专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明授权

US06001881A Ortho-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament comprising them 失效
标题翻译：正取代的苯甲酰胍，其制备方法，它们作为药物或诊断剂的用途，以及包含它们的药物
公开(公告)号：US06001881A
公开(公告)日：1999-12-14
申请号：US868750
申请日：1997-06-04
申请人： Andreas Weichert , Joachim Brendel , Heinz-Werner Kleemann , Hans Jochen Lang , Jan-Robert Schwark , Udo Albus , Wolfgang Scholz
发明人： Andreas Weichert , Joachim Brendel , Heinz-Werner Kleemann , Hans Jochen Lang , Jan-Robert Schwark , Udo Albus , Wolfgang Scholz
IPC分类号： A61K31/165 , A01N1/02 , A01N47/44 , A61K31/10 , A61K31/155 , A61K31/18 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P35/00 , A61P43/00 , C07C279/10 , C07C279/20 , C07C279/22 , C07C303/40 , C07C311/19 , C07C311/47 , C07C317/42 , C07C317/50 , C07C277/08
CPC分类号： A61K31/155 , Y10S514/821 , Y10S514/825
摘要： Benzoylguanidines of the formula I ##STR1## in which: R(1) to R(4) have the meanings given in the claims, are antiarrhythmic pharmaceuticals, having a cardioprotective component, which are also valuable for the prevention of ischemically induced damage, in particular in association with the triggering of ischemically induced cardiac arrhythmias. As a consequence of inhibiting the cellular Na.sup.+ /H.sup.+ exchange mechanism, they are used for treating acute or chronic damage triggered by ischemia. In addition to this, they are notable for their strong inhibitory effect on the proliferation of cells. They are suitable for preventing the genesis of high blood pressure.
摘要翻译：其中：R（1）至R（4）具有权利要求中给出的含义的式I的苯甲酰基胍是具有心脏保护成分的抗心律失常药物，其对于预防缺血诱导的损伤，特别是在关联中也是有价值的引发缺血诱发的心律失常。作为抑制细胞Na + / H +交换机制的结果，它们用于治疗由缺血引起的急性或慢性损伤。除此之外，它们对细胞增殖具有强烈的抑制作用。它们适合于预防高血压的发生。

72. 发明授权

US5962655A Monoazo compound and an intermediate for a fiber-reactive dye compound 失效
标题翻译：单偶氮化合物和纤维反应性染料化合物的中间体
公开(公告)号：US5962655A
公开(公告)日：1999-10-05
申请号：US9499
申请日：1998-01-20
申请人： Nobutaka Kunimi , Shigeru Sasaki , Kouji Toishi , Atsushi Inoue
发明人： Nobutaka Kunimi , Shigeru Sasaki , Kouji Toishi , Atsushi Inoue
IPC分类号： C07C317/18 , C07C317/28 , C07C317/42 , C09B62/44 , C09B62/51 , C09B62/008 , D06P1/38
CPC分类号： C07C317/42 , C07C317/18 , C07C317/28 , C09B62/4401 , C09B62/51
摘要： There is provided a monoazo compound which is useful as a reactive dye for dyeing or printing a fiber material in an orange to scarlet color; and intermediate compounds for producing the compound is provided; the monoazo compound being represented by the following formula (1): ##STR1## wherein m represents 0 or 1; R.sup.1 represents a hydrogen atom or a lower alkyl group; D represents a specific diazo component of benzene type having substitution of a fiber reactive group; B.sup.1 represents a direct bond or connecting group; Z.sup.1 represents an alkylcarbonyl group, phenylcarbonyl group or a fiber-reactive group of vinylsulfone, triazine or pirimidine type; a group represented by --NR.sup.1 -- bonds to 6-position or 7-position of a naphthalene ring;and the intermediate compounds being represented by the following formulae (A) or (B): ##STR2## wherein U represents a connecting group such as alkylene and the like, Y represents vinyl or --CH.sub.2 CH.sub.2 L, and L represents a group eliminatable by an action of alkali.
摘要翻译：提供了一种单偶氮化合物，其可用作用于染色或印刷橙色至猩红色的纤维材料的活性染料; 并提供了用于制备该化合物的中间体化合物; 单偶氮化合物由下式（1）表示：其中m表示0或1; R1表示氢原子或低级烷基; D表示具有纤维反应性基团取代的苯类的特定重氮组分; B1代表直接键或连接基团; Z1表示烷基羰基，苯基羰基或乙烯基砜，三嗪或吡啶啶类的纤维反应性基团; 由-NR1-键键合到萘环的6-位或7-位的基团; 并且中间体化合物由下式（A）或（B）表示：其中U表示连接基团，例如亚烷基等，Y表示乙烯基或-CH 2 CH 2 L，L表示可通过碱的作用消除的基团。

73. 发明授权

US5939563A O-methyloximes of benzopyran-3,4- and benzofuran-2,3-diones and methods for their preparation 失效
标题翻译：苯并吡喃-3,4-和苯并呋喃-2,3-二酮的O-甲基肟及其制备方法
公开(公告)号：US5939563A
公开(公告)日：1999-08-17
申请号：US52048
申请日：1998-03-30
申请人： Ian Richard Matthews
发明人： Ian Richard Matthews
IPC分类号： C07D237/10 , A01N47/06 , A01N47/12 , A01N47/16 , A01N47/18 , A01N47/20 , A01N47/22 , C07C68/02 , C07C69/734 , C07C69/96 , C07C249/04 , C07C249/12 , C07C251/38 , C07C251/48 , C07C269/02 , C07C269/04 , C07C271/28 , C07C271/64 , C07C317/42 , C07C323/20 , C07C323/36 , C07C327/48 , C07C329/02 , C07C329/04 , C07C329/14 , C07C333/04 , C07C333/08 , C07D209/08 , C07D213/04 , C07D213/75 , C07D239/28 , C07D241/14 , C07D277/68 , C07D277/70 , C07D277/82 , C07D295/205 , C07D311/76 , C07D311/02 , C07D307/82
CPC分类号： C07D213/75 , A01N47/06 , A01N47/12 , A01N47/16 , A01N47/18 , A01N47/20 , A01N47/22 , C07C249/04 , C07C249/12 , C07C251/48 , C07C271/28 , C07C271/64 , C07C317/42 , C07C323/36 , C07C327/48 , C07C329/02 , C07C329/04 , C07C333/08 , C07C69/734 , C07C69/96 , C07D295/205 , C07D311/76
摘要： Compounds of formula (XXIII): ##STR1## wherein p is 0 or 1, and processes for making such compounds.
摘要翻译：式（XXIII）化合物：其中p为0或1，以及制备此类化合物的方法。

74. 发明授权

US5866609A Substituted vinylurea derivatives and medicine containing the same 失效
标题翻译：取代的乙烯基脲衍生物和含有其的药物
公开(公告)号：US5866609A
公开(公告)日：1999-02-02
申请号：US899647
申请日：1997-07-24
申请人： Yoshihiko Kanamaru , Hiroyuki Hirota , Akihiro Shibata , Teruo Komoto , Hiroyuki Naito , Koichi Tachibana , Mari Ohtsuka , Fumio Ishii , Susumu Sato
发明人： Yoshihiko Kanamaru , Hiroyuki Hirota , Akihiro Shibata , Teruo Komoto , Hiroyuki Naito , Koichi Tachibana , Mari Ohtsuka , Fumio Ishii , Susumu Sato
IPC分类号： C07C275/28 , C07C275/30 , C07C275/34 , C07C275/40 , C07C275/42 , C07C317/42 , C07C323/44 , C07D211/58 , C07D317/58 , C07D317/66 , A61K31/17 , C07C275/04
CPC分类号： C07C317/42 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/40 , C07C275/42 , C07C323/44 , C07D211/58 , C07D317/58 , C07D317/66 , C07C2101/14
摘要： Disclosed herein are substituted vinylurea derivatives represented by the following general formula (1): ##STR1## wherein R.sup.1 and R.sup.3 are independently a phenyl group which may be substituted, R.sup.2 is a phenyl group which may be substituted, or a cycloalkyl group, and wave lines mean that the bonding state may be either E or Z, with the proviso that the cases where R.sup.1, R.sup.2 and R.sup.3 are unsubstituted phenyl groups, and where R.sup.1 and R.sup.2 are unsubstituted phenyl groups and R.sup.3 is a 4-ethoxyphenyl group are excluded, or salt thereof, and medicines comprising such a derivative as an active ingredient as well as a method of preventing and treating arteriosclerosis with such a medicine. The derivatives or salts thereof selectively and strongly inhibit ACAT in macrophages and are hence useful as prophylactic and therapeutic agents for arteriosclerosis.
摘要翻译：本文公开了由以下通式（1）表示的取代的乙烯基脲衍生物：其中R 1和R 3独立地为可被取代的苯基，R 2为可被取代的苯基或环烷基并且波线意味着键合状态可以是E或Z，条件是其中R1，R2和R3是未取代的苯基，R1和R2是未取代的苯基，R3是4-乙氧基苯基的情况或其盐，以及包含这样的衍生物作为活性成分的药物，以及用这种药物预防和治疗动脉硬化的方法。其衍生物或其盐在巨噬细胞中选择性且强烈地抑制ACAT，因此可用作动脉硬化的预防和治疗剂。

75. 发明授权

US5585513A Fungicides 失效
标题翻译：杀菌剂
公开(公告)号：US5585513A
公开(公告)日：1996-12-17
申请号：US468496
申请日：1995-06-06
申请人： Ian R. Matthews , Christoher R. A. Godfrey , John M. Clough
发明人： Ian R. Matthews , Christoher R. A. Godfrey , John M. Clough
IPC分类号： C07D237/10 , A01N47/06 , A01N47/12 , A01N47/16 , A01N47/18 , A01N47/20 , A01N47/22 , C07C68/02 , C07C69/734 , C07C69/96 , C07C249/04 , C07C249/12 , C07C251/38 , C07C251/48 , C07C269/02 , C07C269/04 , C07C271/28 , C07C271/64 , C07C317/42 , C07C323/20 , C07C323/36 , C07C327/48 , C07C329/02 , C07C329/04 , C07C329/14 , C07C333/04 , C07C333/08 , C07D209/08 , C07D213/04 , C07D213/75 , C07D239/28 , C07D241/14 , C07D277/68 , C07D277/70 , C07D277/82 , C07D295/205 , C07D311/76 , C07C69/76
CPC分类号： C07D213/75 , A01N47/06 , A01N47/12 , A01N47/16 , A01N47/18 , A01N47/20 , A01N47/22 , C07C249/04 , C07C249/12 , C07C251/48 , C07C271/28 , C07C271/64 , C07C317/42 , C07C323/36 , C07C327/48 , C07C329/02 , C07C329/04 , C07C333/08 , C07C69/734 , C07C69/96 , C07D295/205 , C07D311/76
摘要： A compound of the formula: ##STR1## useful as an intermediate in the preparation of fungicides.
摘要翻译：用作制备杀真菌剂的中间体的下式的化合物：。

76. 发明授权

US5550217A Azo dyes 失效
标题翻译：偶氮染料
公开(公告)号：US5550217A
公开(公告)日：1996-08-27
申请号：US328943
申请日：1994-10-25
申请人： Martin Trottmann
发明人： Martin Trottmann
IPC分类号： C09B29/085 , C07C229/16 , C07C229/40 , C07C233/43 , C07C233/54 , C07C233/80 , C07C235/10 , C07C235/16 , C07C253/30 , C07C255/61 , C07C271/28 , C07C275/40 , C07C311/05 , C07C311/08 , C07C317/42 , C09B29/08 , C09B31/043 , D06P1/18 , D06P3/54 , C09B29/00
CPC分类号： C09B31/043 , C07C229/16 , C07C233/43 , C07C235/16 , C07C271/28 , C07C275/40 , C07C311/05 , C07C311/08 , C09B29/0816 , C09B29/0817
摘要： Disperse dyes of formula ##STR1## wherein D is the radical of a diazo component of formula ##STR2## Z.sub.1 is a radical of formula ##STR3## Z.sub.2 is hydrogen or a radical of formula (4), X is hydrogen, halogen, CF.sub.3, R.sub.3, OR.sub.3, NH--CO--R.sub.7, NH--CO--OR.sub.8, NH--SO.sub.2 --R.sub.7 or ##STR4## wherein R.sub.3 is C.sub.1 -C.sub.6 alkyl; R.sub.4 and R.sub.5 are each independently of the other hydrogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy-C.sub.2 -C.sub.4 alkyl; R.sub.7 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.4 alkoxy-C.sub.1 -C.sub.4 alkyl or phenyl; and R.sub.8 is C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.4 alkoxy-C.sub.2 -C.sub.4 alkyl; A.sub.1 is hydrogen, halogen, SO.sub.2 R.sub.3, CF.sub.3, NO.sub.2 or CN; A.sub.2 is hydrogen, halogen or CN; A.sub.3 is hydrogen or halogen, with the proviso that at least one of the substituents X, A.sub.1, A.sub.2 and A.sub.3 may not be hydrogen, and A.sub.4 is hydrogen, halogen, nitro, R.sub.3, NHCOR.sub.3 or OR.sub.3.
摘要翻译：（1）的分散染料其中D是式（2）或（IMAGE）（3）的重氮组分的基团，Z1是下式的基团：（4）Z2是氢或式（4）的基团，X是氢，卤素，CF 3，R 3，OR 3，NH-CO-R 7，NH-CO-OR 8，NH-SO 2 -R 7或者其中R 3是C 1 -C 6烷基; R 4和R 5各自独立地为另一个氢，C 1 -C 4烷基或C 1 -C 4烷氧基-C 2 -C 4烷基; R 7是氢，C 1 -C 6烷基，C 1 -C 4烷氧基-C 1 -C 4烷基或苯基; 并且R 8是C 1 -C 6烷基或C 1 -C 4烷氧基-C 2 -C 4烷基; A1是氢，卤素，SO2R3，CF3，NO2或CN; A2是氢，卤素或CN; A3是氢或卤素，条件是至少一个取代基X，A1，A2和A3可以不是氢，A4是氢，卤素，硝基，R3，NHCOR3或OR3。

77. 发明授权

US5091394A Benzoylguanidines, a process for their preparation, their use as medicaments and medicaments containing them 失效
标题翻译：苯甲酰胺，其制备方法，它们作为含有它们的药物和药物使用
公开(公告)号：US5091394A
公开(公告)日：1992-02-25
申请号：US576937
申请日：1990-09-04
申请人： Heinrich C. Englert , Hans-Jochen Lang , Wolfgang Linz , Bernward Scholkens , Wolfgang Scholz
发明人： Heinrich C. Englert , Hans-Jochen Lang , Wolfgang Linz , Bernward Scholkens , Wolfgang Scholz
IPC分类号： C07C279/22 , A61K31/155 , A61K31/18 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/445 , A61K31/455 , A61K31/535 , A61K31/5375 , A61P9/06 , A61P9/08 , A61P9/10 , C07C277/00 , C07C279/10 , C07C311/15 , C07C311/47 , C07C317/42 , C07C317/44 , C07C323/60 , C07C323/62 , C07C323/65 , C07C323/67 , C07D209/08 , C07D211/28 , C07D295/14 , C07D295/155 , C07D295/195 , C07D295/22 , C07D295/26
CPC分类号： C07D295/26 , C07C311/47 , C07C317/42 , C07C323/67 , C07D209/08 , C07D295/155 , C07C2101/06 , C07C2101/14
摘要： Benzoylguanidines of the formula I ##STR1## where R(1) or R(2) is equal to R(6)--S(O).sub.n -- or R(7)R(8)N--O.sub.2 S--and the other substituent R(1) or R(2) is in each case equal to H, F, Cl, Br, I, alkyl, alkoxy or phenoxy, R(6)--S(O).sub.n or R(7)R(8)N--and R(6) is equal to alkyl, cycloalkyl, cyclopentylmethyl, cyclohexylmethyl or phenyl,R(7) and R(8) are equal to alkyl or phenylakyl or phenyl,and in which R(7) and R(8) may also together be a C.sub.4 -C.sub.7 chain, and in which R(7) and R(8), together with the nitrogen atom to which they are bonded, may be dihydroindole, tetrahydroquinoline or tetrahydroisoquinoline system,and where R(3), R(4) and R(5) are equal to hydrogen or alkyl, or R(3) and R(4) are together an alkylene chain or R(4) and R(5) are together an alkylene chain,and where n is equal to zero, 1 or 2 and their pharmaceutically tolerable salts are outstanding antiarrhythmics.
摘要翻译：其中R（1）或R（2）等于R（6）-S（O）n - 或R（7）R（8）N-O 2 S-的式I的苯甲酰基胍（I）其中R（1）或R（2）各自为H，F，Cl，Br，I，烷基，烷氧基或苯氧基，R（6）-S（O）n或R（7） 8）N-和R（6）等于烷基，环烷基，环戊基甲基，环己基甲基或苯基，R（7）和R（8）等于烷基或苯基烷基或苯基，其中R（7）和R 8）也可以一起是C4-C7链，其中R（7）和R（8）与它们所键合的氮原子一起可以是二氢吲哚，四氢喹啉或四氢异喹啉体系，其中R（3 ），R（4）和R（5）等于氢或烷基，或R（3）和R（4）一起是亚烷基链或R（4）和R（5）一起是亚烷基链，其中n等于零，1或2及其药学上可耐受的盐是出色的抗心律失常药。

78. 发明授权

US5043344A Unsaturated N-benzopyranyllactams 失效
标题翻译：不饱和的N-苯并吡喃内酰胺
公开(公告)号：US5043344A
公开(公告)日：1991-08-27
申请号：US330042
申请日：1989-03-29
申请人： Heinrich C. Englert , Dieter Mania , Bernward Scholkens , Roland Utz
发明人： Heinrich C. Englert , Dieter Mania , Bernward Scholkens , Roland Utz
IPC分类号： C07D405/00 , A61K31/40 , A61K31/44 , A61K31/443 , A61K31/455 , A61K31/505 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P21/02 , A61P25/04 , C07C277/00 , C07C279/28 , C07C317/42 , C07C323/35 , C07C323/65 , C07D217/24 , C07D295/18 , C07D405/04
CPC分类号： C07D405/04 , A61K31/40 , A61K31/44 , A61K31/455 , A61K31/505 , C07C279/28 , C07C317/42 , C07D217/24 , C07D295/18 , C07C2101/14 , C07C2102/10
摘要： Compounds I ##STR1## where R.sup.1 is H, alkyl, alkoxy, CO alkyl, COOH, carboxyalkyl, CONR.sub.2, CN, NO.sub.2, alkylsulfi(o)nyl, arylsulfi(i)-nyl; R.sup.2 is H, OH, alkoxy, alkyl or alkylcarbonyl, R.sup.3 /R.sup.4 are alkyl, m is zero or one and X is --CR.sup.6 .dbd.CR.sup.7 -(--CR.sup.8 .dbd.CR.sup.9) (R.sup.6 R.sup.9 are H or alkyl), where n is zero or 1, are described. They are active antihypertensives and spasmolytics for the bladder, intestine, gall bladder, uterus, trachea and ureter.
摘要翻译：化合物Ⅰ其中R 1是H，烷基，烷氧基，CO烷基，COOH，羧基烷基，CONR2，CN，NO2，烷基亚磺酰基（O）nyl，芳基亚磺酰基（ⅰ） R2是H，OH，烷氧基，烷基或烷基羰基，R3 / R4是烷基，m是0或1，X是-CR6 = CR7 - （ - CR8 = CR9）（R6 R9是H或烷基），其中n是0 或1。它们是膀胱，肠，胆囊，子宫，气管和输尿管的主动抗高血压药和解痉药。

79. 发明授权

US5011837A Aryl cyanoguanidines: potassium channel activators and method of making same 失效
标题翻译：芳基氰胍：钾通道激活剂及其制备方法
公开(公告)号：US5011837A
公开(公告)日：1991-04-30
申请号：US349021
申请日：1989-05-08
申请人： Karnail Atwal , John R. McCullough , Gary J. Grover
发明人： Karnail Atwal , John R. McCullough , Gary J. Grover
IPC分类号： A61K31/40 , A61K31/44 , A61K31/455 , A61K31/505 , C07C279/28 , C07C317/42 , C07D217/24 , C07D295/18
CPC分类号： A61K31/455 , A61K31/40 , A61K31/44 , A61K31/505 , C07C279/28 , C07C317/42 , C07D217/24 , C07D295/18 , C07C2101/14 , C07C2102/10
摘要： Novel compounds of the formula ##STR1## and tautomers thereof, wherein at least one of R.sub.2, R.sub.3 and R.sub.4 is a strong electron withdrawing group, are disclosed. These compounds possess potassium channel activating activity and, as such, are useful as antihypertensive agents. Advantageously, the compounds of the present invention have shown less cardiac effects than known potassium channel activators.Also disclosed is a process for preparing these and other compounds.
摘要翻译：公开了新的式“IMAGE”及其互变异构体，其中R 2，R 3和R 4中的至少一个是强吸电子基团。这些化合物具有钾通道活化活性，因此可用作抗高血压药。有利地，本发明的化合物与已知的钾通道激活剂相比显示较少的心脏作用。还公开了制备这些和其它化合物的方法。

80. 发明授权

US4920135A Insecticidal ureas and thioureas 失效
标题翻译：杀虫脲和硫脲
公开(公告)号：US4920135A
公开(公告)日：1990-04-24
申请号：US306928
申请日：1989-02-07
申请人： Kobus Wellinga , Rudolf Wulder
发明人： Kobus Wellinga , Rudolf Wulder
IPC分类号： A01N43/50 , A01N43/54 , A01N43/88 , A01N47/34 , A01P7/02 , C07C67/00 , C07C275/54 , C07C301/00 , C07C303/40 , C07C311/39 , C07C313/00 , C07C315/04 , C07C317/42 , C07C319/20 , C07C323/44 , C07C325/00 , C07C327/50 , C07C335/26 , C07D213/75 , C07D233/66 , C07D233/72 , C07D273/04 , C07D317/66 , H01L27/00
CPC分类号： C07D233/66 , A01N43/50 , A01N43/54 , A01N43/88 , A01N47/34 , C07C275/54 , C07D233/72 , C07D273/04 , H01L27/00 , Y10S516/01
摘要： Certain organic compounds derived from urea or thiourea having insecticidal activity and methods of their preparation are disclosed. The compounds according to the invention have been found to interfere with the mechanism of metamorphoses which occurs in insects. Hence, the substances according to the invention are specifically active against insects. Owing to this specificity and because of the absence of phytotoxicity effects, the compounds of this invention are of prime importance.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式