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71. 发明授权

US08071691B2 Furanone endcapped polymers 失效
标题翻译：呋喃酮封端的聚合物
公开(公告)号：US08071691B2
公开(公告)日：2011-12-06
申请号：US12299705
申请日：2007-05-14
申请人： Joshua B. Stopek , Joseph Hotter , Steve Tsai
发明人： Joshua B. Stopek , Joseph Hotter , Steve Tsai
IPC分类号： C08G73/02
CPC分类号： C07D307/58 , A61L17/145 , A61L27/34 , A61L31/10 , C07D307/62 , C08F290/06 , C08F290/14 , C08G63/08 , C08G63/912 , C08L53/00 , C08L2666/02
摘要： Polymers endcapped with furanones and compositions containing such polymers are suitable for use in making textiles, medical devices, delivery agents, packaging materials, coatings for such items, and the like.
摘要翻译：用呋喃酮和含有这种聚合物的组合物封端的聚合物适合用于制造纺织品，医疗器械，递送剂，包装材料，用于这些物品的涂层等。

72. 发明申请

US20110268690A1 POLYMERS CONTAINING POLY(HYDROXYALKANOATES) AND AGENTS FOR USE WITH MEDICAL ARTICLES AND METHODS OF FABRICATING THE SAME 有权
标题翻译：含有聚（羟基甘草酸酯）的聚合物和用于医药制品的试剂及其制备方法
公开(公告)号：US20110268690A1
公开(公告)日：2011-11-03
申请号：US13183960
申请日：2011-07-15
申请人： Syed F.A. Hossainy , Stephen D. Pacetti
发明人： Syed F.A. Hossainy , Stephen D. Pacetti
IPC分类号： A61K31/785 , A61K36/8962 , A61K31/439 , A61P7/02 , A61K31/727 , A61K38/22 , A61K38/39 , A61K38/06 , A61K47/34 , A61K31/565
CPC分类号： C08G63/912 , C08B37/0072 , C08B37/0075 , C08G63/06 , C08G63/664 , C08L1/08 , C08L1/286 , C08L5/02 , C08L5/08 , C08L5/10 , C08L25/18 , C08L33/26 , C08L39/06 , C08L67/04 , C08L71/02 , C08L77/12 , C09D101/286 , C09D105/02 , C09D105/08 , C09D105/10 , C09D167/04 , C08L2666/04 , C08L2666/26 , C08L2666/20 , C08L2666/06 , C08L2666/22
摘要： Compositions comprising poly(hydroxyalkanoates) and agents for use with medical articles are described.
摘要翻译：描述了包含聚（羟基链烷酸酯）和用于医疗制品的试剂的组合物。

73. 发明申请

US20110263789A1 CLEAR PAINT COMPOSITIONS COMPRISING HYPERBRANCHED, DENDRITIC, HYDROXYL- FUNCTIONAL POLYESTERS 有权
标题翻译：含有高分子量，羟基，羟基官能聚酯的清漆组合物
公开(公告)号：US20110263789A1
公开(公告)日：2011-10-27
申请号：US12663356
申请日：2008-06-05
申请人： Hitoshi Taniguchi , Eishi Tsukamoto , Hiroyuki Takagi , Andreas Poppe , Günter Klein , Veronika Lackstadter , Bianca Giesen , Petra Wagner , Björn Feldmann , Sabine Holtschulte , Julia Melzer , Tanja Bricke , Oliver Hilge , Benedikt Schnier , Silke Hottenbacher , Ulrike Clausen-Meiring
发明人： Hitoshi Taniguchi , Eishi Tsukamoto , Hiroyuki Takagi , Andreas Poppe , Günter Klein , Veronika Lackstadter , Bianca Giesen , Petra Wagner , Björn Feldmann , Sabine Holtschulte , Julia Melzer , Tanja Bricke , Oliver Hilge , Benedikt Schnier , Silke Hottenbacher , Ulrike Clausen-Meiring
IPC分类号： C09D167/00 , C08G63/91
CPC分类号： C08G18/42 , C08G63/912 , C08L61/28 , C09D167/00 , C08L2666/16
摘要： Disclosed is a hyperbranched, dendritic, hydroxyl-functional polyester comprising an OH number greater than or equal to 180 mg KOH/g as measured via DIN 53240 and to clearcoat compositions comprising said polyesters. Also disclosed are processes for preparing the disclosed polyester, methods of making coated automotive substrates by applying the disclosed clearcoat compositions to automotive substrates, and to coated substrates made therefrom.
摘要翻译：公开了一种超支化树枝状羟基官能聚酯，其包含通过DIN 53240测量的大于或等于180mg KOH / g的OH数，以及包含所述聚酯的透明涂料组合物。还公开了制备所公开的聚酯的方法，通过将所公开的透明涂料组合物应用于汽车基材来制备涂覆的汽车基材的方法以及由其制备的涂布的基材。

74. 发明申请

US20110257343A1 Multifunctional Degradable Nanoparticles with Control over Size and Functionalities 有权
标题翻译：多功能可降解纳米粒子，具有大小和功能的控制
公开(公告)号：US20110257343A1
公开(公告)日：2011-10-20
申请号：US12953173
申请日：2010-11-23
申请人： Eva M. Harth , Alice E. Van Der Ende , Sharon K. Hamilton , Teresa A. Croce
发明人： Eva M. Harth , Alice E. Van Der Ende , Sharon K. Hamilton , Teresa A. Croce
IPC分类号： C08G63/91 , C08G63/08 , C08G16/00 , C08G63/78
CPC分类号： C08G71/02 , A61K47/6935 , A61K49/0043 , A61K49/0054 , A61K49/0067 , A61K49/0093 , B82Y5/00 , C08G63/06 , C08G63/912 , C08J3/12 , C08J3/14 , C08J2300/16
摘要： In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymer and degradable nanoparticles. In one aspect, the invention relates to methods of preparing degradable nanoparticles and, more specifically, methods of controlling particle size during the preparation of degradable nanoparticles. In one aspect, the degradable nanoparticles are useful for complexing, delivering, and releasing payloads, including pharmaceutically active payloads. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：一方面，本发明涉及聚合物，交联聚合物，官能化聚合物，纳米颗粒和官能化纳米颗粒及其制备和使用方法。一方面，本发明涉及可降解聚合物和可降解纳米颗粒。一方面，本发明涉及制备可降解纳米颗粒的方法，更具体地说，涉及在制备可降解纳米颗粒期间控制颗粒尺寸的方法。在一个方面，可降解纳米颗粒可用于络合，递送和释放有效载荷，包括药物活性有效载荷。该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

75. 发明申请

US20110257338A1 HYDROPHILIC MATERIAL, MEDICAL MATERIAL AND SUSTAINED DRUG RELEASE MATERIAL 有权
标题翻译：液体材料，医疗材料和持续的药物释放材料
公开(公告)号：US20110257338A1
公开(公告)日：2011-10-20
申请号：US13121604
申请日：2009-09-29
申请人： Mitsuru Akashi , Michiya Matsusaki , Dongjian Shi , Makoto Onishi , Yotaro Fujita
发明人： Mitsuru Akashi , Michiya Matsusaki , Dongjian Shi , Makoto Onishi , Yotaro Fujita
IPC分类号： C08F8/34 , B82Y30/00
CPC分类号： C08G63/912 , A61K9/5153 , C08G63/664 , G01N2203/00
摘要： A hydrophilic material having a hydrophilic nature and being biocompatible and processable into nanoparticles wherein a hydrophilic monomer such as threitol or a hydrophilic polymer such as polyethylene glycol is attached to the βposition of an α, β-unsaturated carboxyl group of a (co)polymer comprising an aromatic compound such as 4-hydroxycinnamic acid in which an aromatic ring is substituted by the α, β-unsaturated carboxyl group and one or more hydroxyl groups. In particular, a hydrophilic material having a nanoparticle size which is highly dispersible in water, can well migrate into the blood and is useful as a drug carrier, a medical material and a sustained drug release material.
摘要翻译：亲水性材料具有亲水性并且可生物相容并可加工成纳米颗粒，其中亲水性单体例如苏糖醇或亲水性聚合物例如聚乙二醇被连接到（共聚物）的α，β-不饱和羧基的基团上）聚合物，其包含芳族化合物如4-羟基肉桂酸，其中芳环被α，β-不饱和羧基和一个或多个羟基取代。具体而言，具有高度分散于水中的纳米粒子尺寸的亲水性材料能很好地迁移到血液中，可用作药物载体，医疗材料和持续的药物释放材料。

76. 发明授权

US08021652B2 Biodegradable branched polylactide derivatives capable of forming polymeric micelles, and their preparation method and use 有权
标题翻译：能够形成聚合胶束的生物可降解的支链聚丙交酯衍生物及其制备方法和用途
公开(公告)号：US08021652B2
公开(公告)日：2011-09-20
申请号：US10554637
申请日：2004-12-03
申请人： Min-Hyo Seo , Bong-Oh Kim , In-Ja Choi , Myung-Seob Shim
发明人： Min-Hyo Seo , Bong-Oh Kim , In-Ja Choi , Myung-Seob Shim
IPC分类号： A61K31/765
CPC分类号： A61K9/1075 , A61K47/34 , C08G63/08 , C08G63/78 , C08G63/912
摘要： The present invention relates to a biodegradable branched polylactic acid derivative of formula 1, and preparation method and use thereof: 1-(R—X)n wherein each of X, R, I and n is defined as in the detailed description.
摘要翻译：本发明涉及式1的可生物降解的支链聚乳酸衍生物及其制备方法和用途：其中X，R，I和n各自定义如下：式（1）中的1-（R-X）n 描述。

77. 发明授权

US07928180B2 Biodegradable polymer, production method thereof, molded product thereof, and use thereof 有权
标题翻译：可生物降解聚合物及其制备方法及其用途
公开(公告)号：US07928180B2
公开(公告)日：2011-04-19
申请号：US11988008
申请日：2006-06-28
申请人： Manabu Shimoda , Tomoyuki Kawabata , Tadahito Nobori , Makoto Sukegawa
发明人： Manabu Shimoda , Tomoyuki Kawabata , Tadahito Nobori , Makoto Sukegawa
IPC分类号： C08G18/08 , C08G18/28 , C08G63/685
CPC分类号： C08G63/91 , C08G63/912 , C08G73/02 , C08G73/0206 , C08G73/028 , C08L101/16 , Y10T442/60
摘要： The problem of the invention is to provide a novel biodegradable polymer without water solubility (hygroscopicity), but with moldability and excellent water disintegratability and biodegradability, a production method thereof, a molded product thereof and applications thereof. The biodegradable polymer of the invention is a biodegradable polymer having one or more imine bonds within a molecule, characterized in that the imine bond constitutes part of a main chain structure of the biodegradable polymer. The biodegradable polymer preferably comprises a biodegradable unit and an imine unit having one or more imine bonds and has a chemical structure, in which the biodegradable units are linked by the imine unit.
摘要翻译：本发明的问题是提供一种不具有水溶性（吸湿性）但具有成型性和优异的水分解性和生物降解性的新型可生物降解聚合物，其制备方法，其成型产品和应用。本发明的可生物降解的聚合物是在分子内具有一个或多个亚胺键的可生物降解的聚合物，其特征在于亚胺键构成可生物降解的聚合物的主链结构的一部分。生物可降解聚合物优选包含可生物降解的单元和具有一个或多个亚胺键并具有化学结构的亚胺单元，其中可生物降解单元通过亚胺单元连接。

78. 发明申请

US20110060080A1 POLYLACTIC ACID RESIN COMPOSITION 有权
标题翻译：聚酸树脂组合物
公开(公告)号：US20110060080A1
公开(公告)日：2011-03-10
申请号：US12937084
申请日：2009-04-08
申请人： Hiroaki Kishimoto , Akira Takenaka , Yukihiro Kiuchi , Tsunenori Yanagisawa , Kazuhiko Inoue , Masatoshi Iji , Shin Serizawa
发明人： Hiroaki Kishimoto , Akira Takenaka , Yukihiro Kiuchi , Tsunenori Yanagisawa , Kazuhiko Inoue , Masatoshi Iji , Shin Serizawa
IPC分类号： C08K5/5465 , C08K5/548
CPC分类号： C08K9/06 , C08G63/08 , C08G63/912 , C08K5/54 , C09D167/04 , C08L67/04
摘要： The present invention provides a polylactic acid resin composition, containing a polylactic acid resin and a metal hydrate surface-treated with at least one silane coupling agent selected from an amino-silane coupling agent, a mercapto-silane coupling agent and an isocyanate-silane coupling agent, wherein the content of an alkali metal component in the metal hydrate is not more than 0.2% by mass and a polylactic acid resin molded article produced by molding the polylactic acid resin composition.
摘要翻译：本发明提供一种聚乳酸树脂组合物，其含有使用选自氨基 - 硅烷偶联剂，巯基 - 硅烷偶联剂和异氰酸酯 - 硅烷偶联剂中的至少一种硅烷偶联剂表面处理的聚乳酸树脂和金属水合物其中金属水合物中的碱金属成分的含量为0.2质量％以下，聚乳酸树脂成型体通过成型聚乳酸树脂组合物而制造。

79. 发明申请

US20100280561A1 Thermal-Responsive Polymer Networks, Compositions, And Methods And Applications Related Thereto 有权
标题翻译：热响应聚合物网络，组合物及其相关方法和应用
公开(公告)号：US20100280561A1
公开(公告)日：2010-11-04
申请号：US12748301
申请日：2010-03-26
申请人： Jie Song , Jianwen Xu
发明人： Jie Song , Jianwen Xu
IPC分类号： A61B17/56 , C08G63/91 , A61F2/00
CPC分类号： C08G63/912 , A61F2002/30242 , A61F2002/444 , A61F2230/0071 , C08G63/08 , C08G83/002 , C08G2280/00
摘要： The invention relates to materials comprising polymer network containing siloxanes or organic-based core structures, preferably the materials have thermal-responsive properties. In some embodiments, the invention relates to an organic core functionalized with polymers. In another embodiment, organic core-polymer conjugates comprise polylactone segments. The organic core-polymer conjugates may be crosslinked together to form a material, and these materials may be functionalized with bioactive compounds so that the materials have desirable biocompatibility or bioactivity when used in medical devices. In some embodiments, the invention relates to silsesquioxane groups functionalized with polymers. In another embodiment, silsequioxane-polymer conjugates comprise polylactone segments. The silsequioxane-polymer conjugates may be crosslinked together to form a material, and these materials may be functionalized with bioactive compounds so that the materials have desirable biocompatibility or bioactivity when used in medical devices. In further embodiments, the invention relates to composite materials that contain a polymer matrix and aggregates, and in some embodiments, methods of making, and methods of using these materials. Preferably, the aggregates are calcium phosphate aggregates. Preferably, the material is resistant to fracture. In further embodiments, the materials are used in surgical procedures of bone replacement. In further embodiments, the materials contain polyhedral silsesquioxanes and/or biodegradable segments
摘要翻译：本发明涉及包含含有硅氧烷或有机基核心结构的聚合物网络的材料，优选该材料具有热响应特性。在一些实施方案中，本发明涉及用聚合物官能化的有机核。在另一个实施方案中，有机核 - 聚合物缀合物包含聚内酯片段。有机核 - 聚合物共轭物可以一起交联以形成材料，并且这些材料可以用生物活性化合物官能化，使得当用于医疗装置时，这些材料具有期望的生物相容性或生物活性。在一些实施方案中，本发明涉及用聚合物官能化的倍半硅氧烷基团。在另一个实施方案中，硅二恶烷 - 聚合物共轭物包含聚内酯片段。硅氧烷 - 聚合物共轭物可以一起交联以形成材料，并且这些材料可以用生物活性化合物官能化，使得当用于医疗装置时，这些材料具有期望的生物相容性或生物活性。在另外的实施方案中，本发明涉及包含聚合物基质和聚集体的复合材料，并且在一些实施方案中涉及制备方法和使用这些材料的方法。优选地，聚集体是磷酸钙聚集体。优选地，该材料耐断裂。在另外的实施方案中，所述材料用于骨置换的外科手术中。在另外的实施方案中，材料含有多面体倍半硅氧烷和/或可生物降解的片段

80. 发明授权

US07799424B2 Resin composition, molded article and production method thereof 有权
标题翻译：树脂组合物，成型品及其制造方法
公开(公告)号：US07799424B2
公开(公告)日：2010-09-21
申请号：US11887283
申请日：2006-03-27
申请人： Katsuhiko Mochiduki , Takaaki Mihara
发明人： Katsuhiko Mochiduki , Takaaki Mihara
IPC分类号： B32B19/00 , C08G63/00
CPC分类号： C08G63/912 , C08G63/914 , C08L63/06 , C08L67/02 , D01F6/62 , D01F6/92 , Y10T428/29 , Y10T428/2924 , Y10T428/298 , C08L2666/22
摘要： A resin composition includes an aliphatic polyester resin. The resin has carboxyl groups at the end termini of the molecular chain and at least one compound represented by the general formula (I), the compound being added to the resin to cap a part or all of the carboxyl groups at the end termini of the molecular chain of the resin. A process for producing a fiber includes mixing a pellet comprising an aliphatic polyester resin having carboxyl groups at the end termini of the molecular chain with a compound represented by the general formula (I) so that the content of the compound becomes 0.1 to 8% by weight and then melt-spinning the resulting mixture under the conditions of a spinning temperature of 200 to 250 C.°, a melt residence time of 180 to 1800 sec and a spinning rate of 500 to 10000 m/min. (I) wherein at least one of R1 to R3 represents a glycidyl group and the other group or groups independently represents or represent a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, a hydroxyl group or an allyl group.
摘要翻译：树脂组合物包括脂族聚酯树脂。该树脂在分子链的末端具有羧基和至少一种由通式（I）表示的化合物，该化合物加入到树脂中以封端部分或全部羧基末端的羧基分子链的树脂。纤维的制造方法包括将由分子链末端具有羧基的脂肪族聚酯树脂与通式（I）表示的化合物组成的粒料混合，使化合物的含量为0.1〜8％然后在200〜250℃的纺丝温度，180〜1800秒的熔融停留时间和500〜10000m / min的纺丝速度的条件下熔融纺丝得到的混合物。（I）其中R 1至R 3中的至少一个表示缩水甘油基，而另一个基团独立地表示或表示氢原子，具有1至10个碳原子的烷基，羟基或烯丙基。

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