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    • 74. 发明授权
    • Method for the analytical determination of the concentration of a
component of a medical sample
    • 用于分析测定医用样品的成分浓度的方法
    • US5420042A
    • 1995-05-30
    • US84008
    • 1993-06-29
    • Rainer SchaferChristoph BerdingFridl LangWilheim KleiderPeter Wolf
    • Rainer SchaferChristoph BerdingFridl LangWilheim KleiderPeter Wolf
    • G01N33/536G01N33/543G01N33/68G01N33/96G01N33/557
    • G01N33/54313G01N33/68G01N33/96Y10S436/909Y10T436/11
    • Method for the analytical determination of the concentration of a component of a medical sample, in which a reaction of the sample with reagents leads to a time-dependent change S(t) in a measured quantity S and the concentration C correlates according to an evaluation curve C(X) with an input variable X derived from S(t), in which the calibration curve is ambiguous for at least a portion of the possible X values. In order to assign an input variable X to one of the sub-sections and thereby to obtain an unambiguous correlation to a particular concentration C, a training run and an analysis run are performed. In the training run, a discrimination algorithm is performed at least once, in which a discriminator set is generated from measurements of S(t), a score is generated in each case from the latter with a multivariate statistical technique and it is checked whether the scores can be divided into separate subsets, in which the concentrations are correctly assigned to the sub-sections of the calibration curve. The discrimination algorithm is repeated with different discriminator sets generated according to different generation methods from the measurements of S(t), in order to establish an operative discrimination algorithm. In the analysis run, an analysis score is calculated from measurements of S(t) according to the operative discrimination algorithm, the analysis score is compared with the boundary score and the measurement result is assigned to one of the sub-curves of the calibration curve by comparison of the analysis score with the boundary score.
    • 用于分析测定样品与试剂反应导致测量量S和浓度C中的时间依赖性变化S(t)的药物样品成分浓度的分析方法根据评价 具有从S(t)导出的输入变量X的曲线C(X),其中校准曲线对于可能的X值的至少一部分是不明确的。 为了将输入变量X分配给一个子部分,从而获得与特定浓度C的明确相关性,执行训练运行和分析运行。 在训练运行中,至少执行一次鉴别算法,其中通过S(t)的测量产生鉴别器集合,在每种情况下,使用多变量统计技术从后者生成分数,并且检查是否 分数可以分为单独的子集,其中浓度被正确分配到校准曲线的子部分。 根据不同的生成方法从S(t)的测量中产生的不同鉴别器集重复鉴别算法,以便建立可操作的鉴别算法。 在分析运行中,根据手术识别算法从S(t)的测量中计算分析得分,将分析得分与边界得分进行比较,并将测量结果分配给校准曲线的一个子曲线 通过比较分析得分与边界得分。
    • 75. 发明授权
    • Di(hydroxyphenyl)-1,2-4-triazole monomers
    • 二(羟基苯基)-1,2,4-三唑单体
    • US5245043A
    • 1993-09-14
    • US905708
    • 1992-06-29
    • John W. ConnellPaul M. HergenrotherPeter Wolf
    • John W. ConnellPaul M. HergenrotherPeter Wolf
    • C07D249/08C08G73/08
    • C08G73/08
    • The di(hydroxyphenyl)-1,2,4-triazole monomers were first synthesized by reacting bis(4-hydroxyphenyl) hydrazide with aniline hydrochloride at 250.degree. C. in the melt and also by reacting 1,3 or 1,4-bis-(4-hydroxyphenyl)phenylene-dihydrazide with 2 moles of aniline hydrochloride in the melt. Purification of the di(hydroxyphenyl)-1,2,4-triazole monomers was accomplished by recrystallization. Poly(1,2,4-triazoles) (PT) were prepared by the aromatic nucleophilic displacement reaction of di(hydroxyphenyl)-1,2,4-triazole monomers with activated aromatic dihalides or activated aromatic dinitro compounds. The reactions were carried out in polar aprotic solvents such as sulfolane or diphenylsulfone using alkali metal bases such as potassium carbonate at elevated temperatures under nitrogen. This synthetic route has provided high molecular weight PT of new chemical structure, is economically and synthetically more favorable than other routes, and allows for facile chemical structure variation due to the availability of a large variety of activated aromatic dihalides.
    • 二(羟基苯基)-1,2,4-三唑单体首先通过双(4-羟基苯基)酰肼与苯胺盐酸盐在250℃下在熔体中反应,并通过使1,3或1,4-双 - (4-羟基苯基)亚苯基二酰肼与2摩尔苯胺盐酸盐在熔体中反应。 通过重结晶实现二(羟基苯基)-1,2,4-三唑单体的纯化。 通过二(羟基苯基)-1,2,4-三唑单体与活性芳族二卤化物或活性芳族二硝基化合物的芳族亲核取代反应制备聚(1,2,4-三唑)(PT)。 反应在极性非质子溶剂如环丁砜或二苯基砜中,使用碱金属碱如碳酸钾,在氮气下在升高的温度下进行。 这种合成路线提供了新的化学结构的高分子量PT,在经济上和综合性上比其他途径更有利,并且由于大量活性芳族二卤化物的可用性而允许容易的化学结构变化。