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81. 发明授权

US10881746B2 Means and methods to treat dystonia 有权
公开(公告)号：US10881746B2
公开(公告)日：2021-01-05
申请号：US16307609
申请日：2017-06-02
申请人： VIB VZW , KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D
发明人： Rose Goodchild , Micheline Grillet
IPC分类号： A61K48/00 , C12N15/113 , A61P25/28 , C12Q1/02 , A61K31/7105 , A61K31/713 , A61K38/46
摘要： The present application relates to the field of neurological diseases, particularly to dystonia, even more particularly to primary dystonia, most particularly DYT1 primary dystonia. It is disclosed that the DYT1 dystonia causative mutation in TORSIN1A leads to hyperactivation of LIPIN. The invention provides substances modulating LIPIN function, in particular RNA molecules inhibiting LIPIN function and medical uses of these LIPIN inhibitors. Methods are disclosed to screen for medicaments that counteract the effects of TORSIN1A mutation.

82. 发明授权

US10862101B2 Ion insertion battery electrode and method of fabricating same 有权
公开(公告)号：US10862101B2
公开(公告)日：2020-12-08
申请号：US16238455
申请日：2019-01-02
申请人： IMEC vzw , Katholieke Universiteit Leuven , Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO
发明人： Sebastien Moitzheim , Philippe Vereecken , Paul Poodt , Joan Elisabeth Balder
IPC分类号： H01M4/131 , H01M10/0525 , H01M4/04 , H01M4/485 , H01M4/1391 , H01M10/0562 , H01M4/1315 , H01M4/13915 , H01M4/02 , H01M6/40
摘要： The disclosed technology relates to electrode layers of ion insertion type batteries and to electrode layer materials, wherein the electrode layer materials have a good electronic conductivity and a good ion conductivity, and wherein the electrode layers offer a good rate performance and a high storage capacity. The disclosed technology further relates to ion insertion type battery cells and batteries including such electrode layers, e.g., as an anode. The disclosed technology further relates to methods of forming such electrode layers and to methods for fabricating ion insertion type battery cells and batteries. The electrode layers according to the disclosed technology comprise titanium oxide comprising chlorine and may be deposited by atomic layer deposition at temperatures lower than 150° C.

83. 发明授权

US10829562B2 Haemorrhagic disorder due to ventricular assist device 有权
公开(公告)号：US10829562B2
公开(公告)日：2020-11-10
申请号：US16061116
申请日：2016-12-08
申请人： KATHOLIEKE UNIVERSITEIT LEUVEN
发明人： Karen Vanhoorelbeke , Shannen Deconinck , Hendrik Feys , An-Sofie Schelpe
IPC分类号： C07K16/40 , A61K39/395
摘要： The present invention relates to methods of treatment by human ADAMTS13 inhibition in circulatory assist device induced haemorrhagic complication such as a bleeding disorder, in particular, bleeding after left ventricular assist device implantation. The present invention further relates to specific monoclonal antibodies inhibiting ADAMTS13 function.

84. 发明申请

US20200339613A1 MODIFIED PEROVSKITES AND PEROVSKITE LIKES AND USES THEREOF 审中-公开
公开(公告)号：US20200339613A1
公开(公告)日：2020-10-29
申请号：US16961356
申请日：2019-01-14
申请人： KATHOLIEKE UNIVERSITEIT LEUVEN
发明人： Johan Hofkens , Maarten Roeffaers , Haifeng Yuan , Julian Steele
IPC分类号： C07F7/24 , H01L51/00 , H01L27/30
摘要： Present invention concerns optical processing of materials comprising complex phase behaviour, such as perovskites for stabilizing the optically active phase of thin films of materials with complex phase behaviour, such as perovskites.

85. 发明申请

US20200339511A1 Substituted indoline derivatives as dengue viral replication inhibitors 审中-公开
公开(公告)号：US20200339511A1
公开(公告)日：2020-10-29
申请号：US16088459
申请日：2017-03-31
申请人： Janssen Pharmaceuticals, Inc. , Katholieke Universiteit Leuven
发明人： Bart Rudolf, Romanie KESTELEYN , Pierre Jean-Marie, Bernard RABOISSON , Jean-François BONFANTI , Dorothée Alice, Marie-Eve BARDIOT , Arnaud Didier, M MARCHAND
IPC分类号： C07D209/26 , A61K31/405 , A61K45/06 , A61P31/14 , A61K35/76
摘要： The present invention concerns substituted indoline compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination prepara-tions of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

86. 发明授权

US10802743B2 Control plane organization for flexible digital data plane 有权
公开(公告)号：US10802743B2
公开(公告)日：2020-10-13
申请号：US16028328
申请日：2018-07-05
申请人： IMEC vzw , Katholieke Universiteit Leuven
发明人： Francky Catthoor , Praveen Raghavan , Daniele Garbin , Dimitrios Rodopoulos , Odysseas Zografos
IPC分类号： G06F12/00 , G06F3/06 , G11C16/04 , G11C13/00 , G11C7/10 , G06N3/063 , G11C17/16 , G11C11/54 , G06N3/04 , G06N3/08
摘要： A control plane for controlling transfer of data to a data plane is disclosed. In one aspect, the control plane comprises memory cells for storing a digitally coded parameter value and having a data input electrode, a data output electrode and a control electrode, n data input terminals that receive a data input value and apply it to the data input electrode of an associated memory cell, and n data output terminals coupled to a data output electrode of an associated memory cell. The control plane further comprise a first delay line having delay elements and arranged for receiving a stream of control bit values, and a second delay line having delay elements and arranged for receiving a signal for enabling the control bit values in the first delay line, wherein data is transferred in a controlled and synchronized fashion to an output electrode.

87. 发明授权

US10797224B2 Magnetoresistive device and method of fabricating same 有权
公开(公告)号：US10797224B2
公开(公告)日：2020-10-06
申请号：US15904189
申请日：2018-02-23
申请人： IMEC VZW , Katholieke Universiteit Leuven
发明人： Praveen Raghavan , Davide Francesco Crotti , Raf Appeltans
IPC分类号： H01L27/22 , H01L43/02 , G11C5/06 , G11C11/16 , H01L43/12
摘要： The disclosed technology generally relates to magnetoresistive devices, and more particularly to a magnetic tunnel junction (MTJ) device formed in an interconnection structure, and to a method of integrating the (MTJ) device in the interconnection structure. According to an aspect, a device includes a first interconnection level including a first dielectric layer and a first set of conductive paths arranged in the first dielectric layer, a second interconnection level arranged on the first connection level and including a second dielectric layer and a second set of conductive paths arranged in the second dielectric layer, and a third interconnection level arranged on the second interconnection level and including a third dielectric layer and a third set of conductive paths arranged in the third dielectric layer. The device additionally includes a magnetic tunnel junction (MTJ) device including a bottom layer, a top layer and an MTJ structure arranged between the bottom layer and the top layer, wherein the bottom layer is connected to a bottom layer contact portion of the first set of conductive paths and the top layer is connected to a top layer contact portion of the second or third set of conductive paths. The device further includes a multi-level via extending through the second dielectric layer and the third dielectric layer, between a first via contact portion of the first set of conductive paths and a second via contact portion of the third set of conductive paths, wherein a height of the MTJ device corresponds to, or-is less than, a height of the multi-level via, e.g., wherein the height of the MTJ device corresponds to or is less than a height of the second interconnection level.

88. 发明授权

US10797016B2 Method for bonding semiconductor chips to a landing wafer 有权
公开(公告)号：US10797016B2
公开(公告)日：2020-10-06
申请号：US15798939
申请日：2017-10-31
申请人： IMEC VZW , Katholieke Universiteit Leuven
发明人： Vikas Dubey , Eric Beyne , Giovanni Capuz
IPC分类号： H01L23/00
摘要： A method for bonding chips to a landing wafer is disclosed. In one aspect, a volume of alignment liquid is dispensed on a wettable surface of the chip so as to become attached to the surface, after which the chip is moved towards the bonding site on the wafer, the bonding site equally being provided with a wettable surface. A liquid bridge is formed between the chip and the bonding site on the substrate wafer, enabling self-alignment of the chip. Dispensing alignment liquid on the chip and not the wafer is advantageous in terms of mitigating unwanted evaporation of the liquid prior to bonding.

89. 发明申请

US20200290009A1 PATTERNING DEVICE 审中-公开
公开(公告)号：US20200290009A1
公开(公告)日：2020-09-17
申请号：US16886486
申请日：2020-05-28
申请人： Katholieke Universiteit Leuven, K.U.Leuven R&D
发明人： Jeroen Lammertyn , Daan Witters
IPC分类号： B01J19/00 , B01L3/00
摘要： A miniaturized, automated method for controlled printing of large arrays of nano- to femtoliter droplets by actively transporting mother droplets over hydrophilic-in-hydrophobic (“HIH”) micropatches. The technology uses single or double-plate devices where mother droplets can be actuated and HIH micropatches on one or both plates of the device where the droplets are printed. Due to the selective wettability of the hydrophilic micropatches in a hydrophobic matrix, large nano- to femtoliter droplet arrays are created when mother droplets are transported over the arrays. The parent droplets are moved by various droplet actuation principles. Also, a method using two plates placed one top another while being separated by a spacer. One plate is dedicated to confirming and guiding parent droplets by using hydrophilic patches in a hydrophobic matrix, while the other plate contains HIH arrays for printing of the droplets. When the parent droplet guidance plate is rotated over the plate dedicated to printing of nano- to femtoliter droplets, the droplets are dispensed inside the HIH array utilizing their selective wettability. The methods allow the parent droplets to move over the HIH arrays many times, providing advantages for performing bio-assays or miniaturized materials synthesis in nano- to femtoliter sized droplets. With controlled evaporation of the dispensed droplets of solution, large arrays of printed material can be generated in seconds. The methods provide a nano- to femtoliter droplet printing technique for a wide variety of applications, e.g., protein- or cell-based bio-assays or printing of crystalline structures, suspensions of nanoparticles or microelectronic components.

90. 发明授权

US10777471B2 Method of detecting manufacturing defects by thermal stimulation 有权
公开(公告)号：US10777471B2
公开(公告)日：2020-09-15
申请号：US16120061
申请日：2018-08-31
申请人： IMEC vzw , Katholieke Universiteit Leuven
发明人： Kristof J. P. Jacobs , Ingrid De Wolf
IPC分类号： H01L21/66 , H01L23/48 , G01N29/04 , H01L27/06
摘要： The disclosed technology generally relates to semiconductor characterization, and more particularly to detecting manufacturing defects in semiconductor regions. In one aspect, a non-destructive method of detecting a manufacturing defect in a semiconductor device includes providing a semiconductor device comprising an electrically isolated conductive via formed in a semiconductor region. The method additionally includes locally heating to cause a temperature change in a volume of the semiconductor region from a first temperature to a second temperature. The method additionally includes applying an electrical bias between the conductive via and the semiconductor region to form a temperature-dependent depletion region in the semiconductor region. The method additionally includes measuring a first capacitance value and a second capacitance value between the conductive via and the semiconductor region corresponding to the first temperature and the second temperature, respectively, of the volume of the semiconductor region. The method further includes detecting the manufacturing defect based on a difference between the first capacitance value and the second capacitance value.

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