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71. 发明授权

US07067306B2 Device containing cytophilic islands that adhere cells separated by cytophobic regions 失效
标题翻译：包含细胞吸附岛的装置，其附着由细胞疏植区域分离的细胞
公开(公告)号：US07067306B2
公开(公告)日：2006-06-27
申请号：US10032280
申请日：2001-12-21
申请人： Rahul Singhvi , Amit Kumar , George M. Whitesides , Donald E. Ingber , Gabriel P. Lopez , Daniel I. C. Wang , Gregory N. Stephanopoulos
发明人： Rahul Singhvi , Amit Kumar , George M. Whitesides , Donald E. Ingber , Gabriel P. Lopez , Daniel I. C. Wang , Gregory N. Stephanopoulos
IPC分类号： C12Q1/02 , C12Q1/04 , C12N11/02 , C12N11/08
CPC分类号： C12N1/00 , B01J19/0046 , B01J2219/00382 , B01J2219/00385 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B81B2201/0214 , B81C1/00206 , B81C2201/034 , B82Y5/00 , B82Y30/00 , C12N5/0068 , C12N5/067 , C12N2535/10 , C12Q1/02 , C40B60/14
摘要： The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The islands or the regions or both may be formed of a self-assembled monolayer (SAM).
摘要翻译：本发明提供一种用于将细胞粘附在特定和预定位置的装置以及相关方法。该装置包括限定表面的板和多个细胞亲和岛，其附着细胞，由细胞不粘附的细胞渗透区隔离，与细胞色素岛邻接。岛或区域或两者可以由自组装单层（SAM）形成。

72. 发明授权

US06747285B2 Optical modulator/detector based on reconfigurable diffraction grating 有权
$Optical modulator/detector based on reconfigurable diffraction grating$
标题翻译：基于可重构衍射光栅的光学调制器/检测器
公开(公告)号：US06747285B2
公开(公告)日：2004-06-08
申请号：US10003033
申请日：2001-11-01
申请人： Olivier J. A. Schueller , David C. Duffy , John A. Rogers , Scott T. Brittain , George M. Whitesides
发明人： Olivier J. A. Schueller , David C. Duffy , John A. Rogers , Scott T. Brittain , George M. Whitesides
IPC分类号： G01N1506
CPC分类号： B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L2200/0689 , B01L2300/0654 , B01L2300/0861 , B01L2300/123 , B01L2400/0418 , G01N21/45 , G01N21/4788 , Y10T428/24562 , Y10T428/2457 , Y10T428/24744 , Y10T428/31663
摘要： A system is provided for positioning separate portions of a sample in elongate, parallel channels of a sample chamber and for irradiating a sample in the chamber to create a diffraction pattern where the sample and chamber differ in refractive index. The system also can measure absorption of electromagnetic radiation by a sample in the chamber, and can measure the absorption simultaneously with measurement of diffraction by the sample.
摘要翻译：提供了一种用于将样品的分离部分定位在样品室的细长平行通道中并用于在室中照射样品以产生样品和室的折射率不同的衍射图案的系统。该系统还可以测量室内样品对电磁辐射的吸收，并可以通过样品的衍射测量同时测量吸收。

73. 发明授权

US06716378B2 Method for forming hierarchically ordered porous oxides 失效
标题翻译：形成层状有序多孔氧化物的方法
公开(公告)号：US06716378B2
公开(公告)日：2004-04-06
申请号：US10145658
申请日：2002-05-14
申请人： Peidong Yang , Tao Deng , George M. Whitesides , Galen Stucky , Dongyaun Zhao , Bradley Chmelka , David Pine , Pingyun Feng
发明人： Peidong Yang , Tao Deng , George M. Whitesides , Galen Stucky , Dongyaun Zhao , Bradley Chmelka , David Pine , Pingyun Feng
IPC分类号： B29C6500
CPC分类号： C04B35/622 , B82Y30/00 , C04B35/624 , C04B38/0051 , C04B2111/00405 , C04B35/01 , C04B38/0045
摘要： A low-cost, efficient method of preparing hierarchically ordered structures by filling a mold with a self-assembling mixture of hydrolyzed inorganic species and amphiphilic block copolymers and applying pressure to the mixture. Polymerization of the inorganic species within the mixture results in a mesoscopically structured material having molded features. A mesoporous material can be produced by subsequent thermal removal of the copolymers.
摘要翻译：通过用水解无机物质和两亲性嵌段共聚物的自组装混合物填充模具来制备分层结构的低成本，有效的方法，并向混合物施加压力。混合物内的无机物质的聚合导致具有成型特征的中视结构材料。可以通过随后热去除共聚物来制备介孔材料。

74. 发明授权

US06660192B1 Molded waveguides 有权
标题翻译：模制波导
公开(公告)号：US06660192B1
公开(公告)日：2003-12-09
申请号：US09634201
申请日：2000-08-09
申请人： Enoch Kim , Younan Xia , Milan Mrksich , Rebecca J. Jackman , Xiao-Mei Zhao , Stephen P. Smith , Mara G. Prentiss , George M. Whitesides , Christian Marzolin
发明人： Enoch Kim , Younan Xia , Milan Mrksich , Rebecca J. Jackman , Xiao-Mei Zhao , Stephen P. Smith , Mara G. Prentiss , George M. Whitesides , Christian Marzolin
IPC分类号： B29D1100
CPC分类号： B81C1/00206 , A61K47/6957 , B01J19/0046 , B01J2219/00382 , B01J2219/00416 , B01J2219/0043 , B01J2219/00466 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00713 , B29C31/04 , B29C33/42 , B29C37/0053 , B29C39/24 , B29C43/021 , B29C67/246 , B29D11/00346 , B29D11/00663 , B29K2105/0002 , B29L2011/0016 , B81B2201/0214 , B81C1/00031 , B81C99/0085 , B81C2201/034 , B82Y30/00 , C40B60/14 , G01N21/7703 , G01N2021/7776 , G02B6/138 , H05K3/0079 , H05K3/061
摘要： Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraris, etc. can be made. Differences in refractive index of waveguide and cladding can be created by subjecting the waveguide and cladding, made of indentical prepolymeric material, to different polymerization or cross-linking conditions. Interferometers are defined by coupling arrays of waveguides, where coupling can be controlled by altering the difference in refractive index between cladding and waveguide at any desired location of the array. Alteration and refractive index can be created photochemically, chemically, or the like. Sensors also are disclosed, including biochemical sensors.
摘要翻译：化学或生物化学活性剂或其它物质通过提供具有轮廓表面的微胶体并在基底表面上形成结构的化学或生物化学活性剂或流体前体而在基底表面上图案化。化学或生物化学活性剂或流体前体也可以从敷料器中的凹陷转移到基底表面。衬底表面可以是平面的或非平面的。聚合物结构，无机陶瓷和盐等的流体前体可用于在表面形成图案化聚合物制品，无机盐和陶瓷，反应离子蚀刻掩模等。制品可以形成为包括横向尺寸小于约1毫米或更小的部分的图案。涂抹器的压痕图案可以用于将单独的，不同的化学或生物化学活性剂或流体前体转移到基底表面的分离的，分离的区域。可以制作波导阵列，组合化学或生化图谱等。波导和包层的折射率差异可以通过将由凹凸预聚物材料制成的波导和包层进行不同的聚合或交联条件来产生。干涉仪通过耦合波导阵列来定义，其中可以通过改变阵列的任何所需位置处的包层和波导之间的折射率差来控制耦合。改变和折射率可以通过光化学，化学等方式产生。还公开了传感器，包括生化传感器。

75. 发明授权

US06416762B1 Anti-picornaviral ligands via a combinatorial computational and synthetic approach 失效
标题翻译：通过组合计算和合成方法的抗小RNA病毒配体
公开(公告)号：US06416762B1
公开(公告)日：2002-07-09
申请号：US09210282
申请日：1998-12-11
申请人： Diane M. Joseph-McCarthy , Lyle D. Isaacs , George M. Whitesides , Martin Karplus , James M. Hogle , James Li-wen Cheh
发明人： Diane M. Joseph-McCarthy , Lyle D. Isaacs , George M. Whitesides , Martin Karplus , James M. Hogle , James Li-wen Cheh
IPC分类号： A61K39125
CPC分类号： A61K47/6901 , Y10T436/14 , Y10T436/141111 , Y10T436/147777
摘要： The present invention provides structure-based combinatorial libraries of compounds containing the functional group minima of picornaviruses including poliovirus and rhinovirus. The libraries can be used to screen for therapeutical antiviral compounds, e.g., anti-picornaviral capsid-binding compounds.
摘要翻译：本发明提供了包含小核糖核酸病毒（包括脊髓灰质炎病毒和鼻病毒）的功能组最小值的化合物的基于结构的组合文库。文库可以用于筛选治疗性抗病毒化合物，例如抗小RNA病毒衣壳结合化合物。

76. 发明授权

US06355198B1 Method of forming articles including waveguides via capillary micromolding and microtransfer molding 失效
标题翻译：通过毛细管微成型和微转移成型形成包括波导的制品的方法
公开(公告)号：US06355198B1
公开(公告)日：2002-03-12
申请号：US09004583
申请日：1998-01-08
申请人： Enoch Kim , Younan Xia , Milan Mrksich , Rebecca J. Jackman , Xiao-Mei Zhao , Stephen P. Smith , Mara G. Prentiss , George M. Whitesides , Christian Marzolin
发明人： Enoch Kim , Younan Xia , Milan Mrksich , Rebecca J. Jackman , Xiao-Mei Zhao , Stephen P. Smith , Mara G. Prentiss , George M. Whitesides , Christian Marzolin
IPC分类号： B29C3910
CPC分类号： B81C1/00206 , A61K47/6957 , B01J19/0046 , B01J2219/00382 , B01J2219/00416 , B01J2219/0043 , B01J2219/00466 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00713 , B29C31/04 , B29C33/42 , B29C37/0053 , B29C39/24 , B29C43/021 , B29C67/246 , B29D11/00346 , B29D11/00663 , B29K2105/0002 , B29L2011/0016 , B81B2201/0214 , B81C1/00031 , B81C99/0085 , B81C2201/034 , B82Y30/00 , C40B60/14 , G01N21/7703 , G01N2021/7776 , G02B6/138 , H05K3/0079 , H05K3/061
摘要： Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or nonplanar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraris, etc. can be made. Differences in refractive index of waveguide and cladding can be created by subjecting the waveguide and cladding, made of indentical prepolymeric material, to different polymerization or cross-linking conditions. Interferometers are defined by coupling arrays of waveguides, where coupling can be controlled by altering the difference in refractive index between cladding and waveguide at any desired location of the array. Alteration and refractive index can be created photochemically, chemically, or the like. Sensors also are disclosed, including biochemical sensors.
摘要翻译：化学或生物化学活性剂或其它物质通过提供具有轮廓表面的微胶体并在基底表面上形成结构的化学或生物化学活性剂或流体前体而在基底表面上图案化。化学或生物化学活性剂或流体前体也可以从敷料器中的凹陷转移到基底表面。衬底表面可以是平面或非平面的。聚合物结构，无机陶瓷和盐等的流体前体可用于在表面形成图案化聚合物制品，无机盐和陶瓷，反应离子蚀刻掩模等。制品可以形成为包括横向尺寸小于约1毫米或更小的部分的图案。涂抹器的压痕图案可以用于将单独的，不同的化学或生物化学活性剂或流体前体转移到基底表面的分离的，分离的区域。可以制作波导阵列，组合化学或生化图谱等。波导和包层的折射率差异可以通过将由凹凸预聚物材料制成的波导和包层进行不同的聚合或交联条件来产生。干涉仪通过耦合波导阵列来定义，其中可以通过改变阵列的任何所需位置处的包层和波导之间的折射率差来控制耦合。改变和折射率可以通过光化学，化学等方式产生。还公开了传感器，包括生化传感器。

77. 发明授权

US06180239B2 Microcontact printing on surfaces and derivative articles 失效
标题翻译：表面和衍生物品上的微接触印刷
公开(公告)号：US06180239B2
公开(公告)日：2001-01-30
申请号：US08676951
申请日：1996-07-08
申请人： George M. Whitesides , Younan Xia , James L. Wilbur , Rebecca J. Jackman , Enoch Kim , Mara G. Prentiss , Milan Mrksich , Amit Kumar , Christopher B. Gorman , Hans Biebuyck , Karl K. Berggren
发明人： George M. Whitesides , Younan Xia , James L. Wilbur , Rebecca J. Jackman , Enoch Kim , Mara G. Prentiss , Milan Mrksich , Amit Kumar , Christopher B. Gorman , Hans Biebuyck , Karl K. Berggren
IPC分类号： B32B904
CPC分类号： B05D1/283 , B01J2219/00382 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01L3/5085 , B01L3/5088 , B01L2300/0654 , B01L2300/0819 , B01L2300/0851 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C40B60/14 , G02B5/1857 , G02B6/124 , G02B6/136 , G02B2006/12102 , G02B2006/12104 , G02B2006/12107 , G03F7/0002 , G03F7/165 , H01L21/4867 , H01L21/768 , H01L24/95 , H01L2224/83192 , Y10T428/24802 , Y10T428/31504
摘要： Improved method of forming a patterned self-assembled monolayer on a surface and derivative articles are provided. According to one method, an elastomeric stamp is deformed during and/or prior to using the stamp to print a self-assembled molecular monolayer on a surface. According to another method, during monolayer printing the surface is contacted with a liquid that is immiscible with the molecular monolayer-forming species to effect controlled reactive spreading of the monolayer on the surface. Methods of printing self-assembled molecular monolayers on nonplanar surfaces and derivative articles are provided, as are methods of etching surfaces patterned with self-assembled monolayers, including methods of etching silicon. Optical elements including flexible diffraction gratings, mirrors, and lenses are provided, as are methods for forming optical devices and other articles using lithographic molding. A method for controlling the shape of a liquid on the surface of an article is provided, involving applying the liquid to a self-assembled monolayer on the surface, and controlling the electrical potential of the surface.
摘要翻译：提供了在表面和衍生物品上形成图案化自组装单层的改进方法。根据一种方法，弹性印模在使用印模期间和/或之前变形，以在表面上印刷自组装分子单层。根据另一种方法，在单层印刷过程中，表面与与分子单层形成物质不混溶的液体接触，以实现单层在表面上的受控的反应性扩散。提供了在非平面表面和衍生物上印刷自组装分子单层的方法，以及用自组装单层蚀刻表面的方法，包括蚀刻硅的方法。提供包括柔性衍射光栅，反射镜和透镜的光学元件，以及用于使用光刻成型形成光学器件和其它制品的方法。提供了一种用于控制制品表面上的液体形状的方法，包括将液体施加到表面上的自组装单层，并控制表面的电位。

78. 发明授权

US6140138A Electrochemiluminescent metal chelates and means for detection 失效
标题翻译：电化学发光金属螯合物和检测手段
公开(公告)号：US6140138A
公开(公告)日：2000-10-31
申请号：US238224
申请日：1994-05-04
申请人： Allen J. Bard , George M. Whitesides
发明人： Allen J. Bard , George M. Whitesides
IPC分类号： C07F15/00 , G01N33/533 , G01N33/542 , G01N21/76 , G01N31/16
CPC分类号： C07F15/0053 , C07F15/0026 , G01N33/533 , Y10S436/80 , Y10S436/805 , Y10S436/806 , Y10S436/904 , Y10S436/905
摘要： A chemical moiety is disclosed which comprises a chemical, biochemical, or biological substance attached to one or more electrochemiluminescent organometallic compounds. In a preferred embodiment of the invention the substance is attached to one or more ruthenium-containing or osmium-containing luminescent organometallic compounds. Methods are disclosed for detecting low concentrations of the chemical moiety using chemiluminescent, electrochemiluminescent, and photoluminescent means. Compounds are disclosed which are useful for labeling substances of interest with ruthenium-containing and osmium-containing labels or other electrochemiluminescent labels. These labeled substances are useful in methods provided for detecting and quantifying analytes of interest in binding assays and competitive binding assays. The labeled substances are of particular use in homogeneous binding assays. These methods form the bases for systems designed to enable the rapid, efficient, and sensitive determination of a broad array of chemical, biochemical, and biological materials of interest.
摘要翻译：公开了一种化学部分，其包含与一种或多种电化学发光有机金属化合物连接的化学，生物化学或生物物质。在本发明的一个优选实施方案中，该物质与一种或多种含钌或含锇的发光有机金属化合物连接。公开了使用化学发光，电化学发光和光致发光方法检测化学部分的低浓度的方法。公开了可用于用含钌和含锇标记物或其他电化学发光标记物标记物质的化合物。这些标记的物质可用于检测和定量结合测定和竞争性结合测定中感兴趣的分析物的方法。标记物质在均一结合试验中特别有用。这些方法形成了旨在实现快速，有效和敏感地确定所需感兴趣的化学，生物化学和生物材料的广泛系统的系统的基础。

79. 发明授权

US5925379A Interpenetrating polymer networks for sequestration of bile acids 失效
标题翻译：用于螯合胆汁酸的互穿聚合物网络
公开(公告)号：US5925379A
公开(公告)日：1999-07-20
申请号：US826197
申请日：1997-03-27
申请人： W. Harry Mandeville, III , Stephen Randall Holmes-Farley , Thomas X. Neenan , George M. Whitesides
发明人： W. Harry Mandeville, III , Stephen Randall Holmes-Farley , Thomas X. Neenan , George M. Whitesides
IPC分类号： A61K31/74 , A61K31/785 , A61K9/10 , A61K47/32
CPC分类号： A61K31/74 , A61K31/785 , Y10S514/824 , Y10S525/903
摘要： The present invention relates to a method for removing bile salts from a patient, comprising the step of administering to the patient a therapeutically effective amount of a polymer network composition comprising a cationic polymer. In one embodiment, the polymer network is an interpenetrating polymer network. In another embodiment, the polymer network is a semi-interpenetrating polymer network.
摘要翻译：本发明涉及一种从患者中除去胆汁盐的方法，包括向患者施用治疗有效量的包含阳离子聚合物的聚合物网络组合物的步骤。在一个实施方案中，聚合物网络是互穿聚合物网络。在另一个实施方案中，聚合物网络是半互穿聚合物网络。

80. 发明授权

US5731147A Luminescent metal chelate labels and means for detection 失效
标题翻译：发光金属螯合物标签和检测手段
公开(公告)号：US5731147A
公开(公告)日：1998-03-24
申请号：US474760
申请日：1995-06-07
申请人： Allen J. Bard , George M. Whitesides
发明人： Allen J. Bard , George M. Whitesides
IPC分类号： C07F15/00 , G01N33/533 , G01N33/532
CPC分类号： C07F15/0053 , C07F15/0026 , G01N33/533 , Y10S436/80 , Y10S436/805 , Y10S436/806 , Y10S436/904 , Y10S436/905
摘要： A chemical moiety is disclosed which comprises a chemical, biochemicals, or biological substance attached to one or more electrochemiluminescent organometallic compounds. In a preferred embodiment of the invention the substance is attached to one or more ruthenium-containing or osmium-containing luminescent organo-metallic compounds. Methods are disclosed for detecting low concentrations of the chemical moiety using chemiluminescent, electrochemiluminescent, and photo-luminescent means. Compounds are disclosed which are useful for labeling substances of interest with ruthenium-containing and osmium-containing labels or other electrochemiluminescent labels. These labeled substances are useful in methods provided for detecting and quantifying analytes of interest in binding assays and competitive binding assays. The labeled substances are of particular use in homogeneous binding assays. These methods form the bases for systems designed to enable the rapid, efficient, and sensitive determination of a broad array of chemical, biochemical, and biological materials of interest.
摘要翻译：公开了一种化学部分，其包含与一种或多种电化学发光有机金属化合物连接的化学，生物化学或生物物质。在本发明的一个优选实施方案中，该物质与一种或多种含钌或含锇的发光有机金属化合物连接。公开了使用化学发光，电化学发光和光致发光方法检测化学部分的低浓度的方法。公开了可用于用含钌和含锇标记物或其他电化学发光标记物标记物质的化合物。这些标记的物质可用于检测和定量结合测定和竞争性结合测定中感兴趣的分析物的方法。标记物质在均一结合试验中特别有用。这些方法形成了旨在实现快速，有效和敏感地确定所需感兴趣的化学，生物化学和生物材料的广泛系统的系统的基础。

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