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71. 发明授权

US06352832B1 Anti-CCR2 antibodies and methods of use therefor 有权
公开(公告)号：US06352832B1
公开(公告)日：2002-03-05
申请号：US09359193
申请日：1999-07-22
申请人： Gregory J. LaRosa , Christopher Horvath , Walter Newman
发明人： Gregory J. LaRosa , Christopher Horvath , Walter Newman
IPC分类号： G01N3353
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/76
摘要： The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

72. 发明申请

US20200146887A1 SYSTEMS AND METHODS FOR TREATING GLAUCOMA WITH PHOTODISRUPTIVE LASER PULSES 审中-公开
公开(公告)号：US20200146887A1
公开(公告)日：2020-05-14
申请号：US16740456
申请日：2020-01-12
申请人： Christopher Horvath , Vanessa Isabella Vera
发明人： Christopher Horvath , Vanessa Isabella Vera
IPC分类号： A61F9/008 , A61F9/009 , A61F9/007
摘要： The invention relates to systems and methods for delivering highly focused photodisruptive laser pulses with pulse durations

73. 发明授权

US09033963B2 Systems and methods to deliver photodisruptive laser pulses into tissue layers of the anterior angle of the eye 有权
标题翻译：将光致破坏性激光脉冲输送到眼睛前角的组织层中的系统和方法
公开(公告)号：US09033963B2
公开(公告)日：2015-05-19
申请号：US13442854
申请日：2012-04-10
申请人： Vanessa Isabella Vera , Christopher Horvath
发明人： Vanessa Isabella Vera , Christopher Horvath
IPC分类号： A61N5/067 , A61F9/008
CPC分类号： A61F9/00821 , A61F9/00781 , A61F9/00825 , A61F2009/00868 , A61F2009/00891
摘要： The invention relates to systems and methods for measuring the angular accessibility limitations of the anterior angle of the eye, targeting one or multiple treatment zones within the anterior angle area of the eye and delivering highly focused photodisruptive laser pulses with pulse durations
摘要翻译：本发明涉及用于测量眼睛前角的角度可访问性限制的系统和方法，其针对眼睛的前角区域内的一个或多个治疗区域并且递送具有脉冲持续时间<50皮秒的高度聚焦的光破坏性激光脉冲，从而产生通道进入眼睛前角内的各种解剖结构。本发明还包括定制的前房角镜检查透镜系统，患者接口系统和用于将高度聚焦的激光束传送到眼睛的前角区域的激光输送系统。

74. 发明授权

US09023018B2 Surgical laser system with remote control functionality 有权
标题翻译：手术激光系统具有遥控功能
公开(公告)号：US09023018B2
公开(公告)日：2015-05-05
申请号：US12634150
申请日：2009-12-09
申请人： Christopher Horvath , Laszlo Otto Romoda
发明人： Christopher Horvath , Laszlo Otto Romoda
IPC分类号： A61B18/20 , A61F9/008
CPC分类号： A61F9/008 , A61F2009/00872
摘要： Embodiments of the present invention provide a laser surgical system with a basic set of functionality which is remotely controllable to implement an advanced set of functionality. According to one embodiment of the present invention, a basic laser surgical system may be coupled to an advanced control unit such that the basic laser surgical system may be controllable by the advanced control unit to implement a broader set of functionality. By moving less frequently used functionality to an advanced unit, the basic unit may be streamlined with regards to both cost and size, and the learning curve required to utilize the basic unit may be reduced relative to a more feature-ladened unit, allowing the basic unit to be utilized in myriad situations or procedures where an “all-in-one” unit would be less than desirable.
摘要翻译：本发明的实施例提供具有基本功能集的激光手术系统，其可远程控制以实现高级功能集。根据本发明的一个实施例，基本的激光手术系统可以耦合到高级控制单元，使得基本的激光手术系统可以由高级控制单元控制，以实现更广泛的功能。通过将较少使用的功能移动到高级单元，可以在成本和尺寸方面简化基本单元，并且可以相对于更特征加载的单元减少使用基本单元所需的学习曲线，从而允许基本单元单位将用于无数情况或程序中，“一体化”单位不太可取。

75. 发明申请

US20140350533A1 CONTACTLESS PHOTODISRUPTIVE LASER CATARACT SURGERY 审中-公开
标题翻译：无连续光电激光雷射手术
公开(公告)号：US20140350533A1
公开(公告)日：2014-11-27
申请号：US13877166
申请日：2011-10-02
申请人： Christopher Horvath , Vanessa I. Vera
发明人： Christopher Horvath , Vanessa I. Vera
IPC分类号： A61F9/008
CPC分类号： A61F9/00825 , A61F2009/0087 , A61F2009/00889
摘要： Method, apparatus and systems for laser surgery as part of cataract surgery. The implementation thereof includes: A means to perform incisions in the cornea and inside the eye. In particular Limbal Relaxating Incisions and an anterior or posterior capsulotomy/capsulorhexis using a rapid fire sequence of photodisruptive laser pulses, placed to open the capsule for cataract surgery. The system and methods provides the means to target and direct the laser pulse sequence into the desired region of the eye without the need of a patient interface that is locked to the laser delivery system and holds the eye in a fixed position relative to the delivery system.
摘要翻译：用于激光手术的方法，装置和系统作为白内障手术的一部分。其实现包括：在角膜和眼内进行切口的手段。特别是边缘松弛切口和使用光破坏性激光脉冲的快速火焰序列的前部或后部囊切开/撕囊术，放置以打开胶囊用于白内障手术。该系统和方法提供了将激光脉冲序列对准并将其定向到眼睛的期望区域的手段，而不需要将锁定到激光输送系统的患者界面相对于相对于输送系统保持在固定位置。

76. 发明申请

US20110038174A1 OPHTHALMIC ENDOILLUMINATION WITH LIGHT COLLECTOR FOR WHITE PHOSPHOR 有权
标题翻译：用于白色荧光灯的光收集器的眼内透视
公开(公告)号：US20110038174A1
公开(公告)日：2011-02-17
申请号：US12852829
申请日：2010-08-09
申请人： Michael James Papac , Christopher Horvath , Michael J. Yadlowsky , Ronald T. Smith
发明人： Michael James Papac , Christopher Horvath , Michael J. Yadlowsky , Ronald T. Smith
IPC分类号： A61B3/10
CPC分类号： A61B1/0661 , A61B90/30 , A61B2090/306 , A61B2090/309 , G02B6/0008 , G02B6/0096
摘要： In one embodiment, an illuminator configured to emit light into an optical fiber includes at least one pump light source configured to emit short-wavelength light. The illuminator further includes a white phosphor disposed to receive the short-wavelength light and to emit white light in response. The illuminator also includes a light collector configured to collect the short-wavelength light at the white phosphor such that a brightness of the white light is greater than a brightness of the short-wavelength light.
摘要翻译：在一个实施例中，被配置为将光发射到光纤中的照明器包括被配置为发射短波长光的至少一个泵浦光源。照明器还包括布置成接收短波长光并响应地发出白光的白色荧光体。照明器还包括集光器，其被配置为收集白色荧光体上的短波长光，使得白光的亮度大于短波长光的亮度。

77. 发明申请

US20100198200A1 Smart Illumination for Surgical Devices 审中-公开
标题翻译：手术设备的智能照明
公开(公告)号：US20100198200A1
公开(公告)日：2010-08-05
申请号：US12693808
申请日：2010-01-26
申请人： Christopher Horvath
发明人： Christopher Horvath
IPC分类号： A61B17/00 , A61B18/20 , A61F9/007
CPC分类号： A61B17/00 , A61B2017/00115 , A61B2017/00128 , A61B2017/00199 , A61B2017/00212 , A61B2017/00221 , A61B2017/00225 , A61B2017/00367 , A61B2017/00973 , A61B2034/254 , A61B2090/0807 , A61F9/007 , A61F9/00736 , G05G1/305
摘要： In various embodiments, a device (such as a surgical footswitch, handpiece, etc.) and a surgical console may be used by an operator during a surgical procedure and/or in an office. The device may communicate with the surgical console to receive information associated with a procedure (e.g., information relative to the device, console, or other equipment used in a surgical procedure). In some embodiments, the information may be determined/generated at the device (i.e. and not necessarily received from the surgical console). Based on the information, a configuration may be determined (e.g., at the device, at the console, etc.) for one or more indicators on the device to provide at least part of the information to the operator of the device. The at least one indicator on the device may thus be illuminated to provide the operator at least part of the information associated with the procedure.
摘要翻译：在各种实施例中，操作者在手术过程和/或办公室期间可以使用装置（例如手术脚踏开关，手机等）和手术控制台。该装置可以与外科手术台通信以接收与程序相关联的信息（例如，相对于装置，控制台或在外科手术中使用的其它装置的信息）。在一些实施例中，可以在设备处确定/生成信息（即，不一定从外科手术台接收）。基于该信息，可以针对设备上的一个或多个指示符来确定（例如，在设备处，在控制台处等）的配置，以向设备的操作者提供至少一部分信息。因此，设备上的至少一个指示符可以被照亮，以向操作者提供与该过程相关联的信息的至少一部分。

78. 发明申请

US20090171328A1 Surgical Console Display Operable to Provide a Visual Indication of a Status of a Surgical Laser 审中-公开
标题翻译：手术台显示器可操作以提供手术激光器的状态的可视指示
公开(公告)号：US20090171328A1
公开(公告)日：2009-07-02
申请号：US12329683
申请日：2008-12-08
申请人： Christopher Horvath
发明人： Christopher Horvath
IPC分类号： A61B18/20 , A61B19/00
CPC分类号： A61B34/25 , A61B2017/00199 , A61B2017/00212 , A61B2018/00636 , A61F9/008
摘要： A surgical console display operable to provide a visual indication of status of a surgical laser or other surgical instrument or peripheral device coupled to the surgical console is provided in accordance with embodiments of the present invention. This facilitates the surgeon's management of a surgical procedure where a multitude of tasks and surgical control equipment are manipulated during an ocular surgery. The surgical console includes a processing module, an external interface, and a user interface having a display screen. The display screen specifically allows operators to view a status of peripheral devices and/or surgical instruments such as but not limited to a surgical laser.
摘要翻译：根据本发明的实施例，提供可操作以提供外科激光器或耦合到外科手术台的外科手术器械或外围设备的状态的视觉指示的外科手术台显示器。这有助于外科医生对外科手术的管理，其中在眼部手术期间操纵许多任务和手术控制设备。外科手术台包括处理模块，外部接口和具有显示屏的用户界面。显示屏幕特别允许操作者查看外围设备和/或手术器械的状态，例如但不限于手术激光。

79. 发明申请

US20090040181A1 System and Method For Magnetic Hand Controller 审中-公开
标题翻译：磁力手控制器系统与方法
公开(公告)号：US20090040181A1
公开(公告)日：2009-02-12
申请号：US11836426
申请日：2007-08-09
申请人： Lawrence Darnell , Christopher Horvath , Bruno Lassalas
发明人： Lawrence Darnell , Christopher Horvath , Bruno Lassalas
IPC分类号： G06F3/033
CPC分类号： G05G5/05 , G02B21/32 , G05G2009/04766
摘要： Embodiments provide a system and method for magnetic hand controllers. An embodiment of a magnetic hand controller can include a base portion comprising a base magnet, a hand control portion spaced from and movable relative to the base portion, the hand control portion comprising a hand control and a hand control magnet coupled to the hand control and oriented so that the hand control magnet is attracted to the base magnet. The hand control portion may be coupled to a device such that a user may control the device by moving the hand control.
摘要翻译：实施例提供了一种用于磁性手控制器的系统和方法。磁性手控制器的实施例可以包括基部，该基部包括基部磁体，与该基部间隔开并可相对于基部移动的手控制部分，手控制部分包括手控制器和耦合到手控制器的手控制磁体，使得手控磁铁被吸引到基体磁体。手控制部分可以耦合到设备，使得用户可以通过移动手控制来控制设备。

80. 发明申请

US20080117490A1 SYSTEM AND METHOD FOR ILLUMINATION ATTENUATION 有权
标题翻译：用于照明衰减的系统和方法
公开(公告)号：US20080117490A1
公开(公告)日：2008-05-22
申请号：US11561718
申请日：2006-11-20
申请人： John C. Huculak , Christopher Horvath
发明人： John C. Huculak , Christopher Horvath
IPC分类号： G02B26/04
CPC分类号： G02B26/04 , G02B6/266 , G02B6/3552 , G02B6/3568 , Y10S359/90
摘要： Generally speaking, the output brightness of an illuminator is varied by chopping an output light beam such that the beam is alternately interrupted and unhindered. An interrupter can be rapidly moved into and out of the transmission path of a light beam. The brightness of the light beam received at a site will be attenuated based on the amount of time per cycle the light beam remains obstructed versus unhindered.
摘要翻译：一般来说，通过切断输出光束来改变照明器的输出亮度，使得光束被交替地中断和不受阻碍。断路器可以快速地移入和移出光束的传输路径。基于每个周期的时间量，在一个地点接收的光束的亮度将被衰减，而不受阻碍。

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