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71. 发明申请

US20130142695A1 OXYGENATOR WITH INTEGRATED ARTERIAL FILTER INCLUDING FILTER FRAME 有权
标题翻译：带有集成过滤器的过滤器，包括过滤器框架
公开(公告)号：US20130142695A1
公开(公告)日：2013-06-06
申请号：US13750531
申请日：2013-01-25
申请人： Sorin Group Italia S.r.l. , Politecnico di Milano
发明人： Stefano Reggiani , Claudio Silvestri , Alberto Giri , Alberto Redaelli , Gianfranco Beniamino Fiore
IPC分类号： A61M1/16
CPC分类号： A61M1/1698 , A61M1/322 , A61M1/3627
摘要： An oxygenator combines, in a single structure, a heat exchanger, a gas exchanger, an arterial filter, and a filter frame. Such an oxygenator permits fewer fluid connections and thus may simplify an extracorporeal blood circuit, including a heart-lung machine and a blood reservoir, in which it is used. In some embodiments, the oxygenator may be configured to include multiple purge ports for purging bubbles both before and after filtering the blood.
摘要翻译：氧合器在单个结构中结合了热交换器，气体交换器，动脉过滤器和过滤器框架。这种氧合器允许更少的流体连接，并且因此可以简化体外血液回路，包括使用它的心肺机器和血液储存器。在一些实施例中，氧合器可以被配置为包括用于在过滤血液之前和之后净化气泡的多个吹扫端口。

72. 发明申请

US20130110137A1 Surface Treated Polymeric Synthetic Hernia Mesh Prosthesis, Surface Treated Sutures and Staples and Methods of Manufacturing the Same 审中-公开
标题翻译：表面处理聚合物合成疝网假体，表面处理缝线和钉子及其制造方法
公开(公告)号：US20130110137A1
公开(公告)日：2013-05-02
申请号：US13632197
申请日：2012-10-01
申请人： Enrico Nicolo , Linda Cahalan , Greg Johnson , Mark Gartner , Patrick Cahalan , Brian J Fill , Ali HUSSAIN , Jeffrey W. Speakman
发明人： Enrico Nicolo , Linda Cahalan , Greg Johnson , Mark Gartner , Patrick Cahalan , Brian J Fill , Ali HUSSAIN , Jeffrey W. Speakman
IPC分类号： A61L27/24 , A61L27/22
CPC分类号： A61L27/24 , A61L27/227 , A61L31/048 , A61L31/10 , A61L33/0029 , A61L2400/18 , A61M1/1698 , C08L83/04 , C08L23/12
摘要： A variety of polymeric synthetic hernia mesh prosthesis with surface treatment on at least one tissue-facing surface to control tissue adhesion are disclosed including heparin surface treatment which provides heparin present in an amount to yield heparin bioactivity of at least one of i) an ATIII binding of at least 2 pmol/cm2, and ii) a thrombin deactivation of at least 0.2 IU/cm2; an acrylic surface treatment for coupling thereto of a heparin surface treatment, a collagen surface treatment or both; and an amino-functional polysiloxane surface treatment for coupling thereto of a heparin surface treatment. The synthetic hernia mesh may be formed of monofilament or multifilament polypropylene or polyester, and may be formed as a multi-layer prosthesis with an outer layer formed of a polymeric synthetic hernia mesh with surface treatment to control tissue adhesion coupled to one or more polymeric synthetic hernia meshes without such surface treatments.
摘要翻译：公开了在至少一个面向组织的表面上进行表面处理以控制组织粘附的各种聚合合成疝网假体，其包括肝素表面处理，其提供一定量的肝素以产生以下至少一种的肝素生物活性：i）ATIII结合至少2pmol / cm 2，和ii）至少0.2IU / cm 2的凝血酶失活; 用于与肝素表面处理，胶原表面处理或两者结合的丙烯酸表面处理; 和用于与肝素表面处理偶联的氨基官能聚硅氧烷表面处理。合成疝网可以由单丝或多丝聚丙烯或聚酯形成，并且可以形成为具有由聚合物合成疝网形成的外层的多层假体，其具有表面处理以控制与一种或多种聚合物合成没有这种表面处理的疝气网眼。

73. 发明申请

US20130098834A1 MEDIUM, DEVICES AND METHODS 审中-公开
标题翻译：中介，设备和方法
公开(公告)号：US20130098834A1
公开(公告)日：2013-04-25
申请号：US13805810
申请日：2011-06-17
申请人： Jonas Axelsson
发明人： Jonas Axelsson
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , A61M1/16 , A61M1/1698 , A61M1/34 , A61M1/3403 , A61M1/36 , A61M1/3679 , B01J20/3274 , C07K17/02 , C07K17/06 , C07K17/14
摘要： A separation medium is provided, comprising at least one megalin polypeptide and/or at least one cubilin polypeptide immobilized on a support. Also provided are devices comprising the separation medium, as well as methods and uses employing the separation medium for extracorporeal removal of low molecular weight proteins, or fragments or derivatives thereof, from complex biological fluids.
摘要翻译：提供了分离介质，其包含固定在载体上的至少一种巨蛋白多肽和/或至少一种立方克分多肽。还提供了包括分离介质的装置，以及使用分离介质从复杂生物流体体外去除低分子量蛋白质或其片段或衍生物的方法和用途。

74. 发明申请

US20130079608A1 IMPLANTABLE SENSOR METHOD AND SYSTEM 审中-公开
公开(公告)号：US20130079608A1
公开(公告)日：2013-03-28
申请号：US13622927
申请日：2012-09-19
申请人： Medtronic MiniMed, Inc.
发明人： Michael E Miller , Rajiv Shah
IPC分类号： A61B5/00 , A61B5/1455 , A61B5/04 , A61M5/172 , A61B5/145
CPC分类号： A61B5/6847 , A61B5/0031 , A61B5/04 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14552 , A61B5/14865 , A61B5/6882 , A61B17/3468 , A61M1/1698 , A61M5/14276 , A61M5/1723 , A61M2230/20 , A61M2230/201
摘要： Systems and methods for non-vascular sensor implantation and for measuring physiological parameters in areas of a body where the physiological parameters are heterogeneous. An implant unit is implanted in an area of a body and a foreign body capsule is allowed to form around the implant unit area. A sensor may be directed into a body cavity such as, for example, the peritoneal space, subcutaneous tissues, the foreign body capsule, or other area. A subcutaneous area of the body may be tunneled for sensor placement. Spatially separated sensing elements may be used for detecting individual amounts of the physiological parameter. An overall amount of the physiological parameter may be determined by calculating a statistical measurement of the individual sensed amounts in the area. Another embodiment of the invention, a multi-analyte measuring device, may include a substrate having an electrode array on one side and an integrated circuit on another side.

75. 发明授权

US08398858B2 Device for transferring mass and/or exchanging energy 有权
标题翻译：用于传送质量和/或交换能量的装置
公开(公告)号：US08398858B2
公开(公告)日：2013-03-19
申请号：US12529095
申请日：2008-02-26
申请人： Ahmad Ali Kashefi-Khorasani , Bernward Oedekoven , Rainer Dautzenberg
发明人： Ahmad Ali Kashefi-Khorasani , Bernward Oedekoven , Rainer Dautzenberg
IPC分类号： B01D11/00 , B01D61/00 , C02F1/44
CPC分类号： A61M1/1698 , A61M1/1006 , A61M1/1037 , A61M1/106 , A61M1/1098 , A61M1/122 , A61M1/1678 , A61M1/267
摘要： A device is provided for transferring mass and/or exchanging energy between two media, particularly between blood and a gas/gas mixture. The device includes a chamber (2), through which the first medium flows and inside which at least one mass-permeable and/or energy-permeable hollow fiber (5), preferably a plurality of mass-permeable and/or energy-permeable hollow fibers (5), is/ are arranged. The second medium can flow through the at least one hollow fiber (5), while the first medium can flow therearound. At least one pumping element (5), which allows the first medium to be displaced from the chamber (2) and/or to be sucked into the chamber (2), is disposed in the chamber (2) of the device.
摘要翻译：提供了用于在两个介质之间特别是在血液和气/气混合物之间传送质量和/或能量的装置。该装置包括腔室（2），第一介质通过该腔室流过，其中至少一个质量可渗透和/或能量可渗透的中空纤维（5），优选多个质量可渗透和/或能量可渗透的中空纤维纤维（5）。第二介质可以流过至少一个中空纤维（5），而第一介质可以在其周围流动。至少一个允许第一介质从腔室（2）移位和/或被吸入腔室（2）中的泵送元件（5）设置在装置的腔室（2）中。

76. 发明授权

US08394049B2 Blood processing unit with modified flow path 有权
标题翻译：血液处理单元具有改进的流路
公开(公告)号：US08394049B2
公开(公告)日：2013-03-12
申请号：US12860062
申请日：2010-08-20
申请人： Stefano Reggiani , Gianfranco Beniamino Fiore , Alberto Redaelli , Christian Baiotto
发明人： Stefano Reggiani , Gianfranco Beniamino Fiore , Alberto Redaelli , Christian Baiotto
IPC分类号： A61M1/36
CPC分类号： A61M1/1698 , A61M1/32 , A61M1/3627 , A61M1/3666 , A61M1/3667 , A61M2206/10 , A61M2206/14 , A61M2206/16 , A61M2206/18 , A61M2206/20 , B01D63/02 , B01D2313/08 , B01D2313/19 , B01D2313/32 , B01D2313/38 , F28D7/103 , F28D7/1623 , F28D21/0015 , F28D2021/005 , F28F13/06 , F28F21/06 , F28F21/062 , F28F2260/00 , Y10S128/03 , Y10S261/28
摘要： A blood processing apparatus includes a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger is configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. In some instances, a heat exchanger is configured to cause blood flow to follow a spiral flow path.
摘要翻译：血液处理装置包括热交换器和气体交换器。热交换器和气体交换器中的至少一个构造成赋予径向分量以吹动通过热交换器和/或气体交换器的流动。在一些情况下，热交换器被配置为使血液流动遵循螺旋流动路径。

77. 发明申请

US20130004369A1 ARRANGEMENT WITH A BLOOD PUMP AND A GAS EXCHANGER FOR EXTRACORPOREAL MEMBRANE OXYGENATION 有权
公开(公告)号：US20130004369A1
公开(公告)日：2013-01-03
申请号：US13521857
申请日：2011-01-10
申请人： Oliver Marseille
发明人： Oliver Marseille
IPC分类号： A61M1/16
CPC分类号： A61M1/32 , A61M1/1006 , A61M1/101 , A61M1/106 , A61M1/1081 , A61M1/1698 , A61M1/267 , A61M1/367
摘要： The invention relates to an arrangement having a blood pump and a gas exchanger for extracorporeal membrane oxygenation. According to the invention, the blood pump is designed as a pulsatile blood pump and is arranged with the gas exchanger in the same housing. The pulsatile blood pump and the gas exchanger are preferably connected to the same gas source so that the blood pump can be pneumatically driven. The novel ECMO system has a simple design, is flexible, and in particular can be used directly on the patient.

78. 发明申请

US20120277653A1 Combination Oxygenator and Arterial Filter Device With A Fiber Bundle of Continuously Wound Hollow Fibers for Treating Blood in an ExtraCorporeal Blood Circuit 有权
标题翻译：组合式氧合器和动脉过滤装置，连续缠绕空心纤维纤维束，用于治疗体外血液循环中的血液
公开(公告)号：US20120277653A1
公开(公告)日：2012-11-01
申请号：US13097290
申请日：2011-04-29
申请人： Robert Olsen , John L. Knoll
发明人： Robert Olsen , John L. Knoll
IPC分类号： A61M1/16 , B23P17/00
CPC分类号： A61M1/1698 , A61M1/3627 , B01D63/025 , B01D2313/38 , B01D2319/06
摘要： A combination oxygenator and arterial filter device for treating blood in an extracorporeal blood circuit. The device includes a housing maintaining a core and a fiber bundle. The fiber bundle is formed by a plurality of hollow fibers continuously helically wound about the core to form layers of level wound fibers. The layers combine to define an oxygenator region and a radially outward depth filter region. A minimum gap spacing between fibers of the oxygenator region layers is greater than a minimum gap spacing of the depth filter region layers. The fiber bundle can function as a blood oxygenator and exhibits a filtration efficiency of not less than 92% in filtering particles having a particle size of about 45 microns. An oxygenator with integrated arterial filtering capability is provided that minimally impacts the extracorporeal blood circuit prime volume.
摘要翻译：用于治疗体外血液回路中的血液的组合氧合器和动脉过滤装置。该装置包括保持芯部和纤维束的壳体。纤维束由围绕芯连续螺旋缠绕的多个中空纤维形成，以形成水平缠绕纤维层。这些层组合以限定氧合器区域和径向向外深度过滤器区域。氧合器区域层的纤维之间的最小间隙间隔大于深度过滤器区域层的最小间隙间距。纤维束可用作血液充氧器，并且在粒径约45微米的过滤颗粒中显示出不低于92％的过滤效率。提供具有综合动脉过滤功能的充氧器，其最小程度地影响体外血液回路原始体积。

79. 发明申请

US20120226258A1 DEVICE AND METHOD FOR ELIMINATING BIOLOGICALLY HARMFUL SUBSTANCES FROM BODILY FLUIDS 审中-公开
标题翻译：从身体流体中消除生物有害物质的装置和方法
公开(公告)号：US20120226258A1
公开(公告)日：2012-09-06
申请号：US13388640
申请日：2010-08-09
申请人： Veit Otto , Michaela Hajek
发明人： Veit Otto , Michaela Hajek
IPC分类号： A61M1/18
CPC分类号： A61M1/3679 , A61M1/16 , A61M1/1698 , A61M1/34 , A61M1/3406 , A61M1/3475 , A61M1/3489 , A61M1/36 , A61M2202/20 , A61M2205/3334 , A61M2205/3368 , B01D53/22 , B01D53/228 , B01D63/02 , B01D2313/40 , B01D2325/48
摘要： A device for purification of blood, blood substitutes or solutions for the introduction into the human and/or animal blood circulation and for gas exchange in blood, blood substitutes or solutions for the introduction into the human and/or animal blood circulation, includes at least one gas permeable membrane and a carrier, coated with substances for adsorptive removal of toxins of biological and chemical synthetic origin, their metabolites and degradation products present in blood, blood substitutes or solutions for the introduction into the human and/or animal blood circulation, a use of the aforementioned device and a process for gentle and simultaneous removal of toxins of biological and chemical synthetic origin, their metabolites and degradation products present in blood, blood substitutes or solutions for the introduction into the human and/or animal blood circulation and for enrichment of blood, blood substitutes or solutions for the introduction into the human and/or animal blood circulation with oxygen.
摘要翻译：用于净化血液，血液代用品或用于引入人和/或动物血液循环和血液中的气体交换，用于引入人和/或动物血液循环的血液替代物或溶液的溶液的装置至少包括一种透气膜和载体，其涂覆有用于吸附去除生物和化学合成来源的毒素的物质，其存在于血液中的代谢物和降解产物，用于引入人和/或动物血液循环的血液替代物或溶液，使用上述装置和温和地同时去除生物和化学合成来源的毒素，其代谢物和存在于血液中的降解产物，血液替代物或用于引入人和/或动物血液循环和富集的溶液的方法血液，血液代用品或引入人类和/或动物的方法 ood循环与氧气。

80. 发明申请

US20120220916A1 Apparatus For Making Extracorporeal Blood Circulation Available 有权
标题翻译：用于制造体外血液循环的仪器
公开(公告)号：US20120220916A1
公开(公告)日：2012-08-30
申请号：US13466899
申请日：2012-05-08
申请人： Gerhard Brieske , Michael Brieske
发明人： Gerhard Brieske , Michael Brieske
IPC分类号： A61M1/36
CPC分类号： A61M1/3626 , A61M1/1698 , A61M1/32 , A61M1/3627 , A61M1/3666
摘要： The present invention relates to an apparatus for making extracorporeal blood circulation available, in particular a heart-lung machine, comprising a venous connection and an arterial connection, between which a blood reservoir, a blood pump and a bubble detector for the detection of air bubbles are provided, with, downstream of the bubble detector, an arterial line leading to the arterial connection via an arterial clamp and a bypass leading via a bypass clamp back into the blood reservoir which is connected to a pump extracting air from the blood reservoir. In addition, the present invention relates to a method of operating such an apparatus.
摘要翻译：本发明涉及一种用于制造体外血液循环的装置，特别是心肺机，其包括静脉连接和动脉连接，血液储存器，血液泵和用于检测气泡的气泡检测器在气泡检测器的下游设置有通过动脉夹紧器和经由旁路夹具引导通过旁路夹具的旁路的动脉线路，其连接到从血液存储器抽取空气的泵。此外，本发明涉及一种操作这种装置的方法。

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