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1. 发明授权

US08852623B2 Implantable polymeric device for sustained release of dopamine agonist 有权
标题翻译：用于持续释放多巴胺激动剂的可植入聚合物
公开(公告)号：US08852623B2
公开(公告)日：2014-10-07
申请号：US13525193
申请日：2012-06-15
申请人： Rajesh A. Patel , Louis R. Bucalo , Lauren Costantini , Sofie Kleppner
发明人： Rajesh A. Patel , Louis R. Bucalo , Lauren Costantini , Sofie Kleppner
IPC分类号： A61K9/00 , A61K31/48 , A61K9/16 , A61L31/16 , A61K31/485 , A61K31/381 , A61K31/428 , A61K31/4045 , A61K9/14 , A61L31/04
CPC分类号： A61L31/16 , A61K9/0024 , A61K9/146 , A61K9/1635 , A61K31/198 , A61K31/381 , A61K31/4045 , A61K31/428 , A61K31/48 , A61K31/485 , A61L31/048 , A61L31/10 , A61L31/125 , A61L31/146 , A61L2300/20 , A61L2300/40 , A61L2300/41 , A61L2300/602 , A61L2300/606 , A61L2300/62 , A61L2420/04 , C08L31/04
摘要： The present invention provides compositions, methods, and kits for treatment of Parkinson's disease and other conditions for which treatment with a dopamine agonist is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases dopamine agonist continuously with generally linear release kinetics for extended periods of time. Dopamine agonist is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with dopamine agonist.
摘要翻译：本发明提供了用于治疗帕金森病的组合物，方法和试剂盒以及用多巴胺激动剂治疗是治疗有益的其它病症。本发明提供了一种生物相容的非可溶性聚合物装置，其可延长释放动力学持续释放多巴胺激动剂。多巴胺激动剂通过对其被包封的聚合物基质的表面开放的孔释放。该装置可以皮下给予需要用多巴胺激动剂连续治疗的个体。

2. 发明申请

US20080311171A1 IMPLANTABLE POLYMERIC DEVICE FOR SUSTAINED RELEASE OF DOPAMINE AGONIST 审中-公开
标题翻译：用于持续释放多巴胺激动剂的可植入聚合物
公开(公告)号：US20080311171A1
公开(公告)日：2008-12-18
申请号：US12119334
申请日：2008-05-12
申请人： Rajesh A. PATEL , Louis R. Bucalo , Lauren Costantini , Sofie Kleppner
发明人： Rajesh A. PATEL , Louis R. Bucalo , Lauren Costantini , Sofie Kleppner
IPC分类号： A61K9/00 , A61K31/435 , A61K31/437 , A61K31/56 , A61P29/00 , A61P25/16
CPC分类号： A61L31/16 , A61K9/0024 , A61K9/146 , A61K9/1635 , A61K31/198 , A61K31/381 , A61K31/4045 , A61K31/428 , A61K31/48 , A61K31/485 , A61L31/048 , A61L31/10 , A61L31/125 , A61L31/146 , A61L2300/20 , A61L2300/40 , A61L2300/41 , A61L2300/602 , A61L2300/606 , A61L2300/62 , A61L2420/04 , C08L31/04
摘要： The present invention provides compositions, methods, and kits for treatment of Parkinson's disease and other conditions for which treatment with a dopamine agonist is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases dopamine agonist continuously with generally linear release kinetics for extended periods of time. Dopamine agonist is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with dopamine agonist.
摘要翻译：本发明提供了用于治疗帕金森病的组合物，方法和试剂盒以及用多巴胺激动剂治疗是治疗有益的其它病症。本发明提供了一种生物相容的非可溶性聚合物装置，其可延长释放动力学持续释放多巴胺激动剂。多巴胺激动剂通过对其被包封的聚合物基质的表面开放的孔释放。该装置可以皮下给予需要用多巴胺激动剂连续治疗的个体。

3. 发明授权

US5767153A Sustained release emulsions 失效
公开(公告)号：US5767153A
公开(公告)日：1998-06-16
申请号：US488675
申请日：1995-06-07
申请人： Lyle M. Bowman , Rajesh A. Patel , Thomas B. Ottoboni
发明人： Lyle M. Bowman , Rajesh A. Patel , Thomas B. Ottoboni
IPC分类号： A61K9/00 , A61K31/215 , A61K31/19
CPC分类号： A61K9/0048 , Y10S514/912
摘要： Ophthalmic methods and compositions are disclosed where particles of the dispersed phase of emulsions are themselves dispersed and stably maintained in physical separation by lightly crosslinked, water swellable polymers present in an aqueous polymeric system formulated for administration to the eye in drop or ribbon form. Medicament is dissolved in that dispersed phase is delivered over a sustained release period.

4. 发明申请

US20120258161A1 IMPLANTABLE POLYMERIC DEVICE FOR SUSTAINED RELEASE OF DOPAMINE AGONIST 有权
标题翻译：用于持续释放多巴胺激动剂的可植入聚合物
公开(公告)号：US20120258161A1
公开(公告)日：2012-10-11
申请号：US13525193
申请日：2012-06-15
申请人： Rajesh A. PATEL , Louis R. Bucalo , Lauren Costantini , Sofie Kleppner
发明人： Rajesh A. PATEL , Louis R. Bucalo , Lauren Costantini , Sofie Kleppner
IPC分类号： A61K9/00 , A61K31/473 , A61P25/14 , A61P29/00 , A61P15/00 , A61K31/56 , A61P25/16
CPC分类号： A61L31/16 , A61K9/0024 , A61K9/146 , A61K9/1635 , A61K31/198 , A61K31/381 , A61K31/4045 , A61K31/428 , A61K31/48 , A61K31/485 , A61L31/048 , A61L31/10 , A61L31/125 , A61L31/146 , A61L2300/20 , A61L2300/40 , A61L2300/41 , A61L2300/602 , A61L2300/606 , A61L2300/62 , A61L2420/04 , C08L31/04
摘要： The present invention provides compositions, methods, and kits for treatment of Parkinson's disease and other conditions for which treatment with a dopamine agonist is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases dopamine agonist continuously with generally linear release kinetics for extended periods of time. Dopamine agonist is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with dopamine agonist.
摘要翻译：本发明提供了用于治疗帕金森病的组合物，方法和试剂盒以及用多巴胺激动剂治疗是治疗有益的其它病症。本发明提供了一种生物相容的非可溶性聚合物装置，其可延长释放动力学持续释放多巴胺激动剂。多巴胺激动剂通过对其被包封的聚合物基质的表面开放的孔释放。该装置可以皮下给予需要用多巴胺激动剂连续治疗的个体。

5. 发明申请

US20090162412A1 IMPLANTABLE POLYMERIC DEVICE FOR SUSTAINED RELEASE OF DOPAMINE AGONIST 审中-公开
标题翻译：用于持续释放多巴胺激动剂的可植入聚合物
公开(公告)号：US20090162412A1
公开(公告)日：2009-06-25
申请号：US12341766
申请日：2008-12-22
申请人： Rajesh A. Patel , Louis R. Bucalo , Lauren Costantini , Sofie Kleppner
发明人： Rajesh A. Patel , Louis R. Bucalo , Lauren Costantini , Sofie Kleppner
IPC分类号： A61K9/00 , A61P25/00
CPC分类号： A61L31/16 , A61K9/0024 , A61K9/146 , A61K9/1635 , A61K31/198 , A61K31/381 , A61K31/4045 , A61K31/428 , A61K31/48 , A61K31/485 , A61L31/048 , A61L31/10 , A61L31/125 , A61L31/146 , A61L2300/20 , A61L2300/40 , A61L2300/41 , A61L2300/602 , A61L2300/606 , A61L2300/62 , A61L2420/04 , C08L31/04
摘要： The present invention provides compositions, methods, and kits for treatment of Parkinson's disease and other conditions for which treatment with a dopamine agonist is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases dopamine agonist continuously with generally linear release kinetics for extended periods of time. Dopamine agonist is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with dopamine agonist.
摘要翻译：本发明提供了用于治疗帕金森病的组合物，方法和试剂盒以及用多巴胺激动剂治疗是治疗有益的其它病症。本发明提供了一种生物相容的非可溶性聚合物装置，其可延长释放动力学持续释放多巴胺激动剂。多巴胺激动剂通过对其被包封的聚合物基质的表面开放的孔释放。该装置可以皮下给予需要用多巴胺激动剂连续治疗的个体。

6. 发明授权

US5458890A Methods and compositions for flavoring orally-delivered products 失效
标题翻译：用于调味口服产品的方法和组合物
公开(公告)号：US5458890A
公开(公告)日：1995-10-17
申请号：US711259
申请日：1991-06-04
申请人： John H. Williford , Martin Katz , Sergio Nacht , Chung-Heng Cheng , Rajesh A. Patel , Brian J. Picard
发明人： John H. Williford , Martin Katz , Sergio Nacht , Chung-Heng Cheng , Rajesh A. Patel , Brian J. Picard
IPC分类号： A23G3/34 , A23G4/00 , A23G4/20 , A23L27/00 , A61K9/16 , A61K9/68 , A23G3/00 , A23G3/30
CPC分类号： A23G4/20 , A23G3/346 , A23L27/74 , A61K9/1635 , A23G2220/02
摘要： Flavored food and pharmaceutical compositions include one or more flavor additives incorporated within polymeric particles, usually within an internal pore network defined by individual polymeric particles. The polymeric particles are, in turn, dispersed within and/or over a surface of an orally-deliverable matrix material, which is usually a solid or semi-solid substrate. In the case of chewable compositions, the flavor additives will be released into the orally-deliverable matrix material as the composition is chewed and held in the mouth, thus prolonging the flavor of the composition. In the case of dried powders and mixes, the flavor will typically be made available as the product is consumed or be released into the matrix material as the composition is further processed. When two flavors are combined with the polymeric particles, the relative amounts of the additives can be selected to provide simultaneous release and exhaustion of the additives.
摘要翻译：调味食品和药物组合物包括掺入聚合物颗粒内的一种或多种风味添加剂，通常在由单个聚合物颗粒限定的内部孔网内。聚合物颗粒又分散在通常为固体或半固体基质的经口输送的基质材料的表面内和/或之上。在可咀嚼的组合物的情况下，当组合物咀嚼并保持在口中时，风味添加剂将释放到口服递送的基质材料中，从而延长组合物的风味。在干燥粉末和混合物的情况下，当组合物进一步加工时，通常会将产品消耗或释放到基质材料中，从而获得风味。当两种口味与聚合物颗粒结合时，可以选择添加剂的相对量以提供添加剂的同时释放和耗尽。

7. 发明申请

US20130189342A1 HETEROGENEOUS IMPLANTABLE DEVICES FOR DRUG DELIVERY 审中-公开
标题翻译：用于药物递送的异质可植入装置
公开(公告)号：US20130189342A1
公开(公告)日：2013-07-25
申请号：US13634535
申请日：2011-03-16
申请人： Rajesh A. Patel , Sunil R. Bhonsle
发明人： Rajesh A. Patel , Sunil R. Bhonsle
IPC分类号： A61K9/00 , A61K31/485
CPC分类号： A61K9/0024 , A61K9/2086 , A61K9/2886 , A61K31/198 , A61K31/4045 , A61K31/485 , A61K45/06 , A61K47/32
摘要： The present invention comprises compositions, methods and kits for delivering drugs. The invention provides an implantable device for delivery of a pharmaceutical substance to a patient, comprising a core comprising a core polymeric material optionally containing a core pharmaceutical substance, surrounded by a first layer comprising a first-layer pharmaceutical substance and a first-layer polymeric material, optionally surrounded by one or more additional layers comprising an additional pharmaceutical substance and an additional polymeric material, where the core, first, and optional additional polymeric materials may be the same or different, and where the optional core pharmaceutical substance, first-layer pharmaceutical substance, and optional additional pharmaceutical substances are the same or different. Implantation of the device allows a controlled release of drug for an extended period of time. The device may be implanted subcutaneously in an individual in need of continuous treatment with a drug.
摘要翻译：本发明包括用于递送药物的组合物，方法和试剂盒。本发明提供了一种用于将药物物质递送到患者的可植入装置，其包括芯，其包含任选地含有核心药物物质的芯聚合物材料，被包含第一层药物物质的第一层和第一层聚合物材料，任选被包含另外的药物物质和另外的聚合物材料的一个或多个另外的层包围，其中芯，第一和任选的另外的聚合物材料可以相同或不同，并且其中任选的核心药物物质，第一层药物物质和任选的另外的药物相同或不同。装置的植入允许药物长时间控制释放。该装置可以皮下植入需要用药物连续治疗的个体中。

8. 发明申请

US20150302388A1 Design framework and apparatus for paying gratitudes 审中-公开
标题翻译：设计框架和设备，以表示感激之情
公开(公告)号：US20150302388A1
公开(公告)日：2015-10-22
申请号：US14545273
申请日：2015-04-15
申请人： Glenn Robert Seidman , Denise Anne Holt , Rajesh A Patel , Ragin Thakorbhai Desai
发明人： Glenn Robert Seidman , Denise Anne Holt , Rajesh A Patel , Ragin Thakorbhai Desai
IPC分类号： G06Q20/32 , G06Q20/22 , G06Q30/02 , G06Q40/00 , G06Q30/06
CPC分类号： G06Q20/3224 , G06Q30/0279 , G06Q30/0282 , G06Q30/0631 , G06Q40/125
摘要： A computer-implemented method that requires an inventive special-purpose software apparatus is disclosed. The apparatus comprises software subsystems that facilitate Patrons using a Mobile Application, to easily find and then submit gratuity payments to Service Providers.
摘要翻译：公开了一种需要本发明的专用软件设备的计算机实现的方法。该设备包括便利赞助人使用移动应用程序的软件子系统，轻松找到并向服务提供商提供酬金。

9. 发明授权

US07736665B2 Implantable polymeric device for sustained release of buprenorphine 有权
标题翻译：用于持续释放丁丙诺啡的可植入聚合物
公开(公告)号：US07736665B2
公开(公告)日：2010-06-15
申请号：US10453377
申请日：2003-06-02
申请人： Rajesh A. Patel , Louis R. Bucalo
发明人： Rajesh A. Patel , Louis R. Bucalo
IPC分类号： A61F2/00
CPC分类号： A61K9/0024 , A61K31/4748 , A61K31/485 , A61K47/32 , A61L31/048 , A61L31/125 , A61L31/16
摘要： The present invention provides compositions, methods, and kits for treatment of opiate addiction and pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine.
摘要翻译：本发明提供了用于治疗阿片成瘾和疼痛的组合物，方法和试剂盒。本发明提供了一种生物相容的非可溶性聚合物装置，其通过长时间的大体线性释放动力学连续释放丁丙诺啡。丁丙诺啡通过孔被释放，孔通过其被封装在其中的聚合物基质的表面。该装置可以皮下给予需要用丁丙诺非连续治疗的个体。

10. 发明授权

US10111830B2 Heterogeneous implantable devices for drug delivery 有权
公开(公告)号：US10111830B2
公开(公告)日：2018-10-30
申请号：US13634535
申请日：2011-03-16
申请人： Rajesh A. Patel , Sunil R. Bhonsle
发明人： Rajesh A. Patel , Sunil R. Bhonsle
IPC分类号： A61K9/00 , A61K47/32 , A61K31/485 , A61K31/198 , A61K31/4045 , A61K45/06 , A61K9/20 , A61K9/28
摘要： The present invention comprises compositions, methods and kits for delivering drugs. The invention provides an implantable device for delivery of a pharmaceutical substance to a patient, comprising a core comprising a core polymeric material optionally containing a core pharmaceutical substance, surrounded by a first layer comprising a first-layer pharmaceutical substance and a first-layer polymeric material, optionally surrounded by one or more additional layers comprising an additional pharmaceutical substance and an additional polymeric material, where the core, first, and optional additional polymeric materials may be the same or different, and where the optional core pharmaceutical substance, first-layer pharmaceutical substance, and optional additional pharmaceutical substances are the same or different. Implantation of the device allows a controlled release of drug for an extended period of time. The device may be implanted subcutaneously in an individual in need of continuous treatment with a drug.

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