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71. 发明授权

US06333322B1 Nitrogen-containing tricyclic compounds and drugs containing the same 失效
标题翻译：含氮三环化合物和含有这些化合物的药物
公开(公告)号：US06333322B1
公开(公告)日：2001-12-25
申请号：US09125451
申请日：1998-09-21
申请人： Mitsuaki Miyamoto , Tatsuya Yoshiuchi , Keizo Sato , Makoto Kaino , Masayuki Tanaka , Motohiro Soejima , Katsuhiro Moriya , Yoshinori Sakuma , Koji Yamada , Kokichi Harada , Yukio Nishizawa , Seiichi Kobayashi , Makoto Okita , Koichi Katayama
发明人： Mitsuaki Miyamoto , Tatsuya Yoshiuchi , Keizo Sato , Makoto Kaino , Masayuki Tanaka , Motohiro Soejima , Katsuhiro Moriya , Yoshinori Sakuma , Koji Yamada , Kokichi Harada , Yukio Nishizawa , Seiichi Kobayashi , Makoto Okita , Koichi Katayama
IPC分类号： A61K315415
CPC分类号： C07D417/06 , C07D279/22 , C07D279/24 , C07D417/12 , C09B21/00 , C09B57/08
摘要： A phenothiazine, acridan, acridone oxime, acridone hydrazone and dibenzodiazepine derivative represented by formula (I) effective against diseases in which histamine, leukotrienes, etc. participate and effective in preventing or treating diseases in which chemical mediators such as histamine and leukotrienes participate, for example, asthma, allergic rhinitis, atopic dermatitis, urticaria, hay fever, gastrointestinal allergy and food allergy.
摘要翻译：苯并噻嗪，吖啶酮肟，吖啶酮肟，腙酮腙和二苯并二氮杂衍生物，其对组胺，白细胞三烯等参与并有效预防或治疗化学介质如组胺和白三烯参与的疾病有效，例如哮喘，过敏性鼻炎，特应性皮炎，荨麻疹，花粉症，胃肠道过敏和食物过敏。

72. 发明授权

US6121309A Fused-ring carboxylic acid derivatives 失效
标题翻译：稠环羧酸衍生物
公开(公告)号：US6121309A
公开(公告)日：2000-09-19
申请号：US125522
申请日：1998-08-20
申请人： Katsuya Tagami , Hiroyuki Yoshimura , Mitsuo Nagai , Shigeki Hibi , Kouichi Kikuchi , Takashi Sato , Makoto Okita , Yasushi Okamoto , Yumiko Nagasaka , Naoki Kobayashi , Takayuki Hida , Kenji Tai , Naoki Tokuhara , Seiichi Kobayashi
发明人： Katsuya Tagami , Hiroyuki Yoshimura , Mitsuo Nagai , Shigeki Hibi , Kouichi Kikuchi , Takashi Sato , Makoto Okita , Yasushi Okamoto , Yumiko Nagasaka , Naoki Kobayashi , Takayuki Hida , Kenji Tai , Naoki Tokuhara , Seiichi Kobayashi
IPC分类号： C07C69/76 , C07C69/94 , C07D207/32 , C07D207/337 , C07D307/54 , C07D333/24 , C07D405/04 , C07D405/10 , C07D405/14 , C07D407/04 , C07D409/04 , C07D409/10 , C07D409/14 , A61K31/40 , C07D405/00
CPC分类号： C07D207/337 , C07C69/76 , C07C69/94 , C07D307/54 , C07D333/24 , C07D405/04 , C07D405/10 , C07D405/14 , C07D407/04 , C07D409/04 , C07D409/10 , C07D409/14
摘要： The present invention provides a medicament exhibiting excellent retinoic acid receptor agonism.A Carboxylic acid derivative having a fused ring which is represented by the following formula or a pharmacologically acceptable salt thereof: ##STR1## {wherein the symbol ----- represents a single bond or a double bond; X, Y, Z, P, Q, U, V and W are each a group represented by the formula: --O-- or --S--, or a group represented by the formula: ##STR2## [wherein R.sup.k (k:1 to 8) is hydrogen, halogeno, optionally substituted lower alkyl or the like, with either of R.sup.7 and R.sup.8 being a group represented by the formula: ##STR3## (wherein A and B are each independently an optionally substituted aromatic hydrocarbon ring or an optionally substituted unsaturated heterocycle; and D is optionally protected carboxyl)]}.
摘要翻译： PCT No.PCT / JP97 / 00852 Sec。 371日期：1998年8月20日 102（e）1998年8月20日PCT PCT 1997年3月18日PCT公布。公开号WO97 / 34869 日期：1997年9月25日本发明提供了显示出优异的视黄酸受体激动作用的药物。具有由下式表示的稠环的羧酸衍生物或其药理学上可接受的盐：{其中符号+ E，uns ----- + EE表示单键或双键; X，Y，Z，P，Q，U，V和W分别是由下式表示的基团：-O-或-S-，或由下式表示的基团：[其中R k（k：1至8）是氢，卤素，任选取代的低级烷基等，其中R 7和R 8中的任一个是由下式表示的基团：（其中A和B各自独立地是任选取代的芳族烃环或任选取代的不饱和杂环; D 任选保护羧基）]}。

73. 发明授权

US5935938A Substituted liposaccharides useful in the treatment and prevention of endotoxemia 失效
公开(公告)号：US5935938A
公开(公告)日：1999-08-10
申请号：US658656
申请日：1996-06-05
申请人： William J. Christ , Daniel P. Rossignol , Seiichi Kobayashi , Tsutomu Kawata
发明人： William J. Christ , Daniel P. Rossignol , Seiichi Kobayashi , Tsutomu Kawata
IPC分类号： C07H15/12 , A61K31/70 , A61K31/7028 , A61P31/00 , A61P31/04 , C07H3/04 , C07H11/00 , C07H11/04 , C07H13/06 , C07H15/04 , C13K5/00
CPC分类号： C07H15/04 , A61K9/0073 , C07H11/00 , C07H15/12 , C07H3/04
摘要： Novel substituted liposaccharides useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are methods of preparing these agents and intermediates useful therein.

74. 发明授权

US5909975A Multiplex writing implement 失效
标题翻译：复写书写工具
公开(公告)号：US5909975A
公开(公告)日：1999-06-08
申请号：US943074
申请日：1997-10-01
申请人： Seiichi Kobayashi
发明人： Seiichi Kobayashi
IPC分类号： B43K25/02 , B43K24/10 , B43K24/14 , B43K27/00 , B43K7/01
CPC分类号： B43K24/14
摘要： The multiplex writing implement includes: a cylindrical portion formed in the rear of the elliptical cylinder portion of the middle barrel; a rotary shaft which is disposed in the bore of the cylindrical portion so as to rotate in a range of about 180.degree. relative to the middle barrel and has a pair of cam grooves in the peripheral surface thereof; and a rear barrel which fits on the outer periphery of the cylindrical portion and is integrally attached to the rear end of the rotary shaft which is projected out from the rear end of the cylindrical portion, and is constructed such that the rear barrel is rotatable relative to the middle barrel; the pair of sliding pieces which respectively have projections on inner sides facing each other, engaging the cam grooves of the rotary shaft are guided inside the bore of the middle barrel so as to only move forwards and backwards; and the sliding pieces can alternately move forwards and backwards following the rotation of the rotary shaft as the rear barrel is rotated.
摘要翻译：多重书写工具包括：形成在中间筒的椭圆筒部分的后部的圆柱形部分; 旋转轴，其设置在所述圆筒部的孔中，以相对于所述中筒在约180度的范围内旋转，并且在其外周面具有一对凸轮槽; 以及后筒，其配合在所述圆筒部的外周，并且一体地安装在从所述圆筒部的后端突出的所述旋转轴的后端，并且构造成使得所述后筒能够相对旋转到中桶; 一对滑动件在内侧面彼此面对，与旋转轴的凸轮槽接合，在中间筒的孔内被引导以仅向前后移动; 并且当后筒旋转时，滑动件可随着旋转轴的旋转而交替地向前和向后移动。

75. 发明授权

US5655847A Ball-point pen 失效
标题翻译：圆珠笔
公开(公告)号：US5655847A
公开(公告)日：1997-08-12
申请号：US334182
申请日：1994-11-03
申请人： Seiichi Kobayashi , Kazuhiko Furukawa
发明人： Seiichi Kobayashi , Kazuhiko Furukawa
IPC分类号： B43K5/18 , B43K7/01 , B43K7/10 , B43K7/00
CPC分类号： B43K7/10 , B43K5/1881 , B43K7/01
摘要： A ball-point pen of the present invention is provided which includes: a ball-point pen refill being accommodated in the barrel cylinder and having: a tip with a tip ball held at the front end thereof; an ink reservoir which stores low-viscosity oily ink and has an ink follower provided in the rear end of the ink; and a joint disposed between the tip and the ink reservoir. The joint further includes: a valve chamber holding a ball valve in its inside and communicating with the rear end of the tip; and a ball valve seat disposed on the rear side of the valve chamber for the ball valve in order to prevent backward flow of ink. With this configuration, it is possible to provide a ball-point pen which, without need of any cap, can create dense writing traces free from blotting and unevenness even when a low viscosity oily ink is used.
摘要翻译：提供本发明的圆珠笔，其包括：圆珠笔笔芯，其容纳在所述圆柱滚筒中，并具有：尖端，其顶端保持在其前端; 存储低粘度油性墨水并具有设置在墨水后端的墨汁随动物的墨水储存器; 以及设置在尖端和墨水容器之间的接头。接头还包括：阀室，其内部保持有球阀，并与尖端的后端连通; 以及球阀座，其设置在球阀的阀室的后侧，以防止墨的反向流动。利用这种结构，即使使用低粘度的油性油墨，也可以提供一种不需要任何盖子的圆珠笔即可产生无印迹和不均匀的致密书写痕迹。

76. 发明授权

US5283312A Mercapto compound, its preparation process, and sulfur-containing urethane resins and lenses using the same 失效
标题翻译：巯基化合物，其制备方法和含硫聚氨酯树脂和使用其的透镜
公开(公告)号：US5283312A
公开(公告)日：1994-02-01
申请号：US924454
申请日：1992-08-04
申请人： Yoshinobu Kanemura , Katsuyoshi Sasagawa , Seiichi Kobayashi
发明人： Yoshinobu Kanemura , Katsuyoshi Sasagawa , Seiichi Kobayashi
IPC分类号： C07C321/14 , C08G18/38 , G02B1/04 , C07C319/06 , C08G18/08
CPC分类号： C08G18/3876 , C07C321/14 , G02B1/041
摘要： A mercapto compound represented by the following formula (1): ##STR1## is obtained by reacting, in the presence of a mineral acid, thiourea with a compound represented by the following formula (2): wherein X means a hydroxyl group or a chlorine or bromine atom, and then adding a base to alkalinize the reaction mixture so that the reaction product is hydrolyzed.The mercapto compound represented by the formula (1) can be reacted with at least one cyanate compound selected from the group consisting of polyisocyanate compounds, polyisothiocyanate compounds and isocyanate-group-containing isothiocyanate compounds to form a sulfur-containing urethane resin lens made of the resin is colorless and transparent, has high refractive index and low dispersion characteristics, and is excellent especially in heat resistance.
摘要翻译：通过在无机酸存在下硫脲与下式（2）表示的化合物反应得到下式（1）表示的巯基化合物：（*化学结构*）（1）：（*化学式结构*）（2）其中X表示羟基或氯或溴原子，然后加入碱使反应混合物碱化，使反应产物水解。由式（1）表示的巯基化合物可以与至少一种选自多异氰酸酯化合物，多异硫氰酸酯化合物和含异氰酸酯基的异硫氰酸酯化合物的氰酸酯化合物反应，形成含硫聚氨酯树脂透镜树脂是无色透明的，具有高折射率和低分散特性，特别是耐热性优异。

77. 发明授权

US08680295B2 Process for producing bis(thietanylthio)dithiastannolane 有权
标题翻译：双（硫杂环丁基硫基）二硫杂锡烷的制备方法
公开(公告)号：US08680295B2
公开(公告)日：2014-03-25
申请号：US13452038
申请日：2012-04-20
申请人： Masakazu Murakami , Tomoyuki Ando , Seiichi Kobayashi
发明人： Masakazu Murakami , Tomoyuki Ando , Seiichi Kobayashi
IPC分类号： C07D327/02
CPC分类号： C08G75/06 , C08L81/02 , G02B1/041
摘要： A process for producing bis(thietanylthio)dithiastannolane of the following formula: involving the reaction of tetrakis(thietanylthio)tin having the following formula: with 1,2-ethandiethiol.
摘要翻译：制备下式的双（硫杂环丁基硫代）二硫杂锡烷的方法：涉及具有下式的四（硫杂环丁基硫代）锡与1,2-乙二醇的反应。

78. 发明授权

US08637633B2 Polymerizable composition, and resin and optical part using the same 有权
标题翻译：可聚合组合物，以及使用其的树脂和光学部件
公开(公告)号：US08637633B2
公开(公告)日：2014-01-28
申请号：US13611773
申请日：2012-09-12
申请人： Mitsuo Nakamura , Hiroshi Naruse , Atsuo Otsuji , Shinichi Usugi , Masao Imai , Hidetoshi Hayashi , Osamu Kohgo , Hideki Yamamoto , Seiichi Kobayashi
发明人： Mitsuo Nakamura , Hiroshi Naruse , Atsuo Otsuji , Shinichi Usugi , Masao Imai , Hidetoshi Hayashi , Osamu Kohgo , Hideki Yamamoto , Seiichi Kobayashi
IPC分类号： C08G75/04
CPC分类号： C08G75/06 , C08G75/04 , C08G75/08 , C08L81/02 , G02B1/04 , C08L81/00
摘要： A polymerizable composition including a compound represented by following General Formula (1): (in Formula (1), M represents a metal atom; X1 and X2 each independently represents a sulfur atom or an oxygen atom; R1 represents a divalent organic group; m represents an integer of 0 or 1 or greater; p represents an integer of 1 to n; n represents a valence of a metal atom M; and Y's each independently represents an inorganic or organic residue, where when n−p is 2 or greater, Y's may be bonded to each other to form a ring containing a metal atom M), a thiol compound and an episulfide compound.
摘要翻译：一种包含由以下通式（1）表示的化合物的可聚合组合物：（式（1）中，M表示金属原子; X1和X2各自独立地表示硫原子或氧原子; R1表示二价有机基团; m 表示0或1以上的整数，p表示1〜n的整数，n表示金属原子M的化合价，Y表示各自独立地表示无机或有机残基，np为2以上时，Y可以彼此键合形成含有金属原子M），硫醇化合物和环硫化合物的环。

79. 发明授权

US08586695B2 Polymerization catalyst for polythiourethane optical material, polymerizable composition containing the same, polythiourethane resin obtained from the composition, and process for producing the resin 有权
标题翻译：聚硫氨酯类光学材料用聚合催化剂，含有它们的聚合性组合物，由该组合物得到的聚硫氨酯树脂，以及该树脂的制造方法
公开(公告)号：US08586695B2
公开(公告)日：2013-11-19
申请号：US12948988
申请日：2010-11-18
申请人： Nobuo Kawato , Masanori Iwazumi , Hidetoshi Hayashi , Seiichi Kobayashi
发明人： Nobuo Kawato , Masanori Iwazumi , Hidetoshi Hayashi , Seiichi Kobayashi
IPC分类号： C08G18/00
CPC分类号： C08G18/3876 , C08G18/1875 , C08G18/757 , C08G18/7642 , G02B1/04 , Y10T428/31551 , C08L75/04 , C08L81/00
摘要： By using an amine hydrochloride represented by the formula (1) as a catalyst, a polythiourethane resin which is suitably used for a transparent resin for optical use, can be obtained without using an organotin compound which has been conventionally used as a catalyst for polythiourethane resins and without being affected by the acidity of an additive: wherein R1, R2 and R3 independently represent a monovalent or higher valent linear aliphatic, branched aliphatic, cyclic aliphatic or aromatic organic residue which may have a hydroxyl group or an amino group; and R1, R2 and R3 may be arbitrarily bonded to each other to form a ring.
摘要翻译：通过使用由式（1）表示的胺盐酸盐作为催化剂，可以在不使用常规用作聚硫氨酯树脂的催化剂的有机锡化合物的情况下获得适合用于光学用透明树脂的聚硫氨酯树脂并且不受添加剂的酸度的影响：其中R1，R2和R3独立地表示可以具有羟基或氨基的一价或更高价的直链脂族，支链脂族，环状脂族或芳族有机残基; 并且R 1，R 2和R 3可以彼此任意地键合形成环。

80. 发明授权

US08394891B2 Additive for polymerizable composition, polymerizable composition containing the same and use of the polymerizable composition 有权
标题翻译：可聚合组合物的添加剂，含有它们的可聚合组合物和可聚合组合物的用途
公开(公告)号：US08394891B2
公开(公告)日：2013-03-12
申请号：US12811713
申请日：2008-12-11
申请人： Tomoyuki Ando , Seiichi Kobayashi
发明人： Tomoyuki Ando , Seiichi Kobayashi
IPC分类号： C08K5/37 , C07F9/90 , C07F7/22
CPC分类号： C07F7/003 , C07C321/14 , C07F7/30 , C08K5/372 , C08L63/00 , G02B1/041 , C08L75/04 , C08L81/00
摘要： The additive for a polymerizable composition according to the present invention contains a compound represented by the general formula (a). In the general formula (a), R represents a saturated hydrocarbon group having 1 to 3 carbon atoms. M represents Sn, Sb, Bi, or Ge. m represents 0 or 1. R and M are not directly bonded when m is 0. n represents an integer of 1 to 3. X represents a monovalent linking group, and a plurality of X may be the same as or different from each other. When two or more linking groups X are bonded with the metal atom M, the linking groups X may combine together to form a ring.
摘要翻译：根据本发明的可聚合组合物的添加剂含有通式（a）表示的化合物。在通式（a）中，R表示碳原子数1〜3的饱和烃基。 M表示Sn，Sb，Bi或Ge。 m表示0或1.当m为0时，R和M不直接键合.n表示1〜3的整数.X表示一价连接基，多个X可以相同也可以不同。当两个或多个连接基团X与金属原子M键合时，连接基团X可以结合在一起形成环。

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