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71. 发明申请

US20150079191A1 CURED GEL AND METHOD OF MAKING 审中-公开
标题翻译：固化凝胶和制备方法
公开(公告)号：US20150079191A1
公开(公告)日：2015-03-19
申请号：US14511765
申请日：2014-10-10
申请人： ATRIUM MEDICAL CORPORATION
发明人： Roger LABRECQUE , Philip MCNAMARA , Joseph FERRARO , Lisa ROGERS , Paul MARTAKOS , Theodore KARWOSKI , Steve A. HERWECK , Keith M. FAUCHER , Thomas M. SWANICK
IPC分类号： A61K35/60 , A61L27/36 , A61K9/06 , A61K38/13
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A cured non-polymeric gel including a plurality of non-polymeric cross-links. The non-polymeric cross-links result from curing an oil or oil composition at selected curing conditions to achieve a desired amount of cross-linking to form the non-polymeric get. The desired amount of cross-linking is selected based on a desired rate of degradation of the gel after the gel is implanted. The oil or oil composition comprises one or more of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or alphalinolenic acid (ALA).
摘要翻译：包含多个非聚合物交联的固化的非聚合凝胶。非聚合交联是由选择的固化条件下固化油或油组合物得到所需量的交联以形成非聚合物的。基于在凝胶注入后凝胶的降解速率来选择所需量的交联。油或油组合物包含二十碳五烯酸（EPA），二十二碳六烯酸（DHA）或阿拉伯糖酸（ALA）中的一种或多种。

72. 发明申请

US20150073476A1 SHAPE MEMORY POLYMER COMPOSITIONS 审中-公开
标题翻译：形状记忆聚合物组合物
公开(公告)号：US20150073476A1
公开(公告)日：2015-03-12
申请号：US14350037
申请日：2012-10-05
申请人： Smith & Nephew PLC
发明人： Malcolm Brown , Horacio Montes de Oca Balderas , Michael Andrew Hall , Alan William Bull , David Franklin Farrar , Philip Caton-Rose , Philip David Coates , Glen Thompson , Michael Martyn , Ian MacMillan Ward , Mark James Bonner , Peter John Hine , Paul Unwin , Robin Anthony Chivers , Michael Woodhead
IPC分类号： A61L31/14 , A61L31/06 , A61L31/12 , A61B17/04 , A61L31/16
CPC分类号： B29C43/52 , A61B17/0401 , A61B17/122 , A61B17/844 , A61B17/864 , A61B17/8645 , A61B17/866 , A61B17/8685 , A61B2017/00004 , A61B2017/00411 , A61B2017/00867 , A61B2017/00871 , A61B2017/0403 , A61B2017/0404 , A61B2017/0412 , A61B2017/042 , A61B2017/0427 , A61B2017/0438 , A61B2017/0454 , A61B2017/8655 , A61F2/0811 , A61F2002/0835 , A61F2002/0888 , A61L31/06 , A61L31/127 , A61L31/14 , A61L31/141 , A61L31/148 , A61L31/16 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61L2300/414 , A61L2300/604 , A61L2400/16 , A61L2430/34 , B29K2101/12 , B29K2509/00 , C08J5/046 , C12Y304/21005 , C08L67/04
摘要： The present invention relates to compositions comprising shape memory polymer (SMP) materials and uses thereof. Particularly, although not exclusively, the present invention relates to biocompatible shape memory polymer (SMP) materials and uses thereof in the medical field.
摘要翻译：本发明涉及包含形状记忆聚合物（SMP）材料及其用途的组合物。特别地，尽管不是排他地，本发明涉及生物相容形状记忆聚合物（SMP）材料及其在医学领域中的用途。

73. 发明申请

US20150071981A1 SUSTAINED-RELEASE DRUG CARRIER COMPOSITION 审中-公开
标题翻译：持续释放药物载体组合物
公开(公告)号：US20150071981A1
公开(公告)日：2015-03-12
申请号：US14523893
申请日：2014-10-26
申请人： POLYPID LTD.
发明人： Noam EMANUEL
IPC分类号： A61K47/34 , A61K47/42 , A61K31/65 , A61L31/16 , A61K31/56 , A61K47/28 , A61L31/10 , A61K47/24 , A61K31/427
CPC分类号： A61K47/24 , A61K9/0087 , A61K31/192 , A61K31/427 , A61K31/56 , A61K31/65 , A61K47/22 , A61K47/28 , A61K47/34 , A61K47/42 , A61L27/18 , A61L27/54 , A61L27/58 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/204 , A61L2300/222 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/412 , A61L2300/602 , A61L2300/606 , A61L2300/802 , A61L2420/04 , C08L67/04
摘要： The present invention provides compositions for extended release of an active ingredient, comprising a lipid-saturated matrix formed from a biodegradable polymer. The present invention also provides methods of producing the matrix compositions and methods for using the matrix compositions to provide controlled release of an active ingredient in the body of a subject in need thereof.
摘要翻译：本发明提供了用于延长释放活性成分的组合物，其包含由可生物降解的聚合物形成的脂质饱和基质。本发明还提供了生产基质组合物的方法和使用该基质组合物来提供活性成分在有需要的受试者体内的受控释放的方法。

74. 发明申请

US20150005272A1 METHODS FOR REDUCING OR PREVENTING TRANSPLANT REJECTION IN THE EYE AND INTRAOCULAR IMPLANTS FOR USE THEREFOR 有权
公开(公告)号：US20150005272A1
公开(公告)日：2015-01-01
申请号：US14481778
申请日：2014-09-09
申请人： Allergan, Inc.
发明人： Vernon G. Wong
IPC分类号： A61K9/00 , A61K31/573 , A61K47/34
CPC分类号： A61K31/573 , A61F9/0008 , A61F9/0017 , A61F2210/0004 , A61K9/0048 , A61K9/0051 , A61K9/1641 , A61K9/1647 , A61K31/56 , A61K31/715 , A61K31/765 , A61K45/06 , A61K47/34 , A61L27/54 , A61L2300/222 , A61L2300/41 , A61L2300/416 , A61L2300/604 , A61K2300/00
摘要： Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.

75. 发明授权

US08877224B2 Compositions for preventing cardiac arrhythmia 有权
标题翻译：用于预防心律失常的组合物
公开(公告)号：US08877224B2
公开(公告)日：2014-11-04
申请号：US13480140
申请日：2012-05-24
申请人： Robert G. Matheny , Beecher C. Lewis
发明人： Robert G. Matheny , Beecher C. Lewis
IPC分类号： A61K35/12 , A61K35/38 , A61P9/06 , A61P3/06 , A61K35/37 , A61P29/00 , A61K35/407 , A61K35/34 , A61K35/36
CPC分类号： A61K35/12 , A61K35/28 , A61K35/34 , A61K35/36 , A61L27/00 , A61L27/3633 , A61L27/3637 , A61L27/3683 , A61L27/3839 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/236 , A61L2300/41 , A61L2300/422 , A61L2300/64 , A61L2430/20
摘要： Disclosed herein are compositions and methods for treating or preventing a cardiac arrhythmia in a subject.
摘要翻译：本文公开了用于治疗或预防受试者心律失常的组合物和方法。

76. 发明申请

US20140309691A1 MEDICAL DEVICES CONTAINING SHAPE MEMORY POLYMER COMPOSITIONS 审中-公开
标题翻译：包含形状记忆聚合物组合物的医疗装置
公开(公告)号：US20140309691A1
公开(公告)日：2014-10-16
申请号：US14350030
申请日：2012-10-05
申请人： Smith & Nephew PLC
发明人： Malcolm Brown , Horacio Montes de Oca Balederas , Michael Andrew Hall , Alan William Bull , David Franklin Farrar , Philip Caton-Rose , Philip David Coates , Glen Thompson , Michael Martyn , Ian MacMillian Ward , Mark James Bonner , Peter John Hine
IPC分类号： A61B17/04
CPC分类号： B29C43/52 , A61B17/0401 , A61B17/122 , A61B17/844 , A61B17/864 , A61B17/8645 , A61B17/866 , A61B17/8685 , A61B2017/00004 , A61B2017/00411 , A61B2017/00867 , A61B2017/00871 , A61B2017/0403 , A61B2017/0404 , A61B2017/0412 , A61B2017/042 , A61B2017/0427 , A61B2017/0438 , A61B2017/0454 , A61B2017/8655 , A61F2/0811 , A61F2002/0835 , A61F2002/0888 , A61L31/06 , A61L31/127 , A61L31/14 , A61L31/141 , A61L31/148 , A61L31/16 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61L2300/414 , A61L2300/604 , A61L2400/16 , A61L2430/34 , B29K2101/12 , B29K2509/00 , C08J5/046 , C12Y304/21005 , C08L67/04
摘要： The present invention relates at least in part to surgical devices which comprise a shape memory polymer material composition. Particularly, although not exclusively, the present invention relates to a fixation device e.g. an anchor device e.g. a suture anchor which comprises a shape memory material. Included in the present invention are anchor devices e.g. suture anchors which are formed entirely of a shape memory polymer material. Embodiments of the present invention comprise hybrid suture anchors, particularly suture anchors which are formed from a shape memory polymer material and a non-shape memory material. Methods of securing an anchor in a bone or tissue are also included in the present invention.
摘要翻译：本发明至少部分地涉及包括形状记忆聚合物材料组合物的手术装置。特别地，尽管不是唯一地，本发明涉及一种固定装置，例如，锚装置例如包括形状记忆材料的缝合锚。包括在本发明中的是锚装置，例如，缝合锚完全由形状记忆聚合物材料形成。本发明的实施例包括由形状记忆聚合物材料和非形状记忆材料形成的混合缝合锚，特别是缝合锚。将锚固在骨骼或组织中的方法也包括在本发明中。

77. 发明申请

US20140302114A1 IMPLANTABLE MEDICAL DEVICES WITH INCREASED IMMUNE TOLERANCE, AND METHODS FOR MAKING AND IMPLANTING 有权
标题翻译：具有增加的免疫耐受性的可植入医疗装置以及制造和植入方法
公开(公告)号：US20140302114A1
公开(公告)日：2014-10-09
申请号：US14350617
申请日：2012-10-10
申请人： AMPIO PHARMACEUTICALS, INC.
发明人： David Bar-Or
IPC分类号： A61L27/54 , A61L27/28
CPC分类号： A61L27/28 , A61K31/495 , A61K31/496 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/204 , A61L2300/41 , A61L2300/606 , F04C2270/0421
摘要： The present invention relates to the contacting of one or more surfaces of an implantable medical device with one or more diketopiperazines (DKPs).
摘要翻译：本发明涉及可植入医疗装置的一个或多个表面与一种或多种二酮哌嗪（DKP）的接触。

78. 发明授权

US08852623B2 Implantable polymeric device for sustained release of dopamine agonist 有权
标题翻译：用于持续释放多巴胺激动剂的可植入聚合物
公开(公告)号：US08852623B2
公开(公告)日：2014-10-07
申请号：US13525193
申请日：2012-06-15
申请人： Rajesh A. Patel , Louis R. Bucalo , Lauren Costantini , Sofie Kleppner
发明人： Rajesh A. Patel , Louis R. Bucalo , Lauren Costantini , Sofie Kleppner
IPC分类号： A61K9/00 , A61K31/48 , A61K9/16 , A61L31/16 , A61K31/485 , A61K31/381 , A61K31/428 , A61K31/4045 , A61K9/14 , A61L31/04
CPC分类号： A61L31/16 , A61K9/0024 , A61K9/146 , A61K9/1635 , A61K31/198 , A61K31/381 , A61K31/4045 , A61K31/428 , A61K31/48 , A61K31/485 , A61L31/048 , A61L31/10 , A61L31/125 , A61L31/146 , A61L2300/20 , A61L2300/40 , A61L2300/41 , A61L2300/602 , A61L2300/606 , A61L2300/62 , A61L2420/04 , C08L31/04
摘要： The present invention provides compositions, methods, and kits for treatment of Parkinson's disease and other conditions for which treatment with a dopamine agonist is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases dopamine agonist continuously with generally linear release kinetics for extended periods of time. Dopamine agonist is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with dopamine agonist.
摘要翻译：本发明提供了用于治疗帕金森病的组合物，方法和试剂盒以及用多巴胺激动剂治疗是治疗有益的其它病症。本发明提供了一种生物相容的非可溶性聚合物装置，其可延长释放动力学持续释放多巴胺激动剂。多巴胺激动剂通过对其被包封的聚合物基质的表面开放的孔释放。该装置可以皮下给予需要用多巴胺激动剂连续治疗的个体。

79. 发明申请

US20140256695A1 INJECTABLE FILLER 审中-公开
标题翻译：注射灌装机
公开(公告)号：US20140256695A1
公开(公告)日：2014-09-11
申请号：US13872071
申请日：2012-11-11
申请人： Phi Nguyen , Loc Phan , Bao Tran , Thuan Nguyen
发明人： Phi Nguyen , Loc Phan , Bao Tran , Thuan Nguyen
IPC分类号： A61L27/26 , A61L27/54 , A61L27/52 , A61L27/50
CPC分类号： A61L27/26 , A61L27/50 , A61L27/52 , A61L27/54 , A61L2300/402 , A61L2300/41 , A61L2300/43 , A61L2300/604 , A61L2400/06 , A61L2430/34 , C08L5/08 , C08L67/04
摘要： Systems and method are disclosed for forming a biocompatible cross-linked polymer having an interpenetrating polymer network (IPN) by cross-linking a heteropolysaccharide to form a single cross-linked material; and performing one or more additional cross-linkings on the single cross-linked material to form a multiple cross-linked material, wherein the multiple cross-linked material has one or more IPN regions resisting biodegradation in a human body than the single cross-linked material and one or more single cross-linked extensions radiating out from the IPN, wherein the combination of the IPN and the extension provide biodegradation resistance, soft touch feeling, and ease of insertion into the human body.
摘要翻译：公开了用于形成具有互穿聚合物网络（IPN）的生物相容性交联聚合物的系统和方法，所述交联聚合物通过交联杂多糖以形成单一交联材料; 并且在所述单个交联材料上进行一个或多个另外的交联以形成多重交联材料，其中所述多个交联材料具有一个或多个IPN区域，所述IPN区域在人体内抵抗比单个交联的材料材料和从IPN辐射出的一个或多个单个交联延伸部，其中IPN和延伸部的组合提供了抗生物降解性，柔软的触感和容易插入人体内。

80. 发明授权

US08821586B2 Porous implant grain or granule 有权
标题翻译：多孔植入物颗粒或颗粒
公开(公告)号：US08821586B2
公开(公告)日：2014-09-02
申请号：US12071507
申请日：2008-02-21
申请人： Lars Magnus Bjursten , Bengt Mjöberg , Niklas Axén
发明人： Lars Magnus Bjursten , Bengt Mjöberg , Niklas Axén
IPC分类号： A61F2/02
CPC分类号： A61L27/06 , A61F2/28 , A61F2002/3092 , A61F2310/00023 , A61F2310/00616 , A61K9/0024 , A61L27/54 , A61L27/56 , A61L2300/406 , A61L2300/41 , A61L2300/412
摘要： An implant with anti-inflammatory or antibacterial effects, or both, for implantation in a human or animal body, the implant having a set of porous grains or granules, wherein at least a plurality of the porous grains or granules include titanium, one or more titanium oxides or titanium alloy and have a titanium oxide layer on their surface and have a mean length from one side to the opposite side, through a geometrical center, of at least 200 μm and up to 5 mm and a mean specific surface area of at least 0.15 m2/g according to the BET method. Also featured is a population of grains or granules having anti-inflammatory or antibacterial effects, or both. Further featured is a method of producing an implant, a method for deriving a population of grains or granules, and a method for treating a condition with a porous grain or granule.
摘要翻译：一种植入物，具有抗炎或抗菌作用，或两者用于植入人或动物体内，植入物具有一组多孔颗粒或颗粒，其中至少多个多孔颗粒或颗粒包括钛，一种或多种钛氧化物或钛合金，并且在其表面上具有氧化钛层，并且具有从一侧到另一侧的平均长度，通过几何中心至少为200μm至高达5mm，平均比表面积为至少0.15m2 / g。还有特征是具有抗炎或抗菌作用的谷物或颗粒群体，或两者。进一步的特征是生产植入物的方法，衍生谷物或颗粒群体的方法，以及用多孔颗粒或颗粒处理病症的方法。

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