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71. 发明申请

US20140330100A1 CARBON NANOSTRUCTURE ELECTROCHEMICAL SENSOR AND METHOD 审中-公开
标题翻译：碳纳米结构电化学传感器及方法
公开(公告)号：US20140330100A1
公开(公告)日：2014-11-06
申请号：US14344018
申请日：2012-09-10
申请人： Chunhong Li , David J. Ruggieri
发明人： Chunhong Li , David J. Ruggieri
IPC分类号： G01N27/26 , A61B5/145 , A61B5/1486 , G01N27/30 , G01N27/327
CPC分类号： G01N27/26 , A61B5/14539 , A61B5/1486 , B82Y30/00 , B82Y40/00 , B82Y99/00 , C01B32/174 , G01N27/302 , G01N27/327 , H01M8/04671 , Y10S977/742 , Y10S977/75 , Y10S977/752 , Y10S977/847 , Y10S977/902
摘要： Carbon nanostructures may be protected and functionalized using a layer-by-layer method whereby functional groups on the carbon nanostructure surface may be further derivatized to incorporate additional functional moieties. Exemplary moieties include redox mediator molecules, crown ethers, catalysts, boric acids, carbohydrates, oligonucleotides, DNA or RNA aptamers, peptide aptamers, proteins such as enzymes and antibodies, quantum dots and nanoparticles, cells, cell organelles, or other cellular components. The density of functional groups or functional moieties on carbon nanostructure surfaces may also be controlled as well as the degree of surface hydrophilicity of the nanostructure. Carbon nanostructures functionalized using such a layer-by-layer method may be used to disperse, sort, separate and purify carbon nanostructures and may be used as sensing elements such as voltammetric, amperometric, and potentiometric pH sensors or as biometric sensing elements and electrodes and intracorporeal sensors and electrode.
摘要翻译：可以使用逐层方法来保护和官能化碳纳米结构，由此碳纳米结构表面上的官能团可被进一步衍生化以引入额外的官能部分。示例性部分包括氧化还原介体分子，冠醚，催化剂，硼酸，碳水化合物，寡核苷酸，DNA或RNA适体，肽适体，诸如酶和抗体的蛋白质，量子点和纳米颗粒，细胞，细胞器细胞器或其它细胞组分。也可以控制碳纳米结构表面上的官能团或官能团的密度以及纳米结构的表面亲水性程度。使用这种逐层方法功能化的碳纳米结构可以用于分散，分类，分离和净化碳纳米结构，并且可以用作感测元件，例如伏安法，电流计和电位pH传感器，或者用作生物测定元件和电极，体内传感器和电极。

72. 发明申请

US20140318991A1 System and method for quality assurance of a biosensor test strip 有权
标题翻译：生物传感器试片质量保证的系统和方法
公开(公告)号：US20140318991A1
公开(公告)日：2014-10-30
申请号：US14330610
申请日：2014-07-14
申请人： Roche Diagnostics Operations, Inc. , Roche Operations Ltd.
发明人： Michael J. Celentano , Henning Groll , James L. Pauley , Steven K. Moore
IPC分类号： G01N27/327
CPC分类号： G01N27/327 , G01N27/3273 , G01N27/3274 , G01N27/4163
摘要： The present invention provides a test strip for measuring a signal of interest in a biological fluid when the test strip is mated to an appropriate test meter, wherein the test strip and the test meter include structures to verify the integrity of the test strip traces, to measure the parasitic resistance of the test strip traces, and to provide compensation in the voltage applied to the test strip to account for parasitic resistive losses in the test strip traces.
摘要翻译：本发明提供了一种测试条，用于在将测试条配合到适当的测试仪器时测量生物流体中感兴趣的信号，其中测试条和测试仪包括用于验证测试条迹线的完整性的结构，测量测试条迹线的寄生电阻，并对施加到测试条上的电压进行补偿，以考虑测试条迹线中的寄生电阻损耗。

73. 发明申请

US20140302095A1 MYCOBACTERIUM TUBERCULOSIS PORINS AND TOXINS AND RELATED METHODS 有权
标题翻译： MYCOBACTERIUM TUBERCULOSIS PORINS和毒素及相关方法
公开(公告)号：US20140302095A1
公开(公告)日：2014-10-09
申请号：US14342057
申请日：2012-08-30
申请人： Michael Niederweis , Olga Danilchanka
发明人： Michael Niederweis , Olga Danilchanka
IPC分类号： C07K14/35 , G01N27/327 , G01N33/50
CPC分类号： C07K14/35 , A61K39/00 , C07K2319/21 , C07K2319/22 , C07K2319/40 , C07K2319/42 , C07K2319/50 , G01N27/327 , G01N33/5008 , G01N33/6872 , G01N2333/35
摘要： Provided herein are isolated polypeptides comprising the amino-terminal domain of Mycobacterium tuberculosis porin A (MtpA), wherein the polypeptide is a porin monomer. Also provided are isolated polypeptides comprising the carboxy-terminal domain of Mycobacterium tuberculosis porin A, wherein the polypeptide is a toxin. Also provided are methods of treating or preventing a Mycobacterium tuberculosis (Mtb) infection in a subject with or at risk of developing a Mtb infection. Further provided are chimeric porin polypeptides comprising a first polypeptide comprising an amino-terminal domain of Mycobacterium tuberculosis porin and a second polypeptide comprising an antigen and the use the chimeric porin polypeptides in methods of eliciting an immune response in a subject.
摘要翻译：本文提供包含结核分枝杆菌孔蛋白A（MtpA）的氨基末端结构域的分离的多肽，其中多肽是孔蛋白单体。还提供了包含结核分枝杆菌孔蛋白A的羧基末端结构域的分离的多肽，其中多肽是毒素。还提供了在具有或有发生Mtb感染风险的受试者中治疗或预防结核分枝杆菌（Mtb）感染的方法。还提供了嵌合孔蛋白多肽，其包含包含结核分枝杆菌孔蛋白的氨基末端结构域的第一多肽和包含抗原的第二多肽，并且在受试者中引发免疫应答的方法中使用嵌合孔蛋白多肽。

74. 发明申请

US20140291143A1 CARRIER MATERIAL FOR ELECTRICALLY POLARIZABLE BIOMATERIALS, POLYELECTROLYTE MATERIALS, ATOMS, IONS AND MOLECULES; ITS MANUFACTURE AND USE 审中-公开
标题翻译：电气极化生物材料载体材料，聚电解质材料，原子，离子和分子; 其制造和使用
公开(公告)号：US20140291143A1
公开(公告)日：2014-10-02
申请号：US14342094
申请日：2012-08-31
申请人： Heidemarie Schmidt , Christine Baumgart , Ilona Skorupa , Manfred Helm , Oliver G. Schmidt , Martin Müller
发明人： Heidemarie Schmidt , Christine Baumgart , Ilona Skorupa , Manfred Helm , Oliver G. Schmidt , Martin Müller
IPC分类号： G01N27/28
CPC分类号： G01N27/28 , B01L3/502761 , G01N27/327 , G01N33/54366
摘要： Carriers for biomaterials, for polyelectrolyte materials, for electrically polarizable atoms, ions, molecules are provided wherein the material of the carriers is compatible with materials that are used in microelectronics. The arrangement of the biomaterials or biomolecules and optionally of biomolecules, biomaterials, biological functional units or cells adsorbed thereon can be affected with the carrier in a specific manner. Complex molecular machines can be built and tested by the carriers.
摘要翻译：提供用于聚电解质材料，用于电极化原子，离子，分子的生物材料的载体，其中载体的材料与用于微电子学的材料相容。生物材料或生物分子以及任选的生物分子，生物材料，生物功能单元或吸附在其上的细胞的布置可以以特定的方式用载体影响。复杂的分子机器可以由载体构建和测试。

75. 发明授权

US08846129B2 Biological sensing structures and methods of forming the same 有权
标题翻译：生物传感结构及其形成方法
公开(公告)号：US08846129B2
公开(公告)日：2014-09-30
申请号：US13372141
申请日：2012-02-13
申请人： Hung-Hua Lin , Li-Cheng Chu , Ming-Tung Wu , Yuan-Chih Hsieh , Lan-Lin Chao , Chia-Shiung Tsai
发明人： Hung-Hua Lin , Li-Cheng Chu , Ming-Tung Wu , Yuan-Chih Hsieh , Lan-Lin Chao , Chia-Shiung Tsai
IPC分类号： B05D3/10 , C12Q1/68 , H01L21/311
CPC分类号： G01N21/55 , G01N21/01 , G01N21/253 , G01N27/327 , G01N33/483 , G01N2021/0106 , G01N2201/0636
摘要： A method of forming of biological sensing structures including a portion of a substrate is recessed to form a plurality of mesas in the substrate. Each of the plurality of mesas has a top surface and a sidewall surface. A first light reflecting layer is deposited over the top surface and the sidewall surface of each mesa. A filling material is formed over a first portion of the first light reflecting layer. A stop layer is deposited over the filling material and a second portion of the first light reflecting layer. A sacrificial layer is formed over the stop layer and is planarized exposing the stop layer. A first opening is formed in the stop layer and the first light reflecting layer. A second light reflecting layer is deposited over the first opening. A second opening is formed in the second light reflecting layer.
摘要翻译：形成包括衬底的一部分的生物感测结构的方法被凹进以在衬底中形成多个台面。多个台面中的每一个具有顶表面和侧壁表面。第一光反射层沉积在每个台面的顶表面和侧壁表面上。在第一光反射层的第一部分上形成填充材料。沉积在填充材料上的停止层和第一光反射层的第二部分。牺牲层形成在停止层上并且被平坦化地暴露停止层。在停止层和第一光反射层中形成第一开口。第二光反射层沉积在第一开口上。在第二光反射层中形成第二开口。

76. 发明申请

US20140287336A1 NANODEVICES FOR GENERATING POWER FROM MOLECULES AND BATTERYLESS SENSING 有权
标题翻译：用于从分子和无电池感测产生电力的纳米器件
公开(公告)号：US20140287336A1
公开(公告)日：2014-09-25
申请号：US14250737
申请日：2014-04-11
申请人： LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
发明人： Yinmin Wang , Xianying Wang , Alex V. Hamza
IPC分类号： G01N27/417 , H01M8/02 , H01M8/24 , H01M4/90
CPC分类号： H01M8/00 , B82Y15/00 , B82Y30/00 , G01N27/327 , G01N27/417 , H01M4/00 , H01M4/90 , H01M4/9016 , H01M8/0284 , H01M8/0286 , H01M8/0289 , H01M8/22 , H01M8/222 , H02N11/002
摘要： A nanoconverter or nanosensor is disclosed capable of directly generating electricity through physisorption interactions with molecules that are dipole containing organic species in a molecule interaction zone. High surface-to-volume ratio semiconductor nanowires or nanotubes (such as ZnO, silicon, carbon, etc.) are grown either aligned or randomly-aligned on a substrate. Epoxy or other nonconductive polymers are used to seal portions of the nanowires or nanotubes to create molecule noninteraction zones. By correlating certain molecule species to voltages generated, a nanosensor may quickly identify which species is detected. Nanoconverters in a series parallel arrangement may be constructed in planar, stacked, or rolled arrays to supply power to nano- and micro-devices without use of external batteries. In some cases breath, from human or other life forms, contain sufficient molecules to power a nanoconverter. A membrane permeable to certain molecules around the molecule interaction zone increases specific molecule nanosensor selectivity response.
摘要翻译：公开了一种纳米转换器或纳米传感器，其能够通过与分子相互作用区中是含有偶极子的有机物质的分子的物理吸附相互作用直接发电。高比表面积体积比的半导体纳米线或纳米管（例如ZnO，硅，碳等）生长在衬底上对准或随机排列。环氧或其它非导电聚合物用于密封纳米线或纳米管的部分以产生分子非相互作用区。通过将某些分子物种与产生的电压相关联，纳米传感器可以快速识别哪个物种被检测到。串联并联布置的纳米转换器可以被构造成平面，堆叠或卷绕的阵列，以在不使用外部电池的情况下向纳米和微器件供电。在某些情况下，来自人类或其他生命形式的呼吸含有足够的分子来为纳米转换器供电。分子相互作用区周围某些分子可渗透的膜增加了特定分子纳米传感器的选择性响应。

77. 发明申请

US20140262774A1 ELECTROLYTE SENSOR AND METHOD FOR PRODUCING THEREOF 审中-公开
标题翻译：电解质传感器及其生产方法
公开(公告)号：US20140262774A1
公开(公告)日：2014-09-18
申请号：US14292949
申请日：2014-06-02
申请人： Saket S. Bhatia , Ankush S. Bhatia
发明人： Saket S. Bhatia , Ankush S. Bhatia
IPC分类号： G01N27/327
CPC分类号： G01N27/07 , A61B5/202 , A61B5/6804 , A61B5/6808 , G01N27/327 , G01N27/403 , G01N33/493 , Y10T29/49181
摘要： Provided is an electrolyte sensor that uses conductive elastomer electrodes. Examples of the intended analytes for sensor use include those found in urine, saliva, blood, feces, and spinal fluid, although other analytes exist for electrolyte detection. Conductive elastomer trace electrodes are separated by a channel or gap which can be bridged by an electrolyte and thereby complete an electrical circuit to an alarm or other circuitry. Channel or gap distances vary the level of electrical resistance associated with detecting certain analytes.
摘要翻译：提供使用导电弹性体电极的电解质传感器。用于传感器使用的预期分析物的实例包括在尿液，唾液，血液，粪便和脊髓液中发现的那些，尽管存在用于电解质检测的其它分析物。导电弹性体迹线电极被通道或间隙隔开，通道或间隙可由电解质桥接，从而完成电路到报警器或其他电路。通道或间隙距离会改变与检测某些分析物相关的电阻水平。

78. 发明授权

US08828200B2 Electrochemical sensor for the determination of an analyte concentration 有权
标题翻译：用于测定分析物浓度的电化学传感器
公开(公告)号：US08828200B2
公开(公告)日：2014-09-09
申请号：US12367725
申请日：2009-02-09
申请人： Michael Marquant , Gregor Bainczyk
发明人： Michael Marquant , Gregor Bainczyk
IPC分类号： G01N27/327 , A61B5/1486 , A61B5/145
CPC分类号： G01N27/4166 , A61B5/14532 , A61B5/14865 , C25D5/48 , G01N27/301 , G01N27/327 , G01N27/3272 , G01N33/4833 , H01R43/16 , Y10T29/49204
摘要： The invention relates to an electrochemical sensor for the determination of a concentration of at least one analyte in a medium, in particular a body tissue and/or a body fluid, to an apparatus that includes the electrochemical sensor, and to a use of the electrochemical sensor, and finally to a method for producing it. The electrochemical sensor has an isolation element and at least two electrodes. The at least two electrodes comprise at least one working electrode and at least one further electrode, in particular at least one counter electrode and/or at least one reference electrode. The at least two electrodes run parallel to one another and form an electrochemical measuring cell of the electrochemical sensor.
摘要翻译：本发明涉及一种电化学传感器，用于确定介质中的至少一种分析物，特别是身体组织和/或体液的浓度，包括电化学传感器的装置，以及使用电化学传感器，最后是一种生产它的方法。电化学传感器具有隔离元件和至少两个电极。至少两个电极包括至少一个工作电极和至少一个另外的电极，特别是至少一个对电极和/或至少一个参考电极。至少两个电极彼此平行地延伸并形成电化学传感器的电化学测量单元。

79. 发明申请

US20140246335A1 METHOD OF DETERMINING HEMATOCRIT VALUE, QUANTATIVE ANALYSIS METHOD, AND SENSOR CHIP 审中-公开
标题翻译：确定HEMATOCRIT值的方法，定量分析方法和传感器芯片
公开(公告)号：US20140246335A1
公开(公告)日：2014-09-04
申请号：US14278410
申请日：2014-05-15
申请人： Murata Manufacturing Co., Ltd.
发明人： Hideaki OOE , Jun TAKAGI , Kenji YOKOYAMA , Atsunori HIRATSUKA , Nobuyuki YOSHIDA , Noriko SASAKI
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , G01N27/327 , G01N27/3274
摘要： A technique and a sensor chip allowing determination of a hematocrit value of a blood sample in a short period of time with low cost are provided. A response current obtained by sweep of a voltage applied across a working electrode for determination and a counter electrode for determination included in a sensor chip is measured and a hematocrit value is derived based on followability of the response current to temporal change in swept applied voltage. Therefore, it is not necessary to stand by until oxidation reduction reaction of an oxidation reducing substance is stabilized for determining a hematocrit value as in a conventional method of determining a hematocrit value, and thus a hematocrit value of a blood sample can be determined in a short period of time. Since no oxidation reducing substance is necessary for determining a hematocrit value, a hematocrit value can be determined with low cost.
摘要翻译：提供了一种技术和传感器芯片，其允许以低成本在短时间内确定血液样本的血细胞比容值。测量通过扫描施加在用于确定的工作电极上的电压和用于包括在传感器芯片中的用于确定的对电极而获得的响应电流，并且基于响应电流对扫描施加电压的时间变化的跟随性导出血细胞比容值。因此，如以往的确定血细胞比容值的方法那样，在氧化还原物质的氧化还原反应稳定化以确定血细胞比容值的前提下，不需要等待，因此血液样品的血细胞比容值可以在很短的时间。由于不需要氧化还原物质来确定血细胞比容值，因此可以以低成本确定血细胞比容值。

80. 发明申请

US20140235457A1 SYSTEMS AND METHODS FOR GENETIC AND BIOLOGICAL ANALYSIS 有权
公开(公告)号：US20140235457A1
公开(公告)日：2014-08-21
申请号：US14119859
申请日：2012-05-29
申请人： Hesaam Esfandyarpour , Kosar Baghbani Parazi , Mark F. Oldham , Eric S. Nordman , Richard T. Reel , Susanne Baumhueter , Cheryl Heiner , Frank Lee
发明人： Hesaam Esfandyarpour , Kosar Baghbani Parazi , Mark F. Oldham , Eric S. Nordman , Richard T. Reel , Susanne Baumhueter , Cheryl Heiner , Frank Lee
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , G01N27/327 , G01N33/54313 , G01N33/5438 , C12Q2527/119 , C12Q2563/116 , C12Q2565/607 , C12Q2549/126
摘要： The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.

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