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    • 72. 发明申请
    • Substituted sulfonylaminoarylmethyl cyclopropanecarboxamide as VR1 receptor antagonists
    • US20060211741A1
    • 2006-09-21
    • US11384127
    • 2006-03-17
    • Takeshi HanazawaMisato HiranoTadashi InoueSatoshi NagayamaKazunari NakaoYuji ShishidoHirotaka Tanaka
    • Takeshi HanazawaMisato HiranoTadashi InoueSatoshi NagayamaKazunari NakaoYuji ShishidoHirotaka Tanaka
    • A61K31/4412A61K31/18C07D213/75
    • C07C61/28C07C61/40C07C311/08C07C317/44C07C323/62C07C2601/02C07D213/26C07D213/56C07D213/74C07D213/76
    • This invention provides a compound of the formula (I): wherein A and B are independently CR12 or N; D and E are each independently CR9 or N; R1 represents (C1-C6)alkyl; R2 represents hydrogen, halogen, hydroxy, (C1-C6)alkyl, halo(C1-C6)alkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy or (C1-C6)alkoxy-(C1-C6)alkyl; R3, R4, R5, R6, R10 and R11 each independently represent hydrogen, halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, hydroxy(C1-C6)alkyl or (C1-C6)alkoxy-(C1-C6)alkyl; or R3 and R4 are taken together with the carbon atom to which they are attached to form a 3- to 7-membered carbocyclic ring or heterocyclic ring in which one or two non-adjacent carbon atoms are optionally replaced by an oxygen atom, a sulfur atom or NH; R7 and R9 each independently represent hydrogen, halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy, hydroxy(C1-C6)alkoxy, (C1-C6)alkoxy-(C1-C6)alkyl, (C1-C6)alkoxy-(C1-C6)alkoxy, (C1-C6)alkylthio, (C1-C6)alkylsulfinyl, (C1-C6)alkylsulfonyl, NH2, [(C1-C6)alkyl]NH—, [(C1-C6)alkyl]2N—, H2N—(C1-C6)alkoxy, (C1-C6)alkyl-NH—(C1-C6)alkoxy, [(C1-C6)alkyl]2N(C1-C6)alkoxy; H2N—(C1-C6)alkoxy-(C1-C6)alkyl, (C1C6)alkyl-NH—(C1-C6)alkoxy-(C1-C6)alkyl, [(C1-C6)alkyl]2N(C1-C6)alkoxy-(C1-C6)alkyl or 5- or 6-membered heterocyclic ring containing at least one nitrogen atom; R8 represents halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy, hydroxy(C1-C6)alkoxy, (C1-C6)alkoxy-(C1-C6)alkyl, (C1-C6)alkoxy-(C1-C6)alkoxy, halo(C1-C6)alkylsulfonyl, halo(C1-C6)alkylsulfinyl, halo(C1-C6)alkoxy, halo(C1-C6)alkylthio, [(C1-C6)alkyl]NH— or [(C1-C6)alkyl]2N—; or R7 and R8, when E is CR9, are taken together with the carbon atoms to which they are attached form a 5-8 membered carbocyclic or heterocyclic ring, in which one or two non-adjacent carbon atoms are optionally replaced by oxygen, sulfur, N or NH groups, wherein the carbocyclic ring or the heterocyclic ring is unsubstituted or substituted with one or more substituents each independently selected from the group consisting of hydroxy, (C1-C6)alkyl, (C1-C6)alkoxy and hydroxy(C1-C6)alkyl; and R12 represents hydrogen, halogen, (C1-C6)alkyl or hydroxy(C1-C6)alkyl; or a pharmaceutically acceptable salt or solvate thereof. These compounds are useful for the treatment of disease conditions caused by overactivation of VR1 receptor such of pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
    • 75. 发明授权
    • Disk drive
    • 磁盘驱动器
    • US06314077B1
    • 2001-11-06
    • US09295385
    • 1999-04-21
    • Yuji ShishidoTakashi Mochida
    • Yuji ShishidoTakashi Mochida
    • G11B1700
    • G11B33/08
    • A disk drive includes a drive unit including a mechanical chassis, a spindle motor for rotating a turn table on which a recording medium disk is supported, and a pickup movable in the radial direction of the recording medium disk supported by the turn table for reproducing and/or recording signals from and/or in the recording medium disk; a base chassis for supporting the drive unit via an elastic body; a self-aligning mechanism including a holder rotatable together with a rotor portion of the spindle motor and a balance member movable in the holder; and a counter weight disposed at a position suitable to allow the center of gravity of the drive unit to be located in conformity to or in proximity to the rotational center of the spindle motor.
    • 磁盘驱动器包括一个驱动单元,它包括一个机械底盘,一个主轴电机,用于旋转支撑记录介质盘的转台,以及一个可在由转盘支撑的记录介质盘的径向上移动的拾取器,用于再现; /或记录来自和/或记录介质盘的信号; 底座,用于经由弹性体支承驱动单元; 自对准机构,其包括与所述主轴电动机的转子部分一起旋转的保持器和可在所述保持器中移动的平衡构件; 以及设置在适于允许驱动单元的重心位于与主轴电动机的旋转中心一致或接近的位置处的配重。
    • 76. 发明授权
    • Substituted azaheterocyclecarboxylic acid
    • 取代的氮杂环羧酸
    • US6083943A
    • 2000-07-04
    • US280403
    • 1999-03-19
    • Masaya IkunakaYuji ShishidoMasami Nakane
    • Masaya IkunakaYuji ShishidoMasami Nakane
    • A61K31/40A61K31/445C07D207/14C07D211/56
    • A61K31/40A61K31/445C07D207/14C07D211/56
    • A compound of the chemical formula (I) and its pharmaceutically acceptable salt: ##STR1## wherein Y is C.sub.2 -C.sub.4 alkylene; Z is a valence bond or C.sub.1 -C.sub.6 alkylene; R.sup.1 is substituted or unsubstituted aryl (e.g., phenyl and naphthyl) or heteroaryl (e.g., thienyl and furyl); R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl; R.sup.3 is hydrogen, hydroxy or the like; R.sup.4 is substituted or unsubstituted benzyl or the like. Typical examples are (2S*,3S*,4R*,5R*)-4-Carboxy-3-[N-(5-Isopropyl-2-methoxy-benzyl)amino]-5-methyl-2-phenylpyrrolidine and (2S*,3S*,5S*)-5-Carboxy-3-[N-(2-methoxy-5-trifluoromethoxybenzyl)amino]-2-phenylpiperidine. The novel substituted azaheterocyclecarboxylic acids in this invention have excellent substance P antagonistic activity and are thus useful for the treatment of gastrointestinal disorders, central nervous system disorders, allergy, inflammatory diseases, asthma, pain, emesis or migraine in mammals, especially humans.
    • 化学式(I)的化合物及其药学上可接受的盐:其中Y是C 2 -C 4亚烷基; Z是价键或C1-C6亚烷基; R 1是取代或未取代的芳基(例如苯基和萘基)或杂芳基(例如噻吩基和呋喃基); R2是氢或C1-C6烷基; R3是氢,羟基等; R4是取代或未取代的苄基等。 典型实例是(2S *,3S *,4R *,5R *)-4-羧基-3- [N-(5-异丙基-2-甲氧基 - 苄基)氨基] -5-甲基-2-苯基吡咯烷和(2S *,3S *,5S *)-5-羧基-3- [N-(2-甲氧基-5-三氟甲氧基苄基)氨基] -2-苯基哌啶。 本发明中的新型取代的氮杂环羧酸具有优异的物质P拮抗活性,因此可用于治疗哺乳动物,特别是人类的胃肠疾病,中枢神经系统疾病,变态反应,炎性疾病,哮喘,疼痛,呕吐或偏头痛。
    • 77. 发明授权
    • Spindle motor and recording medium assembly
    • 主轴电机和记录介质总成
    • US5434730A
    • 1995-07-18
    • US178937
    • 1994-01-07
    • Yuji Shishido
    • Yuji Shishido
    • G11B17/02G11B19/20G11B25/04
    • G11B19/2009G11B17/02G11B25/043
    • A spindle motor and recording medium assembly having a rotary shaft, and a rotary portion. The rotary portion includes a recording medium, a fixing member, a boss, and rotating motor elements including an annular magnet and a rotary yoke, wherein the boss secures the recording medium, wherein the rotary shaft and the boss are integrally joined together and the center of gravity of the rotary portion in a direction along the rotary shaft is positioned in a portion where the rotary shaft and the boss are connected to each other. In a preferred embodiment in which the recording medium is a hard disk, the hard disk is attached to the boss in such a position that a line running through the center of the thickness of the hard disk extends so as not to deviate from a portion where the rotary shaft and the boss are connected to each other.
    • 主轴电动机和记录介质组件,其具有旋转轴和旋转部分。 旋转部分包括记录介质,固定构件,凸台和包括环形磁体和旋转磁轭的旋转电动机元件,其中凸台固定记录介质,其中旋转轴和凸台一体地接合在一起,并且中心 沿着旋转轴的方向的旋转部分的重力位于旋转轴和凸台彼此连接的部分中。 在其中记录介质是硬盘的优选实施例中,硬盘以这样的位置附接到凸台,即,穿过硬盘的厚度中心的线延伸,以便不偏离其中 旋转轴和凸台彼此连接。