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71. 发明申请

US20050074870A1 Apparatuses and methods for reducing albumin in samples 有权
标题翻译：用于减少样品中白蛋白的装置和方法
公开(公告)号：US20050074870A1
公开(公告)日：2005-04-07
申请号：US10922560
申请日：2004-08-19
申请人： William Galbraith
发明人： William Galbraith
IPC分类号： G01N33/48 , A01N1/02 , C12M1/34 , G01N33/53 , G01N33/567 , G01N33/68 , G01N33/96
CPC分类号： G01N33/96 , G01N2333/765
摘要： The present invention is directed to apparatuses and methods for reducing the content of albumin in serum, plasma and/or blood samples. The apparatuses comprise an insoluble support with a ligand attached thereto. According to certain embodiments of the invention, the ligand is a bromosulfophthalein, Cibacron Blue or Warfarin ligand or salts or esters thereof. Also provided are methods of making the apparatus, as well as kits and albumin-depleted samples produced by the methods of the present invention.
摘要翻译：本发明涉及用于降低血清，血浆和/或血液样品中白蛋白含量的装置和方法。这些装置包含与其连接的配体的不溶性载体。根据本发明的某些实施方案，配体是溴磺酞，Cibacron Blue或华法林配体或其盐或酯。还提供了制备该装置的方法，以及通过本发明的方法产生的试剂盒和白蛋白贫化样品。

72. 发明申请

US20050048657A1 Method of using a hematology control product 审中-公开
标题翻译：使用血液控制产品的方法
公开(公告)号：US20050048657A1
公开(公告)日：2005-03-03
申请号：US10909594
申请日：2004-08-02
申请人： Carole Young , Michael Elliott , Nancy Naylor-Schlipp , Timothy Fischer
发明人： Carole Young , Michael Elliott , Nancy Naylor-Schlipp , Timothy Fischer
IPC分类号： G01N15/10 , G01N15/12 , G01N15/14 , G01N33/48 , G01N33/50 , G01N33/92 , G01N33/96
CPC分类号： G01N15/1012 , G01N15/12 , G01N33/5094 , G01N33/92 , G01N33/96 , G01N2015/1062 , G01N2015/1087 , G01N2015/1486 , G01N2015/1493 , G01N2496/05 , G01N2496/10 , Y10T436/101666 , Y10T436/102499 , Y10T436/105831 , Y10T436/106664 , Y10T436/107497 , Y10T436/108331
摘要： A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an instrument. The spatial position of a control product sample is analyzed. Alternatively, the spatial position of a statistically significant number of patient blood samples can be used. The method enables the monitoring of an instrument for problems associated with debris and noise caused by red cell lysis inefficiency; instrument reagents pump volume settings; instrument laser alignments; instrument gain settings; and flow noise caused by partial plugs, residual plugs or other flow problems. The method provides a more specific indication of the type and cause of an instrument malfunctioning than non specific flagging provided by prior art methods.
摘要翻译：一种用于诊断仪器故障原因的质量控制方法。该方法使用样品的物理性质的测量来诊断仪器故障的原因。分析对照产品样品的空间位置。或者，可以使用统计学上显着数量的患者血液样本的空间位置。该方法能够监测仪器与由红细胞裂解无效率引起的碎片和噪声相关的问题; 仪器试剂泵体积设置; 仪器激光对准仪器增益设置; 和由部分插头，残留插头或其他流量问题引起的流动噪声。该方法提供了与现有技术方法提供的非特定标记相比，仪器故障的类型和原因的更具体的指示。

73. 发明授权

US06127111A Lyophilized platelet composition containing chloroquine, hydroxychloroquine, camoquin, quinacrine or procaine 失效
标题翻译：含有氯喹，羟氯喹，卡莫喹，喹吖啶或普鲁卡因的冻干血小板组合物
公开(公告)号：US06127111A
公开(公告)日：2000-10-03
申请号：US915558
申请日：1997-08-21
申请人： Konrad Braun
发明人： Konrad Braun
IPC分类号： A61K35/19 , A61P7/00 , G01N33/96 , A01N1/02 , A01N63/00
CPC分类号： G01N33/96 , A61K35/19 , G01N2496/05
摘要： The present invention relates to preparations of functionally active platelets and to a process for stabilizing these functionally active platelets by means of freeze-drying. In particular, a lyophilized or reconstituted platelet composition containing an anticoagulant, an cake forming agent ad an inhibitor of platelet function selected from the group consisting of chloroquine, hydroxychloroquine, camoquin, quinacrine and procaine is disclosed.
摘要翻译：本发明涉及功能活性血小板的制剂和通过冷冻干燥来稳定这些功能活性血小板的方法。特别地，公开了一种冻干或重构的血小板组合物，其含有选自氯喹，羟氯喹，卡莫喹，奎那康和普鲁卡因的抗凝血剂，成饼剂和抗血小板功能抑制剂。

74. 发明授权

US6103242A Method of controlling blood sugar levels using Coccoloba uvifera 失效
标题翻译：使用Coccoloba uvifera控制血糖水平的方法
公开(公告)号：US6103242A
公开(公告)日：2000-08-15
申请号：US422761
申请日：1999-10-21
申请人： William Buckley
发明人： William Buckley
IPC分类号： A61K36/70 , A61P3/10 , G01N33/66 , G01N33/96 , A61K35/78
CPC分类号： A61K36/70
摘要： A method of treating diabetes in a patient comprising the steps of administering a first quantity of an ingestible medium of coccoloba uvifera leaf extract to the patient, monitoring the patient's change in serum glucose level, and modifying, if needed, the first quantity of the ingestible medium of coccoloba uvifera leaf extract wherein the patient's serum glucose level is reduced to normal levels. Normal levels are generally considered to be about 110 to 130 mg serum glucose per liter. Accordingly, monitoring and adjustment in the dosages of the ingestible medium of coccoloba uvifera leaf extract are increased until the patient's serum glucose level is reduced to 130 mg per liter or less. The patient's serum glucose level may be monitored daily or twice daily depending on the severity of the patient's condition. While the ingestible medium of coccoloba uvifera leaf may be ingested daily, dosages may be staggered to several times a week provided the patient's condition is properly monitored.
摘要翻译：一种治疗患者糖尿病的方法，包括以下步骤：向患者施用第一数量的可肠溶紫杉叶提取物的摄取性培养基，监测患者血清葡萄糖水平的变化，以及如果需要，修饰第一数量的可摄取网状紫菜叶提取物的培养基，其中患者的血清葡萄糖水平降低至正常水平。正常水平通常被认为是每升约110-130毫克血清葡萄糖。因此，增加了可溶性墨西哥叶片提取物的可摄入培养基的剂量的监测和调整，直到将患者的血清葡萄糖水平降低至每升或更低的130mg。患者的血清葡萄糖水平可以每天或每天监测一次，具体取决于患者病情的严重程度。虽然可以每天摄取可摄入的可可叶树叶的培养基，但如果适当地监测患者的状况，则剂量可以每周交错数次。

75. 发明授权

US5994140A Stable coagulation controls 失效
标题翻译：稳定的凝血控制
公开(公告)号：US5994140A
公开(公告)日：1999-11-30
申请号：US21305
申请日：1998-02-10
申请人： Roy E. Speck
发明人： Roy E. Speck
IPC分类号： C12Q1/56 , G01N33/86 , G01N33/96
CPC分类号： C12Q1/56 , G01N33/86 , G01N33/96 , G01N2333/755 , G01N2333/8117 , G01N2333/96444 , G01N2333/974 , G01N2496/05 , Y10T436/10 , Y10T436/101666 , Y10T436/106664 , Y10T436/108331
摘要： A coagulation control sample material for reproducibly monitoring coagulation control capability in a human patient wherein the coagulation control sample material has a predetermined clotting time within the range of from normal to abnormal human clotting times, the control comprising mammalian blood coagulation factors and an amount of at least one non-primate mammalian coagulation factor wherein when the coagulation control sample material has an abnormal human clotting time, the coagulation control comprises an amount of at least one non-primate plasma which has been treated with an adsorbent that adsorbs factors II, VII, IX and X and wherein the coagulation control is stable in the absence of buffer.
摘要翻译：一种用于可重复地监测人类患者凝血控制能力的凝固控制样品材料，其中所述凝固对照样品材料具有在正常至异常人凝血时间范围内的预定凝血时间，所述对照包括哺乳动物血液凝固因子和至少一种非灵长类动物哺乳动物凝血因子，其中当凝血对照样品材料具有异常的人凝血时间时，凝血控制包含一定量的至少一种非吸收性血浆，其已用吸附因子II，VII， IX和X，其中凝血控制在没有缓冲液的情况下是稳定的。

76. 发明授权

US5925533A Tropinin I calibrator and method of use thereof in a sandwich immunoassay 失效
标题翻译：托品蛋白I校准品及其在三明治免疫测定中的应用方法
公开(公告)号：US5925533A
公开(公告)日：1999-07-20
申请号：US763374
申请日：1996-12-13
申请人： Margit Doth , Christoph Petry , Nicole Petesch
发明人： Margit Doth , Christoph Petry , Nicole Petesch
IPC分类号： G01N33/53 , C07K14/47 , G01N33/531 , G01N33/543 , G01N33/68 , G01N33/96
CPC分类号： G01N33/531 , G01N33/6854 , G01N33/96 , Y10S435/967 , Y10S435/972 , Y10S436/811 , Y10S436/815 , Y10S530/807 , Y10T436/10 , Y10T436/105831
摘要： A conjugate consisting of a sequence of the analyte and an antibody against one of the antibodies used in the test can be employed, in aqueous solution and in precisely known quantity, as a stable calibrator in a sandwich immunoassay for detecting the analyte.
摘要翻译：由分析物的序列和针对测试中使用的抗体的抗体组成的缀合物可以在水溶液中以精确已知的量作为用于检测分析物的夹心免疫测定中的稳定校准物。

77. 发明授权

US5891730A Method to prepare dye-based reference material 失效
标题翻译：制备基于染料的参考材料的方法
公开(公告)号：US5891730A
公开(公告)日：1999-04-06
申请号：US810214
申请日：1997-02-28
申请人： Jay J. Li , Justin E. Davey , David P. Swist , Liann Voo
发明人： Jay J. Li , Justin E. Davey , David P. Swist , Liann Voo
IPC分类号： G01N33/72 , A61B5/145 , A61B5/1455 , A61B5/1495 , G01N1/00 , G01N21/01 , G01N21/27 , G01N33/58 , G01N33/96 , G01N31/00
CPC分类号： G01N33/96 , G01N2496/15 , G01N2496/70 , G01N33/583 , Y10T436/10 , Y10T436/102499 , Y10T436/105831 , Y10T436/109163
摘要： Provided is a method of preparing dye-based reference materials useful for calibrating or qualifying instrument systems that are diagnostic spectroscopically for hemoglobin and CO-ox fractions. The dye-based reference materials are non-proteinaceous and may be interpreted by CO-oximeter instrument systems as providing a spectrum substantially equivalent to the spectrum of blood, particularly with regard to hemoglobin and hemoglobin CO-ox fractions. Dye-based reference materials may be formulated to provide CO-ox fractions approximating those seen in a clinical setting, including normal physiological CO-ox fractions. The dye-based reference materials may be combined with other ingredients thus making the materials useful as references for pH and blood gas instruments and/or electrolyte instruments in addition to CO-oximeter instrument systems.
摘要翻译：提供了一种制备用于校准或鉴定对血红蛋白和CO-ox级分进行光谱诊断的仪器系统的基于染料的参考物质的方法。基于染料的参考材料是非蛋白质的，并且可以由CO-血氧计仪器系统解释为提供基本上等于血液谱的光谱，特别是关于血红蛋白和血红蛋白CO-ox级分。可以配制基于染料的参考物质，以提供接近在临床环境中观察到的CO-Ox级分，包括正常的生理性CO-ox级分。基于染料的参考材料可以与其他成分组合，因此除了CO-血氧仪仪器系统之外，这些材料可用作pH和血气仪器和/或电解质仪器的参考。

78. 发明授权

US5846738A Synthetic standard for immunoassays 失效
标题翻译：免疫测定合成标准
公开(公告)号：US5846738A
公开(公告)日：1998-12-08
申请号：US762695
申请日：1996-12-12
申请人： Christoph Seidel , Peter Bialk , Herbert Von der Eltz
发明人： Christoph Seidel , Peter Bialk , Herbert Von der Eltz
IPC分类号： G01N33/53 , A61K38/00 , C07K14/47 , G01N1/00 , G01N33/531 , G01N33/541 , G01N33/68 , G01N33/86 , G01N33/96
CPC分类号： C07K14/4716 , G01N33/531 , G01N33/6887 , G01N33/86 , G01N33/96 , A61K38/00 , G01N2333/4712 , G01N2333/75 , Y10S435/961 , Y10S435/967 , Y10S435/973 , Y10S530/806 , Y10T436/10
摘要： A conjugate of at least two binding sites that bind specifically to the analyte-specific binding region of the receptor that is used for detection in a test, wherein the binding sites are linked by at least one soluble carrier substance and the conjugate is a product of a synthetic or recombinant production, dissolved in an aqueous solution in an exactly known amount is particularly suitable as a stable calibrator in a test for the detection of an analyte.
摘要翻译：至少两个结合位点的缀合物，其特异性结合于用于检测的受体的分析物特异性结合区域，其中所述结合位点通过至少一种可溶性载体物质连接，所述缀合物是以完全已知的量溶解在水溶液中的合成或重组生产特别适合作为检测分析物的测试中的稳定校准物。

79. 发明授权

US5823196A Method for detecting alcohol consumption rates 失效
标题翻译：酒精消费率检测方法
公开(公告)号：US5823196A
公开(公告)日：1998-10-20
申请号：US669836
申请日：1996-06-26
申请人： James W. Harasymiw
发明人： James W. Harasymiw
IPC分类号： G01N33/72 , G01N33/96 , G06F19/00 , A61B19/00
CPC分类号： G01N33/96 , G01N33/72 , G06F19/366 , G01N2496/80 , G06F19/363
摘要： A method for assessing or determining alcohol consumption rates including using a blood specimen from a human subject to develop an individual blood constituent panel; comparing the individual panel with a reference blood constituent panel to provide categories corresponding to rates of alcohol consumption; and identifying the category of consumption rate. The methods of the invention can be varied through modification of one of several statistical models used therewith to preferentially weigh the analysis and identify one consumption category over another. Multi-variate and similar such statistical techniques correlate comparisons of individual/subject blood and reference panel constituents with recognized consumption rates.
摘要翻译：一种用于评估或确定酒精消耗率的方法，包括使用来自人类受试者的血液样本来开发个体血液成分面板; 将单个面板与参考血液成分面板进行比较，以提供与酒精消耗率相对应的类别; 并确定消费率的类别。本发明的方法可以通过修改其中使用的几种统计模型中的一种来优化权重来分析并且识别一种消费类别。多变量和类似的这种统计技术将个体/受试者血液和参照组成分的比较与公认的消费率相关联。

80. 发明授权

US5801007A Methods for calibrating chemical assays 失效
标题翻译：校准化学测定方法
公开(公告)号：US5801007A
公开(公告)日：1998-09-01
申请号：US721984
申请日：1997-04-07
申请人： Willaim John Simpson , Julian Mark Pye
发明人： Willaim John Simpson , Julian Mark Pye
IPC分类号： G01N33/50 , C12Q1/66 , G01N21/77 , G01N21/78 , G01N33/58 , G01N33/96 , C12Q1/00 , C12Q1/34 , C12Q1/42
CPC分类号： C12Q1/66 , Y10S435/968 , Y10S435/975
摘要： Methods for internally and externally photostandardizing chemical assays, e.g. an ATP-bioluminescence assay. A pre-determined amount of a photosensitive derivative of the analyte of interest is used in the assay protocol which releases a known amount of the free analyte when it is exposed to a flash of visible light of pre-determined duration and intensity. By monitoring the response of a test property of the assay to the release of a known quantity of analyte, a standard value can be calculated which allows either direct determination of the amount of analyte originally present in the assayed sample or production of a photocalibration series against which results of an assayed sample can be compared.
摘要翻译： PCT No.PCT / GB95 / 00794 Sec。 371日期1997年4月7日 102（e）日期1997年4月7日PCT提交1995年4月6日PCT公布。公开号WO95 / 27797 1995年10月19日的日期内部和外部光标化化学测定法的方法。 ATP生物发光测定法。在测定方案中使用预定量的感兴趣的分析物的光敏衍生物，其在释放已知量的游离分析物时，其暴露于预定持续时间和强度的可见光的闪光。通过监测测定的测试性质以释放已知量的分析物的响应，可以计算标准值，其允许直接测定最初存在于测定样品中的分析物的量或产生光学校准系列反对可以比较测定样品的结果。

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