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1. 发明申请

US20190247820A1 RELATING TO SUBSTRATES FOR THE ATTACHMENT OF MOLECULES 审中-公开
公开(公告)号：US20190247820A1
公开(公告)日：2019-08-15
申请号：US16388527
申请日：2019-04-18
申请人： Randox Laboratories Ltd. , Randox Teoranta
发明人： Peter Fitzgerald , John Lamont , Ivan McConnell , Elouard Benchikh , Deepesh Upadhyay , Ciaran Richardson
IPC分类号： B01J19/00 , C12M1/00 , G01N33/543 , C09D11/102 , C09D11/03
CPC分类号： B01J19/0046 , B01J2219/00608 , B01J2219/00637 , C09D11/03 , C09D11/102 , C12M1/00 , G01N33/54393
摘要： A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.

2. 发明授权

US10279332B2 Substrates for the attachment of molecules 有权
公开(公告)号：US10279332B2
公开(公告)日：2019-05-07
申请号：US15983484
申请日：2018-05-18
申请人： Randox Laboratories Ltd. , Randox Teoranta
发明人： Peter Fitzgerald , John Lamont , Ivan McConnell , Elouard Benchikh , Deepesh Upadhyay , Ciaran Richardson
IPC分类号： B01J19/00 , C09D11/03 , C09D11/102 , C12M1/00 , G01N33/543
摘要： A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.

3. 发明申请

US20180339282A1 SUBSTRATES FOR THE ATTACHMENT OF MOLECULES 审中-公开
公开(公告)号：US20180339282A1
公开(公告)日：2018-11-29
申请号：US15983484
申请日：2018-05-18
申请人： Randox Laboratories Ltd. , Randox Teoranta
发明人： Peter Fitzgerald , John Lamont , Ivan McConnell , Elouard Benchikh , Deepesh Upadhyay , Ciaran Richardson
IPC分类号： B01J19/00 , C09D11/03 , C09D11/102 , C12M1/00
CPC分类号： B01J19/0046 , B01J2219/00608 , B01J2219/00637 , C09D11/03 , C09D11/102 , C12M1/00 , G01N33/54393
摘要： A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.

4. 发明申请

US20150126385A1 BIOMARKER-BASED METHODS AND BIOCHIPS FOR AIDING THE DIAGNOSIS OF STROKE 审中-公开
标题翻译：基于生物标记的方法和生物技术用于帮助诊断诊断
公开(公告)号：US20150126385A1
公开(公告)日：2015-05-07
申请号：US14361880
申请日：2012-12-03
申请人： Randox Laboratories Ltd.
发明人： John Lamont , Ivan Mc Connell , Peter Fitzgerald
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/158 , G01N33/6842 , G01N2333/4737 , G01N2333/5412 , G01N2333/70503 , G01N2333/70525 , G01N2333/70542 , G01N2333/70564 , G01N2333/7151 , G01N2800/2871 , G01N2800/32 , G01N2800/60
摘要： The present invention provides biomarker-based methods for diagnosing stroke in a patient suspected of having suffered a stroke, and also for discriminating between ischemic stroke and transient ischemic attack. Substrates comprising probes for specific combinations of biomarkers useful in the methods of the invention are also described.
摘要翻译：本发明提供了用于诊断疑似患有中风的患者的中风的基于生物标志物的方法，并且还用于区分缺血性卒中和短暂性脑缺血发作。还描述了包含用于本发明方法中的生物标志物的特定组合的探针的底物。

5. 发明申请

US20220412994A1 BIOMARKER OF DRUG-INDUCED CELLULAR TOXICITY AND DEPRESSION 有权
公开(公告)号：US20220412994A1
公开(公告)日：2022-12-29
申请号：US17775217
申请日：2020-11-06
申请人： Randox Laboratories Ltd
发明人： Paul Innocenzi , Mark Ruddock , John Lamont , Peter Fitzgerald
IPC分类号： G01N33/68
摘要： Described is the use of GFAP as a marker of drug-induced cellular toxicity and depression.

6. 外观设计

USD815752S1 Biochip well 有权
公开(公告)号：USD815752S1
公开(公告)日：2018-04-17
申请号：US29510481
申请日：2014-11-28
申请人： Randox Laboratories Ltd.
设计人： Stuart Jackson , Ivan McConnell , John Lamont , Peter Fitzgerald

7. 发明申请

US20180011115A1 DIAGNOSIS OF RISK OF UROTHELIAL CANCER 审中-公开
公开(公告)号：US20180011115A1
公开(公告)日：2018-01-11
申请号：US15547608
申请日：2016-01-29
申请人： Randox Laboratories Ltd.
发明人： Mark W. Ruddock , Cherith N. Reid , Kate E. Williamson , John Lamont , Peter Fitzgerald
IPC分类号： G01N33/86
CPC分类号： G01N33/86 , G01N33/57407 , G01N33/6893 , G01N2800/50 , G01N2800/709
摘要： The present invention related to a method for detecting a history of exposure to a chemical(s) comprising measuring the concentration of thrombomodulin in a sample isolated from a subject, and determining whether the concentration of thrombomodulin is altered compared to control reference levels.

8. 发明申请

US20150219670A1 KIDNEY DISEASE BIOMARKER 审中-公开
标题翻译： KIDNEY疾病生物标志
公开(公告)号：US20150219670A1
公开(公告)日：2015-08-06
申请号：US14421382
申请日：2013-08-12
申请人： Randox Laboratories Ltd.
发明人： Ivan McConnell , Stephen Peter Fitzgerald , John Lamont , Claran Richardson
IPC分类号： G01N33/68 , G01N33/70 , G01N33/573
CPC分类号： G01N33/6893 , C07K14/475 , C07K14/8139 , C12N9/104 , G01N33/573 , G01N33/6845 , G01N33/70 , G01N33/92 , G01N2333/47 , G01N2333/8139 , G01N2333/9108 , G01N2333/91188 , G01N2800/347 , G01N2800/50 , G01N2800/56
摘要： The present invention provides a method of stratifying a patient suffering from CKD into one of stages 1-3 of CKD, comprising determining the level of the biomarkers FABP1, γ-GT, AST, creatinine and cystatin C in a sample obtained from the patient and comparing the level of FABP1 in the sample to a control value and the levels of γ-GT, AST, creatinine and cystatin C in the sample to a range of control values for each biomarker, wherein an increased level of FABP1 compared to the control value and levels of γ-GT, AST, creatinine and cystatin C within the range of control values for each biomarker indicate that the patient suffers from stage 1 CKD or wherein an increased level of FABP1 compared to the control value, levels of γ-GT and AST within the range of control values for each biomarker, and increased levels of creatinine and cystatin C compared to an upper threshold of the control range for these biomarkers indicate that the patient suffers from stage 2 or stage 3 CKD.
摘要翻译：本发明提供了将患有CKD的患者分为CKD的1-3期的方法，包括测定从患者获得的样品中生物标志物FABP1，γ-GT，AST，肌酐和半胱氨酸蛋白酶抑制剂C的水平，以及将样品中FABP1的水平与对照值和样品中的γ-GT，AST，肌酐和半胱氨酸蛋白酶抑制剂C的水平进行比较，对每种生物标志物的对照值范围进行比较，其中FABP1水平与对照值相比增加并且每个生物标志物的对照值范围内的γ-GT，AST，肌酐和半胱氨酸蛋白酶抑制剂C的水平表明患者患有1期CKD或其中FABP1水平与对照值相比增加，γ-GT水平和在每个生物标志物的对照值范围内的AST和与这些生物标志物的对照范围的上限阈值相比，肌酐和半胱氨酸蛋白酶抑制剂C的水平升高表明患者患有2期或3期CKD。

9. 发明授权

US11467163B2 Determination of glycosylation signature 有权
公开(公告)号：US11467163B2
公开(公告)日：2022-10-11
申请号：US16065646
申请日：2016-12-23
申请人： Randox Laboratories Ltd. , Randox Teoranta
发明人： Ivan McConnell , Peter Fitzgerald , John Lamont , Ciaran Richardson
IPC分类号： G01N33/574
摘要： The present invention describes methods of determining the glycosylation signature and determining the level of a protein in a sample obtained from a patient.
The present invention also describes use of a patient protein glycosylation profile to identify the presence or absence of a disease in subjects.

10. 发明授权

US11383216B2 Relating to substrates for the attachment of molecules 有权
公开(公告)号：US11383216B2
公开(公告)日：2022-07-12
申请号：US16424330
申请日：2019-05-28
申请人： Randox Laboratories Ltd. , Randox Teoranta
发明人： Peter Fitzgerald , John Lamont , Ivan McConnell , Elouard Benchikh , Deepesh Upadhyay , Ciaran Richardson
IPC分类号： B01J19/00 , C09D11/102 , C09D11/03 , G01N33/543 , C12M1/00
摘要： A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.

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