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71. 发明申请

US20100028948A1 METHODS OF ADMINISTERING/DOSING ANTI-RSV ANTIBODIES FOR PROPHYLAXIS AND TREATMENT 失效
标题翻译：用于预防和治疗的抗RSV抗体的方法
公开(公告)号：US20100028948A1
公开(公告)日：2010-02-04
申请号：US12476183
申请日：2009-06-01
申请人： James F. Young , Scott Koenig , Leslie S. Johnson , William D. Huse , Jeffrey D. Watkins , Herren Wu
发明人： James F. Young , Scott Koenig , Leslie S. Johnson , William D. Huse , Jeffrey D. Watkins , Herren Wu
IPC分类号： C12P21/00 , C07H21/00 , C12N15/63 , C12N5/00
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a RSV antigen, and methods using said compositions for detection or diagnosis a RSV infection.
摘要翻译：本发明包括免疫特异性结合一种或多种RSV抗原的新型抗体及其片段，以及包含所述抗体和抗体片段的组合物。本发明包括预防人类呼吸道合胞病毒（RSV）感染的方法，包括向所述人施用预防有效量的一种或多种免疫特异性结合一种或多种RSV抗原的抗体或其片段，其中一定的血清滴度为所述抗体或抗体片段在所述人受试者中实现。本发明还包括用于治疗或改善与人类RSV感染有关的症状的方法，包括向所述人施用治疗有效量的一种或多种免疫特异性结合一种或多种RSV抗原的抗体或其片段，其中一定所述抗体或抗体片段的血清滴度在所述人受试者中实现。本发明还包括包含免疫特异性结合RSV抗原的抗体或其片段的组合物，以及使用所述组合物检测或诊断RSV感染的方法。

72. 发明授权

US07435421B2 Derivatives of choline binding proteins for vaccines 失效
标题翻译：用于疫苗的胆碱结合蛋白的衍生物
公开(公告)号：US07435421B2
公开(公告)日：2008-10-14
申请号：US11062080
申请日：2005-02-18
申请人： Theresa M. Wizemann , Scott Koenig , Leslie S. Johnson
发明人： Theresa M. Wizemann , Scott Koenig , Leslie S. Johnson
IPC分类号： A61K39/00 , A61K39/38 , A61K39/02 , A61K39/085 , A61K39/09 , A61K38/00 , A61K38/16 , A01N37/18
CPC分类号： C07K14/3156 , A61K39/00
摘要： The present invention provides bacterial immunogenic agents for administration to humans and non-human animals to stimulate an immune response. It particularly relates to the vaccination of mammalian species with pneumococcal derived polypeptides that include an alpha helix but exclude a choline binding region as a mechanism for stimulating production of antibodies that protect the vaccine recipient against infection by pathogenic bacterial species. In another aspect the invention provides antibodies against such proteins and protein complexes that may be used as diagnostics and/or as protective/treatment agents for pathogenic bacterial species.
摘要翻译：本发明提供用于给予人和非人动物以刺激免疫应答的细菌免疫原性试剂。其特别涉及哺乳动物物种与肺炎球菌来源的多肽的免疫接种，包括α螺旋，但不排除胆碱结合区域，作为刺激保护疫苗接受者免受病原菌种感染的抗体产生的机制。在另一方面，本发明提供了抗这种蛋白质和蛋白质复合物的抗体，其可以用作诊断和/或作为病原菌种的保护/治疗剂。

73. 发明授权

US07122194B2 Vaccine compositions comprising Streptococcus pneumoniae polypeptides having selected structural motifs 有权
标题翻译：包含具有选定结构基序的肺炎链球菌多肽的疫苗组合物
公开(公告)号：US07122194B2
公开(公告)日：2006-10-17
申请号：US10412850
申请日：2003-04-14
申请人： Leslie S. Johnson , John E. Adamou
发明人： Leslie S. Johnson , John E. Adamou
IPC分类号： A61K39/02 , A61K49/00
CPC分类号： A61K39/092 , A61K2039/505 , C07K14/3156 , C07K16/1275
摘要： A vaccine composition is disclosed that comprises polypeptides and fragments of polypeptides containing histidine triad residues or coiled-coil regions, some of which polypeptides or fragments lie between 80 and 680 residues in length. Also disclosed are processes for preventing infection caused by S. pneumoniae comprising administering of vaccine compositions.
摘要翻译：公开了包含多肽和含有组氨酸三联体残基或螺旋卷曲区域的多肽片段的疫苗组合物，其中一些多肽或片段长度在80至680个残基之间。还公开了防止由肺炎链球菌引起的感染的方法，包括施用疫苗组合物。

74. 发明授权

US06863893B2 Derivatives of choline binding proteins for vaccines 失效
公开(公告)号：US06863893B2
公开(公告)日：2005-03-08
申请号：US10254995
申请日：2002-09-25
申请人： Theresa M. Wizemann , Scott Koenig , Leslie S. Johnson
发明人： Theresa M. Wizemann , Scott Koenig , Leslie S. Johnson
IPC分类号： C12N15/09 , A61K39/00 , A61K39/09 , A61K39/395 , A61K39/40 , A61P31/04 , A61P37/04 , C07K14/315 , C07K16/12 , A61K39/02 , A61K39/085 , C07K14/00 , A16K38/00 , A16K38/16
CPC分类号： C07K14/3156 , A61K39/00
摘要： The present invention provides bacterial immunogenic agents for administration to humans and non-human animals to stimulate an immune response. It particularly relates to the vaccination of mammalian species with pneumococcal derived polypeptides that include an alpha helix but exclude a choline binding region as a mechanism for stimulating production of antibodies that protect the vaccine recipient against infection by pathogenic bacterial species. In another aspect the invention provides antibodies against such proteins and protein complexes that may be used as diagnositics and/or as protective/treatment agents for pathogenic bacterial species.

75. 发明授权

US06855493B2 Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment 失效
公开(公告)号：US06855493B2
公开(公告)日：2005-02-15
申请号：US09996265
申请日：2001-11-28
申请人： James F. Young , Scott Koenig , Leslie S. Johnson , William D. Huse , Jeffrey D. Watkins
发明人： James F. Young , Scott Koenig , Leslie S. Johnson , William D. Huse , Jeffrey D. Watkins
IPC分类号： C07K16/10 , C12Q1/70 , A61K39/395
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a RSV antigen, and methods using said compositions for detection or diagnosis a RSV infection

76. 发明授权

US06833356B1 Pneumococcal protein homologs and fragments for vaccines 失效
标题翻译：肺炎球菌蛋白同源物和疫苗片段
公开(公告)号：US06833356B1
公开(公告)日：2004-12-21
申请号：US09645835
申请日：2000-08-25
申请人： Scott Koenig , Jon Heinrichs , Leslie S. Johnson , John E. Adamou
发明人： Scott Koenig , Jon Heinrichs , Leslie S. Johnson , John E. Adamou
IPC分类号： C07K1400
CPC分类号： C07K14/3156
摘要： The invention is directed to isolated polypeptides bearing sequence homology to the Sp36 protein found in pneumococcal organisms, such as Streptococcus pneumoniae. Polynucleotides encoding such polypeptides are also disclosed. The invention also relates to antibodies specific for the disclosed polypeptides and to uses of such antibodies in the treatment of diseases caused by staphylococci as well as group A and B streptococci. In addition, the invention relates to the use of the disclosed polypeptides in compositions and as vaccines and for prophylactic uses such as in vaccination of animals, especially humans, against a wide variety of streptococcal, staphylococcal and other diseases.
摘要翻译：本发明涉及与肺炎球菌生物体如肺炎链球菌中发现的Sp36蛋白具有序列同源性的分离的多肽。还公开了编码这种多肽的多核苷酸。本发明还涉及对于所公开的多肽具有特异性的抗体以及此类抗体用于治疗由葡萄球菌以及A和B组链球菌引起的疾病的用途。此外，本发明涉及所公开的多肽在组合物中的用途，以及作为预防用途的预防用途，例如针对各种链球菌，葡萄球菌和其它疾病的动物，特别是人类的疫苗接种。

77. 发明授权

US06689369B2 Immunogenic pneumococcal protein and vaccine compositions thereof 有权
标题翻译：免疫原性肺炎球菌蛋白及其疫苗组合物
公开(公告)号：US06689369B2
公开(公告)日：2004-02-10
申请号：US09844124
申请日：2001-04-27
申请人： Scott Koenig , Leslie S. Johnson , John E. Adamou
发明人： Scott Koenig , Leslie S. Johnson , John E. Adamou
IPC分类号： A61K3909
CPC分类号： C07K14/3156 , A61K39/00 , A61K2035/11 , A61K2039/505 , A61K2039/53
摘要： The present invention relates to novel immunogenic polypeptides, and therapeutically active fragments thereof, and vaccines, and vaccine compositions, for the prevention and treatment of streptococcal infection, especially by Streptococcus pneumoniae. The invention also relates to antibodies against the disclosed polypeptides, as well as methods of disease prevention and/or treatment.
摘要翻译：本发明涉及用于预防和治疗链球菌感染的新型免疫原性多肽及其治疗活性片段，疫苗和疫苗组合物，特别是由肺炎链球菌（Streptococcus pneumoniae）。本发明还涉及针对所公开的多肽的抗体，以及疾病预防和/或治疗的方法。

78. 发明授权

US06503511B1 Derivatives of choline binding proteins for vaccines 有权
标题翻译：用于疫苗的胆碱结合蛋白的衍生物
公开(公告)号：US06503511B1
公开(公告)日：2003-01-07
申请号：US09286981
申请日：1999-04-06
申请人： Theresa M. Wizemann , Scott Koenig , Leslie S. Johnson
发明人： Theresa M. Wizemann , Scott Koenig , Leslie S. Johnson
IPC分类号： A61K3902
CPC分类号： C07K14/3156 , A61K39/00
摘要： The present invention provides bacterial immunogenic agents for administration to humans and non-human animals to stimulate an immune response. It particularly relates to the vaccination of mammalian species with pneumococcal derived polypeptides that include an alpha helix but exclude a choline binding region as a mechanism for stimulating production of antibodies that protect the vaccine recipient against infection by pathogenic bacterial species. In another aspect the invention provides antibodies against such proteins and protein complexes that may be used as diagnositics and/or as protective/treatment agents for pathogenic bacterial species.
摘要翻译：本发明提供用于给予人和非人动物以刺激免疫应答的细菌免疫原性试剂。其特别涉及哺乳动物物种与肺炎球菌来源的多肽的免疫接种，包括α螺旋，但不排除胆碱结合区域，作为刺激保护疫苗接受者免受病原菌种感染的抗体产生的机制。在另一方面，本发明提供抗这种蛋白质和蛋白质复合物的抗体，其可以用作诊断和/或作为病原菌物种的保护/治疗剂。

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