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71. 发明授权

US6013651A Meta-azacyclic amino benzoic acid compounds and derivatives thereof 失效
标题翻译：元 - 氮杂环丁氨基苯甲酸化合物及其衍生物
公开(公告)号：US6013651A
公开(公告)日：2000-01-11
申请号：US34758
申请日：1998-03-04
申请人： Thomas E. Rogers , Peter G. Ruminski
发明人： Thomas E. Rogers , Peter G. Ruminski
IPC分类号： C07C275/42 , C07C279/18 , C07C279/24 , C07C279/28 , C07C311/19 , C07C311/37 , C07C317/50 , C07C323/59 , C07C323/62 , C07C323/63 , C07C335/22 , C07C335/28 , C07D207/14 , C07D211/72 , C07D213/55 , C07D213/61 , C07D215/14 , C07D223/12 , C07D231/06 , C07D231/12 , C07D231/14 , C07D233/50 , C07D239/14 , C07D239/26 , C07D239/54 , C07D239/545 , C07D249/14 , C07D295/215 , C07D307/54 , C07D307/79 , C07D307/81 , C07D317/60 , C07D319/18 , C07D333/24 , C07D333/28 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12 , C07H15/203 , A61K31/505 , C07D239/02
CPC分类号： C07C275/42 , C07C279/18 , C07C279/24 , C07C279/28 , C07C311/19 , C07C311/37 , C07C317/50 , C07C323/59 , C07C323/62 , C07C323/63 , C07C335/22 , C07C335/28 , C07D207/14 , C07D211/72 , C07D213/55 , C07D213/61 , C07D215/14 , C07D223/12 , C07D231/06 , C07D231/12 , C07D231/14 , C07D233/50 , C07D239/14 , C07D239/26 , C07D239/545 , C07D249/14 , C07D295/215 , C07D307/54 , C07D307/79 , C07D307/81 , C07D317/60 , C07D319/18 , C07D333/24 , C07D333/28 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12 , C07H15/203
摘要： The present invention is directed to compounds of the formula ##STR1## and pharmaceutically acceptable salts and isomers thereof.
摘要翻译：本发明涉及下式的化合物及其药学上可接受的盐和异构体。

72. 发明授权

US5886015A Benzyloxy substituted aromatics and their use as fungicides and insecticides 失效
标题翻译：苄氧基取代的芳族化合物及其作为杀真菌剂和杀虫剂的用途
公开(公告)号：US5886015A
公开(公告)日：1999-03-23
申请号：US867376
申请日：1997-06-02
申请人： Ronald Ross , Ted Tsutomu Fujimoto , Steven Howard Shaber
发明人： Ronald Ross , Ted Tsutomu Fujimoto , Steven Howard Shaber
IPC分类号： C07D231/06 , C07D231/12 , C07D261/04 , C07D261/06 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04 , A61K31/42 , A61K31/415 , C07D231/10
CPC分类号： C07D231/06 , C07D231/12 , C07D261/04 , C07D261/06 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04
摘要： Compounds with fungicidal and insecticidal properties having formula ##STR1## wherein A is N or CH; V is O or NH; m and n are independently 0 and 1 provided that m+n is not 2, and U and W are independently O or N;such that when U and W are both N and n is 0 and m is 1, the bond between the 1 and 5 atoms is a double bond and the bond between the C.sub.3 -C.sub.4 atoms is a single or double bond, and when n is 1 and m is 0, the bond between the 2 and 3 atoms is a double bond and the bond between the C.sub.4 -C.sub.5 atoms is a single or double bond;and that when U is O and W is N and n=m=0, the bond between the 1 and 5 atoms is a double bond and the bond between the C.sub.3 -C.sub.4 atoms is a single or double bond;and that when U is N and W is O and n=m=0, the bond between the 2 and 3 atoms is a double bond and the bond between the C.sub.4 -C.sub.5 atoms is a single or double bond;X is independently selected from hydrogen, halo, (C.sub.1 -C.sub.4)alkyl, and C.sub.1 -C.sub.4)alkoxy;R is independently selected from hydrogen, (C.sub.1 -C.sub.12)alkyl, halo(C.sub.1 -C.sub.12)alkyl, (C.sub.2 -C.sub.8)alkenyl, (C.sub.2 -C.sub.8)alkynyl(C.sub.1 -C.sub.12)alkoxy(C.sub.1 -C.sub.12)alkyl, (C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkyl(C.sub.1 -C.sub.4)alkyl, aryl, aralkyl, heterocyclic andR.sub.1 is independently selected from hydrogen, (C.sub.1 -C.sub.6)alkyl, and aryl; andZ is selected from (C.sub.1 -C.sub.6)alkyl, halo(C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.7) cycloalkyl, (C.sub.3 -C.sub.7)cycloalkyl(C.sub.1 -C.sub.4)alkyl, aryl and aralkyl.
摘要翻译：具有式（I）的具有杀真菌和杀虫性质的化合物，其中A是N或CH; V是O或NH; m和n分别为0和1，条件是m + n不为2，U和W独立地为O或N; 使得当U和W均为N且n为0且m为1时，1至5个原子之间的键为双键，并且C 3 -C 4原子之间的键为单键或双键，并且当n为 1和m为0，2和3原子之间的键是双键，C4-C5原子之间的键是单键或双键; 当U为O且W为N且n = m = 0时，1与5原子之间的键为双键，C3-C4原子之间的键为单键或双键; 当U为N且W为O且n = m = 0时，2和3原子之间的键为双键，C4-C5原子之间的键为单键或双键; X独立地选自氢，卤素，（C1-C4）烷基和C1-C4）烷氧基; （C 1 -C 12）烷基，（C 2 -C 8）烯基，（C 2 -C 8）炔基（C 1 -C 12）烷氧基（C 1 -C 12）烷基， -C 7）环烷基，（C 3 -C 7）环烷基（C 1 -C 4）烷基，芳基，芳烷基，杂环和R 1独立地选自氢，（C 1 -C 6）烷基和芳基; （C 1 -C 6）烷基，（C 3 -C 7）环烷基，（C 3 -C 7）环烷基（C 1 -C 4）烷基，芳基和芳烷基。

73. 发明授权

US5852210A Cinnamic acid derivatives 失效
标题翻译：肉桂酸衍生物
公开(公告)号：US5852210A
公开(公告)日：1998-12-22
申请号：US825080
申请日：1997-03-27
申请人： Barbara B. Chen , Helen Y. Chen , Michael Clare , Stephen H. Docter , Ish Kumar Khanna , Francis Jan Koszyk , James W. Malecha , Julie Marion Miyashiro , Thomas D. Penning , Joseph G. Rico , Peter G. Ruminski , Mark A. Russell , Richard Mathias Weier , Xiangdong Xu , Stella S. Yu , Yi Yu
发明人： Barbara B. Chen , Helen Y. Chen , Michael Clare , Stephen H. Docter , Ish Kumar Khanna , Francis Jan Koszyk , James W. Malecha , Julie Marion Miyashiro , Thomas D. Penning , Joseph G. Rico , Peter G. Ruminski , Mark A. Russell , Richard Mathias Weier , Xiangdong Xu , Stella S. Yu , Yi Yu
IPC分类号： A61K31/00 , A61K31/195 , A61K31/215 , A61K31/216 , A61K31/275 , A61K31/277 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/42 , A61K31/421 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/505 , A61K31/506 , A61K31/54 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/14 , A61P19/00 , A61P19/10 , A61P35/00 , A61P35/04 , C07C205/34 , C07C205/35 , C07C205/37 , C07C205/44 , C07C205/45 , C07C205/56 , C07C205/57 , C07C275/42 , C07C279/18 , C07C279/22 , C07C279/24 , C07D231/06 , C07D233/50 , C07D233/54 , C07D233/64 , C07D239/14 , C07D239/42 , C07D263/32 , C07D279/06 , C07D401/12 , C07D403/12 , C07C241/00 , C07C205/00 , C07D233/44 , C07D239/02
CPC分类号： C07D231/06 , C07C205/34 , C07C205/35 , C07C205/37 , C07C205/44 , C07C205/45 , C07C205/56 , C07C205/57 , C07C275/42 , C07C279/18 , C07C279/22 , C07C279/24 , C07D233/50 , C07D233/64 , C07D239/14 , C07D239/42 , C07D263/32 , C07D279/06 , C07D401/12 , C07D403/12
摘要： The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗αvβ3整联蛋白的方法。

74. 发明授权

US5518656A Fluorescent detecting agents 失效
标题翻译：荧光检测剂
公开(公告)号：US5518656A
公开(公告)日：1996-05-21
申请号：US376398
申请日：1995-01-23
申请人： Yasusi Furuta , Yoshisada Tamura
发明人： Yasusi Furuta , Yoshisada Tamura
IPC分类号： C07D231/06 , C07D263/62 , C07D263/64 , C09K11/06
CPC分类号： C07D231/06 , C07D263/64 , C09K11/06
摘要： A fluorescent detecting agent comprising a naphthalene compound of formula (I) ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each represents an alkyl group of 4 to 8 carbon atoms and/or a pyraxoline compound of formula (II) ##STR2## wherein R.sup.3 and R.sup.4 may be the same or different and each represents hydrogen, an alkoxy group of 1 to 8 carbon atoms or an alkyl group of 4 to 8 carbon atoms, provided that at least one of R.sup.3 and R.sup.4 represents an alkyl group of 4 to 8 carbon atoms. They are used for a visual inspection or an automatic optical inspection (AOI) and a fluorescent penetrant examination.
摘要翻译：包含式（I）的萘化合物（I）的荧光检测剂，其中R 1和R 2可以相同或不同，并且各自表示4至8个碳原子的烷基和/或式（ⅩⅤ）的吡咯啉化合物 II）其中R 3和R 4可以相同或不同，并且各自表示氢，1至8个碳原子的烷氧基或4至8个碳原子的烷基，条件是R3中的至少一个 R4表示4〜8个碳原子的烷基。它们用于目视检查或自动光学检查（AOI）和荧光渗透检查。

75. 发明授权

US5510361A Di-tert-butylphenol compounds with heterocyclic moiety, useful as anti-inflammatory agents 失效
标题翻译：具有杂环部分的二叔丁基苯酚化合物，可用作抗炎剂
公开(公告)号：US5510361A
公开(公告)日：1996-04-23
申请号：US326619
申请日：1994-10-20
申请人： Michael W. Scherz , Stanislaw Pikul
发明人： Michael W. Scherz , Stanislaw Pikul
IPC分类号： A61K31/415 , A61K31/42 , A61P25/04 , A61P29/00 , C07D231/06 , C07D231/08 , C07D261/04 , A61K31/41
CPC分类号： C07D231/06 , C07D231/08 , C07D261/04
摘要： The subject invention relates to compounds having the structure: ##STR1## wherein a) each R is independently alkyl having from 1 to about 7 carbon atoms;b) Z is O or N--X;c) X is selected from hydrogen, alkyl having from 1 to about 7 carbon atoms, C(O)Y, C(S)Y, and SO.sub.2 Y;d) Y is selected from R', OR' and NR'.sub.2 ; ande) R' is selected from hydrogen, alkyl having from 1 to about 7 carbon atoms, and phenyl.The subject invention also relates to pharmaceutical compositions comprising the above compounds, and methods of treating inflammation or pain using the compounds.
摘要翻译：本发明涉及具有以下结构的化合物：其中a）每个R独立地为具有1至约7个碳原子的烷基; b）Z是O或N-X; c）X选自氢，具有1至约7个碳原子的烷基，C（O）Y，C（S）Y和SO 2 Y; d）Y选自R'，OR'和NR'2; 和e）R'选自氢，具有1至约7个碳原子的烷基和苯基。本发明还涉及包含上述化合物的药物组合物，以及使用该化合物治疗炎症或疼痛的方法。

76. 发明授权

US5466397A Nonlinear optically active pyrazolines and polymeric compositions containing moieties derived therefrom 失效
标题翻译：非线性光学活性吡唑啉和含有衍生自其的部分的聚合物组合物
公开(公告)号：US5466397A
公开(公告)日：1995-11-14
申请号：US159010
申请日：1993-11-29
申请人： Stephen E. Bales , David J. Brennan , Robert J. Gulotty, Jr. , Muthiah N. Inbasekaran , Michael N. Mang , Mark D. Newsham
发明人： Stephen E. Bales , David J. Brennan , Robert J. Gulotty, Jr. , Muthiah N. Inbasekaran , Michael N. Mang , Mark D. Newsham
IPC分类号： C07D231/06 , C07D303/22 , C07D405/14 , C08G59/06 , C08G59/26 , C08G59/62 , C08G64/12 , G02F1/361 , F21V9/00 , C08F2/46
CPC分类号： C07D231/06 , C07D303/22 , C07D405/14 , C08G59/066 , C08G59/26 , C08G59/621 , C08G64/12 , G02F1/3612 , G02F1/3616
摘要： Disclosed are compounds containing substituted pyrazoline which exhibit nonlinear optical activity on orientation and to oriented polymeric compositions comprising moieties derived therefrom in the backbone of the polymer. Also disclosed are the processes for making the oriented polymeric composition of the invention.
摘要翻译：公开了含有取代的吡唑啉的化合物，其在取向上表现出非线性光学活性，并且包含在聚合物的主链中由其衍生的部分的定向聚合物组合物。还公开了制备本发明的取向聚合物组合物的方法。

77. 发明授权

US5428044A Anti-inflammatory 4-aminophenyl derivatives 失效
标题翻译：抗炎4-氨基苯基衍生物
公开(公告)号：US5428044A
公开(公告)日：1995-06-27
申请号：US138375
申请日：1993-10-15
申请人： John R. Bantick , David N. Hardern , Richard A. Appleton , John Dixon , David J. Wilkinson
发明人： John R. Bantick , David N. Hardern , Richard A. Appleton , John Dixon , David J. Wilkinson
IPC分类号： A61K31/35 , A61K31/15 , A61K31/352 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/433 , A61K31/44 , A61K31/4427 , A61K31/455 , A61K31/465 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , A61K31/53 , A61P29/00 , A61P43/00 , C07D209/60 , C07D213/82 , C07D215/38 , C07D231/06 , C07D231/38 , C07D233/88 , C07D235/30 , C07D237/20 , C07D237/22 , C07D237/24 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/28 , C07D249/04 , C07D249/08 , C07D249/14 , C07D251/02 , C07D253/06 , C07D253/07 , C07D261/14 , C07D263/48 , C07D285/08 , C07D285/12 , C07D285/135 , C07D311/92 , C07D333/36 , C07D333/40 , C07D401/08 , C07D401/10 , C07D401/12 , C07D521/00 , A61K31/535 , A01N43/56
CPC分类号： C07D213/82 , C07D215/38 , C07D231/06 , C07D231/12 , C07D231/38 , C07D233/56 , C07D233/88 , C07D235/30 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/48 , C07D241/20 , C07D249/04 , C07D249/08 , C07D249/14 , C07D253/07 , C07D261/14 , C07D263/48 , C07D285/08 , C07D285/135 , C07D311/92 , C07D333/36 , C07D401/12
摘要： There are disclosed compounds of the formula (I): ##STR1## in which the variables R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, and X are defined in the specification. The compounds are useful as pharmaceuticals, especially as anti-inflammatory agents.
摘要翻译：公开了式（I）化合物：其中变量R1，R2，R3，R4，R5，R6和X在本说明书中定义。这些化合物可用作药物，特别是作为抗炎剂。

78. 发明授权

US5369121A Arthropodicidal pyrazolines, pyrazolidines and hydrazines 失效
标题翻译：节肢动物杀菌吡唑啉，吡唑啉和肼
公开(公告)号：US5369121A
公开(公告)日：1994-11-29
申请号：US917073
申请日：1992-07-31
申请人： Charles R. Harrison , George P. Lahm
发明人： Charles R. Harrison , George P. Lahm
IPC分类号： A01N43/90 , A01N43/56 , A01N47/24 , A01N47/34 , A01N47/38 , A01N47/42 , A01N47/44 , C07C281/06 , C07C281/08 , C07C281/16 , C07D209/40 , C07D231/04 , C07D231/06 , C07D231/56 , C07D307/82 , C07D333/66 , C07D401/06 , C07D401/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/052 , C07D495/04 , C07D231/54
CPC分类号： C07D231/06 , A01N43/56 , A01N47/24 , A01N47/34 , A01N47/38 , A01N47/42 , A01N47/44 , C07C281/06 , C07D231/04 , C07D491/04 , C07C2102/08
摘要： Compounds of Formula I ##STR1## wherein Q, W, R.sup.1 and m are as defined in the text; these compounds being useful in controlling agronomic and nonagronomic arthropods.
摘要翻译： PCT No.PCT / US91 / 00013 Sec。 371日期：1992年7月31日 102（e）日期1992年7月31日PCT 1991年1月8日PCT。1991年1月8日公告I化合物其中Q，W，R1和m如文中所定义; 这些化合物可用于控制农艺和非农学节肢动物。

79. 发明授权

US5308545A Pyrazoline compounds 失效
标题翻译：吡唑啉化合物
公开(公告)号：US5308545A
公开(公告)日：1994-05-03
申请号：US983343
申请日：1992-11-30
申请人： Hans R. Meyer
发明人： Hans R. Meyer
IPC分类号： C07D231/06 , D06L3/12 , C09K11/06
CPC分类号： C07D231/06 , D06L3/1257
摘要： The invention relates to pyrazoline compounds of formula ##STR1## wherein R.sub.1 is hydrogen or methyl, R.sub.2 and R.sub.3 are each independently of the other methyl, ethyl or hydroxyethyl, R.sub.4 is hydrogen or chlorine, R.sub.5 and R.sub.6 are each independently of the other hydrogen or methyl, R.sub.7 is hydrogen, methyl or phenyl, n is 0 or 1, with the proviso that, if n is 0 and R.sub.4 to R.sub.7 are hydrogen, R.sub.2 is methyl and R.sub.3 is hydroxyethyl, and X.sup..crclbar. is a C.sub.1 -C.sub.3 alkanoate, C.sub.1 -C.sub.4 alkanephosphonate, C.sub.1 -C.sub.4 alkanesulfonate, phosphite, sulfamate or glycolate anion and, if R.sub.1 is methyl, X.sup..crclbar. is also a methosulfate, chloride or bromide ion, to the preparation of said compounds, to the use thereof as fluorescent whitening agents, and to novel hydrazine intermediates of formula ##STR2## wherein R.sub.2 and R.sub.3 are methyl, ethyl or hydroxyethyl, and the acetone hydrazones and salts thereof.
摘要翻译：本发明涉及式Ia的吡唑啉化合物，其中R 1是氢或甲基，R 2和R 3各自独立地是另一个甲基，乙基或羟乙基，R 4是氢或氯，R 5和R 6各自独立地是其他氢或甲基，R7为氢，甲基或苯基，n为0或1，条件是如果n为0，R4至R7为氢，R2为甲基，R3为羟乙基，X（ - ）为 C1-C3链烷酸酯，C1-C4烷基膦酸酯，C1-C4烷基磺酸酯，亚磷酸酯，氨基磺酸酯或乙醇酸根阴离子，如果R1是甲基，则X（ - ）也是所述化合物的制备方法中的硫酸氢盐，氯化物或溴离子作为荧光增白剂，以及具有式“IMAGE”的新型肼中间体，其中R 2和R 3为甲基，乙基或羟乙基，以及丙酮腙及其盐。

80. 发明授权

US5196408A N-sulfenylated pyrazolines, compositions and use 失效
标题翻译： N-磺酰化吡唑啉，组合物和用途
公开(公告)号：US5196408A
公开(公告)日：1993-03-23
申请号：US659402
申请日：1991-03-12
申请人： Mohamed A. H. Fahmy, deceased , Charles R. Harrison , George P. Lahm , Thomas M. Stevenson
发明人： Mohamed A. H. Fahmy, deceased , Charles R. Harrison , George P. Lahm , Thomas M. Stevenson
IPC分类号： A01N47/38 , C07D231/06 , C07D231/54
CPC分类号： C07D231/06 , A01N47/38 , C07D231/54
摘要： N-sulfenylated and N-acrylated pyrazoline arthropodicides, compositions containing them and methods for controlling arthropods by applying compounds of the invention to them or to their environment. The pyrazolines are selected from those of Formulae I to III wherein R.sub.1, R.sub.2, R.sub.3, Q, A, B, J, K, Y, m, n and p are as defined in the test: ##STR1##
摘要翻译： PCT No.PCT / US89 / 04078 Sec。 371日期1991年3月12日 102（e）1991年3月12日PCT PCT。1989年9月26日。N-亚磺酰化和N-丙烯酸化的吡唑啉节肢动物杀虫剂，含有它们的组合物和通过将本发明的化合物施用于它们或其环境来控制节肢动物的方法。吡唑啉选自式I至III的那些，其中R 1，R 2，R 3，Q，A，B，J，K，Y，m，n和p如测试中所定义： III

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