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1. 发明授权

US5686571A Platelet aggregation inhibitors 失效
标题翻译：血小板聚集抑制剂
公开(公告)号：US5686571A
公开(公告)日：1997-11-11
申请号：US484779
申请日：1995-06-07
申请人： Robert M. Scarborough , David Lawrence Wolf , Israel F. Charo
发明人： Robert M. Scarborough , David Lawrence Wolf , Israel F. Charo
IPC分类号： A61K38/00 , A61K38/12 , A61K38/17 , A61K38/57 , C07K14/46 , C07K14/75 , C07K14/755 , C07K14/78 , A16K38/00 , C07K5/00 , C07K7/00
CPC分类号： A61K38/12 , A61K38/1703 , A61K38/57 , C07K14/46 , C07K14/75 , C07K14/755 , C07K14/78
摘要： An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K.sup.* -(G/Sar)-D wherein K.sup.* is a modified lysyl residue of the formula R.sup.1.sub.2 N(CH.sub.2).sub.4 CHNHCO-- wherein each R.sup.1 is independently H, alkyl(1-6C) or at most one R.sup.1 is R.sup.2 --C.dbd.NR.sup.3 wherein R.sup.2 is H, alkyl(1-6C), phenyl or benzyl, or is NR.sup.4.sub.2 in which each R.sup.4 is independently H or alkyl(1-6C) and R.sup.3 is H, alkyl(1-6C), phenyl or benzyl, or R.sup.2 --C.dbd.NR.sup.3 is a radical selected from the group consisting of: ##STR1## where m is an integer of 2-3, and each R.sup.5 is independently H or alkyl(1-6C); and wherein one or two (CH.sub.2) may be replaced by O or S provided said O or S is not adjacent to another heteroatom are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.
摘要翻译：描述了基于特异性受体结合筛选蛇毒用于存在或不存在血小板聚集抑制剂（PAI）的测定法。使用该测定，完成了广泛的蛇毒样品中PAIs的鉴定和表征。描述和表征了来自这些活性蛇毒中的几种的分离和纯化的PAI。另外，缺少Arg-Gly-Asp（RGD）粘附序列但含有K * - （G / Sar）-D的PAI，其中K *是式R 12 N（CH 2）4 CHNHCO-的修饰的赖氨酰残基，其中每个R 1独立地 H，烷基（1-6C）或至多一个R1是R2-C = NR3，其中R2是H，烷基（1-6C），苯基或苄基，或是NR42，其中每个R4独立地是H或烷基（1- 6C），R3是H，（1-6C）烷基，苯基或苄基，或R2-C = NR3是选自下组的基团：其中m是2-3的整数，并且每个R 5 独立地是H或（1-6C）烷基; 并且其中一个或两个（CH 2）可以被O或S替代，条件是所述O或S不与另一个杂原子相邻，并且显示出特异性抑制纤维蛋白原或血管性血友病因子与GP IIb-IIIa的结合。

2. 发明授权

US07927611B2 Compounds and methods for diagnosis and immunotherapy of tuberculosis 失效
公开(公告)号：US07927611B2
公开(公告)日：2011-04-19
申请号：US11929064
申请日：2007-10-30
申请人： Antonio Campos-Neto , Yasir Skeiky , Pamela Ovendale , Shyian Jen , Michael Lodes
发明人： Antonio Campos-Neto , Yasir Skeiky , Pamela Ovendale , Shyian Jen , Michael Lodes
IPC分类号： A16K39/04 , A16K39/38 , A16K39/00 , A16K39/02 , A16K38/00
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.

3. 发明授权

US07632921B2 Site-directed modification of FVIII 有权
标题翻译： FVIII的定点修饰
公开(公告)号：US07632921B2
公开(公告)日：2009-12-15
申请号：US11273896
申请日：2005-11-14
申请人： Clark Q. Pan , John E. Murphy , Baisong Mei , Jonathan S. Strauss , Hendri Tjandra , Jianmin Chen , Thomas Barnett , Liang Tang , Deqian Wang
发明人： Clark Q. Pan , John E. Murphy , Baisong Mei , Jonathan S. Strauss , Hendri Tjandra , Jianmin Chen , Thomas Barnett , Liang Tang , Deqian Wang
IPC分类号： A16K38/00 , C12P21/04
CPC分类号： A61K38/37 , A61K38/00 , A61K47/60 , C07K14/755 , C07K17/08 , C07K2319/00
摘要： This invention relates to Factor VIII muteins that are covalently bound, at one or more predefined sites that are not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity, are capable of correcting human factor VIII deficiencies and have improved pharmacokinetic properties.
摘要翻译：本发明涉及在一个或多个不是N-末端胺的预定位点上与一种或多种生物相容性聚合物如聚乙二醇共价结合的因子VIII突变蛋白。突变蛋白偶联物保留FVIII促凝血活性，能够校正人因子VIII缺乏并具有改善的药代动力学性质。

4. 发明授权

US07252818B2 Method of producing biologically active human acidic fibroblast growth factor and its use in promoting angiogenesis 有权
标题翻译：生物活性人酸性成纤维细胞生长因子的生产方法及其在促进血管生成中的应用
公开(公告)号：US07252818B2
公开(公告)日：2007-08-07
申请号：US10649480
申请日：2003-08-27
申请人： Thomas J. Stegmann
发明人： Thomas J. Stegmann
IPC分类号： A16K38/00 , C07K14/50
CPC分类号： A61K38/1825 , C07K14/501 , C12N15/70
摘要： The present invention relates to the treatment of coronary heart disease by revascularization therapy, and more particularly to the intramyocardial injection of a pharmaceutical composition comprising a recombinant fibroblast growth factor-1 protein or a fragment of a recombinant fibroblast growth factor-1 protein, optionally, with a physiologic glue for inducing local neoangiogenesis in ischemic myocardium. Methods of producing the recombinant fibroblast growth factor 1 protein and fragments are also disclosed.
摘要翻译：本发明涉及通过血运重建治疗冠状动脉心脏病的治疗，更具体地涉及心肌内注射包含重组成纤维细胞生长因子-1蛋白或重组成纤维细胞生长因子-1蛋白片段的药物组合物，任选地，用于诱导缺血心肌局部新血管发生的生理胶。还公开了生产重组成纤维细胞生长因子1蛋白和片段的方法。

5. 发明授权

US07927610B2 Compounds and methods for diagnosis and immunotherapy of tuberculosis 有权
标题翻译：结核病诊断和免疫治疗的化合物和方法
公开(公告)号：US07927610B2
公开(公告)日：2011-04-19
申请号：US11929022
申请日：2007-10-30
申请人： Antonio Campos-Neto , Yasir Skeiky , Pamela Ovendale , Shyian Jen , Michael Lodes
发明人： Antonio Campos-Neto , Yasir Skeiky , Pamela Ovendale , Shyian Jen , Michael Lodes
IPC分类号： A16K39/04 , A16K39/38 , A16K39/00 , A16K39/02 , A16K38/00
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
摘要翻译：公开了用于诊断结核病或诱导针对结核病的保护性免疫的化合物和方法。提供的化合物包括含有至少一种免疫原性部分的一种或多种分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的分枝杆菌感染。还提供了针对这种多肽的抗体。此外，这些化合物可以配制成针对分枝杆菌感染免疫的疫苗和/或药物组合物。

6. 发明授权

US07041794B2 Polynucleotides and polypeptides of the erythropoietin gene 失效
公开(公告)号：US07041794B2
公开(公告)日：2006-05-09
申请号：US10113824
申请日：2002-03-29
申请人： Jean-Louis Escary
发明人： Jean-Louis Escary
IPC分类号： C07K14/00 , C07K17/00 , A16K38/00
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/505 , C12Q1/6886 , C12Q2600/136
摘要： The present invention relates to new polynucleotides deriving from the nucleotide sequence of the EPO gene and comprising new SNPs, new polypeptides derived from the natural EPO protein and comprising at least one mutation caused by the SNPs of the invention as well as their therapeutic uses.

7. 发明授权

US06863893B2 Derivatives of choline binding proteins for vaccines 失效
公开(公告)号：US06863893B2
公开(公告)日：2005-03-08
申请号：US10254995
申请日：2002-09-25
申请人： Theresa M. Wizemann , Scott Koenig , Leslie S. Johnson
发明人： Theresa M. Wizemann , Scott Koenig , Leslie S. Johnson
IPC分类号： C12N15/09 , A61K39/00 , A61K39/09 , A61K39/395 , A61K39/40 , A61P31/04 , A61P37/04 , C07K14/315 , C07K16/12 , A61K39/02 , A61K39/085 , C07K14/00 , A16K38/00 , A16K38/16
CPC分类号： C07K14/3156 , A61K39/00
摘要： The present invention provides bacterial immunogenic agents for administration to humans and non-human animals to stimulate an immune response. It particularly relates to the vaccination of mammalian species with pneumococcal derived polypeptides that include an alpha helix but exclude a choline binding region as a mechanism for stimulating production of antibodies that protect the vaccine recipient against infection by pathogenic bacterial species. In another aspect the invention provides antibodies against such proteins and protein complexes that may be used as diagnositics and/or as protective/treatment agents for pathogenic bacterial species.

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