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71. 发明申请

US20130224277A1 POROUS POLYSACCHARIDE SCAFFOLD COMPRISING NANO-HYDROXYAPATITE AND USE FOR BONE FORMATION 审中-公开
标题翻译：包含纳米羟基磷灰石的多糖多糖和用于骨形成的多糖多糖
公开(公告)号：US20130224277A1
公开(公告)日：2013-08-29
申请号：US13819546
申请日：2011-08-30
申请人： Joëlle Amedee , Didier Letourneur , Catherine Le Visage , Sidi Mohammed Derkaoui , Jean-Christophe Fricain , Sylvain Catros
发明人： Joëlle Amedee , Didier Letourneur , Catherine Le Visage , Sidi Mohammed Derkaoui , Jean-Christophe Fricain , Sylvain Catros
IPC分类号： A61L27/46 , A61L27/56
CPC分类号： A61L27/12 , A61L27/20 , A61L27/46 , A61L27/56 , A61L2300/112 , A61L2400/08 , A61L2400/12 , A61L2430/02 , C08B37/0018 , C08B37/0021 , C08J9/0061 , C08J9/26 , C08J9/28 , C08J2201/026 , C08J2201/0444 , C08J2201/0484 , C08J2205/022 , C08J2207/10 , C08J2305/00 , C08J2405/02
摘要： The present invention relate to three dimensional porous polysaccharide matrices able to induce mineralisation of a tissue in osseous site, as well as in non-osseous site, in the absence of stem cells or growth factors.
摘要翻译：本发明涉及在不存在干细胞或生长因子的情况下，能够在骨骼部位以及非骨骼部位诱导组织的矿化的三维多孔多糖基质。

72. 发明申请

US20120309245A1 POROUS, LOW DENSITY NANOCLAY COMPOSITE 有权
标题翻译：多孔，低密度纳米复合材料
公开(公告)号：US20120309245A1
公开(公告)日：2012-12-06
申请号：US13484322
申请日：2012-05-31
申请人： QI LIAO , WALTER A. SCRIVENS , PHILIP T. WILSON , DARIN L. DOTSON , HAO ZHOU
发明人： QI LIAO , WALTER A. SCRIVENS , PHILIP T. WILSON , DARIN L. DOTSON , HAO ZHOU
IPC分类号： C08K3/34 , C08L61/28 , B32B27/04 , C08L29/04
CPC分类号： C08K3/346 , C04B33/04 , C04B38/0045 , C04B2111/2046 , C04B2111/52 , C04B2235/349 , C04B2235/5454 , C04B2235/606 , C08J3/075 , C08J9/008 , C08J9/28 , C08J2201/0484 , C08J2305/00 , C08J2305/12 , C08J2329/04 , C08J2361/28 , C08J2389/00 , C08J2405/12 , C08K5/053 , C08L5/12 , C08L29/04 , Y10T442/2861 , C04B38/0054 , C04B38/0605
摘要： Disclosed are porous, low density nanoclay composites that exhibit highly homogeneous microcellular morphology and methods for forming the nanocomposites. The nanocomposites include a three-dimensional matrix having a non-lamellar, generally isotropic cellular structure with little or no macroscopic pores. The nanocomposites also include a gel that may be a noncovalently cross-linked, thermoreversible gel. The nanocomposites may include a binder and/or fibrous reinforcement materials. The nanocomposites may be formed according to a freeze-drying process in which ice crystal growth is controlled to prevent formation of macroscopic pores in the composite materials.
摘要翻译：公开了多孔，低密度纳米粘土复合材料，其表现出高度均匀的微孔形态和形成纳米复合材料的方法。纳米复合材料包括具有非层状，通常各向同性的细胞结构，具有很少或不具有宏观孔的三维基质。纳米复合材料还包括可以是非共价交联的热可逆凝胶的凝胶。纳米复合材料可以包括粘合剂和/或纤维增强材料。可以根据冷冻干燥方法形成纳米复合材料，其中控制冰晶生长以防止在复合材料中形成宏观孔。

73. 发明申请

US20110201117A1 FORMING POROUS SCAFFOLD FROM CELLULOSE DERIVATIVES 审中-公开
公开(公告)号：US20110201117A1
公开(公告)日：2011-08-18
申请号：US12809534
申请日：2008-12-18
申请人： Zhilian Yue , Feng Wen , Hanry Yu
发明人： Zhilian Yue , Feng Wen , Hanry Yu
IPC分类号： C12N5/071
CPC分类号： B32B3/26 , A61L27/20 , A61L27/56 , C08B11/20 , C08J9/28 , C08J2201/024 , C08J2201/026 , C08J2201/0484 , C08J2201/0524 , C08J2205/044 , C08J2207/10 , C08J2301/28 , C08L1/14 , Y10T428/249921 , Y10T428/249978 , Y10T428/249979 , C08L1/28
摘要： Scaffold comprises a polymer defining macropores and comprising hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, which is crosslinked through the self-crosslinkable group. The macropores have an average pore size larger than 50 microns and are at least partially interconnected. In one method, bicontinuous emulsion comprising a continuous aqueous phase and a continuous polymer phase is formed. The polymer phase comprises hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, and is crosslinked through the self-crosslinkable group to form a polymer defining at least partially interconnected pores. In another method, phase separation is induced in a solution comprising a polymer precursor and water to form a bicontinuous emulsion comprising a continuous polymer phase and a continuous aqueous phase. The polymer precursor comprises a self-crosslinkable group and is crosslinked through the self-crosslinkable group in the emulsion to form a polymer defining at least partially interconnected macropores.

74. 发明申请

US20110159272A1 FORMING POROUS SCAFFOLD FROM CELLULOSE DERIVATIVES 有权
标题翻译：从纤维素衍生物形成多孔的SCAFF
公开(公告)号：US20110159272A1
公开(公告)日：2011-06-30
申请号：US12824105
申请日：2010-06-25
申请人： Zhilian Yue , Feng Wen , Hanry Yu
发明人： Zhilian Yue , Feng Wen , Hanry Yu
IPC分类号： B32B3/26 , C08B15/10
CPC分类号： B32B3/26 , A61L27/20 , A61L27/56 , C08B11/20 , C08J9/28 , C08J2201/024 , C08J2201/026 , C08J2201/0484 , C08J2201/0524 , C08J2205/044 , C08J2207/10 , C08J2301/28 , C08L1/14 , Y10T428/249921 , Y10T428/249978 , Y10T428/249979 , C08L1/28
摘要： Scaffold comprises a polymer defining macropores and comprising hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, which is crosslinked through the self-crosslinkable group. The macropores have an average pore size larger than 50 microns and are at least partially interconnected. In one method, bicontinuous emulsion comprising a continuous aqueous phase and a continuous polymer phase is formed. The polymer phase comprises hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, and is crosslinked through the self-crosslinkable group to form a polymer defining at least partially interconnected pores. In another method, phase separation is induced in a solution comprising a polymer precursor and water to form a bicontinuous emulsion comprising a continuous polymer phase and a continuous aqueous phase. The polymer precursor comprises a self-crosslinkable group and is crosslinked through the self-crosslinkable group in the emulsion to form a polymer defining at least partially interconnected macropores.
摘要翻译：脚手架包含限定大孔的聚合物，并且包含部分由包含自交联基团的取代基取代的羟丙基纤维素，所述取代基通过自交联基团交联。大孔具有大于50微米的平均孔径并且至少部分互连。在一种方法中，形成包含连续水相和连续聚合物相的双连续乳液。聚合物相包含部分由包含自交联基团的取代基取代的羟丙基纤维素，并且通过自交联基团交联以形成限定至少部分互连的孔的聚合物。在另一种方法中，在包含聚合物前体和水的溶液中诱导相分离以形成包含连续聚合物相和连续水相的双连续乳液。聚合物前体包含自交联基团，并且通过乳液中的自交联基团交联以形成限定至少部分互连的大孔的聚合物。

75. 发明申请

US20090047322A1 Degradable Hydrophilic Block Copolymers with Improved Biocompatibility for Soft Tissue Regeneration 有权
标题翻译：可降解的亲水嵌段共聚物具有改善的生物相容性用于软组织再生
公开(公告)号：US20090047322A1
公开(公告)日：2009-02-19
申请号：US12224891
申请日：2007-03-07
申请人： Jakob Vange , Khadija Schwach-Abdellaoui , Hanne Everland , Peter Sylvest Nielsen , Brian Nielsen , Lene Karin Jespersen , Lene Feldskov Nielsen
发明人： Jakob Vange , Khadija Schwach-Abdellaoui , Hanne Everland , Peter Sylvest Nielsen , Brian Nielsen , Lene Karin Jespersen , Lene Feldskov Nielsen
IPC分类号： C08F283/01 , B32B5/22 , A61F2/02 , C12N5/06 , A61C13/00
CPC分类号： C08G63/664 , A61L15/26 , A61L15/425 , A61L27/18 , A61L27/56 , C08G2261/126 , C08J9/28 , C08J2201/0482 , C08J2201/0484 , C08J2367/04 , C12N5/0068 , C12N2533/30 , C12N2533/40 , Y10T428/249958 , C08L67/04
摘要： The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for supporting cell adhesion or the in-growth for regeneration of tissue. The polymer is of the formula A—O—(CHR1CHR2O)n-B wherein A is a poly(lactide-co-glycolide) residue, the molar ratio of (i) lactide units [—CH(CH3)—COO—] and (ii) glycolide units [—CH2—COO—] in the poly(lactide-co-glycolide) residue being in the range of 80:20 to 10:90, B is either a poly(lactide-co-glycolide) residue or hydrogen, C1-6-alkyl or hydroxy protecting groups, one of R1 and R2 is hydrogen or methyl, and the other is hydrogen, n is 10-1000, the molar ratio of (iii) polyalkylene glycol units [-(CHR1CHR2O)—] to the combined amount of (i) lactide units and (ii) glycolide units in the poly(lactide-co-glycolide) residue(s) is at the most 14:86, and the molecular weight of the copolymer is at least 20,000 g/mol.
摘要翻译：本申请公开了可生物降解的聚合物，包括这种聚合物的多孔和其它材料，以及这种材料的各种医学用途，包括用作支撑细胞粘附的支架或用于组织再生的生长的用途。聚合物具有式AO-（CHR1CHR2O）nB，其中A是聚（丙交酯 - 共 - 乙交酯）残基，（i）丙交酯单元[-CH（CH 3）-COO-]和（ii）乙交酯的摩尔比聚丙交酯 - 共 - 乙交酯残基中的单元[-CH2-COO-]为80:20至10:90，B为聚（丙交酯 - 共 - 乙交酯）残基或氢，C1- 6-烷基或羟基保护基，R1和R2之一是氢或甲基，另一个是氢，n是10-1000，（iii）聚亚烷基二醇单元[ - （CHR1CHR2O） - ]与组合的摩尔比（I）丙交酯单元和（ii）聚（丙交酯 - 共 - 乙交酯）残基中的乙交酯单元的量最多为14:86，共聚物的分子量为至少20,000g / mol。

76. 发明申请

US20080071050A1 Crosslinked polysaccharide sponge 失效
公开(公告)号：US20080071050A1
公开(公告)日：2008-03-20
申请号：US11976809
申请日：2007-10-29
申请人： Tomoya Sato
发明人： Tomoya Sato
IPC分类号： C08F28/06 , C08F24/00
CPC分类号： C08J9/28 , C08B11/12 , C08B11/20 , C08B15/005 , C08B37/00 , C08B37/003 , C08B37/0069 , C08B37/0072 , C08B37/0075 , C08B37/0084 , C08F28/06 , C08F251/00 , C08F251/02 , C08J2201/0484 , C08J2305/00 , C08L5/00 , C08L51/02 , Y10T428/249953
摘要： A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution with light to crosslink the photoreactive polysaccharide, thereby obtaining the polysaccharide sponge. The process includes simplified steps requiring no removal of solvent, and has such an advantage that impurities are easily removed therefrom.

77. 发明申请

US20080050793A1 Method of drying biological material 有权
标题翻译：生物材料干燥方法
公开(公告)号：US20080050793A1
公开(公告)日：2008-02-28
申请号：US11701096
申请日：2007-02-01
申请人： Timothy Durance , Parastoo Yaghmaee , Shafique Ahmad , Guopeng Zhang
发明人： Timothy Durance , Parastoo Yaghmaee , Shafique Ahmad , Guopeng Zhang
IPC分类号： C12N13/00
CPC分类号： C08J9/28 , C08J2201/0484 , C08J2201/0504 , C08J2301/00 , F26B5/048 , F26B5/06
摘要： A method for producing foams containing biological materials is described. A solid or semi-solid paste is formed by combining biologically active material with a protecting agent in an aqueous solvent. The paste formed is allowed to set, and may optionally then be apportioned into the desired shape. The paste may be frozen to allow formation of ice crystals to act as porogens. Subsequently, the paste is exposed to travelling wave radiant energy under vacuum (t-REV) for drying. This causes the solvent to boil off, leaving dried material containing the biologically active material, the protecting agent, and a relatively low water content. Biologically active materials which can be used include cells, microbial cultures, live attenuated microbes, probiotics, yeasts, enzymes, vaccines, proteins, and any heat-sensitive biological material. By directing energy via a travelling wave through a sample, good control of temperature and process conditions can be achieved. The method provides an alternative to the conventional methods of particulate leaching or freeze drying.
摘要翻译：描述了生产含有生物材料的泡沫体的方法。通过在水性溶剂中将生物活性物质与保护剂组合而形成固体或半固体糊状物。允许形成的糊料固化，然后可任选地分配成所需的形状。可以将糊状物冷冻以允许形成冰晶以充当致孔剂。随后，将该糊剂暴露于真空下的行波辐射能（t-REV）以进行干燥。这导致溶剂沸腾，留下含有生物活性物质的干燥物质，保护剂和相对较低的含水量。可以使用的生物活性材料包括细胞，微生物培养物，活减毒微生物，益生菌，酵母，酶，疫苗，蛋白质和任何热敏生物材料。通过将能量经由行波引导通过样品，可以实现温度和工艺条件的良好控制。该方法提供了常规的微粒浸出或冷冻干燥方法的替代方案。

78. 发明授权

US06867240B2 Porous composite materials 失效
标题翻译：多孔复合材料
公开(公告)号：US06867240B2
公开(公告)日：2005-03-15
申请号：US09939838
申请日：2001-08-27
申请人： Peter X. Ma , Ruiyun Zhang
发明人： Peter X. Ma , Ruiyun Zhang
IPC分类号： C08J9/28 , C12N5/00 , G01N15/14 , C08J9/00
CPC分类号： C08J9/28 , C08J2201/0482 , C08J2201/0484 , C08J2367/00 , C12N5/0068 , C12N2533/12 , C12N2533/18 , C12N2533/30 , C12N2533/40 , G01N15/14
摘要： Methods and compositions are described that provide three dimensional porous matrices as structural templates for cells. The porous matrices of the present invention have desirable mechanical properties suitable to a variety of applications, including platforms for in vitro cell cultivation, implants for tissue and organ engineering, and materials suitable for chromatography and filtration.
摘要翻译：描述了提供三维多孔基质作为细胞结构模板的方法和组合物。本发明的多孔基质具有适合于各种应用的理想的机械性能，包括用于体外细胞培养的平台，用于组织和器官工程的植入物，以及适用于色谱和过滤的材料。

79. 发明授权

US06693180B2 Composite sponge wound dressing made of &bgr;-Chitin and Chitosan and method for producing the same 有权
标题翻译：由β-甲壳素和壳聚糖制成的复合海绵伤口敷料及其制备方法
公开(公告)号：US06693180B2
公开(公告)日：2004-02-17
申请号：US10115007
申请日：2002-04-04
申请人： Jui-Sheng Lee , Chun-Yuan Hsu , Wei-Hsin Lin
发明人： Jui-Sheng Lee , Chun-Yuan Hsu , Wei-Hsin Lin
IPC分类号： C08B3708
CPC分类号： C08J9/26 , A61L15/28 , A61L15/425 , C08J2201/0484 , C08J2305/08 , C08L5/08 , C08L2203/02 , C08L2666/26
摘要： The present invention relates to a composite sponge wound dressing and method for producing the same. Chitosan and &bgr;-Chitin is mixed in a specific ratio for forming the sponge for wound repairing. Particularly, when said ratio is between 0.1˜1, the composite sponge wound dressing has a better absorption and tensile strength.
摘要翻译：复合海绵伤口敷料及其制造方法技术领域本发明涉及复合海绵状伤口敷料及其制造方法。将壳聚糖和β-甲壳素以特定比例混合以形成用于伤口修复的海绵。特别是，当所述比例在0.1〜1之间时，复合海绵伤口敷料具有较好的吸收和拉伸强度。

80. 发明授权

US5362761A Process for fabricating porous silicone product 失效
标题翻译：制造多孔硅酮产品的方法
公开(公告)号：US5362761A
公开(公告)日：1994-11-08
申请号：US134837
申请日：1993-10-12
申请人： Tadashi Uragami , Yoshiaki Tanaka , Masaru Ozaki , Tatsuya Nakamura
发明人： Tadashi Uragami , Yoshiaki Tanaka , Masaru Ozaki , Tatsuya Nakamura
IPC分类号： B01D67/00 , B01D71/70 , C08J9/26 , C08J9/28
CPC分类号： C08J9/26 , B01D67/003 , B01D67/0095 , B01D71/70 , B01D2323/14 , B01D2323/30 , C08J2201/0484 , C08J2383/04
摘要： A process of fabricating a porous silicone product utilizing a silicone emulsion capable of forming an elastomer by removal of water therefrom. The silicone emulsion comprises a water emulsion of an organopolysiloxane, a cross-linking agent, and a curing catalyst. The process comprises the steps of freezing the silicone emulsion, and drying the frozen silicone emulsion, whereby water is sublimed therefrom and the porous silicone product is obtained. The resulting porous silicone product is best utilized as a selective permeable membrane for separation of a liquid component from a liquid solution containing two or more liquid components.
摘要翻译：使用能够通过从其中除去水形成弹性体的硅氧烷乳液制造多孔硅氧烷产品的方法。硅氧烷乳液包含有机聚硅氧烷，交联剂和固化催化剂的水乳液。该方法包括冷冻硅氧烷乳液和干燥冷冻的硅氧烷乳液的步骤，由此从中升华水，得到多孔硅氧烷产品。得到的多孔硅酮产品最好用作用于从含有两种或多种液体组分的液体溶液中分离液体组分的选择性渗透膜。

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