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71. 发明授权

US07598249B2 Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase 有权
标题翻译：哌嗪基和哌啶基脲作为脂肪酸酰胺水解酶的调节剂
公开(公告)号：US07598249B2
公开(公告)日：2009-10-06
申请号：US11321710
申请日：2005-12-29
申请人： Richard Apodaca , J. Guy Breitenbucher , Kanaka Pattabiraman , Mark Seierstad , Wei Xiao
发明人： Richard Apodaca , J. Guy Breitenbucher , Kanaka Pattabiraman , Mark Seierstad , Wei Xiao
IPC分类号： A61K31/497 , A61K31/445 , A01N43/40 , C07D241/04 , C07D211/00 , C07D295/00
CPC分类号： C07D295/195 , C07D207/335 , C07D209/08 , C07D209/14 , C07D209/82 , C07D211/16 , C07D213/38 , C07D213/56 , C07D213/61 , C07D213/75 , C07D215/12 , C07D215/18 , C07D239/42 , C07D241/42 , C07D295/20 , C07D295/215 , C07D307/79 , C07D307/81 , C07D317/46 , C07D317/58 , C07D319/16 , C07D319/18 , C07D333/58 , C07D333/60 , C07D401/12 , C07D405/12 , C07D417/12
摘要： Certain piperazinyl and piperidinyl urea compounds are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis).
摘要翻译：某些哌嗪基和哌啶基脲化合物可用作FAAH抑制剂。此类化合物可用于治疗由脂肪酰胺水解酶（FAAH）活性介导的疾病状态，病症和病症的药物组合物和方法。因此，可以施用化合物以治疗例如焦虑，疼痛，炎症，睡眠障碍，进食障碍或运动障碍（例如多发性硬化症）。

72. 发明申请

US20090170870A1 AMIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS 有权
标题翻译：含有AMIDINE的化合物作为MUSCARINIC受体拮抗剂有用
公开(公告)号：US20090170870A1
公开(公告)日：2009-07-02
申请号：US12333628
申请日：2008-12-12
申请人： YuHua Ji , Craig Husfeld , Rick Lee , YongQi Mu , Cameron Smith
发明人： YuHua Ji , Craig Husfeld , Rick Lee , YongQi Mu , Cameron Smith
IPC分类号： A61K31/495 , C07D295/125 , C07D211/58 , C07D405/06 , A61K31/496 , A61K31/4015 , A61P11/00 , A61K31/4535 , A61K31/4468 , C07D409/06 , C07D207/12
CPC分类号： C07D295/195 , C07D207/12 , C07D211/58 , C07D409/12
摘要： The invention relates to compounds of formula I: or a pharmaceutically acceptable salt thereof, where R1-3, R5, R7, a, b, Q, X, X′, X″, Y, Z, and Ar are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also relates to pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，其中R1-3，R5，R7，a，b，Q，X，X'，X“，Y，Z和Ar定义如规格。这些化合物是毒蕈碱受体拮抗剂。本发明还涉及含有这种化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺病的方法。

73. 发明申请

US20090143431A1 PESTICIDE NAPHTHYLOXY SUBSTITUTED PHENYLAMIDINE DERIVATIVES 有权
标题翻译：杀虫剂萘磺酸取代的苯甲酰胺衍生物
公开(公告)号：US20090143431A1
公开(公告)日：2009-06-04
申请号：US12063654
申请日：2006-09-12
申请人： Klaus Kunz , Jorg Greul , Oliver Guth , Benoit Hartmann , Kerstin Ilg , Wahed Moradi , Thomas Seitz , Peter Dahmen , Arnd Voerste , Ulrike Wachendorff-Neumann , Ralf Dunkel , Ronald Ebbert , Eva-Maria Franken
发明人： Klaus Kunz , Jorg Greul , Oliver Guth , Benoit Hartmann , Kerstin Ilg , Wahed Moradi , Thomas Seitz , Peter Dahmen , Arnd Voerste , Ulrike Wachendorff-Neumann , Ralf Dunkel , Ronald Ebbert , Eva-Maria Franken
IPC分类号： A01N37/52 , C07D211/22 , C07C257/18 , A01P7/04 , A01N43/40 , A01P3/00
CPC分类号： C07C257/12 , C07D295/195
摘要： The present invention relates to 2,5-di-substituted-4-naphthyloxy-substituted-phenyl-amidine derivatives of formula (I) wherein the substituents are as in the description, their process of preparation, their use as fungicide or insecticide active agents, particularly in the form of fungicide or insecticide compositions, and methods for the control of phytopathogenic fungi or damaging insects, notably of plants, using these compounds or compositions.
摘要翻译：本发明涉及式（I）的2,5-二取代-4-萘氧基取代的苯基 - 脒衍生物，其中取代基如说明书，其制备方法，它们作为杀真菌剂或杀虫剂活性剂，特别是以杀真菌剂或杀虫剂组合物的形式，以及使用这些化合物或组合物来控制植物病原性真菌或损害昆虫，特别是植物的昆虫的方法。

74. 发明授权

US06355796B1 Processes and intermediate compounds for the preparation of 2-(N,N-disubstituted) amino-4-(perfluoroalkyl)-1, 3- oxazin-6-one and 6-(perfluoroalkyl) uracil compounds 失效
标题翻译：用于制备2-（N，N-二取代的）氨基-4-（全氟烷基）-1,3-恶嗪-6-酮和6-（全氟烷基）尿嘧啶化合物的方法和中间体化合物
公开(公告)号：US06355796B1
公开(公告)日：2002-03-12
申请号：US09496763
申请日：2000-02-03
申请人： Venkataraman Kameswaran
发明人： Venkataraman Kameswaran
IPC分类号： C07D26506
CPC分类号： C07D239/54 , C07D261/20 , C07D265/10 , C07D275/04 , C07D295/195 , C07D413/04 , C07D417/04
摘要： An improved process and intermediate compounds for the preparation of 2-(N,N-disubstituted)amino-4-(perfluoroalkyl)-1,3-oxazin-6-one compounds having the structural formula I and an improved process for the preparation of 6-(perfluoroalkyl)uracil compounds having the structural formula V
摘要翻译：用于制备具有结构式I的2-（N，N-二取代的）氨基-4-（全氟烷基）-1,3-恶嗪-6-酮化合物的改进方法和中间体化合物，以及制备6 - 具有结构式V的（全氟烷基）尿嘧啶化合物

75. 发明授权

US06313150B1 &agr;-substituted phenylacetic acid derivative, its production and agricultural fungicide containing it 有权
标题翻译： α-取代苯乙酸衍生物，其生产和农药杀菌剂含有它
公开(公告)号：US06313150B1
公开(公告)日：2001-11-06
申请号：US09590293
申请日：2000-06-09
申请人： Toshikazu Ohtsuka , Takami Murashi , Shinji Suzuki , Michio Masuko , Hideyuki Takenaka
发明人： Toshikazu Ohtsuka , Takami Murashi , Shinji Suzuki , Michio Masuko , Hideyuki Takenaka
IPC分类号： A61K31165
CPC分类号： C07D295/195 , C07C57/48 , C07C57/58 , C07C59/68 , C07C69/734 , C07C69/736 , C07C229/36 , C07C235/34 , C07C237/20 , C07C251/16 , C07C251/24 , C07C257/14 , C07C317/18 , C07C317/46 , C07C323/45 , C07C323/56 , C07C323/60 , C07C327/22 , C07C327/44 , C07C327/58 , C07C2601/02 , C07C2601/14 , C07C2602/08
摘要： An &agr;-substituted phenylacetic acid derivative useful as an agricultural fungicide, represented by general formula (I), or a salt thereof, a process for producing the same, an intermediate for the production thereof, and an agricultural fungicide containing the same as the active ingredient, wherein R1 represents halogen, alkyl, OH, alkylthio, alkylsulfinyl, alkylsulfonyl, amino or nitro; Q represents aryl, heterocycle, mono- or disubstituted methyleneamino, (substituted amino-)methyl, alkyl, alkenyl, alkynyl, substituted carbonyl or substituted sulfonyl; X represents hydrogen, halogen, alkyl or OH; Y represents OH, alkylthio or amino; Z represents oxygen or sulfur; M represents oxygen, S(O)i (i being 0, 1 or 2), NR2 (R2 being hydrogen, alkyl or acyl) or a single bond; and n represents 0, 1 or 2.
摘要翻译：用作农业杀真菌剂的由通式（I）表示的α-取代苯乙酸衍生物或其盐，其制备方法，其制备中间体和含有该活性成分的农用杀真菌剂成分，其中R1表示卤素，烷基，OH，烷硫基，烷基亚磺酰基，烷基磺酰基，氨基或硝基; Q表示芳基，杂环，单取代或二取代的亚甲基氨基，（取代的氨基）甲基，烷基，烯基，炔基，取代的羰基或取代的磺酰基; X表示氢，卤素，烷基或OH; Y表示OH，烷硫基或氨基; Z表示氧或硫; M表示氧，S（O）i（i为0,1或2），NR2（R2为氢，烷基或酰基）或单键; n表示0,1或2。

76. 发明授权

US06281206B1 Amidino protease inhibitors 有权
公开(公告)号：US06281206B1
公开(公告)日：2001-08-28
申请号：US09502005
申请日：2000-02-11
申请人： Tianbao Lu , Bruce E. Tomczuk , Carl R. Illig , Richard M. Soll
发明人： Tianbao Lu , Bruce E. Tomczuk , Carl R. Illig , Richard M. Soll
IPC分类号： A61K31445
CPC分类号： C07D295/195 , C07C309/73 , C07C311/21 , C07D211/22 , C07D211/26
摘要： Amidino and benzamidino compounds, including compounds of the formula: wherein R1-R4, R6-R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit a number of proteolytic enzymes are described. Also described are methods for preparing the compounds of Formula I.

77. 发明授权

US5646278A Amidrazones and their use as insecticidal and agents 失效
标题翻译：氨喋呤及其用作杀虫剂和药剂
公开(公告)号：US5646278A
公开(公告)日：1997-07-08
申请号：US431154
申请日：1995-04-28
申请人： Joseph Augustus Furch , David George Kuhn , David Allen Hunt
发明人： Joseph Augustus Furch , David George Kuhn , David Allen Hunt
IPC分类号： A01N37/28 , A01N37/52 , A01N43/40 , A01N43/54 , C07C257/22 , C07D207/14 , C07D207/32 , C07D207/335 , C07D213/20 , C07D295/195 , C07D307/52 , C07D213/76 , C07D237/20 , C07D239/42
CPC分类号： C07D207/335 , A01N37/28 , A01N37/52 , A01N43/40 , A01N43/54 , C07C257/22 , C07D207/14 , C07D213/20 , C07D295/195 , C07D307/52 , C07C2101/02 , C07C2101/14 , C07C2102/42 , C07C2103/74
摘要： There are provided substituted acid amide, arylhydrazone compounds (amidrazones) of formula I ##STR1## the use thereof for the control of insect and acarid pests and methods and compositions for the protection of crops from the damage and loss caused by said pests.
摘要翻译：提供式I的取代的酰胺，芳基腙化合物（氨基腙）（I）其用于控制昆虫和螨虫害虫的用途，以及用于保护作物免受所述害虫引起的损害和损失的方法和组合物。

78. 发明授权

US5523325A Amidrazones and their use as pesticides 失效
标题翻译：氨喋呤及其用作农药
公开(公告)号：US5523325A
公开(公告)日：1996-06-04
申请号：US118915
申请日：1993-09-09
申请人： Richard M. Jacobson
发明人： Richard M. Jacobson
IPC分类号： C07D295/12 , A01N37/52 , A01N43/36 , A01N43/40 , A01N43/84 , C07C251/86 , C07C257/22 , C07C313/18 , C07C327/56 , C07D295/195 , A61K31/15 , A61K31/165 , C07C251/80
CPC分类号： C07D295/195 , A01N37/52 , C07C257/22
摘要： This invention relates to amidrazones, insecticidal amidrazone compositions, and methods of using such compositions.
摘要翻译：本发明涉及氨基腙，杀虫脒组合物和使用这些组合物的方法。

79. 发明授权

US4781752A Haloacetamidines compositions and the herbicidal use thereof 失效
标题翻译：卤乙酰胺组合物及其除草用途
公开(公告)号：US4781752A
公开(公告)日：1988-11-01
申请号：US512941
申请日：1983-07-11
申请人： Eugene G. Teach
发明人： Eugene G. Teach
IPC分类号： C07C259/14 , C07C275/40 , C07C275/56 , C07D263/04 , C07D277/04 , C07D295/195 , A01N33/02
CPC分类号： C07D263/04 , C07C259/14 , C07C275/40 , C07C275/56 , C07D277/04 , C07D295/195
摘要： Dichloroacetamidines having the formula ##STR1## in which A and B are independently selected from hydrogen, fluorine, chlorine, bromine and methyl, provided that at least one of A or B is other than hydrogen;M is hydrogen or methyl;X is selected from the group consisting of trifluoromethyl, lower alkyl, nitro, chloro, bromo, fluoro, cyano, lower alkoxy acetyl, lower alkylthio, trifluoromethylthio, and 3,3-diloweralkyl ureido;Y is selected from the group consisting of hydrogen, lower alkyl, chloro, fluoro, nitro, trifluoromethyl, and lower alkoxy;Z is selected from the group consisting of hydrogen and chloro;R.sub.1 is selected from the group consisting of hydrogen, alkyl and allyl;R.sub.2 is selected from the group consisting of alkyl, allyl, benzyl, hydroxyalkyl, alkynyl, N-alkyl amido, alkoxyalkyl, dialkoxyalkyl, alkoxy, cyano alkyl, substituted phenyl wherein the substituent is selected from the group trifluoromethyl, dichloro and 3,3-dimethylureido; andR.sub.1 and R.sub.2 taken together with the nitrogen is selected from the group consisting of alkyl substituted oxazolidyl, morpholinyl, piperidinyl and pyrrolidinyl; and salts thereof; useful as herbicides.
摘要翻译：具有式“IMAGE”的二氯乙酰胺，其中A和B独立地选自氢，氟，氯，溴和甲基，条件是A或B中的至少一个不是氢; M是氢或甲基; X选自三氟甲基，低级烷基，硝基，氯，溴，氟，氰基，低级烷氧基乙酰基，低级烷硫基，三氟甲硫基和3,3-二低级烷基脲基; Y选自氢，低级烷基，氯，氟，硝基，三氟甲基和低级烷氧基; Z选自氢和氯; R1选自氢，烷基和烯丙基; R 2选自烷基，烯丙基，苄基，羟基烷基，炔基，N-烷基酰胺基，烷氧基烷基，二烷氧基烷基，烷氧基，氰基烷基，取代的苯基，其中取代基选自三氟甲基，二氯和3,3- 二甲基脲基; 并且R 1和R 2与氮一起选自烷基取代的恶唑烷基，吗啉基，哌啶基和吡咯烷基; 及其盐; 用作除草剂。

80. 发明授权

US4686228A Quinoline therapeutic agents 失效
公开(公告)号：US4686228A
公开(公告)日：1987-08-11
申请号：US925029
申请日：1986-10-30
申请人： Simon F. Campbell , John D. Hardstone
发明人： Simon F. Campbell , John D. Hardstone
IPC分类号： C07D215/20 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/53 , A61P9/12 , C07D215/42 , C07D215/48 , C07D295/195 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12
CPC分类号： C07D295/195 , C07C255/00 , C07D215/42 , C07D215/48 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： A series of novel 2-substituted 4-amino-6,7-dimethoxyquinoline derivatives have been prepared, including their pharmaceutically acceptable acid addition salts. These particular compounds are useful in therapy as highly potent antihypertensive agents. Preferred member compounds include 4-amino-2-[4-(2-furoyl)piperazin-1-yl]-6,7-dimethoxyquinoline, 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinoline and 4-amino-6,7-dimethoxy-2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl)quinoline, respectively. Methods for preparing these compounds from known starting materials are provided.

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