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81. 发明申请

US20120232628A1 DRUG ELUTING LEAD SYSTEMS 有权
标题翻译：药物引导系统
公开(公告)号：US20120232628A1
公开(公告)日：2012-09-13
申请号：US13370269
申请日：2012-02-09
申请人： C. Lance Boling , Daniel Chao , Martha J. Morrell , Benjamin D. Pless , Thomas K. Tcheng , Brett M. Wingeier
发明人： C. Lance Boling , Daniel Chao , Martha J. Morrell , Benjamin D. Pless , Thomas K. Tcheng , Brett M. Wingeier
IPC分类号： A61N1/05
CPC分类号： A61N1/0529 , A61N1/0536 , A61N1/0539 , A61N1/0551 , A61N1/36082 , B22F3/10 , B22F2003/241 , B22F2003/242 , B22F2998/10 , B22F3/24
摘要： Medical electrical lead systems and related methods are described. The lead systems may be configured to be at least partially implanted in neural tissue of a subject, such as a brain of a subject. Some variations of the lead systems may comprise a lead body, an electrode connected to the lead body, and a bioactive agent. The electrode and/or lead body may comprise a substrate, and the bioactive agent may be supported by the substrate (e.g., by a substantial portion of the area of the substrate). Methods described herein may comprise contacting the substrate of a lead body and/or an electrode of a medical electrical lead system with at least one bioactive agent, where the lead body and the electrode are connected to each other.
摘要翻译：描述医用电引线系统及相关方法。引导系统可以被配置为至少部分地植入受试者的神经组织，例如受试者的脑部。引线系统的一些变型可以包括引线体，连接到引线主体的电极和生物活性剂。电极和/或引线主体可以包括衬底，并且生物活性剂可以由衬底支撑（例如，通过衬底的大部分区域）。本文描述的方法可以包括将铅体的基底和/或医用电引线系统的电极与至少一种生物活性剂接触，其中引线体和电极彼此连接。

82. 发明授权

US08249712B2 Treatment and warning of recurring therapy and other events using an implantable device 有权
标题翻译：使用植入式装置对复发性治疗和其他事件进行治疗和警告
公开(公告)号：US08249712B2
公开(公告)日：2012-08-21
申请号：US13293476
申请日：2011-11-10
申请人： Benjamin D Pless
发明人： Benjamin D Pless
IPC分类号： A61N1/372
CPC分类号： A61N1/36082 , A61B5/04001 , A61B5/04004 , A61B5/0476 , A61B5/4094 , A61N1/0529 , A61N1/0531 , A61N1/0539
摘要： An implantable neurostimulator system is capable of responsively treating epileptiform activity with electrical stimulation and other therapies and is further configured to detect periods of increased susceptibility to clinical seizures. The event densities of therapy applications (or detections or other events) in time are observed and calculated, and if high enough, measures are taken to warn the patient or provide additional therapy.
摘要翻译：可植入式神经刺激器系统能够通过电刺激和其它治疗来响应性地治疗癫痫样活性，并且还被配置为检测对临床发作敏感性增加的时期。观察和计算治疗应用（或检测或其他事件）的事件密度，如果足够高，采取措施来警告患者或提供额外的治疗。

83. 发明授权

US08140160B2 Systems and methods for interacting with an implantable medical device 有权
标题翻译：用于与可植入医疗装置相互作用的系统和方法
公开(公告)号：US08140160B2
公开(公告)日：2012-03-20
申请号：US11436190
申请日：2006-05-16
申请人： Benjamin D. Pless , David R. Fischell , Barbara Gibb , Lisa Guzzo , Adrian R. M. Upton
发明人： Benjamin D. Pless , David R. Fischell , Barbara Gibb , Lisa Guzzo , Adrian R. M. Upton
IPC分类号： A61N1/36
CPC分类号： A61B5/076 , A61B5/0006 , A61B5/0031 , A61B5/0478 , A61B5/0482 , A61B5/4094 , A61B5/686 , A61B5/742 , A61B5/7475 , A61N1/36064 , A61N1/36135 , A61N1/37252 , A61N1/37258 , A61N1/37282 , G06F19/00
摘要： An interactive implantable medical device system includes an implantable medical device and a network-enabled external device capable of bi-directional communication and interaction with the implantable medical device. The external device is programmed to interact with other similarly-enabled devices. The system facilitates improved patient care by eliminating unnecessary geographic limitations on implantable medical device interrogation and programming, and by allowing patients, physicians, and other users to access medical records, history, and information and to receive status and care-related alerts and messages anywhere there is access to a communications network.
摘要翻译：交互式可植入医疗装置系统包括能够与可植入医疗装置进行双向通信和交互的可植入医疗装置和能够启用网络的外部装置。外部设备被编程为与其他类似启用的设备进行交互。该系统通过消除对植入式医疗设备询问和编程的不必要的地理限制，以及允许患者，医生和其他用户访问医疗记录，历史和信息以及随时接收状态和护理相关的警报和消息来促进改善患者护理可以访问通信网络。

84. 发明授权

US08140152B2 Functional ferrule 有权
标题翻译：功能套圈
公开(公告)号：US08140152B2
公开(公告)日：2012-03-20
申请号：US12774707
申请日：2010-05-05
申请人： Michael S. John , Brett Wingeier , Thomas K. Tcheng , Benjamin D. Pless
发明人： Michael S. John , Brett Wingeier , Thomas K. Tcheng , Benjamin D. Pless
IPC分类号： A61N1/00
CPC分类号： A61N1/0529 , A61B8/0808 , A61N1/0531 , A61N1/0534 , A61N1/0539
摘要： Described here are intracranial ferrules, systems, and methods for sensing and stimulating neural tissues. The ferrules are generally designed to include a holding area for retaining an implantable device. In some variations, the ferrule itself may perform the sensing and stimulating functions. In other variations, the ferrule may function to sense data from neural tissues and the implantable device may function to stimulate neural tissues. In yet other variations, the ferrule may function to stimulate, and the implantable device may function to sense data from, the neural tissues. The sensing and stimulating functions may be used to detect and/or treat various neurological conditions.
摘要翻译：这里描述了用于感测和刺激神经组织的颅内套圈，系统和方法。套圈通常设计成包括用于保持可植入装置的保持区域。在一些变型中，套圈本身可以执行感测和刺激功能。在其他变型中，套圈可用于感测来自神经组织的数据，并且可植入装置可用于刺激神经组织。在另外的变型中，套圈可以起刺激的作用，并且可植入装置可用于从神经组织感测数据。感测和刺激功能可用于检测和/或治疗各种神经疾病。

85. 发明申请

US20120059430A1 Treatment and warning of recurring therapy and other events using an implantable device 有权
公开(公告)号：US20120059430A1
公开(公告)日：2012-03-08
申请号：US13293476
申请日：2011-11-10
申请人： Benjamin D. Pless
发明人： Benjamin D. Pless
IPC分类号： A61N1/372
CPC分类号： A61N1/36082 , A61B5/04001 , A61B5/04004 , A61B5/0476 , A61B5/4094 , A61N1/0529 , A61N1/0531 , A61N1/0539
摘要： An implantable neurostimulator system is capable of responsively treating epileptiform activity with electrical stimulation and other therapies and is further configured to detect periods of increased susceptibility to clinical seizures. The event densities of therapy applications (or detections or other events) in time are observed and calculated, and if high enough, measures are taken to warn the patient or provide additional therapy.

86. 发明授权

US08073545B2 Treatment and warning of recurring therapy and other events using an implantable device 有权
标题翻译：使用植入式装置对复发性治疗和其他事件进行治疗和警告
公开(公告)号：US08073545B2
公开(公告)日：2011-12-06
申请号：US11490818
申请日：2006-07-21
申请人： Benjamin D. Pless
发明人： Benjamin D. Pless
IPC分类号： A61N1/372
CPC分类号： A61N1/36082 , A61B5/04001 , A61B5/04004 , A61B5/0476 , A61B5/4094 , A61N1/0529 , A61N1/0531 , A61N1/0539
摘要： An implantable neurostimulator system is capable of responsively treating epileptiform activity with electrical stimulation and other therapies and is further configured to detect periods of increased susceptibility to clinical seizures. The event densities of therapy applications (or detections or other events) in time are observed and calculated, and if high enough, measures are taken to warn the patient or provide additional therapy.
摘要翻译：可植入式神经刺激器系统能够通过电刺激和其它治疗来响应性地治疗癫痫样活性，并且还被配置为检测对临床发作敏感性增加的时期。观察和计算治疗应用（或检测或其他事件）的事件密度，如果足够高，采取措施来警告患者或提供额外的治疗。

87. 发明授权

US08073544B2 Neurostimulator involving stimulation strategies and process for using it 有权
标题翻译：神经刺激器涉及刺激策略和使用它的过程
公开(公告)号：US08073544B2
公开(公告)日：2011-12-06
申请号：US11142063
申请日：2005-05-31
申请人： Benjamin D. Pless
发明人： Benjamin D. Pless
IPC分类号： A61N1/00 , A61B5/05
CPC分类号： A61N1/36064 , A61N1/36082 , A61N1/36135 , A61N1/36178
摘要： This is a neurostimulator that is configured to treat epilepsy and other neurological disorders using certain stimulation strategies, particularly changing various pulse parameters, during the imposition of a burst of those pulses. The invention includes the processes embodying those stimulation strategies.
摘要翻译：这是一种神经刺激器，其被配置为在施加这些脉冲的突发期间使用某些刺激策略来治疗癫痫和其他神经障碍，特别是改变各种脉冲参数。本发明包括体现这些刺激策略的过程。

88. 发明申请

US20110218591A1 Differential Neurostimulation Therapy Driven By Physiological Therapy 有权
标题翻译：差异神经刺激治疗由生理治疗驱动
公开(公告)号：US20110218591A1
公开(公告)日：2011-09-08
申请号：US13109970
申请日：2011-05-17
申请人： Benjamin D. Pless , Thomas K. Tcheng
发明人： Benjamin D. Pless , Thomas K. Tcheng
IPC分类号： A61N1/36
CPC分类号： A61N1/36135 , A61B5/0006 , A61B5/0022 , A61B5/0031 , A61B5/021 , A61B5/026 , A61B5/04012 , A61B5/0476 , A61B5/0488 , A61B5/076 , A61B5/14542 , A61B5/14546 , A61B5/4812 , A61B5/4836 , A61B5/686 , A61B5/743 , A61M5/14276 , A61N1/0529 , A61N1/0531 , A61N1/0539 , A61N1/36064 , A61N1/36067 , A61N1/36078 , A61N1/36139
摘要： An implantable neurostimulator system adapted to provide therapy for various neurological disorders is capable of varying therapy delivery strategies based on the context, physiological or otherwise, into which the therapy is to be delivered. Responsive and scheduled therapies can be varied depending on various sensor measurements, calculations, inferences, and device states (including elapsed times and times of day) to deliver an appropriate course of therapy under the circumstances.
摘要翻译：适用于为各种神经障碍提供治疗的可植入神经刺激器系统能够基于要递送治疗的上下文（生理或其他）改变治疗递送策略。根据各种传感器测量，计算，推断和设备状态（包括经过时间和时间），在这种情况下提供适当的治疗方案，响应和预定的治疗方法可以不同。

89. 发明申请

US20110213442A1 NEUROSTIMULATOR INVOLVING STIMULATION STRATEGIES AND PROCESS FOR USING IT 有权
标题翻译：涉及刺激策略的神经细胞和使用它的过程
公开(公告)号：US20110213442A1
公开(公告)日：2011-09-01
申请号：US13106747
申请日：2011-05-12
申请人： Benjamin D. Pless
发明人： Benjamin D. Pless
IPC分类号： A61N1/36
CPC分类号： A61N1/36064 , A61N1/36082 , A61N1/36135 , A61N1/36178
摘要： This is a neurostimulator that is configured to treat epilepsy and other neurological disorders using certain stimulation strategies, particularly changing various pulse parameters, during the imposition of a burst of those pulses. The invention includes the processes embodying those stimulation strategies.
摘要翻译：这是一种神经刺激器，其被配置为在施加这些脉冲的突发期间使用某些刺激策略来治疗癫痫和其他神经障碍，特别是改变各种脉冲参数。本发明包括体现这些刺激策略的过程。

90. 发明授权

US07821642B2 Method and system of device identification 有权
标题翻译：设备识别方法和系统
公开(公告)号：US07821642B2
公开(公告)日：2010-10-26
申请号：US12626417
申请日：2009-11-25
申请人： Benjamin D. Pless
发明人： Benjamin D. Pless
IPC分类号： G01B9/02
CPC分类号： G06K9/2036 , G06K9/00577
摘要： A medical device susceptible to identification using interference patterns for performing device identification is disclosed. A source signal may be directed from an energy source towards the surface of a device for reflection therefrom. An interference pattern may be detected from the surface of the device, such as by a sensor. A determination as to whether a match exists between the representation of the interference pattern and a stored representation of an interference pattern may be performed. If a match exists, the device may be identified based on the stored representation of the interference pattern. Otherwise, a representation of the interference pattern may be stored and a unique identifier may be assigned to the stored representation of the interference pattern.
摘要翻译：公开了一种易于识别使用干扰图案进行设备识别的医疗设备。源信号可以从能量源朝向装置的表面引导以从其反射。可以从设备的表面（例如通过传感器）检测干涉图案。可以执行关于在干涉图案的表示和存储的干涉图案的表示之间是否存在匹配的确定。如果存在匹配，则可以基于存储的干涉图案的表示来识别该设备。否则，可以存储干扰图案的表示，并且可以将唯一标识符分配给所存储的干涉图案的表示。

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