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71. 发明申请

US20140079771A1 METHODS AND COMPOSITIONS FOR TREATMENT OF METABOLIC DISORDERS 有权
标题翻译：用于治疗代谢性疾病的方法和组合物
公开(公告)号：US20140079771A1
公开(公告)日：2014-03-20
申请号：US14021825
申请日：2013-09-09
申请人： Beth Israel Deaconess Medical Center, Inc.
发明人： Mark A. EXLEY , Lydia Lynch , Donal O'Shea , Cliona O'Farrelly , Steven P. Balk
IPC分类号： A61K39/395 , A61K35/14 , A61K45/06 , A61K31/7032
CPC分类号： A61K39/3955 , A61K31/70 , A61K31/7032 , A61K35/17 , A61K45/06
摘要： The present invention relates to the discovery that increases in invariant NKT cell (iNKT) number and/or activity can reduce the incidence or severity of metabolic disorders such as obesity and diabetes. The invention accordingly features methods, kits, and compositions for the treatment of such metabolic disorders by administration of a composition capable of increasing iNKT activity.
摘要翻译：本发明涉及不变量NKT细胞（iNKT）数量和/或活性的增加可降低代谢紊乱如肥胖症和糖尿病的发生率或严重程度的发现。因此，本发明具有通过施用能够增加iNKT活性的组合物来治疗这些代谢紊乱的方法，试剂盒和组合物。

72. 发明申请

US20140073885A1 MULTI-CHANNEL MEDICAL IMAGING SYSTEM 审中-公开
标题翻译：多通道医学成像系统
公开(公告)号：US20140073885A1
公开(公告)日：2014-03-13
申请号：US14082899
申请日：2013-11-18
申请人： John V. Frangioni
发明人： John V. Frangioni
IPC分类号： A61B1/04 , A61K49/00 , A61B1/313 , A61B19/00 , A61B5/026 , A61B1/06
CPC分类号： A61B1/043 , A61B1/0005 , A61B1/00186 , A61B1/0638 , A61B1/0684 , A61B1/3132 , A61B5/0071 , A61B5/0086 , A61B5/0261 , A61B90/361 , A61K49/006 , B82Y5/00 , B82Y10/00
摘要： A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remain in a subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may provide an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide used to capture images. The system may be configured for use in open surgical procedures by providing an operating area that is closed to ambient light. The systems described herein provide two or more diagnostic imaging channels for capture of multiple, concurrent diagnostic images and may be used where a visible light image may be usefully supplemented by two or more images that are independently marked for functional interest.
摘要翻译：医学成像系统提供可见光和荧光图像的同时呈现。该系统可以使用保留在受试者的血液中的小分子形式的染料数分钟，允许对象的循环系统的实时成像叠加在受试者的常规可见光图像上。该系统可以提供激发光源来激发用于捕获图像的相同光导中的荧光物质和用于一般照明的可见光源。该系统可以被配置为在开放式外科手术中使用，通过提供一个与环境光线接近的操作区域。本文描述的系统提供用于捕获多个并发诊断图像的两个或更多个诊断成像通道，并且可以在可见光图像可以被独立地标记为功能感兴趣的两个或更多个图像有用地补充的情况下使用。

73. 发明申请

US20140044737A1 RBP4 IN INSULIN SENSITIVITY/RESISTANCE, DIABETES, AND OBESITY 审中-公开
标题翻译： RBP4在胰岛素敏感性/耐药性，糖尿病和肥胖中的作用
公开(公告)号：US20140044737A1
公开(公告)日：2014-02-13
申请号：US14062777
申请日：2013-10-24
申请人： BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
发明人： Barbara B. Kahn , Qin Yang , Tim Graham , Odile Peroni
IPC分类号： A61K31/167
CPC分类号： A61K31/167 , A61K48/00 , A61K49/0008 , C07K14/705 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5088 , G01N33/6893 , G01N2500/00 , G01N2800/042
摘要： Methods for screening molecules that modulate the activity of Retinol Binding Protein 4 (RBP4) and their use in treatment of insulin resistance are described. Also described are methods of diagnosing insulin resistance and related conditions by detecting modulation of RBP4 activity.
摘要翻译：描述了筛选调节视黄醇结合蛋白4（RBP4）活性的分子及其在治疗胰岛素抵抗中的应用的方法。还描述了通过检测RBP4活性的调节来诊断胰岛素抵抗和相关条件的方法。

74. 发明授权

US08552050B2 Activators of pyruvate kinase M2 and methods of treating disease 有权
标题翻译：丙酮酸激酶M2的活化剂和治疗疾病的方法
公开(公告)号：US08552050B2
公开(公告)日：2013-10-08
申请号：US12672827
申请日：2008-08-18
申请人： Lewis C. Cantley , Matthew G. Vander Heiden , Heather R. Christofk
发明人： Lewis C. Cantley , Matthew G. Vander Heiden , Heather R. Christofk
IPC分类号： A01N43/56 , A01N43/08 , A01N37/10 , A01N41/06 , A61K31/415 , A61K31/34 , A61K31/19 , A61K31/18 , C07D231/00 , C07D307/02 , C07C63/04 , C07C303/00 , C07C307/00 , C07C309/00 , C07C311/00
CPC分类号： A61K45/06
摘要： The invention described herein features methods, compositions, and kits for the use of activators of PKM2 for the treatment, prevention, or amelioration of diseases related to PKM2 function, including, e.g., cancer, diabetes, atherosclerosis, restenosis, obesity, autoimmune disorders, and proliferative disorders.
摘要翻译：本文描述的发明特征在于使用PKM2激活剂用于治疗，预防或改善与PKM2功能有关的疾病的方法，组合物和试剂盒，包括例如癌症，糖尿病，动脉粥样硬化，再狭窄，肥胖症，自身免疫性疾病，和增殖性疾病。

75. 发明申请

US20130252821A1 METHODS AND COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF DISEASES CHARACTERIZED BY VASCULAR LEAK, HYPOTENSION, OR A PROCOAGULANT STATE 审中-公开
标题翻译：通过血管渗漏，血压异常或程序性疾病治疗和诊断疾病的方法和组合
公开(公告)号：US20130252821A1
公开(公告)日：2013-09-26
申请号：US13608606
申请日：2012-09-10
申请人： Vikas P. Sukhatme , S. Ananth Karumanchi , Samir M. Parikh
发明人： Vikas P. Sukhatme , S. Ananth Karumanchi , Samir M. Parikh
IPC分类号： C12Q1/68
CPC分类号： C07K16/22 , A61K31/4409 , A61K31/551 , A61K38/1891 , A61K49/0008 , C07K14/515 , C07K2317/76 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/6893 , G01N2333/485 , G01N2333/515 , G01N2333/525 , G01N2333/5412 , G01N2333/545 , G01N2333/9129 , G01N2800/32
摘要： Disclosed herein are methods for treating a vascular leak disorder, hypotension, or a procoagulant state using angiopoietin-2 (Ang-2) antagonist compounds. Also disclosed are methods for treating a vascular leak disorder associated with high dose IL-2 therapy using angiopoietin-2 antagonist compounds. Methods for diagnosing and monitoring vascular leak disorders, hypotension, or a procoagulant state that include the measurement of Ang-2 polypeptide or nucleic acid levels are also disclosed. Methods for inducing a vascular leak using an Ang-2 agonist are also disclosed.
摘要翻译：本文公开了使用血管生成素-2（Ang-2）拮抗剂化合物治疗血管渗漏障碍，低血压或促凝血状态的方法。还公开了使用血管生成素-2拮抗剂化合物治疗与高剂量IL-2治疗相关的血管渗漏障碍的方法。还公开了用于诊断和监测包括Ang-2多肽或核酸水平测量的血管渗漏障碍，低血压或促凝血状态的方法。还公开了使用Ang-2激动剂诱导血管渗漏的方法。

76. 发明申请

US20130243352A1 Global Error Minimization In Image Mosaicking Using Graph Laplacians And Its Applications In Microscopy 有权
标题翻译：使用图形拉普拉斯算子的图像拼接中的全局误差最小化及其在显微镜中的应用
公开(公告)号：US20130243352A1
公开(公告)日：2013-09-19
申请号：US13810940
申请日：2011-07-25
申请人： Parmeshwar Khurd , Rafiou Oketokoun , Ali Kamen , Leo Grady , Hari Sundar , John V. Frangioni
发明人： Parmeshwar Khurd , Rafiou Oketokoun , Ali Kamen , Leo Grady , Hari Sundar , John V. Frangioni
IPC分类号： G06T11/60
CPC分类号： G06T11/60 , G06T3/0068 , G06T3/4038 , G06T7/32 , G06T2200/32 , G06T2207/10056 , G06T2207/30024
摘要： An image mosaicking method includes performing pairwise registration of a plurality of tiles (101), determining absolute homographies for each of the plurality of tiles according to the pairwise registration (102B), and performing a blending of the plurality of tiles to obtain a stitched image according to the absolute homographies (103)
摘要翻译：图像拼接方法包括执行多个瓦片（101）的配对注册，根据成对配准（102B）确定多个瓦片中的每一个的绝对同位素，并且执行多个瓦片的混合以获得缝合图像根据绝对同位素（103）

77. 发明申请

US20130224109A1 COMPOSITIONS AND METHODS FEATURING IL-6 AND IL-21 ANTAGONISTS 审中-公开
标题翻译：特征IL-6和IL-21拮抗剂的组合物和方法
公开(公告)号：US20130224109A1
公开(公告)日：2013-08-29
申请号：US13810956
申请日：2011-07-20
申请人： Terry Strom , Maria Koulmanda
发明人： Terry Strom , Maria Koulmanda
IPC分类号： A61K39/395 , C07K16/46
CPC分类号： A61K39/3955 , A61K38/20 , A61K45/06 , C07K14/54 , C07K16/248 , C07K16/468 , C07K2317/76 , C07K2319/30 , A61K2300/00
摘要： The present invention features compositions for inhibiting both the IL-6 and the IL-21 pathways and methods of making and using such compositions. Our work to date indicates the importance of the redundancy of IL-6 and IL-21 to perform certain crucial functions. The pathways can be inhibited by inhibiting the ligands (i.e., IL-6 and IL-21) and/or their respective receptors (i.e., the IL-6 receptor and IL-21 receptor). Alternatively, or in addition, upstream and downstream effectors in the IL-6 and IL-21 pathways can be blocked. The agents used can be antibody or antibody-based proteins or peptides including circulating receptors, optionally coupled to an immunoglobulin or a portion thereof (e.g., the Fc region). Also provided are methods for using the compositions, for example, in organ transplantation, tissue grafting, or autoimmune disorders.
摘要翻译：本发明的特征在于抑制IL-6和IL-21途径的组合物以及制备和使用这些组合物的方法。我们迄今为止的工作表明，IL-6和IL-21的冗余对于执行某些关键功能的重要性。可通过抑制配体（即IL-6和IL-21）和/或它们各自的受体（即IL-6受体和IL-21受体）来抑制途径。或者或另外，可以阻断IL-6和IL-21途径中的上游和下游效应物。使用的药剂可以是抗体或基于抗体的蛋白质或包括任选与免疫球蛋白或其部分（例如，Fc区）偶联的循环受体）的肽。还提供了使用组合物例如器官移植，组织移植或自身免疫疾病的方法。

78. 发明申请

US20130217656A1 METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING LUPUS 审中-公开
标题翻译：用于诊断和治疗LUPUS的方法和组合物
公开(公告)号：US20130217656A1
公开(公告)日：2013-08-22
申请号：US13816676
申请日：2011-08-12
申请人： George C. Tsokos
发明人： George C. Tsokos
IPC分类号： C12Q1/68 , G01N33/68
CPC分类号： C12Q1/689 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N33/6893
摘要： The present invention relates to methods, compositions, and diagnostic tests for diagnosing and treating lupus and other related diseases or disease subsets. In particular, the method, compositions, and diagnostic tests relate to a combination of one or more genes, where the expression of these genes indicates a predisposition to develop, or a diagnosis of, lupus and other related diseases or disease subsets.
摘要翻译：本发明涉及用于诊断和治疗狼疮等疾病或疾病子集的方法，组合物和诊断试验。特别地，方法，组合物和诊断测试涉及一种或多种基因的组合，其中这些基因的表达表示发展的倾向或狼疮和其他相关疾病或疾病亚群的诊断。

79. 发明授权

US08455615B2 Methods and compositions for prostate cancer immunotherapy 失效
标题翻译：前列腺癌免疫治疗的方法和组成
公开(公告)号：US08455615B2
公开(公告)日：2013-06-04
申请号：US12990438
申请日：2009-04-30
申请人： Martin G. Sanda , Mohamed S. Arredouani
发明人： Martin G. Sanda , Mohamed S. Arredouani
IPC分类号： C07K14/00
CPC分类号： A61K39/0011 , A61K38/08 , A61K38/10 , A61K45/06
摘要： The present invention features methods and compositions (e.g., immune response stimulating peptides (e.g., ERG or SIM2 peptides), activated immune cells, antigen-presenting cells, and antibodies or antigen-binding fragments thereof) for generating an immune response for the treatment of cancer (e.g., prostate cancer).
摘要翻译：本发明的特征在于产生用于治疗的免疫应答的方法和组合物（例如，免疫应答刺激肽（例如，ERG或SIM2肽），活化的免疫细胞，抗原呈递细胞和抗体或其抗原结合片段）癌症（如前列腺癌）。

80. 发明申请

US20130136745A1 SOLUBLE ENDOGLIN AND USES THEREOF 有权
标题翻译：可溶性内酰胺酶及其用途
公开(公告)号：US20130136745A1
公开(公告)日：2013-05-30
申请号：US13521849
申请日：2011-01-11
申请人： Mourad Toporsian
发明人： Mourad Toporsian
IPC分类号： C07K14/705 , C12N15/113 , G01N33/68 , C07K16/28
CPC分类号： C12N15/1136 , A61K38/00 , C07K14/70596 , C07K16/2896 , C07K2317/34 , C12N15/1138 , Y02A50/411
摘要： The invention provides isolated soluble endoglin polypeptides, nucleic acids encoding soluble endoglin polypeptides, antibodies that specifically bind soluble endoglin polypeptides, and kits containing these materials. The invention also provides methods for treating or decreasing the likelihood of developing a soluble endoglin-mediated disorder in a subject requiring the administration of an agent capable of reducing the expression or biological activity of a soluble endoglin polypeptide and methods for treating or decreasing the likelihood of developing a soluble endoglin-preventive disorder in a subject requiring the administration of a soluble endoglin polypeptide or a nucleic acid encoding the soluble endoglin polypeptide. The invention further provides methods for the diagnosis of a soluble endoglin-mediated disorder or a soluble endoglin-preventive disorder and methods for identifying a compound to treat a soluble endoglin-mediated or a soluble endoglin-preventive disorder.
摘要翻译：本发明提供分离的可溶内皮糖蛋白多肽，编码可溶内皮糖蛋白多肽的核酸，特异性结合可溶内皮糖蛋白多肽的抗体和含有这些材料的试剂盒。本发明还提供了治疗或降低在需要施用能够降低可溶内皮糖蛋白多肽的表达或生物学活性的试剂的受试者中发展可溶内皮糖蛋白介导的病症的可能性的方法和用于治疗或降低在需要施用可溶内皮糖蛋白多肽或编码可溶内皮糖蛋白多肽的核酸的受试者中开发可溶内皮糖蛋白预防性疾病。本发明还提供了用于诊断可溶内皮因素介导的病症或可溶内皮糖蛋白预防障碍的方法以及用于鉴定化合物以治疗可溶内皮糖蛋白介导的或可溶内皮抑素的预防障碍的方法。

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