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71. 发明申请

US20060052716A1 Delivering ablation therapy in a heart chamber 失效
标题翻译：在心室进行消融治疗
公开(公告)号：US20060052716A1
公开(公告)日：2006-03-09
申请号：US11265142
申请日：2005-11-03
申请人： Graydon Beatty , Jonathan Kagan , Jeffrey Budd
发明人： Graydon Beatty , Jonathan Kagan , Jeffrey Budd
IPC分类号： A61B5/05
CPC分类号： A61B5/6853 , A61B5/04085 , A61B5/042 , A61B5/0422 , A61B5/0428 , A61B5/0538 , A61B5/1076 , A61B5/6858 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B18/24 , A61B2018/00214 , A61B2018/00267 , A61B2018/00839 , A61B2560/045 , A61B2562/0209 , A61B2562/043 , A61B2562/046 , A61N1/3625 , A61N1/3702 , Y10T29/49117
摘要： A method of representing the geometry of at least a portion of a human heart chamber includes positioning a catheter in a heart chamber. The position of the catheter in the heart chamber is determined. The catheter is re-positioned and the position is re-determined a plurality of times to determine the geometry of at least a portion of the heart chamber. A three-dimensional, anatomical representation of at least a portion of the heart chamber is then created.
摘要翻译：表示人心室的至少一部分的几何形状的方法包括将导管定位在心室中。确定导管在心室中的位置。重新定位导管并且重新确定位置多次以确定心室的至少一部分的几何形状。然后产生心室的至少一部分的三维解剖学表示。

72. 发明申请

US20050177181A1 Devices and methods for treating morbid obesity 审中-公开
标题翻译：用于治疗病态肥胖的装置和方法
公开(公告)号：US20050177181A1
公开(公告)日：2005-08-11
申请号：US11025364
申请日：2004-12-29
申请人： Jonathan Kagan , Mitchell Dann , Greg Fluet , Sayeed Ikramuddin , Paul Swain , Richard Thomas , Gerard Hoffmann , Mary Wilmore
发明人： Jonathan Kagan , Mitchell Dann , Greg Fluet , Sayeed Ikramuddin , Paul Swain , Richard Thomas , Gerard Hoffmann , Mary Wilmore
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/08 , A61B17/11 , A61F2/04 , A61F5/00
CPC分类号： A61B17/00234 , A61B17/0401 , A61B17/0487 , A61B17/06166 , A61B17/1114 , A61B2017/00004 , A61B2017/00296 , A61B2017/00876 , A61B2017/00991 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0496 , A61F2/04 , A61F2/848 , A61F5/0076 , A61F5/0086
摘要： The present invention provides devices and methods for attachment of an implanted device, such as an artificial stoma device, a gastrointestinal sleeve device or an attachment cuff, within a patient's digestive tract for treatment of obesity. Special surgical fasteners provide a lasting and durable attachment to the gastrointestinal tissue without causing excessive pressure that could result in tissue erosion and detachment of the implanted device. Fastener delivery devices that facilitate peroral placement and deployment of fasteners and secondary devices are also provided. Also described are implantable devices and attachment means that avoid causing excessive pressure within the tissue by having compliance that is compatible with the gastrointestinal tissues where it is attached.
摘要翻译：本发明提供了用于在患者的消化道内将植入装置（例如人工造口装置，胃肠套筒装置或附件袖带）附接以用于治疗肥胖的装置和方法。特殊的外科紧固件提供持久且持久的附着到胃肠道组织，而不会引起可能导致植入装置的组织侵蚀和脱离的过大的压力。还提供了促进紧固件和辅助装置的口腔放置和部署的紧固件输送装置。还描述了可植入装置和附接装置，其通过具有与其所附接的胃肠组织相容的顺应性来避免在组织内引起过大的压力。

73. 发明授权

US5810807A Sphincterotome with deflectable cutting plane and method of using the same 失效
标题翻译：具有可偏转切割平面的括约肌切开术及其使用方法
公开(公告)号：US5810807A
公开(公告)日：1998-09-22
申请号：US732092
申请日：1996-10-15
申请人： Robert A. Ganz , Jonathan Kagan , Ricci D. Smelser , Brian D. Zelickson , Robert D. Mackie
发明人： Robert A. Ganz , Jonathan Kagan , Ricci D. Smelser , Brian D. Zelickson , Robert D. Mackie
IPC分类号： A61B18/14 , A61B17/36
CPC分类号： A61B18/1492 , A61B2018/00553 , A61B2018/00916
摘要： A sphincterotome adapted to be used in the lumen of an endoscope for cutting a sphincter in a patient's body using a cutting wire energized by an electrosurgical unit. The sphincterotome has a distal end segment and cutting plane orienting mechanism extending through the length of a sphincterotome tubular body between a handle assembly at the proximal end of the sphincterotome body and a distal end segment thereof for shifting the cutting plane laterally with respect to the longitudinal axis of the sphincterotome tubular body exiting the endoscope lumen. The lateral shift is in at least one lateral direction from an un-shifted position of the cutting plane with respect to the longitudinal axis whereby in use during a sphincterotomy, the cutting wire may be oriented into alignment with a particular feature of the sphincter, e.g. the twelve o'clock position of the sphincter of Oddi and papilla of Vater, without having to reposition the endoscope and/or withdraw and reposition the sphincterotome in the endoscope lumen.
摘要翻译：一种适于在内窥镜的内腔中使用的切口切割器，其使用由电外科单元激励的切割线来切割患者体内的括约肌。括约肌切开机具有远端段和切割平面定向机构，其延伸穿过括约肌切开管体的长度，在括约肌切开体本体的近端处的手柄组件和其远端段之间，用于相对于纵向方向横向移动切割平面离开内窥镜腔的括约肌切断管管体的轴线。横向移位在切割平面相对于纵向轴线的未偏移位置的至少一个横向方向上，从而在括约肌切开术期间的使用中，切割线可以定向成与括约肌的特定特征对准，例如， Oddi括约肌和Vater乳头的十二点钟位置，而不必重新定位内窥镜和/或撤回和重新定位内窥镜腔内的括约肌切开术。

74. 发明授权

US5795331A Balloon catheter for occluding aneurysms of branch vessels 失效
标题翻译：用于闭塞分支血管动脉瘤的气囊导管
公开(公告)号：US5795331A
公开(公告)日：1998-08-18
申请号：US148374
申请日：1994-01-24
申请人： Andrew H. Cragg , Jonathan Kagan
发明人： Andrew H. Cragg , Jonathan Kagan
IPC分类号： A61M25/00 , A61B17/00 , A61B17/12 , A61F2/958 , A61M29/00 , A61M31/00
CPC分类号： A61M25/1002 , A61B17/12022 , A61B17/12036 , A61B17/1204 , A61B17/12113 , A61B17/12136 , A61B17/12186 , A61B17/00491 , A61M2025/105 , A61M2025/1052 , A61M2025/1072
摘要： A method and apparatus for delivering occluding agents through an opening in a blood vessel wall and into an aneurysm chamber or a branch vessel by introducing a balloon catheter, inflating the balloon to seal the blood vessel lumen around the vessel opening, and delivering the occluding agent through the opening. The inflation of the balloon positions an exit port laterally in the vessel in alignment with the vessel opening for delivering of the occluding agent therethrough. In one embodiment, the balloon encircles the distal end segment of the catheter body, and the delivery exit port is supported on the inflated surface of the balloon. In a second embodiment, the balloon is formed and extends around a major circumferential section of the distal end segment, and the delivery exit port is formed in the remaining minor circumferential section for lateral movement into alignment with the vessel opening as the balloon fills the blood vessel on inflation. The inflated balloon maintains the occluding agent therein until it forms an occluding cast, and the balloon wall shapes the occluding cast into conformance with the blood vessel lumen. The catheter body is formed with lumens for balloon inflation/deflation, the passage over a guide wire, the delivery of the occluding agent and the venting during delivery or aspiration prior to delivery. More than one delivery exit port and associated lumen may be provided for venting during delivery and/or for the delivery of a two component occluding agent. The catheter body and the balloon are preferably formed integrally of coaxial tubes with delivery/venting lumens formed in the outer tube and a common inner lumen for inflation/deflation of the balloon, terminating in a self sealing distal valve for receiving the guide wire. Liquid occluding agents or mechanical thrombus forming devices my be delivered thereby into the aneurysm chamber or branch vessel to occlude it.
摘要翻译：一种用于通过引入球囊导管，通过血管壁中的开口输送闭塞剂并进入动脉瘤腔室或分支血管的方法和装置，使球囊膨胀以密封容器开口周围的血管腔，并输送闭塞剂通过开放。气囊的膨胀将容器中的出口端口横向定位成与容器开口对齐，用于通过其输送阻塞剂。在一个实施例中，气囊环绕导管主体的远端部分，并且输送出口支撑在气囊的充气表面上。在第二实施例中，气囊被形成并围绕远端段的主圆周部分延伸，并且输送出口形成在剩余的小圆周部分中，用于侧向移动，以随着气囊填充血液而与血管开口对准船只通货膨胀充气气囊将闭塞剂保持在其中，直到其形成闭塞的铸件，并且气囊壁使闭塞的铸件成形为与血管内腔一致。导管体形成有用于球囊充气/放气的内腔，导丝上的通道，封闭剂的输送以及在输送期间的输送或抽吸期间的排气。可以提供多于一个输送出口和相关腔，用于在递送期间和/或用于递送双组分闭塞剂时排出。导管体和气囊优选地由同轴管一体形成，其中形成在外管中的输送/排出腔和用于气囊膨胀/放气的公共内腔，终止于用于接纳导丝的自密封远端阀。液体封闭剂或机械性血栓形成装置，由此被输送到动脉瘤腔室或分支血管中以封闭它。

75. 发明授权

US5624379A Endoscopic probe with discrete rotatable tip 失效
标题翻译：具有分立旋转尖端的内窥镜探头
公开(公告)号：US5624379A
公开(公告)日：1997-04-29
申请号：US543180
申请日：1995-10-13
申请人： Robert A. Ganz , Jonathan Kagan , Brian D. Zelickson , Ricci D. Smelser
发明人： Robert A. Ganz , Jonathan Kagan , Brian D. Zelickson , Ricci D. Smelser
IPC分类号： A61B10/00 , A61B10/06 , A61B17/00 , A61B17/28 , A61B1/00
CPC分类号： A61B10/06 , A61B2017/003 , A61B2017/2905 , A61B2017/2927 , A61B2017/2929
摘要： An endoscopic probe has an elongate flexible member and a radially extending tip rotatably mounted on a remote end thereof. A wire extends through the elongate flexible member and into the tip. The wire rotates relative to the elongate flexible member to rotate the radially extending tip to any desired orientation about the axis of the elongate flexible member.
摘要翻译：内窥镜探针具有细长的柔性构件和可旋转地安装在其远端上的径向延伸的尖端。线延伸穿过细长的柔性构件并进入尖端。线相对于细长的柔性构件旋转，以将径向延伸的尖端旋转到围绕细长柔性构件的轴线的任何期望的取向。

76. 发明授权

US5297549A Endocardial mapping system 失效
标题翻译：心内膜测绘系统
公开(公告)号：US5297549A
公开(公告)日：1994-03-29
申请号：US950448
申请日：1992-09-23
申请人： Graydon E. Beatty , Jonathan Kagan , Jeffrey R. Budd
发明人： Graydon E. Beatty , Jonathan Kagan , Jeffrey R. Budd
IPC分类号： A61B5/0408 , A61B5/042 , A61B5/0428 , A61B5/053 , A61B5/04
CPC分类号： A61B5/0535 , A61B5/042 , A61B5/0422 , A61B5/0538 , A61B5/6853 , A61B5/6858 , A61B2560/045 , A61B2562/0209 , A61B2562/043 , A61B5/0428
摘要： An array of electrode sites are placed in a heart chamber. The shape of the chamber and the location of the electrodes is determined via impedance plethysmography. Electrical measurements taken from the electrode array and referenced to a surface contacting electrode is used to generate a three-dimensional map of electrical activity. A two-dimensional map of the electrical activity within the endocardial surface is also computed.
摘要翻译：电极位置阵列放置在心室中。通过阻抗体积描记法确定腔室的形状和电极的位置。使用从电极阵列获取并参考表面接触电极的电测量来产生电活动的三维图。还计算了心内膜表面内电活动的二维图。

77. 发明授权

US5026367A Laser angioplasty catheter and a method for use thereof 失效
标题翻译：激光血管成形术导管及其使用方法
公开(公告)号：US5026367A
公开(公告)日：1991-06-25
申请号：US169937
申请日：1988-03-18
申请人： Michael E. Leckrone , Jonathan Kagan , Darryl A. Knight , Larry A. Gunseor
发明人： Michael E. Leckrone , Jonathan Kagan , Darryl A. Knight , Larry A. Gunseor
IPC分类号： A61B17/00 , A61B17/22 , A61B18/00 , A61B18/24
CPC分类号： A61B18/245 , A61B2017/00154 , A61B2017/0084 , A61B2017/22054 , A61B2017/22067 , A61B2017/22069 , A61B2018/1861
摘要： The disclosure relates to a device for use in removing undesired material, e.g., an occlusion or plaque, from a duct or blood vessel within a patient's body. The device comprises a catheter adapted to be disposed within a duct and having a distal end portion with a tip and a tapered surface extending from the tip to the side of the catheter. The catheter has a lumen extending through the length thereof. The intersection of the lumen and the tapered surface forming an elongated opening. Pulsed laser energy is applied by an optical fiber extending through the lumen to the elongated openings and thereby the undesired material. An inflatable bladder is provided for positioning the distal end portion of the catheter adjacent the inner surface of the duct to position the elongated opening adjacent the undesired material to be removed. A filament extending through the catheter and connected to the distal end portion can be rotated at the proximal end of the catheter to rotatably position the distal portion thereof.
摘要翻译：本公开涉及一种用于从患者体内的管道或血管中除去不期望的材料（例如闭塞或斑块）的装置。该装置包括适于设置在管道内的导管，该导管具有具有尖端的远端部分和从尖端延伸到导管侧面的锥形表面。导管具有延伸穿过其长度的内腔。管腔和锥形表面的交点形成一个细长的开口。脉冲激光能量通过延伸穿过内腔的光纤施加到细长的开口，从而由不需要的材料施加。提供了一种可膨胀的囊，用于将导管的远端部分定位在管道的内表面附近，以将细长的开口定位成邻近待去除的不需要的材料。延伸穿过导管并连接到远端部分的细丝可以在导管的近端处旋转，以可旋转地定位其远端部分。

78. 发明授权

US09060844B2 Apparatus and methods for treatment of morbid obesity 有权
标题翻译：用于治疗病态肥胖的装置和方法
公开(公告)号：US09060844B2
公开(公告)日：2015-06-23
申请号：US10698148
申请日：2003-10-31
申请人： Jonathan Kagan , James Balliro , David Carr-Locke , Mitchell Dann , Lee Guterman , Sayeed Ikramuddin , James Leary , Richard Thomas
发明人： Jonathan Kagan , James Balliro , David Carr-Locke , Mitchell Dann , Lee Guterman , Sayeed Ikramuddin , James Leary , Richard Thomas
IPC分类号： A61M25/00 , A61F5/00 , A61F2/04
CPC分类号： A61F5/0079 , A61F2/04 , A61F5/0083 , A61F5/0086 , A61F2220/0008
摘要： Apparatus and methods are described for treatment of morbid obesity using minimally invasive techniques. The apparatus includes a system of components that may be used separately or in combination for effectively reducing stomach volume, bypassing a portion of the stomach and/or small intestines, reducing nutrient absorption in the stomach and/or small intestines and/or depositing minimally or undigested food farther than normal into the intestines, thereby stimulating intestinal responses. The components described include an artificial stoma device, a gastric sleeve device, an intestinal sleeve device, a combined gastrointestinal sleeve device and permanent and detachable attachment systems. Also described are devices for delivering and deploying the components of the system.
摘要翻译：描述了使用微创技术治疗病态肥胖症的装置和方法。该装置包括可以单独使用或组合使用以有效地减少胃体积，绕过胃和/或小肠的一部分的组件系统，减少胃和/或小肠中的营养吸收和/或最小化或未消化的食物比正常进食更远，从而刺激肠道反应。所描述的组件包括人工造口装置，胃套筒装置，肠套管装置，组合的胃肠套管装置和永久和可拆卸的附接系统。还描述了用于递送和部署系统的部件的装置。

79. 发明授权

US08603074B2 Absorbable, reduced-pressure manifolds and systems 有权
标题翻译：可吸收的减压歧管和系统
公开(公告)号：US08603074B2
公开(公告)日：2013-12-10
申请号：US12491845
申请日：2009-06-25
申请人： Jonathan Kagan
发明人： Jonathan Kagan
IPC分类号： A61M27/00
CPC分类号： A61F13/00068 , A61F2/2846 , A61F2002/30032 , A61F2013/00536 , A61F2250/003 , A61M1/0023 , A61M1/0088 , Y10T29/49826
摘要： A reduced-pressure treatment system includes an isolation device for isolating a tissue site from surrounding tissue for reduced-pressure treatment that is formed from a first material having a first bio-absorption term and at least a second material having a second and different bio-absorption term. The different materials allow the isolation device initially to function well for reduced-pressure treatment and then to experience degradation at a quicker pace which facilitates healing. In addition, a reduced-pressure manifold for treating a tissue site is presented that includes a flexible barrier member formed from a first material, which has a first bio-absorption term and formed with a first plurality of apertures; a second material, which has a second bio-absorption term, disposed within the plurality of apertures; wherein the first bio-absorption term is greater than the second bio-absorption term; and a reduced-pressure delivery member coupled to the barrier member for delivering reduced pressure to the second surface of the barrier member during reduced-pressure treatment.
摘要翻译：减压治疗系统包括隔离装置，用于从具有第一生物吸收术语的第一材料形成的减压治疗用于隔离组织部位与周围组织，并且至少具有第二和不同生物吸收术语的第二材料，吸收期。不同的材料允许隔离装置最初对减压治疗有效，然后以更快的速度体验降解，这有利于愈合。另外，提出了一种用于治疗组织部位的减压歧管，其包括由具有第一生物吸收术语并形成有第一多个孔的第一材料形成的柔性阻挡构件; 第二材料，其具有设置在所述多个孔内的第二生物吸收项; 其中所述第一生物吸收项大于所述第二生物吸收项; 以及联接到所述阻挡构件的减压输送构件，用于在减压处理期间将减压输送到所述阻挡构件的第二表面。

80. 发明授权

US08372060B2 Catheter/filament style device and methods for treatment of wounds beneath the surface of the skin 有权
标题翻译：用于治疗皮肤表面下面的伤口的导管/细丝样式装置和方法
公开(公告)号：US08372060B2
公开(公告)日：2013-02-12
申请号：US12465462
申请日：2009-05-13
申请人： Jonathan Kagan
发明人： Jonathan Kagan
IPC分类号： A61M1/00
CPC分类号： A61B17/12022 , A61B17/12099 , A61B17/1214 , A61B17/12186 , A61B2017/00004 , A61B2017/1205 , A61B2017/22038
摘要： A reduced pressure treatment system includes a filament delivery conduit having a distal end positioned at a subcutaneous tissue site of a patient and a proximal end positioned extracorporeal to the patient. A continuous filament is positioned in the filament delivery conduit such that one end of the continuous filament extends from the proximal end of the filament delivery conduit and another end of the continuous filament extends from the distal end of the filament delivery conduit. The continuous filament forms a filament mass adjacent the tissue site. A reduced pressure delivery conduit is adapted to fluidly communicate with a reduced pressure source and the filaments mass to deliver a reduced pressure to the tissue site through the filament mass.
摘要翻译：减压治疗系统包括细丝输送导管，其具有位于患者的皮下组织部位的远端以及定位在患者体外的近端。连续细丝被定位在细丝输送导管中，使得连续细丝的一端从细丝输送导管的近端延伸，连续细丝的另一端从细丝输送导管的远端延伸。连续细丝在组织部位附近形成丝质量。减压输送导管适于与减压源和细丝质量流体连通，以通过细丝团向组织部位递送减压。

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