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71. 发明授权

US06881401B1 Methods of treatment of immune system related disorders using Neutrokine-alpha 有权
标题翻译：使用Neutrokine-α治疗免疫系统相关疾病的方法
公开(公告)号：US06881401B1
公开(公告)日：2005-04-19
申请号：US09589285
申请日：2000-06-08
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
IPC分类号： A61K38/00 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/24 , C12P21/08 , A61K38/18 , A61K38/19 , C07K14/475
CPC分类号： C07K16/24 , A61K38/00 , C07H21/04 , C07K14/52 , C07K14/715 , C07K2317/622
摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

72. 发明授权

US06806351B2 Secreted protein HBJFE12 失效
标题翻译：分泌蛋白HBJFE12
公开(公告)号：US06806351B2
公开(公告)日：2004-10-19
申请号：US09774639
申请日：2001-02-01
申请人： Steven M. Ruben , Daniel R. Soppet , Reinhard Ebner , Henrik S. Olsen , Paul E. Young , John M. Greene , Ann M. Ferrie , Guo-Liang Yu , Jian Ni , Craig A. Rosen , Laurie A. Brewer , Fouad Janat
发明人： Steven M. Ruben , Daniel R. Soppet , Reinhard Ebner , Henrik S. Olsen , Paul E. Young , John M. Greene , Ann M. Ferrie , Guo-Liang Yu , Jian Ni , Craig A. Rosen , Laurie A. Brewer , Fouad Janat
IPC分类号： C07K14435
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

73. 发明授权

US06562579B1 Diagnostic methods using antibodies to Neutrokine-alpha 有权
标题翻译：使用Neutrokine-α抗体的诊断方法
公开(公告)号：US06562579B1
公开(公告)日：2003-05-13
申请号：US09588947
申请日：2000-06-08
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
IPC分类号： G01N3353
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

74. 发明授权

US08071092B1 Methods of inhibiting B lymphocytes using antibodies to Neutrokine-alpha 有权
标题翻译：使用Neutrokine-α抗体抑制B淋巴细胞的方法
公开(公告)号：US08071092B1
公开(公告)日：2011-12-06
申请号：US09589288
申请日：2000-06-08
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： A61K39/395 , C07K16/22 , C07K14/475
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

75. 发明申请

US20090169565A1 NEUTROKINE-ALPHA ANTIBODIES AND METHODS OF USE THEREOF 有权
标题翻译： NEUTROKINE-ALPHA抗体及其使用方法
公开(公告)号：US20090169565A1
公开(公告)日：2009-07-02
申请号：US12393693
申请日：2009-02-26
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
IPC分类号： A61K39/395 , C07K16/18 , G01N33/53 , A61P37/00
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a Neutrokine-alpha antibody and a process for producing a Neutrokine-alpha antibody. The invention further relates to screening methods for identifying compounds that inhibit or enhance the action of Neutrokine-alpha. Also provided are diagnostic methods for detecting autoimmune disorders and therapeutic methods for treating autoimmune disorders using a Neutrokine-alpha antibody.
摘要翻译：本发明涉及一种Neutrokine-α抗体及其制备Neutrokine-α抗体的方法。本发明还涉及用于鉴定抑制或增强中枢神经素α作用的化合物的筛选方法。还提供了用于检测自身免疫疾病的诊断方法和使用中和碱α抗体治疗自身免疫疾病的治疗方法。

76. 发明授权

US08173122B2 Methods of treatment using antibodies to neutrokine-alpha 有权
标题翻译：使用抗中性白细胞抗体α的治疗方法
公开(公告)号：US08173122B2
公开(公告)日：2012-05-08
申请号：US12170333
申请日：2008-07-09
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： A61K39/395 , A61K38/18 , A61K38/19 , A61K38/22 , C07K16/22 , C07K14/475
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

77. 发明申请

US20110165160A1 NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT 审中-公开
标题翻译： NEUTROKINE-ALPHA和NEUTROKINE-ALPHA SPLICE变体
公开(公告)号：US20110165160A1
公开(公告)日：2011-07-07
申请号：US12965535
申请日：2010-12-10
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： A61K39/395 , C12N5/09 , A61K38/02 , C12Q1/02 , A61P35/02
CPC分类号： G01N33/56972 , A61K31/519 , A61K38/00 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/70575 , C07K14/715 , C07K16/24 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N2333/52 , G01N2800/24
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译：本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。

78. 发明申请

US20110052590A1 NEUTROKINE-ALPHA ANTIBODIES AND METHODS OF USE THEREOF 有权
标题翻译： NEUTROKINE-ALPHA抗体及其使用方法
公开(公告)号：US20110052590A1
公开(公告)日：2011-03-03
申请号：US12870548
申请日：2010-08-27
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： A61K39/395 , C07K16/24 , G01N33/53 , A61P37/06
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a Neutrokine-alpha antibody and a process for producing a Neutrokine-alpha antibody. The invention further relates to screening methods for identifying compounds that inhibit or enhance the action of Neutrokine-alpha. Also provided are diagnostic methods for detecting autoimmune disorders and therapeutic methods for treating autoimmune disorders using a Neutrokine-alpha antibody.
摘要翻译：本发明涉及一种Neutrokine-α抗体及其制备Neutrokine-α抗体的方法。本发明还涉及用于鉴定抑制或增强中枢神经素α作用的化合物的筛选方法。还提供了用于检测自身免疫疾病的诊断方法和使用中和碱α抗体治疗自身免疫疾病的治疗方法。

79. 发明授权

US06812327B1 Neutrokine-alpha polypeptides 有权
标题翻译：中枢神经素α多肽
公开(公告)号：US06812327B1
公开(公告)日：2004-11-02
申请号：US09507968
申请日：2000-02-22
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
IPC分类号： A61K3816
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。特别地提供编码人Neutrokine-α和/或Neutrokine-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 Neutrokine-α和/或Neutrokine-αSV激动剂和Neutrokine-α和/或Neutrokine-αSV活性的拮抗剂。也生产相同。本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

80. 发明授权

US06689579B1 Polynucleotides encoding neutrokine-&agr; 失效
标题翻译：编码中性粒细胞α的多核苷酸
公开(公告)号：US06689579B1
公开(公告)日：2004-02-10
申请号：US09005874
申请日：1998-01-12
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： C12P2102
CPC分类号： C07H21/04 , A61K38/00 , C07K14/52
摘要： The present invention relates to a novel Neutrokine-&agr; protein which is a member of the TNF protein family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-&agr; protein including soluble forms of the extracellular domain. Neutrokine-&agr; polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-&agr; activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及作为TNF蛋白家族成员的新型中枢神经素α蛋白。特别地，提供编码人Neutrokine-α蛋白的分离的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定中枢神经素-α活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

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