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71. 发明申请

US20070009391A1 Compliant microfluidic sample processing disks 有权
标题翻译：符合微流体样品处理盘
公开(公告)号：US20070009391A1
公开(公告)日：2007-01-11
申请号：US11174680
申请日：2005-07-05
申请人： William Bedingham , Barry Robole
发明人： William Bedingham , Barry Robole
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/502738 , B01L7/52 , B01L2200/027 , B01L2200/0689 , B01L2300/044 , B01L2300/0803 , B01L2300/0887 , B01L2300/1805
摘要： Microfluidic sample processing disks with a plurality of fluid structures formed therein are disclosed. Each of the fluid structures preferably includes an input well and one or more process chambers connected to the input well by one or more delivery channels. The process chambers may be arranged in a compliant annular processing ring that is adapted to conform to the shape of an underlying thermal transfer surface under pressure. That compliance may be delivered in the disks of the present invention by locating the process chambers in an annular processing ring in which a majority of the volume is occupied by the process chambers. Compliance within the annular processing ring may alternatively be provided by a composite structure within the annular processing ring that includes covers attached to a body using pressure sensitive adhesive.
摘要翻译：公开了具有形成在其中的多个流体结构的微流体样品处理盘。每个流体结构优选地包括输入井和通过一个或多个输送通道连接到输入井的一个或多个处理室。处理室可以布置成柔顺的环形加工环，其适于在压力下符合下面的热转印表面的形状。通过将处理室定位在其中大部分体积被处理室占据的环形处理环中，可以在本发明的盘中传送顺从性。环形加工环内的合规性可替代地由环形加工环内的复合结构提供，其包括使用压敏粘合剂附接到主体的盖。

72. 发明申请

US20060269451A1 Sample processing devices and carriers 失效
公开(公告)号：US20060269451A1
公开(公告)日：2006-11-30
申请号：US11497828
申请日：2006-08-02
申请人： William Bedingham , Chad Carter , Robert Harkins , Michael Harms , Christopher Kokaisel , Diane North , Kenneth Wood
发明人： William Bedingham , Chad Carter , Robert Harkins , Michael Harms , Christopher Kokaisel , Diane North , Kenneth Wood
IPC分类号： B01L3/00
CPC分类号： G01N35/00069 , B01L3/5025 , B01L3/50255 , B01L3/502707 , B01L3/502738 , B01L7/52 , B01L7/525 , B01L9/527 , B01L2200/0642 , B01L2200/0689 , B01L2200/142 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , B01L2400/0409 , B01L2400/0481 , B01L2400/0655 , B01L2400/0661 , F27B9/16 , F27D5/00 , Y10T436/25 , Y10T436/2575
摘要： Methods and devices for thermal processing of multiple samples at the same time are disclosed. The assemblies include carriers and sample processing devices with process arrays that include conduits useful in distributing sample materials to a group pf process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas. The carriers may be used to apply selective compression to the sample processing devices.

73. 发明申请

US20060223172A1 Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector 有权
标题翻译：具有将多个光模块耦合到公共检测器的光纤束的多重荧光检测装置
公开(公告)号：US20060223172A1
公开(公告)日：2006-10-05
申请号：US11174755
申请日：2005-07-05
申请人： William Bedingham , Peter Ludowise , Barry Robole
发明人： William Bedingham , Peter Ludowise , Barry Robole
IPC分类号： C12M1/34 , G01N21/66
CPC分类号： G01J3/4406 , G01J3/0218 , G01N21/6428 , G01N21/6452 , G01N2021/6484 , G01N2201/024
摘要： Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system is described that includes a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of optical modules. Each of the optical modules is optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of optical modules conveys the fluorescent light from the multiple optical modules to a single detector.
摘要翻译：描述了用于在实时PCR（聚合酶链式反应）中检测多种靶物种的技术。例如，描述了包括数据采集装置和耦合到数据采集装置的检测装置的系统。检测装置包括具有多个处理室的旋转盘，该多个处理室具有发射不同波长的荧光的多种物质。该装置还包括多个光学模块。每个光学模块被光学配置以激发物种并捕获由不同波长的物质发射的荧光。耦合到多个光学模块的光纤束将来自多个光学模块的荧光传送到单个检测器。

74. 发明申请

US20060189000A1 Sample processing devices 有权
公开(公告)号：US20060189000A1
公开(公告)日：2006-08-24
申请号：US11399244
申请日：2006-04-06
申请人： William Bedingham , James Aysta , Barry Robole , Kenneth Wood
发明人： William Bedingham , James Aysta , Barry Robole , Kenneth Wood
IPC分类号： G01N33/00
CPC分类号： G01N35/00069 , B01L3/5025 , B01L3/50255 , B01L3/502707 , B01L3/502738 , B01L7/52 , B01L7/525 , B01L9/527 , B01L2200/0642 , B01L2200/0689 , B01L2200/142 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , B01L2400/0409 , B01L2400/0481 , B01L2400/0655 , B01L2400/0661 , F27B9/16 , F27D5/00 , Y10T436/25 , Y10T436/2575
摘要： Methods and devices for thermal processing of multiple samples at the same time are disclosed. The sample processing devices provide process arrays that include conduits useful in distributing sample materials to a group pf process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas.

75. 发明申请

US20060188396A1 Sample processing devices 有权
公开(公告)号：US20060188396A1
公开(公告)日：2006-08-24
申请号：US11399243
申请日：2006-04-06
申请人： William Bedingham , James Aysta , Barry Robole , Kenneth Wood
发明人： William Bedingham , James Aysta , Barry Robole , Kenneth Wood
IPC分类号： G01N31/22
CPC分类号： G01N35/00069 , B01L3/5025 , B01L3/50255 , B01L3/502707 , B01L3/502738 , B01L7/52 , B01L7/525 , B01L9/527 , B01L2200/0642 , B01L2200/0689 , B01L2200/142 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , B01L2400/0409 , B01L2400/0481 , B01L2400/0655 , B01L2400/0661 , F27B9/16 , F27D5/00 , Y10T436/25 , Y10T436/2575
摘要： Methods and devices for thermal processing of multiple samples at the same time are disclosed. The sample processing devices provide process arrays that include conduits useful in distributing sample materials to a group pf process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas.

76. 发明申请

US20060076346A1 Enhanced sample processing devices, systems and methods 有权
公开(公告)号：US20060076346A1
公开(公告)日：2006-04-13
申请号：US11287074
申请日：2005-11-23
申请人： William Bedingham , Barry Robole
发明人： William Bedingham , Barry Robole
IPC分类号： H05B6/80
CPC分类号： G01N35/00069 , B01L3/5025 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/027 , B01L2300/0681 , B01L2300/0806 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1861 , B01L2400/0409 , B01L2400/0661 , B01L2400/0677 , B03C1/30 , F27B9/16 , F27D5/00 , G01N35/0098 , H05B6/80 , Y10T436/2575
摘要： Devices, systems, and methods for processing sample materials. The sample materials may be located in a plurality of process chambers in the device, which is rotated during heating of the sample materials.

77. 发明申请

US20050142571A1 Methods for nucleic acid isolation and kits using solid phase material 审中-公开
标题翻译：核酸分离方法和使用固相物质的试剂盒
公开(公告)号：US20050142571A1
公开(公告)日：2005-06-30
申请号：US10852645
申请日：2004-05-24
申请人： Ranjani Parthasarathy , Katya Ericson , William Bedingham
发明人： Ranjani Parthasarathy , Katya Ericson , William Bedingham
IPC分类号： C12N15/10 , C12Q1/68 , C07H21/04 , C12N1/08
CPC分类号： C12N15/10
摘要： The present invention provides methods and kits for isolating nucleic acid from a sample, preferably from a biological sample, using solid phase material.
摘要翻译：本发明提供了使用固相材料从样品中分离核酸，优选从生物样品中分离核酸的方法和试剂盒。

78. 发明申请

US20050142570A1 Methods for nucleic acid isolation and kits using a microfluidic device and sedimenting reagent 审中-公开
标题翻译：使用微流体装置和沉淀试剂进行核酸分离的方法和试剂盒
公开(公告)号：US20050142570A1
公开(公告)日：2005-06-30
申请号：US10852022
申请日：2004-05-24
申请人： Ranjani Parthasarathy , Katya Ericson , William Bedingham
发明人： Ranjani Parthasarathy , Katya Ericson , William Bedingham
IPC分类号： B01L3/00 , C07H21/04 , C12N15/10 , C12Q1/68
CPC分类号： B01L3/502738 , B01L3/502753 , B01L2200/0605 , B01L2200/10 , B01L2300/0803 , B01L2400/0409 , B01L2400/0677 , C07H21/04 , C12Q1/6806 , C12Q2565/629
摘要： The present invention provides methods and kits for isolating nucleic acid from a sample, preferably from a biological sample, using a microfluidic device and sedimenting reagent.
摘要翻译：本发明提供了使用微流体装置和沉降试剂从样品中分离核酸，优选来自生物样品的方法和试剂盒。

79. 发明申请

US20130211265A1 MULTIFUNCTIONAL MEDICAL DEVICE FOR TELEMEDICINE APPLICATIONS 审中-公开
标题翻译：用于远程应用的多功能医疗设备
公开(公告)号：US20130211265A1
公开(公告)日：2013-08-15
申请号：US13879643
申请日：2011-10-12
申请人： William Bedingham , Thomas P. Schmidt , Bernard A. Gonzalez , Shaun M. Krueger
发明人： William Bedingham , Thomas P. Schmidt , Bernard A. Gonzalez , Shaun M. Krueger
IPC分类号： A61B5/00
CPC分类号： A61B5/0024 , A61B5/002 , A61B5/0022 , A61B2560/0443 , A61B2562/226 , G06F19/3418 , G06Q50/22
摘要： A multifunction medical device includes a housing configured for hand-held manipulation, a processing unit within the housing, and a connector on the outer surface of the housing. The connector is coupled to the processing unit and operable to connect to a plurality of different types of medical sensors. The processing unit is configured to determine a type of a medical sensor coupled to the connector.
摘要翻译：多功能医疗装置包括构造成用于手持操作的壳体，壳体内的处理单元以及壳体外表面上的连接器。连接器耦合到处理单元并且可操作以连接到多种不同类型的医疗传感器。处理单元被配置为确定耦合到连接器的医疗传感器的类型。

80. 发明授权

US08469741B2 Stretchable conductive connector 有权
标题翻译：可拉伸导电连接器
公开(公告)号：US08469741B2
公开(公告)日：2013-06-25
申请号：US12990057
申请日：2009-04-29
申请人： Craig D. Oster , Hatim M. Carim , Vinod P. Menon , William Bedingham
发明人： Craig D. Oster , Hatim M. Carim , Vinod P. Menon , William Bedingham
IPC分类号： H01R13/40
CPC分类号： H01R13/2421 , H01R13/2414 , H01R13/33 , Y10T29/49117
摘要： A stretchable conductive connector. The conductive connector can include a viscoelastic support member having a variable length, and a conductor coupled to the support member. The conductor can include at least one bend to accommodate the variable length of the viscoelastic support member.
摘要翻译：可伸缩导电连接器。导电连接器可以包括具有可变长度的粘弹性支撑构件和连接到支撑构件的导体。导体可以包括至少一个弯曲部以适应粘弹性支撑构件的可变长度。

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