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    • 86. 发明授权
    • Process for preparing 3-hydroxyesters from epoxide derivatives
    • 从环氧化物衍生物制备3-羟基酯的方法
    • US06600065B2
    • 2003-07-29
    • US10272380
    • 2002-10-17
    • Byeong No LeeEun Joo JangHyung Soo ChoByung Soon Chun
    • Byeong No LeeEun Joo JangHyung Soo ChoByung Soon Chun
    • C07C6966
    • C07C67/37C07C69/675
    • Disclosed herein is a novel process for preparing 3-hydroxyesters, comprising: (a) reacting an epoxide derivative with carbon monoxide and alcohol in a solvent at a temperature of 30˜150° C. under a pressure of 50˜3000 psig by using a catalyst system consisting of a catalytic amount of a cobalt compound and optionally an effective amount of a promoter to produce a 3-hydroxyester or a derivative thereof; (b) separating the resulting product and the solvent from the cobalt compound and the promoter in a stripping column at a temperature of −30˜200° C. in an atmosphere of a stabilizing gas; and (c) recycling a part or all of the separated cobalt compound and promoter to the step (a) and repeating the steps (a) through (c).
    • 本文公开了一种制备3-羟基酯的新方法,其包括:(a)使环氧化物衍生物与一氧化碳和醇在溶剂中在30〜150℃的温度下在50〜3000psig的压力下反应, 催化剂体系由催化量的钴化合物和任选的有效量的助催化剂组成,以产生3-羟基酯或其衍生物; (b)在稳定气体的气氛中,在-30〜200℃的温度下,将得到的产物和溶剂与汽提塔中的钴化合物和助催化剂分离; 和(c)将部分或全部分离的钴化合物和促进剂再循环到步骤(a)并重复步骤(a)至(c)。