专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5428044A Anti-inflammatory 4-aminophenyl derivatives 失效
标题翻译：抗炎4-氨基苯基衍生物
公开(公告)号：US5428044A
公开(公告)日：1995-06-27
申请号：US138375
申请日：1993-10-15
申请人： John R. Bantick , David N. Hardern , Richard A. Appleton , John Dixon , David J. Wilkinson
发明人： John R. Bantick , David N. Hardern , Richard A. Appleton , John Dixon , David J. Wilkinson
IPC分类号： A61K31/35 , A61K31/15 , A61K31/352 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/433 , A61K31/44 , A61K31/4427 , A61K31/455 , A61K31/465 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , A61K31/53 , A61P29/00 , A61P43/00 , C07D209/60 , C07D213/82 , C07D215/38 , C07D231/06 , C07D231/38 , C07D233/88 , C07D235/30 , C07D237/20 , C07D237/22 , C07D237/24 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/28 , C07D249/04 , C07D249/08 , C07D249/14 , C07D251/02 , C07D253/06 , C07D253/07 , C07D261/14 , C07D263/48 , C07D285/08 , C07D285/12 , C07D285/135 , C07D311/92 , C07D333/36 , C07D333/40 , C07D401/08 , C07D401/10 , C07D401/12 , C07D521/00 , A61K31/535 , A01N43/56
CPC分类号： C07D213/82 , C07D215/38 , C07D231/06 , C07D231/12 , C07D231/38 , C07D233/56 , C07D233/88 , C07D235/30 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/48 , C07D241/20 , C07D249/04 , C07D249/08 , C07D249/14 , C07D253/07 , C07D261/14 , C07D263/48 , C07D285/08 , C07D285/135 , C07D311/92 , C07D333/36 , C07D401/12
摘要： There are disclosed compounds of the formula (I): ##STR1## in which the variables R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, and X are defined in the specification. The compounds are useful as pharmaceuticals, especially as anti-inflammatory agents.
摘要翻译：公开了式（I）化合物：其中变量R1，R2，R3，R4，R5，R6和X在本说明书中定义。这些化合物可用作药物，特别是作为抗炎剂。

2. 发明授权

US4424231A Compounds 失效
标题翻译：化合物
公开(公告)号：US4424231A
公开(公告)日：1984-01-03
申请号：US359817
申请日：1982-03-19
申请人： John R. Bantick , John Fuher , David N. Hardern , Thomas B. Lee
发明人： John R. Bantick , John Fuher , David N. Hardern , Thomas B. Lee
IPC分类号： A61K31/19 , C07C43/225 , C07C43/23 , C07C45/00 , C07C45/71 , C07C47/565 , C07C59/52 , C07C59/70 , C07C59/74 , C07C59/90 , C07C65/11 , C07C65/24 , C07C65/40 , C07D209/42 , C07D307/84 , C07D307/85 , C07D311/06 , C07D311/08 , C07D311/16 , C07D333/70 , A61K31/34 , C07D307/80 , C07D307/83
CPC分类号： C07D333/70 , C07C323/00 , C07C43/225 , C07C43/23 , C07C45/00 , C07C45/71 , C07C47/565 , C07C59/70 , C07C59/74 , C07C59/90 , C07C65/24 , C07C65/40 , C07D209/42 , C07D307/85 , C07D311/16 , Y10S514/826 , Y10S514/849
摘要： There are described compounds of formula I, ##STR1## in which Ra, Rb, Rc, Rd, Re, Rf and Rg, which may be the same or different, each represent hydrogen, amino, hydroxy, alkoxy, alkenyloxy, halogen, acyl, alkenyl, alkyl, or alkoxy substituted by phenyl, Rh is hydrogen, alkyl or --COOH. X is a hydrocarbon chain containing from 2 to 10 carbon atoms and optionally substituted by a hydroxy group, A has no significance or represents Y, OY, or SY and Y represents a C 1 to 4 hydrocarbon chain which is optionally substituted by alkyl C 1 to 4, E and G, which may be the same or different, each represent --O--, --S-- or --CH.sub.2 --, provided that at least one of E and G is --O-- or --S--, L, together with the carbon atoms to which it is attached, forms a benzene, furan, thiophene, pyrrole, or pyran-2-one ring, and pharmaceutically acceptable derivatives thereof.
摘要翻译：描述了式I，其中R a，R b，R c，R d，R e，R f和R g可以相同或不同的化合物，其分别代表氢，氨基，羟基，烷氧基，烯氧基，卤素，酰基，烯基，烷基或被苯基取代的烷氧基，Rh是氢，烷基或-COOH。 X是含有2至10个碳原子并且任选被羟基取代的烃链，A没有意义或代表Y，OY或SY，Y代表任选被烷基C 1取代的C 1至4烃链至4，E和G可以相同或不同，各自表示-O - ， - S-或-CH 2 - ，条件是E和G中的至少一个是-O-或-S-，L，一起与其连接的碳原子形成苯，呋喃，噻吩，吡咯或吡喃-2-酮，以及其药学上可接受的衍生物。

3. 发明授权

US4213903A Basic amino acid salts of chromones 失效
标题翻译：色酮的碱性氨基酸盐
公开(公告)号：US4213903A
公开(公告)日：1980-07-22
申请号：US869653
申请日：1978-01-16
申请人： John R. Bantick , David N. Hardern , Thomas B. Lee
发明人： John R. Bantick , David N. Hardern , Thomas B. Lee
IPC分类号： C07D311/26 , C07D257/04 , C07D311/22
CPC分类号： C07D311/26
摘要： The present invention relates to salts with basic amino sugars or basic amino acids of certain 2-carboxy or 2-tetrazolo-chromones.
摘要翻译：本发明涉及具有某些2-羧基或2-四唑基 - 色酮的碱性氨基糖或碱性氨基酸的盐。

4. 发明授权

US4518612A Naphthalene and 2-oxo-benzopyran acids and derivatives and pharamaceutical use thereof 失效
标题翻译：萘和2-氧代 - 苯并吡喃酸及其衍生物和药物用途
公开(公告)号：US4518612A
公开(公告)日：1985-05-21
申请号：US563709
申请日：1983-12-21
申请人： John R. Bantick , John Fuher , David N. Hardern , Thomas B. Lee
发明人： John R. Bantick , John Fuher , David N. Hardern , Thomas B. Lee
IPC分类号： A61K31/19 , C07C43/225 , C07C43/23 , C07C45/00 , C07C45/71 , C07C47/565 , C07C59/52 , C07C59/70 , C07C59/74 , C07C59/90 , C07C65/11 , C07C65/24 , C07C65/40 , C07D209/42 , C07D307/84 , C07D307/85 , C07D311/06 , C07D311/08 , C07D311/16 , C07D333/70 , A61K31/35 , C07D311/12
CPC分类号： C07D333/70 , C07C323/00 , C07C43/225 , C07C43/23 , C07C45/00 , C07C45/71 , C07C47/565 , C07C59/70 , C07C59/74 , C07C59/90 , C07C65/24 , C07C65/40 , C07D209/42 , C07D307/85 , C07D311/16 , Y10S514/826 , Y10S514/849
摘要： There are described compounds of formula I, ##STR1## in which Ra, Rb, Rc, Rd, Re, Rf and Rg, which may be the same or different, each represent hydrogen, amino, hydroxy, alkoxy, alkenyloxy, halogen, acyl, alkenyl, alkyl, or alkoxy substituted by phenyl,Rh is hydrogen, alkyl or --COOH.X is a hydrocarbon chain containing from 2 to 10 carbon atoms and optionally substituted by a hydroxy group,A has no significance or represents Y, OY, or SY and Y represents a C 1 to 4 hydrocarbon chain which is optionally substituted by alkyl C 1 to 4,E and G, which may be the same or different, each represent --O--, --S-- or --CH.sub.2 --, provided that at least one of E and G is --O-- or --S--,L, together with the carbon atoms to which it is attached, forms a benzene, furan, thiophene, pyrrole, or pyran-2-one ring,and pharmaceutically acceptable derivatives thereof.

5. 发明授权

US4810719A Anti-inflammator 1,n-diarylpyrazol-3-amines 失效
标题翻译：抗炎剂1，正二芳基吡唑-3-胺
公开(公告)号：US4810719A
公开(公告)日：1989-03-07
申请号：US733591
申请日：1985-05-10
申请人： Richard A. Appleton , Sidney C. Burford , David N. Hardern , David Wilkinson
发明人： Richard A. Appleton , Sidney C. Burford , David N. Hardern , David Wilkinson
IPC分类号： A61K31/415 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/505 , A61P29/00 , C07D213/57 , C07D231/06 , C07D231/38 , C07D333/00 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/00 , C07D403/04 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/14 , C07D417/04 , C07D417/12
CPC分类号： C07D231/06 , C07C255/00 , C07D213/57 , C07D231/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D409/04 , C07D417/04 , C07D417/12
摘要： There are described compounds of formula I, ##STR1## in which either R.sub.2 represents hydrogen, alkyl or Ar.sub.2, andR.sub.3 represents hydrogen, alkyl or alkyl substituted by Ar.sub.3 ;or R.sub.2 and R.sub.3 together form the chain --(CH.sub.2).sub.m --;R.sub.4 and R.sub.5, which may be the same or different, each independently represent hydrogen, halogen, Ar, alkyl, or alkyl substituted by Ar,Ar.sub.1, Ar.sub.2 and Ar, which may be the same or different each independently represent aryl or aryl substituted by one or more ofhalogen, hydroxy, --CN, --COR.sub.6, trihalomethyl, alkoxy, alkoxy substituted by --COR.sub.6, alkoxy substituted by --NR.sub.7 R.sub.8, alkyl, alkyl substituted by --COR.sub.6, alkyl substituted by NR.sub.7 R.sub.8, alkoxy substituted by Ar.sub.3, S(O).sub.n R.sub.9, --NR.sub.7 R.sub.8 or OAr.sub.3 ;R.sub.6 represents --OR.sub.10, --NR.sub.7 R.sub.8, hydrogen or alkyl;R.sub.7 and R.sub.8, which may be the same or different, each independently represent hydrogen, alkyl, alkanoyl or Ar.sub.3 ;R.sub.9 represents alkyl or Ar.sub.3 ;R.sub.10 represents hydrogen, alkyl or Ar.sub.3 ;m represents an integer from 3 to 6 inclusive;n represents 0, 1 or 2; andAr.sub.3 represents unsubstituted aryl;or a pharmaceutically acceptable derivative thereof.There are also described compositions containing the compounds and methods for their preparation.The compounds are indicated for use as pharmaceutical, e.g. anti-inflammatory, agents.
摘要翻译：描述式I化合物，其中R 2表示氢，烷基或Ar 2，R 3表示氢，被Ar 3取代的烷基或烷基; 或R 2和R 3一起形成链 - （CH 2）m - ; R 4和R 5可以相同或不同，各自独立地表示氢，卤素，Ar，烷基或被Ar，Ar1，Ar2和Ar取代的烷基，它们可以相同或不同，各自独立地表示被一个或多个卤素，羟基，-CN，-COR 6，三卤代甲基，烷氧基，被-COR 6取代的烷氧基，被-NR 7 R 8取代的烷氧基，被-COR 6取代的烷基，被NR 7 R 8取代的烷基，被Ar 3取代的烷氧基，S（ O）n R 9，-NR 7 R 8或OAr 3; R6表示-OR10，-NR7R8，氢或烷基; R 7和R 8可以相同或不同，各自独立地表示氢，烷基，烷酰基或Ar 3; R9代表烷基或Ar3; R 10表示氢，烷基或Ar 3; m表示3〜6的整数， n表示0,1或2; 和Ar 3表示未取代的芳基; 或其药学上可接受的衍生物。还描述了含有这些化合物的组合物及其制备方法。化合物指示用作药物，例如，抗炎，药剂。

6. 发明授权

US5376663A Macrocyclic compounds 失效
标题翻译：大环化合物
公开(公告)号：US5376663A
公开(公告)日：1994-12-27
申请号：US391538
申请日：1989-07-25
申请人： Martin E. Cooper , David K. Donald , David N. Hardern
发明人： Martin E. Cooper , David K. Donald , David N. Hardern
IPC分类号： C07D498/18 , C07D498/22 , C07H19/01 , A61K31/395 , A61K31/445 , C07D498/16
CPC分类号： C07D498/18 , C07D498/22 , C07H19/01
摘要： Compounds of formula (I), in which [R.sup.1 and R.sup.2 ], [R.sup.3 and R.sup.4 ] and [R.sup.5 and R.sup.6 ] represent a carbon-carbon bond or two hydrogen atoms; R.sup.2 additionally represents alkyl; R.sup.7, R.sup.8 and R.sup.9 represent groups including H or OH, R.sup.10 has various significances including alkyl and alkenyl; X and Y represent groups including O and (H, OH); R.sup.14, R.sup.15, R.sup.16, R.sup.17, R.sup.18, R.sup.19, R.sup.22 and R.sup.23 represent H or alkyl; R.sup.20 and R.sup.21 represent groups including O, (H, OH) and (H, O-alkyl), n is 1, 2 or 3, and in addition, Y, R.sup.10 and R.sup.23, together with the carbon atoms to which they are attached, may represent a heterocyclic ring, (with certain provisos) are described. Processes for making the compounds and pharmaceutical formulations containing them, e.g. for use as immunosuppressive agents, are also described. ##STR1##
摘要翻译： PCT No.PCT / GB88 / 01093 Sec。 371日期：1989年7月25日 102（e）日期1989年7月25日PCT提交1988年12月2日PCT公布。出版物WO89 / 05304 （I）化合物，其中[R 1和R 2]，[R 3和R 4]和[R 5和R 6]表示碳 - 碳键或两个氢原子; R2另外表示烷基; R7，R8和R9表示包括H或OH的基团，R10具有各种含义，包括烷基和烯基; X和Y表示包括O和（H，OH）的基团; R14，R15，R16，R17，R18，R19，R22和R23表示H或烷基; R 20和R 21表示包括O，（H，OH）和（H，O-烷基），n为1,2或3的基团，此外，Y，R 10和R 23与它们所连接的碳原子一起可以表示杂环（具有一定条件）。制备化合物和含有它们的药物制剂的方法，例如也用作免疫抑制剂。

7. 发明授权

US4956378A 4,5-dihydro pyrazole compounds 失效
标题翻译： 4,5-二氢吡唑化合物
公开(公告)号：US4956378A
公开(公告)日：1990-09-11
申请号：US286268
申请日：1989-02-10
申请人： Sidney C. Burford , David N. Hardern
发明人： Sidney C. Burford , David N. Hardern
IPC分类号： C07D231/06 , C07D401/04 , C07D401/12
CPC分类号： C07D231/06 , C07D401/04 , C07D401/12
摘要： There are described compounds of formula I, ##STR1## in which Ar.sub.1 and Ar.sub.2, which may be the same or different, each independently represent phenyl or pyridinyl, the phenyl or the pyridinyl each optionally being substituted by one or more of halogen; hydroxy; --COOR.sub.12 ; trihalomethyl; alkoxy C1 to 6; alkyl C1 to 6; --NR.sub.1 R.sub.2 ; alkoxy C1 to 6 substituted by --NR.sub.1 R.sub.2 or by phenyl; or alkyl C1 to 6 substituted by --NR.sub.1 R.sub.2 or by --COOR.sub.12 ;R.sub.1 and R.sub.2, which may be the same or different, each independently represent hydrogen or alkyl C1 to 6,R.sub.3 represents hydrogen, alkyl C1 to 6, alkanoyl C1 to 6, benzoyl, --COOR.sub.8, or --CONHR.sub.11,R.sub.4, R.sub.5, R.sub.6 and R.sub.7, which may be the same or different each independently represent hydrogen, alkyl C1 to 6 or phenyl;R.sub.8 represents alkyl C1 to 6 or aryl,R.sub.11 represents alkyl C1 to 6 or aryl,R.sub.12 represents hydrogen or alkyl C1 to 6, and pharmaceutically acceptable derivatives thereof.There are also described compositions containing the compounds and methods for their preparation. The compounds are indicated for use as pharmaceutical, e.g. antiinflammatory agents.

8. 发明授权

US4824859A Pyrazoline compounds compositions and use 失效
标题翻译：吡唑啉化合物组合物和用途
公开(公告)号：US4824859A
公开(公告)日：1989-04-25
申请号：US606867
申请日：1984-05-03
申请人： Sidney C. Burford , David N. Hardern
发明人： Sidney C. Burford , David N. Hardern
IPC分类号： C07D231/06 , C07D401/04 , C07D401/12 , A61K31/415
CPC分类号： C07D231/06 , C07D401/04 , C07D401/12
摘要： There are described compounds of formula I, ##STR1## in which Ar.sub.1 and Ar.sub.2, which may be the same or different, each independently represent phenyl or pyridinyl, the phenyl or the pyridinyl each optionally being substituted by one or more of halogen; hydroxy; --COOR.sub.12 ; trihalomethyl; alkoxy C1 to 6; alkyl C1 to 6; --NR.sub.1 R.sub.2 ; alkoxy C1 to 6 substituted by --NR.sub.1 R.sub.2 or by phenyl; or alkyl C1 to 6 substituted by --NR.sub.1 R.sub.2 or by --COOR.sub.12 ;R.sub.1 and R.sub.2, which may be the same or different, each independently represent hydrogen or alkyl C1 to 6,R.sub.3 represents hydrogen, alkyl C1 to 6, alkanoyl C1 to 6, benzoyl, --COOR.sub.8, or --CONHR.sub.11,R.sub.4, R.sub.5, R.sub.6 and R.sub.7, which may be the same or different each independently represent hydrogen, alkyl C1 to 6 or phenyl,R.sub.8 represents alkyl C1 to 6 or aryl,R.sub.11 represents alkyl C1 to 6 or aryl,R.sub.12 represents hydrogen or alkyl C1 to 6, and pharmaceutically acceptable derivatives thereof.There are also described compositions containing the compounds and methods for their preparation.The compounds are indicated for use as pharmaceutical, eg antiinflammatory agents.
摘要翻译：描述了式I的化合物，其中Ar 1和Ar 2可以相同或不同，各自独立地表示苯基或吡啶基，苯基或吡啶基各自任选被一个或多个卤素取代; 羟基; -COOR12; 三卤甲基烷氧基C1至6; 烷基C1至6; -NR1R2; 被-NR 1 R 2取代的C 1-6烷氧基或苯基取代; 或被-NR 1 R 2或-COOR 12取代的C 1-6的烷基; R1和R2可以相同或不同，各自独立地表示氢或C1至6的烷基，R3表示氢，C1至6的烷基，C1至6的烷酰基，苯甲酰基，-COOR8或-CONHR11，R4，R5，R6 和R 7可以相同或不同，各自独立地表示氢，烷基C1至6或苯基，R8表示烷基C1至6或芳基，R11表示烷基C1至6或芳基，R12表示氢或C1-6烷基，和药学上可接受的衍生物还描述了含有这些化合物的组合物及其制备方法。化合物被指示用作药物，例如抗炎剂。

9. 发明授权

US5179087A Macrocyclic compounds 失效
标题翻译：大环化合物
公开(公告)号：US5179087A
公开(公告)日：1993-01-12
申请号：US568855
申请日：1990-08-17
申请人： David K. Donald , David N. Hardern , Martin E. Cooper , Mark Furber
发明人： David K. Donald , David N. Hardern , Martin E. Cooper , Mark Furber
IPC分类号： C07D498/18 , A61K31/445 , A61P37/06 , C07H19/01
CPC分类号： C07H19/01
摘要： There are described compounds of formula I, ##STR1## wherein R.sup.1 represents H or OH; R.sup.2 represents H; in addition, R.sup.1 and R.sup.2 may together represent a second carbon-carbon bond between the carbon atoms to which they are attached; R.sup.3 represents OH or OCH.sub.3 ; X represents O or (H,OH); and Y represents O or N--OR.sup.4, in which R.sup.4 represents H or alkyl C.sub.1-6 ; provided that when R.sup.1 is OH, R.sup.2 is H and X is O, then Y does not represent O.Processes for their production and compositions containing them, eg. for use as immunosuppressive agents, are also described.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式