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71. 发明申请

US20150056712A1 Methods for Analyzing Cysteamine Compositions 有权
标题翻译：分析半胱胺组合物的方法
公开(公告)号：US20150056712A1
公开(公告)日：2015-02-26
申请号：US14306820
申请日：2014-06-17
申请人： Raptor Pharmaceuticals Inc.
发明人： Kathlene Powell , Ramesh Muttavarapu
IPC分类号： G01N33/15 , G01N30/06 , G01N30/02
CPC分类号： G01N30/74 , B01D15/325 , G01N21/33 , G01N30/02 , G01N30/06 , G01N30/16 , G01N30/34 , G01N30/88 , G01N33/15 , G01N2030/027 , G01N2030/8818 , Y10T436/173845
摘要： Methods of analyzing purity of compositions comprising cysteamine and detecting impurities in cysteamine compositions are described.
摘要翻译：描述了分析包含半胱胺的组合物的纯度和检测半胱胺组合物中的杂质的方法。

72. 发明申请

US20150004714A1 SPECTROMETRIC DEVICE FOR THE ANALYSIS OF ENVIRONMENTAL AND GEOLOGICAL SAMPLES 有权
标题翻译：用于分析环境和地质样品的光谱仪器
公开(公告)号：US20150004714A1
公开(公告)日：2015-01-01
申请号：US14373295
申请日：2013-01-18
申请人： HANBY INTERNATIONAL, LLC
发明人： John David Hanby
IPC分类号： G01N33/24 , B32B37/22 , B32B37/10 , B32B37/02 , B32B37/06
CPC分类号： G01N33/241 , B32B37/02 , B32B37/06 , B32B37/10 , B32B37/22 , B32B2307/70 , B32B2307/73 , B32B2323/04 , B32B2323/10 , B32B2383/00 , B32B2581/00 , G01N21/78 , G01N21/8483 , G01N30/74 , G01N33/00 , G01N35/00009 , G01N35/021 , G01N2001/4061 , G01N2035/023 , G01N2035/1032 , Y10T156/1095 , Y10T436/21
摘要： A system and method for analyzing contaminants such as hydrocarbons in soil and ground water utilizes a reaction device comprising a catalyst encapsulated in a permeable material and processes that device in contact with a contaminant in an analytical device in order to generate a spectrogram indicative of the contaminants in the soil and ground water.
摘要翻译：用于分析土壤和地下水中的污染物如烃类的系统和方法利用包含包封在可渗透材料中的催化剂的反应装置，并处理与分析装置中的污染物接触的装置，以便产生指示污染物的光谱图在土壤和地下水中。

73. 发明申请

US20140332674A1 FLOW CELL AND LIQUID ANALYZER 有权
标题翻译：流动池和液体分析仪
公开(公告)号：US20140332674A1
公开(公告)日：2014-11-13
申请号：US14363366
申请日：2012-10-30
申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION
发明人： Yusuke Goto , Masao Kamahori , Yu Ishige , Hiroshi Sasaki , Hideyuki Akiyama , Shintaro Kubo
IPC分类号： G01N21/31 , G01N1/00
CPC分类号： G01N21/31 , G01N1/00 , G01N21/0303 , G01N21/05 , G01N21/3577 , G01N30/74 , G01N2021/0346 , G01N2021/052
摘要： To prevent lowering of sensitivity of a flow cell based on total reflection of light at an outer face of a glass capillary at a joint part with a pipe, the flow cell includes, at joint parts with a pipe 605 to introduce solution to a glass capillary 601 and with a pipe to discharge solution from the capillary, an inorganic material layer 602 that reflects measurement light to modify the outer face of the glass capillary as well as a reinforcement layer 711 to modify the surface thereof.
摘要翻译：为了防止基于在与管的接合部分处的玻璃毛细管的外表面处的光的全反射降低流动池的灵敏度，流动池在与管605的接合部分处包括将溶液引入玻璃毛细管 601，并且具有用于从毛细管排出溶液的管，反射测量光以改变玻璃毛细管的外表面的无机材料层602以及改进其表面的加强层711。

74. 发明申请

US20140326055A1 CHROMATOGRAPHY OF METAL COMPLEXES 有权
标题翻译：金属复合物的色谱
公开(公告)号：US20140326055A1
公开(公告)日：2014-11-06
申请号：US14330745
申请日：2014-07-14
申请人： Urszula J. SLOMCZYNSKA , Bobby N. TRAWICK , Dennis P. RILEY , Arati NAIK
发明人： Urszula J. SLOMCZYNSKA , Bobby N. TRAWICK , Dennis P. RILEY , Arati NAIK
IPC分类号： G01N30/50 , G01N30/74
CPC分类号： G01N30/50 , B01D15/3828 , B01D15/3833 , B01D2015/3838 , G01N30/02 , G01N30/74 , G01N30/96 , G01N2030/027
摘要： A high performance liquid chromatography method to routinely and reproducibly detect and quantitate metal complexes is provided. The metal complexes used in the method of the invention can be different metal complexes, or they can be stereoisomers of the same metal complexes. The high performance liquid chromatography method of the present invention is suitable for the separation of diastereomers of the same metal complexes. Also provided is a chiral high performance liquid chromatography method to separate enantiomers of metal complexes. Superoxide dismutase mimetic compounds are also provided.
摘要翻译：提供了一种常规和可重复检测和定量金属络合物的高效液相色谱法。用于本发明方法的金属络合物可以是不同的金属络合物，或它们可以是相同金属络合物的立体异构体。本发明的高效液相色谱法适用于分离相同金属络合物的非对映异构体。还提供了用于分离金属络合物的对映异构体的手性高效液相色谱法。还提供了超氧化物歧化酶模拟化合物。

75. 发明授权

US08865075B2 Multi-task immunoaffinity device secured to a peripheral box and integrated to a capillary electrophoresis apparatus 有权
标题翻译：多任务免疫亲和装置固定到外围盒并集成到毛细管电泳装置中
公开(公告)号：US08865075B2
公开(公告)日：2014-10-21
申请号：US13284087
申请日：2011-10-28
申请人： Norberto A. Guzman
发明人： Norberto A. Guzman
IPC分类号： G01N21/00 , G01N33/543 , B01L3/00 , G01N33/53 , G01N27/447 , B01L9/00 , G01N30/74 , G01N30/46 , G01N30/32
CPC分类号： G01N27/44743 , B01L3/50 , B01L3/502 , B01L3/5025 , B01L9/527 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2200/0668 , B01L2200/0673 , B01L2200/10 , B01L2300/021 , B01L2300/0627 , B01L2300/0809 , B01L2300/0861 , B01L2400/0415 , B01L2400/06 , B01L2400/082 , G01N30/466 , G01N30/74 , G01N33/53 , G01N33/543 , G01N2030/326
摘要： The present invention relates to an immunoaffinity device for capturing one or more analytes present at high or low concentrations in simple or complex matrices. The device is designed as a modular, multi-task immunoaffinity device secured to a peripheral box and connected to capillary electrophoresis or liquid chromatography for the isolation, enrichment, separation and identification of polymeric macromolecules, primarily protein biomarkers. In one embodiment, two devices are coupled in-tandem to perform separately and sequentially microreactions and concentrations of proteins. In this embodiment, biological samples containing proteins can be subjected to proteolytic processing in the first device, and the resulting peptides subjected to selective purification and concentration in the second device.
摘要翻译：本发明涉及用于捕获以简单或复杂基质中高或低浓度存在的一种或多种分析物的免疫亲和装置。该设备被设计为固定到外围盒并连接到毛细管电泳或液相色谱的模块化多任务免疫亲和装置，用于分离，富集，分离和鉴定聚合物大分子，主要是蛋白质生物标志物。在一个实施方案中，两个装置串联耦合以执行分开且顺序的微反应和蛋白质浓度。在本实施例中，含有蛋白质的生物样品可以在第一装置中进行蛋白水解处理，所得到的肽在第二装置中进行选择性纯化和浓缩。

76. 发明授权

US08784626B2 Bio-analysis using ball-ended incident and output optical fibers 有权
标题翻译：使用球形入射和输出光纤的生物分析
公开(公告)号：US08784626B2
公开(公告)日：2014-07-22
申请号：US13016944
申请日：2011-01-28
申请人： Varouj D. Amirkhanian , Shou-Kuan Tsai
发明人： Varouj D. Amirkhanian , Shou-Kuan Tsai
IPC分类号： B03C5/02 , G01N27/447
CPC分类号： G01N27/44721 , G01N27/44756 , G01N30/74
摘要： A detection optics configuration for bio-analysis, in which the direction of incident radiation, the axis of the separation channel, and the direction of collection of the output radiation are coplanar at the detection zone. The detection configuration incorporates ball-end optical fibers to direct incident radiation at and collection of output radiation from the detection zone. The detection optics configuration may be implemented in an improved bio-separation instrument, in particular a capillary electrophoresis instrument.
摘要翻译：用于生物分析的检测光学配置，其中入射辐射的方向，分离通道的轴线和输出辐射的收集方向在检测区域是共面的。检测配置包括球端光纤以将入射辐射引导并收集来自检测区域的输出辐射。检测光学配置可以在改进的生物分离仪器，特别是毛细管电泳仪中实现。

77. 发明申请

US20140192343A1 Vacuum Ultraviolet Absorption Spectroscopy System And Method 有权
标题翻译：真空紫外吸收光谱系统及方法
公开(公告)号：US20140192343A1
公开(公告)日：2014-07-10
申请号：US13792853
申请日：2013-03-11
申请人： VUV ANALYTICS, INC.
发明人： Dale A. Harrison , Anthony T. Hayes , Phillip Walsh
IPC分类号： G01J3/02 , G01N30/02
CPC分类号： G01N30/78 , G01J3/02 , G01N21/0332 , G01N21/05 , G01N21/15 , G01N21/33 , G01N30/02 , G01N30/74 , G01N33/0004 , G01N33/0027 , G01N2021/0325 , G01N2021/151 , G01N2021/158 , G01N2021/335 , G01N2030/025 , G01N2030/027 , G01N2201/024 , G01N2201/0633 , G01N2201/12 , G01N30/7266
摘要： An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples. Vacuum ultra-violet wavelengths may be utilized. Some of the disclosed techniques can be used for detecting the presence of trace concentrations of gaseous species. A preferable gas flow cell is disclosed. Some of the disclosed techniques may be used with a gas chromatography system so as to detect and identify species eluted from the column. Some of the disclosed techniques may be used in conjunction with an electrospray interface and a liquid chromatography system so as to detect and identify gas phase ions of macromolecules produced from solution. Some of the disclosed techniques may be used to characterize chemical reactions. Some of the disclosed techniques may be used in conjunction with an ultra short-path length sample cell to measure liquids.
摘要翻译：提供了一种有效的吸收光谱系统。光谱系统可以被配置为测量固体，液体或气体样品。可以使用真空紫外线波长。一些所公开的技术可用于检测痕量浓度的气态物质的存在。公开了一种优选的气体流通池。所公开的技术中的一些可以与气相色谱系统一起使用，以便检测和鉴定从柱洗脱的物质。所公开的技术中的一些可以与电喷雾界面和液相色谱系统结合使用，以便检测和鉴定由溶液产生的大分子的气相离子。所公开的技术中的一些可以用于表征化学反应。一些所公开的技术可以与超短路径长度的样品池结合使用以测量液体。

78. 发明申请

US20140114586A1 Method of Improving the Resolution of Compounds Eluted from a Chromatography Device 有权
标题翻译：提高色谱装置洗脱化合物分辨率的方法
公开(公告)号：US20140114586A1
公开(公告)日：2014-04-24
申请号：US14137787
申请日：2013-12-20
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Hans PFAFF
IPC分类号： G01N30/72 , G01N30/86 , G01N30/02
CPC分类号： G01N30/72 , G01N30/02 , G01N30/74 , G01N30/8624 , G01N30/8631 , G01N30/8637 , G01N30/8675
摘要： A method of and apparatus for improving the resolution of compounds eluted from a separation device are disclosed, particularly suited for use in the fields of gas or liquid chromatography. Embodiments of the invention provide that spectroscopic data are measured from an effluent eluted from a chromatography device as a function of elution time; peaks in intensity are identified to form a first set of identified peaks; peaks not due to an eluting compound are discarded from the first set of identified peaks thereby forming a second set of identified peaks from those retained; each peak in the second set of peaks is transformed into a first model peak centered on the elution time of each peak in the second set of peaks; some or all the model peaks created are added together to create a new chromatogram; and all identified peaks in intensity in the second set of peaks having elution times within a given time period of identified peaks in intensity in the new chromatogram are grouped together and assigned to a single eluted compound thereby forming a processed data set.
摘要翻译：公开了一种用于提高从分离装置洗脱的化合物的分辨率的方法和装置，特别适用于气相色谱或液相色谱领域。本发明的实施方案提供了从作为洗脱时间的函数的从色谱装置洗脱的流出物测量光谱数据; 识别出强度峰，形成第一组鉴定峰; 不是由洗脱化合物引起的峰从第一组鉴定的峰中被丢弃，从而形成从保留的那些出现的第二组鉴定的峰; 将第二组峰中的每个峰转化为以第二组峰中每个峰的洗脱时间为中心的第一模型峰; 创建的一些或所有模型峰被添加在一起以创建新的色谱图; 并且在新的色谱图中在确定的强度峰值的给定时间段内具有洗脱时间的第二组峰中的所有鉴定的峰强度被分组在一起并分配给单个洗脱的化合物，从而形成经处理的数据集。

79. 发明申请

US20140104598A1 Lamp Temperature Management Systems and Methods for Liquid Chromatography Analyzers 有权
标题翻译：液相色谱分析仪的灯温度管理系统和方法
公开(公告)号：US20140104598A1
公开(公告)日：2014-04-17
申请号：US13781183
申请日：2013-02-28
申请人： PERKINELMER HEALTH SCIENCES, INC.
发明人： Gregory Hanlon , Timothy Neal
IPC分类号： G01N21/01
CPC分类号： G01N30/74 , F21V29/67 , F21V29/673 , F21V29/677 , G01J3/0286 , G01J3/10 , G01N21/01 , G01N21/0332 , G01N30/8651 , G01N2201/061 , G01N2201/08
摘要： A liquid sample analyzer includes a flow cell, a light source, and a lamp temperature management system. The flow cell is configured to receive a flow of a liquid sample from a liquid sample source. The light source includes a lamp configured to emit light to illuminate the flow of the liquid sample in the flow cell. The lamp temperature management system includes: an air flow generator operable to generate a turbulent air flow to cool the lamp; a thermally conductive primary housing encapsulating the lamp such that a primary air gap is provided between the primary housing and the lamp; and a thermally conductive secondary housing surrounding the primary housing and configured to deflect the turbulent air flow away from the primary housing.
摘要翻译：液体样品分析仪包括流动池，光源和灯温度管理系统。流动池被配置为从液体样品源接收液体样品的流动。光源包括配置为发射光以照亮流动池中的液体样品的流动的灯。灯温度管理系统包括：气流发生器，其可操作以产生湍流空气流以冷却灯; 封装灯的导热初级壳体，使得在主壳体和灯之间提供一次气隙; 以及导热次级壳体，其围绕所述主壳体并且构造成使所述紊流空气流偏离所述主壳体。

80. 发明申请

US20140090452A1 CHROMATOGRAPHY OF METAL COMPLEXES 有权
公开(公告)号：US20140090452A1
公开(公告)日：2014-04-03
申请号：US13869577
申请日：2013-04-24
申请人： Galera Therapeutics, LLC
发明人： Urszula J. Slomczynska , Bobby N. Trawick , Dennis P. Riley , Arati Naik
IPC分类号： G01N30/74
CPC分类号： G01N30/50 , B01D15/3828 , B01D15/3833 , B01D2015/3838 , G01N30/02 , G01N30/74 , G01N30/96 , G01N2030/027
摘要： A high performance liquid chromatography method to routinely and reproducibly detect and quantitate metal complexes is provided. The metal complexes used in the method of the invention can be different metal complexes, or they can be stereoisomers of the same metal complexes. The high performance liquid chromatography method of the present invention is suitable for the separation of diastereomers of the same metal complexes. Also provided is a chiral high performance liquid chromatography method to separate enantiomers of metal complexes. Superoxide dismutase mimetic compounds are also provided.

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