classifiers (RFC), logistic regression or another appropriate systems biology or statistical approach in a sample obtained from the subject, vi. inputting each of the biomarker values into an algorithm or algorithms to produce an output value; and vii. correlating the output value with a stratified risk level of underlying serious disease, wherein the likelihood of having bladder cancer is combined with the stratified risk level of having serious disease, wherein the risk of having bladder cancer and/or serious disease is categorised as: high-risk bladder cancer requiring immediate cystoscopy; low-risk bladder cancer requiring urgent cystoscopy; high-risk control requiring close evaluation and further investigation; or low-risk control requiring primary care monitoring.
摘要翻译：本发明提供了一种定义患有膀胱癌的受试者的可能性的方法，包括以下步骤：（A）通过以下步骤评估受试者患膀胱癌的可能性：i。识别适合于该受试者的至少一个亚群体群体; ii。确定从受试者获得的样品中根据亚群体组选择的一种或多种生物标志物的水平; iii。将每个生物标记值输入到算法中以产生输出值; 和iv。将输出值与患有膀胱癌的患者的可能性相关联，其中根据吸烟习惯，性别，存在/不存在石头疾病，良性前列腺增生病史（BPE）或抗高血压药物处方选择亚群体组，抗血小板和/或抗溃疡药物，以及（B）通过以下方式确定受试者的严重疾病分层风险水平：v。确定一个或多个特定于使用随机森林分类器定义的风险分类器的生物标志物的水平 RFC），逻辑回归或从该主题获得的样本中的其他适当的系统生物学或统计学方法，vi。将每个生物标记值输入算法或算法以产生输出值; 和vii。将输出值与潜在严重疾病的分层风险水平相关联，其中膀胱癌的可能性与具有严重疾病的分层风险水平相结合，其中具有膀胱癌和/或严重疾病的风险被分类为：高膀胱癌需要立即膀胱镜检查; 低危膀胱癌需要紧急膀胱镜检查; 高风险控制需要进行密切的评估和进一步的调查; 或需要初级保健监测的低风险控制。

85. 发明申请

US20150198590A1 TROPOMYOSIN ISOFORMS RELATED TO ALZHEIMERS DISEASE AND MILD COGNITIVE IMPAIRMENT 有权
标题翻译：与阿尔茨海默病相关的TROMOMYOSIN ISOFORMS和MILD认知障碍
公开(公告)号：US20150198590A1
公开(公告)日：2015-07-16
申请号：US14411496
申请日：2013-07-08
申请人： Randox Laboratories Ltd.
发明人： Maria Zellner , Ellen Umlauf
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N33/6896 , G01N2333/4712 , G01N2800/2814 , G01N2800/2821
摘要： The present invention provides an in vitro method to aid the diagnosis of Alzheimer's disease (AD) or Mild Cognitive Impairment (MCI), comprising determining the level of expression of one or more tropomyosin isoform(s) corresponding to P09493-3 and/or P09493-1 in a patient's sample. A kit comprising probes that bind to tropomyosin isoforms P09493-3 and P09493-1 is also provided
摘要翻译：本发明提供了一种有助于诊断阿尔茨海默病（AD）或轻度认知障碍（MCI）的体外方法，其包括确定对应于P09493-3和/或P09493的一种或多种原肌球蛋白同种型的表达水平 -1在患者的样品中。还提供了包含结合原肌球蛋白异构体P09493-3和P09493-1的探针的试剂盒

86. 发明申请

US20150073820A1 RISK STRATIFICATION OF SUSPECTED AMI PATIENTS 审中-公开
标题翻译：可疑的AMI患者的风险分析
公开(公告)号：US20150073820A1
公开(公告)日：2015-03-12
申请号：US14478437
申请日：2014-09-05
申请人： RANDOX LABORATORIES LTD.
发明人： DAVID MCENEANEY
IPC分类号： G06F19/00
CPC分类号： G16H50/20 , G16H50/30
摘要： The current invention enables a method to improve early diagnosis and risk stratification of AMI in patients presenting with chest pain. A quick and accurate diagnosis/risk stratification means that high risk patients can be assigned to the appropriate treatment pathway and low risk patients can be reassured that they have not suffered an AMI and alternative causes of chest pain can be investigated. The method of the present invention is based on the outcome of three factors determined on admission; Electrocardiogram, cardiac troponin level and H-FABP level. Dependent on the results of these three tests the subject can be placed into an appropriate risk category for an AMI having recently occurred and the appropriate treatment pathway can be initiated.
摘要翻译：本发明使得能够改善患有胸痛的患者中AMI的早期诊断和风险分层的方法。快速，准确的诊断/风险分层意味着高风险患者可以分配到适当的治疗途径，低风险患者可以放心，他们没有遭受AMI，可以调查胸痛的其他原因。本发明的方法是基于入院确定的三个因素的结果; 心电图，心肌肌钙蛋白水平和H-FABP水平。根据这三项测试的结果，可将受试者置于最近发生的AMI的适当风险类别中，并可开始适当的治疗途径。

87. 发明申请

US20140336283A1 GENETIC FACTORS IN BLOOD PRESSURE 审中-公开
标题翻译：血压中的遗传因素
公开(公告)号：US20140336283A1
公开(公告)日：2014-11-13
申请号：US14367510
申请日：2012-12-21
申请人： RANDOX LABORATORIES LTD.
发明人： Sophie Visvikis-Siest , Said El Shamieh , Helena Murray , John Lamont , Peter Fitzgerald
IPC分类号： C12Q1/68
摘要： The invention describes epistatic interactions between single nucleotide polymorphisms on genes associated with blood pressure and provides an application for their use in a method to determine an individual's susceptibility to hypertension and hence whether anti-hypertensive treatment will be beneficial for said individual. In addition gene expression levels are also linked to blood pressure and may also be used to determine susceptibility to hypertension.
摘要翻译：本发明描述了与血压相关的基因的单核苷酸多态性之间的上位相互作用，并提供了其在确定个体对高血压易感性的方法中的应用，因此抗高血压治疗是否对所述个体有益。此外，基因表达水平也与血压相关，也可用于确定对高血压的易感性。

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