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71. 发明授权

US08945472B2 Optimized detector readout for biosensor 有权
公开(公告)号：US08945472B2
公开(公告)日：2015-02-03
申请号：US12810531
申请日：2008-12-18
申请人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiels
发明人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiels
IPC分类号： G01N21/00 , G01N21/552 , G01N21/27 , G09G3/32 , G01J1/46 , G01N21/65 , G01J1/44 , G01N15/02
CPC分类号： G06T7/0012 , A61M2205/3306 , G01J1/44 , G01J1/46 , G01N15/0205 , G01N15/0211 , G01N21/274 , G01N21/552 , G01N21/65 , G01N2201/0691 , G06T2207/10004 , G06T2207/10152 , G06T2207/30004 , G09G3/3233 , G09G2300/0443 , G09G2300/0809 , G09G2340/0435 , Y10S435/808 , Y10S436/805 , Y10T436/25
摘要： The present invention provides a biosensor system comprising a light source, a cartridge adapted to be illuminated by said light source, a light detector adapted for detecting a signal originating from the cartridge, an illumination control means adapted to vary the illumination of the cartridge between at least two different states, a means for generating a first oscillation with a first frequency, and a means for generating a second oscillation with a second frequency, wherein the frame rate of the light detector is triggered by the first oscillation and the illumination control means is triggered by the second oscillation.

72. 发明授权

US08611195B2 Detection of data in burst cutting area of optical disk 有权
标题翻译：检测光盘突发切割区域中的数据
公开(公告)号：US08611195B2
公开(公告)日：2013-12-17
申请号：US12964140
申请日：2010-12-09
申请人： Maarten Kuijper , Bart Van Rompaey , Jacobus Petrus Josephus Heemskerk , Cornelis Marinus Schep , Josephus Arnoldus Henricus Maria Kahlman
发明人： Maarten Kuijper , Bart Van Rompaey , Jacobus Petrus Josephus Heemskerk , Cornelis Marinus Schep , Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： G11B15/52
CPC分类号： G11B7/00736 , G11B7/0053 , G11B7/013 , G11B20/00086 , G11B20/10009 , G11B20/1426 , G11B2020/122 , G11B2020/1453 , G11B2220/2541
摘要： An apparatus generates outgoing data (OD) to be provided on an optical disk (1) in a burst cutting area (2). The burst cutting area (2) further comprises markings (3) which cause a marking frequency spectrum (MFS) when reading out the burst cutting area (2). The apparatus comprises a channel coder (4) which receives processed data (PD) and supplies the outgoing data (OD) having an outgoing data frequency spectrum (DFS) with suppressed DC-content. The apparatus further comprises a data processing device (5) which generates the processed data (PD) to obtain an outgoing frequency spectrum (DFS) wherein a frequency component causing interference with a low frequent component of the markings (3) is suppressed or not present.
摘要翻译：一种装置产生在突发切割区域（2）中提供在光盘（1）上的输出数据（OD）。突发切割区域（2）还包括当读出突发切割区域（2）时引起标记频谱（MFS）的标记（3）。该装置包括一个信道编码器（4），其接收处理后的数据（PD）并提供具有抑制的DC内容的具有输出数据频谱（DFS）的输出数据（OD）。该装置还包括一个产生处理数据（PD）以获得出口频谱（DFS）的数据处理装置（5），其中导致与标记（3）的低频分量干扰的频率分量被抑制或不存在。

73. 发明授权

US08542009B2 Oxygen concentration measurement with GMR 有权
标题翻译：用GMR进行氧浓度测量
公开(公告)号：US08542009B2
公开(公告)日：2013-09-24
申请号：US12990986
申请日：2009-05-04
申请人： Haris Duric , Josephus Arnoldus Henricus Maria Kahlman , Jeroen Veen
发明人： Haris Duric , Josephus Arnoldus Henricus Maria Kahlman , Jeroen Veen
IPC分类号： G01R33/02 , G01R33/12
CPC分类号： G01N27/74 , G01R33/091
摘要： In an embodiment, an oxygen sensor comprises a giant magnetoresistance device (10), and a magnetic field generator (14, 14a, 14b) arranged to generate a magnetic field (12, 12a, 12b) overlapping the giant magnetoresistance device and an examination region (20). A component (Bx) of the magnetic field detected by the giant magnetoresistance device is dependent upon an oxygen concentration in the examination region. In an embodiment, a chip (40) includes one or more electrically conductive traces (14a, 14b) disposed on or in the chip and a giant magnetoresistance device (10) disposed on or in the chip such that electrical current flowing in the trace or traces generates a magnetic field (12a, 12b) that overlaps the magnetic field sensor, said magnetic field being perturbed (Bx) by ambient oxygen (24) such that a signal output by the magnetic field sensor indicates ambient oxygen concentration.
摘要翻译：在一个实施例中，氧传感器包括巨磁电阻装置（10）和布置成产生与巨磁电阻装置重叠的磁场（12,12a，12b）的磁场发生器（14,14a，14b）和检查区（20）。由巨磁电阻装置检测的磁场的分量（Bx）取决于检查区域中的氧浓度。在一个实施例中，芯片（40）包括设置在芯片上或芯片中的一个或多个导电迹线（14a，14b）和设置在芯片上或芯片上的巨磁电阻器件（10），使得流过迹线或轨迹产生与磁场传感器重叠的磁场（12a，12b），所述磁场被环境氧（24）扰动（Bx），使得由磁场传感器输出的信号表示环境氧浓度。

74. 发明授权

US08537237B2 Real-time digital image processing architecture 有权
标题翻译：实时数字图像处理架构
公开(公告)号：US08537237B2
公开(公告)日：2013-09-17
申请号：US12919519
申请日：2008-12-18
申请人： Josephus Arnoldus Henricus Maria Kahlman
发明人： Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： H04N5/235 , H04N5/228 , G06K9/00
CPC分类号： G06T5/002 , G06T2207/10016 , G06T2207/20182 , G06T2207/30072
摘要： A digital image processing device processes digital images provided by a camera of biosensor reader. The device includes a pixel processing unit for evaluating a stream of image values with respect to a given set of processing spots in the image area, thus determining characteristic parameters like the integral of pixel values in the processing spots. The pixel processing unit communicates with a higher-level digital control unit that sets the processing spots to be evaluated and that reads out and post-processes the results of the pixel processing unit.
摘要翻译：数字图像处理装置处理由生物传感器读取器的相机提供的数字图像。该装置包括：像素处理单元，用于相对于图像区域中的一组给定的处理点来评估图像值流，从而确定诸如处理点中的像素值的积分的特征参数。像素处理单元与设置要评估的处理点的上位数字控制单元进行通信，并读出并后处理像素处理单元的结果。

75. 发明申请

US20120329039A1 SUBSTANCE DETERMINING APPARATUS 有权
标题翻译：物质确定装置
公开(公告)号：US20120329039A1
公开(公告)日：2012-12-27
申请号：US13516060
申请日：2010-12-10
申请人： Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon , Johannes Joseph Hubertina Barbara Schleipen , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout
发明人： Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon , Johannes Joseph Hubertina Barbara Schleipen , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout
IPC分类号： G01N33/566 , C12M1/34 , C12Q1/70 , G01N30/00 , G01N33/53
CPC分类号： B01L3/5027 , B01L2200/0605 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0406 , G01N21/552 , G01N21/8483 , G01N33/54373
摘要： The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles attach the substance and bind to a binding surface (30), wherein a sensing signal is generated depending on the bound particles. Binding events indicating a binding of a particle on the binding surface (30) are determined from the generated sensing signal, and the substance within the fluid is determined based on the determined binding events. During a procedure of determining a substance within a fluid, particles may bind to the binding surface and may leave the binding surface. Therefore, during this procedure a number of binding events can be determined being much larger than the number of bound particles. The determination of the substance within the fluid can therefore be based on a very large amount of data, thereby increasing the accuracy of determining the substance within the fluid.
摘要翻译：本发明涉及一种用于确定流体内物质的物质确定装置。颗粒附着物质并结合到结合表面（30），其中根据结合的颗粒产生感测信号。根据产生的感测信号确定指示结合表面（30）上的颗粒结合的结合事件，并且基于所确定的结合事件确定流体内的物质。在确定流体内的物质的过程中，颗粒可能结合到结合表面并且可能离开结合表面。因此，在此过程中，可以确定许多结合事件比结合粒子的数量大得多。因此，流体内的物质的测定可以基于非常大量的数据，从而提高确定流体内物质的准确性。

76. 发明申请

US20110007183A1 REAL-TIME DIGITAL IMAGE PROCESSING ARCHITECTURE 有权
标题翻译：实时数字图像处理架构
公开(公告)号：US20110007183A1
公开(公告)日：2011-01-13
申请号：US12919519
申请日：2008-12-18
申请人： Josephus Arnoldus Henricus Maria Kahlman
发明人： Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： H04N5/235 , H04N5/228
CPC分类号： G06T5/002 , G06T2207/10016 , G06T2207/20182 , G06T2207/30072
摘要： The invention relates to a digital image processing architecture, particularly for processing digital images provided by a camera (101) of a biosensor reader (100). The architecture comprises a pixel processing unit (112) for evaluating a stream of image values (I(x,y,t)) with respect to a given set of processing spots (PSi(t) in the image area, thus determining characteristic parameters like the integral (Ei(t) of pixel values in the processing spots (PSi(t). The pixel processing unit (112) communicates with a higher-level digital control unit (130) that sets the processing spots (PSi(t) to be evaluated and that reads out and post-processes the results of the pixel processing unit (112).
摘要翻译：本发明涉及一种数字图像处理架构，特别是用于处理由生物传感读取器（100）的相机（101）提供的数字图像。该体系结构包括：像素处理单元，用于根据给定的一组处理点（图像区域中的PSi（t））来评估图像值流（I（x，y，t）），从而确定特征参数像处理点（PSi（t））中的像素值的积分（Ei（t）），像素处理单元（112）与设置处理点（PSi（t））的上位数字控制单元被评估，并且读出并后处理像素处理单元（112）的结果。

77. 发明申请

US20100187450A1 MICROELECTRONIC SENSOR DEVICE WITH LIGHT SOURCE AND LIGHT DETECTOR 审中-公开
标题翻译：具有光源和光探测器的微电子传感器装置
公开(公告)号：US20100187450A1
公开(公告)日：2010-07-29
申请号：US12665068
申请日：2008-06-18
申请人： Josephus Arnoldus Henricus Maria Kahlman , Coen Adrianus Verschuren
发明人： Josephus Arnoldus Henricus Maria Kahlman , Coen Adrianus Verschuren
IPC分类号： G01J3/50 , G01N15/06 , H01J3/14
CPC分类号： G01N21/552 , G01N21/274 , G01N21/4788 , G01N21/648 , G01N2021/0378 , G01N2201/0624 , G01N2201/0625 , G01N2201/124
摘要： The invention relates to a method and a microelectronic sensor device for making optical examinations in an investigation region (3). An input light beam (L1) is emitted by a light source (20) into said investigation region (3), and an output light beam (L2) coming from the investigation region (3) is detected by a light detector (30) providing a measurement signal (X). An evaluation unit (40) provides a result signal (R) based on a characteristic parameter (e.g. the intensity) of the input light beam (L1) and the output light beam (L2). Preferably, the input light beam (L1) is modulated with a given frequency (ω) and monitored with a sensor unit (22) that provides a monitoring signal (M). The monitoring signal (M) and the measurement signal (X) can then be demodulated with respect to the monitoring signal, and their ratio can be determined. This allows to obtain a result signal (R) that is largely independent of environmental influences and variations in the light source.
摘要翻译：本发明涉及一种用于在调查区域（3）进行光学检查的方法和微电子传感器装置。输入光束（L1）由光源（20）发射到所述调查区域（3）中，来自调查区域（3）的输出光束（L2）由光检测器（30）检测，提供测量信号（X）。评估单元（40）基于输入光束（L1）和输出光束（L2）的特征参数（例如强度）提供结果信号（R）。优选地，以给定频率（ω）调制输入光束（L1），并用提供监视信号（M）的传感器单元（22）监视输入光束（L1）。监测信号（M）和测量信号（X）可以相对于监视信号被解调，并且可以确定其比例。这允许获得在很大程度上独立于光源的环境影响和变化的结果信号（R）。

78. 发明申请

US20100034060A1 OPTICAL DISC COMPRISING A WATERMARK AND A METHOD AND RECORDER FOR RECORDING SUCH A DISC 失效
标题翻译：包含水印的光盘和用于记录这样一个盘的方法和记录器
公开(公告)号：US20100034060A1
公开(公告)日：2010-02-11
申请号：US12519538
申请日：2007-12-14
申请人： Josephus Arnoldus Henricus Maria Kahlman , Jacobus Maarten Den Hollander
发明人： Josephus Arnoldus Henricus Maria Kahlman , Jacobus Maarten Den Hollander
IPC分类号： G11B3/70 , G11B7/00
CPC分类号： G11B20/00086 , G11B7/24094 , G11B20/0013 , G11B20/00173 , G11B20/00579 , G11B20/00884 , G11B20/14 , G11B23/281 , G11B23/40 , G11B2220/2541
摘要： A visible pattern is obtained by modulating the digital sum value. Because the digital sum value modulation allows the choice of several different channel bits groups between DC control points, the selection of a group of channel bits resulting in a change of reflection. This creation of a visible pattern is highly suitable for Blueray as the parity preserving property of the channel code guarantees disparity inversion by the DC-control bit, which keeps the DSV excursions between hard limits. As a result only small DSV deliberate variations are required to produce a visual watermark, which will not deteriorate the bit-detection margin of the optical disc.
摘要翻译：通过调制数字和值获得可视图案。由于数字和值调制允许在DC控制点之间选择几个不同的信道位组，所以选择一组通道位导致反射变化。这种可见图案的创建非常适合于Blueray，因为通道代码的奇偶校验保留属性保证DC控制位的视差反转，这保持DSV在硬限制之间的偏移。因此，仅需要小的DSV有意的变化来产生视觉水印，这不会使光盘的位检测边缘劣化。

79. 发明授权

US07486206B2 Method for crosstalk reduction between tracks on a recording medium, recording device, playback device and recording medium 失效
标题翻译：在记录介质，记录装置，回放装置和记录介质上的轨迹之间的串扰减小的方法
公开(公告)号：US07486206B2
公开(公告)日：2009-02-03
申请号：US10540675
申请日：2003-12-01
申请人： Josephus Arnoldus Henricus Maria Kahlman
发明人： Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： H03M7/00
CPC分类号： G11B20/1426 , G11B20/22 , G11B2020/1457
摘要： In order to reduce the cross talk between data recorded in adjacent tracks on a record carrier the encoding of the data stream into code words is controlled using control points. The code words in a first track are altered by selecting that value of the control point that results in code words that differ in as many bit positions as possible from the corresponding bit positions in a second track, where the first track and second track are both adjacent to the same third track. Having opposite bit values in corresponding bit positions on the first and second track results in the lowest contribution of these bit positions to the code words stored in the third track.
摘要翻译：为了减少在记录载体上记录在相邻轨道中的数据之间的串扰，使用控制点来控制数据流到码字中的编码。通过选择控制点的值来改变第一轨道中的码字，该值导致与第二轨道中的相应比特位置尽可能多的位位置不同的码字，其中第一轨道和第二轨道都是相邻的第三个轨道。在第一和第二轨道上的相应位位置中具有相对位值导致这些位位置对存储在第三轨道中的代码字的最低贡献。

80. 发明申请

US20080314749A1 Microelectronic Device with Magnetic Excitation Wires 审中-公开
标题翻译：具有励磁线的微电子器件
公开(公告)号：US20080314749A1
公开(公告)日：2008-12-25
申请号：US12159465
申请日：2006-10-25
申请人： Mark Thomas Johnson , Albert Hendrik Jan Immink , Marc Wilhelmus Gijsbert Ponjee , Mirielle Ann Reijme , Josephus Arnoldus Henricus Maria Kahlman , Jeroen Hans Nieuwenhuis , Bart Michiel De Boer
发明人： Mark Thomas Johnson , Albert Hendrik Jan Immink , Marc Wilhelmus Gijsbert Ponjee , Mirielle Ann Reijme , Josephus Arnoldus Henricus Maria Kahlman , Jeroen Hans Nieuwenhuis , Bart Michiel De Boer
IPC分类号： G01N27/26
CPC分类号： G01N33/54326 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2400/0415 , B01L2400/043 , G01N27/745 , G01N33/5438
摘要： The invention relates to a microelectronic device (200), particularly a magnetic biosensor, comprising B/E-electrodes (21) that can generate a magnetic field (B) in a sample chamber (10). The device further comprises E-electrodes (23, 24) that can generate an electrical field (E) in the sample chamber (10) in cooperation with the B/E-electrodes (21). Thus the B/E-electrodes are used for two purposes. Electrical fields (E) in the sample chamber (10) may particularly be used for pumping and/or mixing of a fluid sample or for a stringency test of particle bindings.
摘要翻译：本发明涉及一种微电子器件（200），特别是包括可在样品室（10）中产生磁场（B））的B / E电极（21）的磁性生物传感器。所述装置还包括可与所述B / E电极（21）配合地在样品室（10）中产生电场（E）的E电极（23,24）。因此，B / E电极用于两个目的。样品室（10）中的电场（E）可特别用于泵送和/或混合流体样品或用于颗粒结合的严格性测试。

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