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    • 2. 发明申请
    • Drug delivery device
    • 给药装置
    • US20060084921A1
    • 2006-04-20
    • US11194723
    • 2005-08-01
    • Lawrence Darnell
    • Lawrence Darnell
    • A61M5/178
    • A61M5/14232A61F9/0017A61M5/1424A61M5/1454A61M5/16809A61M5/16877A61M39/285
    • A syringe-like device having a chamber in which a pressurizing piston reciprocates. The chamber is connected on one end to a vial containing a drug to be delivered to an eye and on the other end to a needle or cannula for administering the drug to an eye. Pulling proximally backwards on the piston creates a vacuum in the chamber and draws the drug out of the vial. Upon release of the piston, a spring pushes the piston forward, pressurizing the chamber. Delivery of the drug is controlled by a roller pinching off a section of compliant tubing between the chamber and the cannula, with a design similar to a peristaltic pump. A one-way valve prevents the drug from being expelled back into the vial. The flow rate of the drug out of the cannula can be controlled by rotation of the roller.
    • 一种注射器状装置,具有其中加压活塞往复运动的腔室。 腔室的一端连接到含有待递送至眼睛的药物的小瓶中,另一端连接到用于将药物施用于眼睛的针或套管。 在活塞上向近侧拉动在腔室中产生真空并将药物从小瓶中抽出。 在释放活塞时,弹簧向前推动活塞,对腔室加压。 药物的输送通过辊子夹住室和套管之间的柔性管道的一部分来控制,其设计类似于蠕动泵。 单向阀防止药物被排出回到小瓶中。 可以通过辊的旋转来控制药物离开套管的流速。
    • 3. 发明授权
    • Biological fluid cassette and tubing set
    • 生物流体盒和管组
    • US5891080A
    • 1999-04-06
    • US450537
    • 1995-05-25
    • David SkinkleTimothy IgoeLawrence Darnell
    • David SkinkleTimothy IgoeLawrence Darnell
    • A61M1/36A61M37/00
    • A61M1/3693A61M1/3692A61M1/3696A61M2205/12A61M2205/123Y10T137/85994Y10T137/86027Y10T137/87161
    • An apparatus for managing and controlling fluid flow through a plurality of fluid conduits includes a chassis, a plurality of conduit occluders mounted in the chassis, each occluder for association with at least one of the plurality of fluid conduits and each being selectively actuatable between an open position permitting fluid flow through a respective fluid conduit and a closed position obstructing conduit fluid flow. A single actuator is mounted in the chassis, the actuator for adjusting the plurality of occluders between the open and closed positions. A roller cage is also mounted in the chassis for mechanically interconnecting the actuator to the plurality of conduit occluders so that the single actuator is mechanically capable of maintaining one of the plurality occluders in the closed position while maintaining another of the plurality of occluders in the open position.
    • 用于管理和控制通过多个流体导管的流体流动的装置包括底盘,安装在底盘中的多个导管堵塞器,每个封堵器,用于与多个流体管道中的至少一个相关联,并且每个封闭器可在打开 允许流体流过相应的流体导管并阻塞导管流体流动的封闭位置。 单个致动器安装在底盘中,致动器用于在打开位置和关闭位置之间调节多个闭塞器。 机架中还安装有滚子保持架,用于将致动器机械地互连到多个导管封堵器,使得单个致动器机械地能够将多个封堵器中的一个保持在关闭位置,同时将多个封堵器中的另一个封闭在开放状态 位置。
    • 4. 发明申请
    • Spatially Distributed Spectrally Neutral Optical Attenuator
    • 空间分布光谱中性光衰减器
    • US20090234334A1
    • 2009-09-17
    • US12410115
    • 2009-03-24
    • Alexander ArtsyukhovichT. Scott RoweBruno LassalasLawrence DarnellW. Jake Kozlowski,, JR.
    • Alexander ArtsyukhovichT. Scott RoweBruno LassalasLawrence DarnellW. Jake Kozlowski,, JR.
    • A61F9/007A61B18/18
    • G02B26/02A61B90/30A61B90/36
    • A system, apparatus and method for spatially distributed, spectrally neutral optical attenuation. One embodiment of the apparatus can include: an attenuator fin plate; a set of attenuator fins, wherein each of the fins is operably coupled to the fin plate at a preset fin angle to the fin plate normal such that the attenuator fins maintain their position relative to the fin plate as the fin plate moves; and a motor for rotating the fin plate a set angular distance around an axis of rotation, wherein the axis of rotation is at a preset fin plate angle to a light beam direction of travel and wherein the attenuator fins block varying amounts of the light beam as the fin plate is rotated through the set angular distance. The attenuator fin plate and attenuator fins can be a single, integral component, wherein the attenuator fin plate is etched and stamped to form the attenuator fins, or separately formed components that are attached, for example, to a separate frame. The embodiments of the attenuator of this invention can be configured for use within an ophthalmic high brightness illumination system.
    • 用于空间分布,光谱中性光衰减的系统,装置和方法。 该装置的一个实施例可以包括:衰减器翅板; 一组衰减器翅片,其中每个翼片以与翅片板法线成预定的翅片角度可操作地联接到翅片板,使得当翅片板移动时,衰减器翅片相对于翅片板保持它们的位置; 以及电动机,用于使所述翅片板围绕旋转轴线旋转设定的角度距离,其中所述旋转轴线相对于光束行进方向处于预设的翅片板角度,并且其中所述衰减器散热片将不同量的光束阻挡为 翅片板旋转设定的角度距离。 衰减器翅片板和衰减器翅片可以是单一的整体部件,其中衰减器翅片板被蚀刻和冲压以形成衰减器翅片,或者单独形成的部件,例如附接到单独的框架。 本发明的衰减器的实施例可被配置为在眼科高亮度照明系统内使用。
    • 5. 发明申请
    • Spatially distributed spectrally neutral optical attenuator
    • US20060033926A1
    • 2006-02-16
    • US11204305
    • 2005-08-15
    • Alexander ArtsyukhovichT. RoweBruno LassalasLawrence DarnellW. Kozlowski
    • Alexander ArtsyukhovichT. RoweBruno LassalasLawrence DarnellW. Kozlowski
    • G01B9/02
    • G02B26/02A61B90/30A61B90/36
    • A system, apparatus and method for spatially distributed, spectrally neutral optical attenuation are disclosed. One embodiment of the apparatus comprises: an attenuator fin plate; a set of attenuator fins, wherein each of the fins is operably coupled to the fin plate at a preset fin angle to the fin plate normal such that the attenuator fins maintain their position relative to the fin plate as the fin plate moves; and a means for rotating the fin plate a set angular distance around an axis of rotation, wherein the axis of rotation is at a preset fin plate angle to a light beam direction of travel and wherein the attenuator fins block varying amounts of the light beam as the fin plate is rotated through the set angular distance. The attenuator fin plate and attenuator fins can be a single, integral component, wherein the attenuator fin plate is etched and stamped to form the attenuator fins, or separately formed components that are attached, for example, to a separate frame. The means for rotating the fin plate would then comprise means to rotate the attenuator frame. Means for rotating the attenuator fin plate or frame can include a stepper motor, for discrete step positions, or a continuously variable motor for infinitely variable positioning. The means for rotating the attenuator fin plate or frame can be electronically controlled, for example, by a microprocessor on a printed circuit board or other such controller as known to those having skill in the art. The preset fin angle can be 31 degrees, and the preset fin plate angle can be 90 degrees. Each of the attenuator fins can be operably coupled to the fin plate at the same preset fin angle and the fin plate and/or frame centered on the axis of rotation. Each fin's major axis can be parallel to every other fin's major axis, and the axis of rotation can be parallel to each fin's major axis. The set of attenuator fins can comprise eight attenuator fins and the attenuator fins can be spaced equally apart from one another. The attenuator fin plate and set of attenuator fins can be sized so as to interfere with the entire light beam cross-section/aperture at a position along the set angular distance corresponding to zero percent of the optical beam passing through the attenuator fins. The embodiments of the attenuator of this invention can be configured for use within an ophthalmic high brightness illumination system.
    • 6. 发明授权
    • Centrifugally assisted centrifuge bowl mount
    • 离心辅助离心机碗安装
    • US5591113A
    • 1997-01-07
    • US332820
    • 1994-10-31
    • Lawrence DarnellJames Salter
    • Lawrence DarnellJames Salter
    • B04B7/00B04B15/00
    • B04B7/00Y10T279/11Y10T279/18Y10T279/247
    • A centrifuge is provided with a mounting arrangement that secures a centrifuge bowl to a turntable in response to centrifugal force generated when the turntable is rotated. The centrifuge includes first and second retainers, one of which is connected to the turntable, while the other is connected to the centrifuge bowl. The second retainer engages the first retainer when the first and second retainers are in an interlocking position to secure the centrifuge bowl to the turntable. A movable arm is provided on the turntable and coupled to the second retainer, the movable arm has a ballast that forces the movable arm and second retainer in a first direction in response to centrifugal force generated by rotating the turntable so that the second retainer is forced into the interlocking position with the first retainer. In one embodiment, a vacuum applied to an opening in the turntable assists in mounting a centrifuge bowl to the turntable.
    • 离心机设置有安装装置,其响应于当转台旋转时产生的离心力而将离心机碗固定到转台上。 离心机包括第一和第二保持器,其中之一连接到转盘,而另一个连接到离心机碗。 当第一和第二保持器处于联锁位置以将离心机碗固定到转台时,第二保持器接合第一保持器。 可移动臂设置在转盘上并联接到第二保持器上,可移动臂具有一个压载物,该压载物响应于通过旋转转台而产生的离心力而沿第一方向迫使可动臂和第二保持器,使得第二保持器被迫 进入与第一保持器的联锁位置。 在一个实施例中,施加到转盘中的开口的真空度有助于将离心机碗安装到转台上。
    • 7. 发明授权
    • Multi-tube clamp actuator and mating cartridge
    • 多管夹紧执行器和配合筒
    • US5584320A
    • 1996-12-17
    • US332814
    • 1994-10-31
    • David SkinkleTimothy IgoeLawrence Darnell
    • David SkinkleTimothy IgoeLawrence Darnell
    • A61M1/36F16K7/06
    • A61M1/3693A61M1/3692A61M1/3696A61M2205/12A61M2205/123Y10T137/85994Y10T137/86027Y10T137/87161
    • An apparatus for managing and controlling fluid flow through a plurality of fluid conduits includes a chassis, a plurality of conduit occluders mounted in the chassis, each occluder for association with at least one of the plurality of fluid conduits and each being selectively actuatable between an open position permitting fluid flow through a respective fluid conduit and a closed position obstructing conduit fluid flow. A single actuator is mounted in the chassis, the actuator for adjusting the plurality of occluders between the open and closed positions. A roller cage is also mounted in the chassis for mechanically interconnecting the actuator to the plurality of conduit occluders so that the single actuator is mechanically capable of maintaining one of the plurality occluders in the closed position while maintaining another of the plurality of occluders in the open position.
    • 用于管理和控制通过多个流体导管的流体流动的装置包括底盘,安装在底盘中的多个导管堵塞器,每个封堵器,用于与多个流体管道中的至少一个相关联,并且每个封闭器可在打开 允许流体流过相应的流体导管并阻塞导管流体流动的封闭位置。 单个致动器安装在底盘中,致动器用于在打开位置和关闭位置之间调节多个闭塞器。 机架中还安装有滚子保持架,用于将致动器机械地互连到多个导管封堵器,使得单个致动器机械地能够将多个封堵器中的一个保持在关闭位置,同时将多个封堵器中的另一个封闭在开放状态 位置。