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71. 发明授权

US10295442B2 Two phase immiscible system for the pretreatment of embedded biological samples 有权
公开(公告)号：US10295442B2
公开(公告)日：2019-05-21
申请号：US14001714
申请日：2012-02-28
申请人： Steen Hauge Matthiesen , Søren Nielsen
发明人： Steen Hauge Matthiesen , Søren Nielsen
IPC分类号： G01N1/30 , G01N1/31 , G01N1/36
摘要： The present application provides a two phase immiscible system for the pretreatment of embedded biological samples comprising placing at least one support having an embedded biological sample on its surface into a pretreatment container, adding to the pretreatment container at least one reagent forming a layer, adding a carrier composition to the pretreatment container, such that reagent forming layer is formed on the top of the carrier composition, and in an amount such that the at least one reagent forming layer contacts at least a portion of the embedded biological sample. Pretreatment of the embedded biological samples can include removal of embedding medium from embedded biological, target retrieval and enzyme blocking samples before staining histochemical analysis or other processes. The system also includes an apparatus and processes of automation of the pretreatment methods.

72. 发明申请

US20190113423A1 METHODS FOR PREPARING AND ANALYZING TUMOR TISSUE SAMPLES FOR DETECTION AND MONITORING OF CANCERS 审中-公开
公开(公告)号：US20190113423A1
公开(公告)日：2019-04-18
申请号：US15781082
申请日：2016-12-02
申请人： Clearlight Diagnostics, LLC
发明人： Laurie Goodman , Karl A. Deisseroth
IPC分类号： G01N1/36 , G01N33/483 , G06T7/00 , G01N1/30
摘要： The present invention provides methods for processing and analyzing large intact biological samples, including tumor tissue samples. The methods have a variety of uses, including for the diagnosis and monitoring of tumors and tumor metastasis.

73. 发明申请

US20190078985A1 Hydrogel Encapsulation of Living Organisms for Long-Term Microscopy 审中-公开
公开(公告)号：US20190078985A1
公开(公告)日：2019-03-14
申请号：US16129581
申请日：2018-09-12
申请人： Worcester Polytechnic Institute
发明人： Dirk Albrecht , Ross Lagoy , Kyra Burnett
IPC分类号： G01N1/30 , G01N1/44 , G01N1/36 , G01N33/483
摘要： Devices and methods for capturing and imaging a specimen, such as a living organism, are disclosed. In some embodiments, a method for imaging a living organism in vivo includes placing at least one specimen into a hydrogel polymer on a substrate, and curing the hydrogel to embed the at least one specimen within the cured hydrogel such that the at least one specimen is kept alive and the movement of the at least one specimen within the cured hydrogel is restricted. The at least one embedded specimen can be imaged.

74. 发明申请

US20180372596A1 SAMPLE ENCAPSULATION SYSTEM 审中-公开
公开(公告)号：US20180372596A1
公开(公告)日：2018-12-27
申请号：US15779669
申请日：2016-11-30
申请人： ILLINOIS TOOL WORKS INC.
发明人： Thomas E. Sotomayor
IPC分类号： G01N1/36 , B30B11/34 , G01N1/28 , B30B15/34
摘要： A sample encapsulation system (10) includes a fixture, a base (12), a chamber (14) having an inlet and a chamber housing (16). The housing (16) has inner (36) and outer (38) housings. The chamber (14) is fixedly mounted in the inner housing (36). The base, chamber (14) and housing (16) are affixed relative to one another and movable relative to the fixture. The system includes a cap (78) and a first ram (80) operably mounted to the cap (78) for engaging the chamber inlet. A second ram (24) is positioned in the chamber (14) opposite the inlet and moves toward and away from the first ram (80). The second ram (24) is driven by a cylinder. A heating assembly is positioned in the inner housing (36) and a cooling assembly which includes a cooling jacket (50) defined in part by the inner housing (36) and the outer housing (38) includes a manifold (60). The chamber (14), chamber housing (16) and base (12) are movable toward the cap (78) for engaging the first ram (80) with the chamber inlet during an encapsulation cycle and away from the cap (78), disengaging the first ram (80) from the chamber inlet following an encapsulation cycle. The cooling system includes a vacuum breaker (62) to self-drain following cooling.

75. 发明申请

US20180348105A1 DIRECT METHOD FOR MANUFACTURING LARGE MODEL FRACTURED CORE AND MAINTAINING ORIGINAL OIL-WATER SATURATION 审中-公开
公开(公告)号：US20180348105A1
公开(公告)日：2018-12-06
申请号：US15775391
申请日：2016-12-02
申请人： SOUTHWEST PETROLEUM UNIVERSITY
发明人： Ping GUO , Shuai WU , Wanbo ZHANG , Yisheng HU , Yijian CHEN , Huimin ZHANG , Zhouhua WANG , Jianfen DU , Huang LIU , Hongmei REN
IPC分类号： G01N1/36 , G01N15/08
CPC分类号： G01N1/36 , G01N15/082 , G01N15/088 , G01N33/241 , G01N2001/2873 , G01N2001/366
摘要： A direct method for manufacturing a large model fractured core and maintaining original oil-water saturation, including the following steps: (1) determining the volume V, porosity φ, permeability K, oil saturation So, water saturation Sw and the like of a fractured core to be manufactured; (2) preparing simulated oil, and determining the used oil mass mo=Vo×ρo; (3) under the circumstance of no consideration of oil saturation, acquiring the mass of the used water, cement and quartz sand; (4) while establishing oil saturation, acquiring the mass mw of water for manufacturing the core as mw=a−Vo×ρw; (5) mixing oil, water and an emulsifier evenly to prepare an oil-in-water emulsion; (6) adding cement and quartz sand into the emulsion and stirring evenly to obtain cement slurry; (7) when a cement sample is in a semi-solidified state, cutting the cement sample with a steel wire; and (8) solidifying the cement sample to the end.

76. 发明授权

US10130945B2 Cell pathology tubes and associated cell processing methods 有权
公开(公告)号：US10130945B2
公开(公告)日：2018-11-20
申请号：US15373548
申请日：2016-12-09
申请人： Wake Forest University Health Sciences
发明人： Shaozhou Ken Tian , Kim R. Geisinger
IPC分类号： G01N1/10 , B01L3/00 , C12Q1/24 , G01N1/36
摘要： Cell tubes that can be used both for pathology collection and subsequent cell processing include a tube with a cell bed at a lower portion of the tube. The tube can include a base member that can be detachable from the tube body. The tubes can be used to form cell (cytology) blocks that incorporate the cell bed. The cell bed can be an inert cell bed of paraffin.

77. 发明授权

US10107727B2 Tissue processing reagent 有权
公开(公告)号：US10107727B2
公开(公告)日：2018-10-23
申请号：US15371588
申请日：2016-12-07
申请人： Sakura Finetek U.S.A., Inc.
发明人： Amit D. Shah
IPC分类号： G01N1/30 , G01N1/36
摘要： A method including placing a biological sample taken from a body into a chamber; adding a composition including an acetal solvent to the chamber; and fixating the biological sample. A method including placing a tissue from a body into a chamber; and contacting the tissue with a composition including an acetal solvent as a fixating process.

78. 发明授权

US10086536B2 Metallographic sample preparation method and metallographic sample mold 有权
公开(公告)号：US10086536B2
公开(公告)日：2018-10-02
申请号：US14826598
申请日：2015-08-14
申请人： UNITED TECHNOLOGIES CORPORATION
发明人： Michael J. Minor
IPC分类号： B29C35/08 , G01N1/36 , B29C33/38 , B29C39/10 , B29K63/00 , B29K705/00 , B29L31/40
摘要： The present disclosure relates generally to method for preparing metallographic samples including the steps of placing a specimen into a mold, inserting an epoxy into the mold, and exposing the mold to an ultraviolet light for a duration of time to create a mounting sample. The mold includes a peripheral wall and a bottom defining a cavity therein. The mold is formed from a material that allows ultraviolet light to penetrate the peripheral wall and bottom into the cavity. The mold includes a material operative to allow an ultraviolet light to penetrate the peripheral wall and the bottom surface into the cavity.

79. 发明授权

US10054523B2 Embedding cassette, embedding mold and embedding assembly for biopsy 有权
公开(公告)号：US10054523B2
公开(公告)日：2018-08-21
申请号：US14759229
申请日：2013-11-27
申请人： Sun Mi Jung
发明人： Sun Mi Jung
IPC分类号： G01N1/36
CPC分类号： G01N1/36 , G01N2001/366
摘要： Disclosed is an embedding cassette for biopsy to embed tissue received in an embedding mold provided with a space to receive the tissue when the embedding cassette is combined with the embedding mold, including a body provided with a space communicating with the receipt space of the combined embedding mold so that an injected paraffin solution may coagulate therein during embedding of the tissue and at least one paraffin barrier groove formed at the edge of the lower surface of the body, and, when the embedding cassette is combined with the embedding mold and embedding of the tissue is carried out, the injected paraffin solution flows into the at least one paraffin barrier groove and forms a barrier and, thereby, leakage of the paraffin solution between the embedding cassette and embedding mold is prevented.

80. 发明授权

US10016760B2 Method and apparatus for non-compressed evaluation of tissue specimens 有权
公开(公告)号：US10016760B2
公开(公告)日：2018-07-10
申请号：US15160908
申请日：2016-05-20
申请人： Daniel Rupley
发明人： Daniel Rupley
IPC分类号： G01N3/00 , B01L3/00 , G01N1/36
CPC分类号： B01L3/505 , A61B10/0041 , A61B10/0096 , B01L2200/023 , B01L2200/025 , B01L2300/042 , B01L2300/0832 , G01N1/36
摘要： The present invention provides a method and apparatus for evaluating the margins of a surgically-removed tissue specimen, such as a breast tissue specimen, to determine whether sufficient fatty tissue has been removed from around the lesion or cancerous point. The instant invention provides a solution to the problem of on-site evaluation of the margin sufficiency during the surgical procedure, in that it provides surgeons with an orthogonal view of all sides of the tissue specimen to be evaluated. The specimen evaluation device provides for properly-oriented examination of the removed specimen in a non-compressed, undistorted manner, both by visual inspection and through radiographic evaluation. Through this examination of the properly-oriented specimen, the surgeon may quickly and more accurately be informed of whether there remain cancerous cells in the margins surrounding the sample, which are meant to be free of cancerous cells. Upon evaluation of the margins of the removed sample, the surgeon may then make an on-site determination on whether to proceed with additional surgery or complete the surgical procedure.

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