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71. 发明授权

US09867781B2 Hydrogel encapsulated cells and anti-inflammatory drugs 有权
公开(公告)号：US09867781B2
公开(公告)日：2018-01-16
申请号：US13400382
申请日：2012-02-20
申请人： Daniel G. Anderson , Robert S. Langer , Tram T. Dang
发明人： Daniel G. Anderson , Robert S. Langer , Tram T. Dang
IPC分类号： A61K9/16 , A61K9/00 , A61K31/573 , A61K45/06 , A61K35/39 , G01N33/50 , A61L27/38 , A61L27/48 , A61L27/52 , A61L27/54 , C12N5/071
CPC分类号： A61K9/1641 , A61K9/0019 , A61K31/573 , A61K35/39 , A61K45/06 , A61L27/3804 , A61L27/48 , A61L27/52 , A61L27/54 , A61L2300/41 , A61L2300/622 , A61L2300/64 , C12N5/0676 , C12N2502/1157 , C12N2533/40 , C12N2533/74 , G01N33/5088 , A61K2300/00 , C08L5/04 , C08L5/08
摘要： A composition containing biocompatible hydrogel encapsulating mammalian cells and anti-inflammatory drugs is disclosed. The encapsulated cells have reduced fibrotic overgrowth after implantation in a subject. The compositions contain a biocompatible hydrogel having encapsulated therein mammalian cells and anti-inflammatory drugs or polymeric particles loaded with anti-inflammatory drugs. The anti-inflammatory drugs are released from the composition after transplantation in an amount effective to inhibit fibrosis of the composition for at least ten days. Methods for identifying and selecting suitable anti-inflammatory drug-loaded particles to prevent fibrosis of encapsulated cells are also described. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.

72. 发明授权

US09492400B2 Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals 有权
标题翻译：涂覆的控释聚合物颗粒作为用于生物药物的高效口服递送载体
公开(公告)号：US09492400B2
公开(公告)日：2016-11-15
申请号：US11666908
申请日：2005-11-04
申请人： Sangyong Jon , Omid C. Farokhazd , Robert S. Langer , Jianjun Cheng
发明人： Sangyong Jon , Omid C. Farokhazd , Robert S. Langer , Jianjun Cheng
IPC分类号： A61K9/16 , A61K9/50 , A61K9/51 , A61K9/00
CPC分类号： A61K9/5138 , A61K9/0043 , A61K9/0065 , A61K9/5036 , A61K9/5153 , A61K9/5192 , A61K38/28
摘要： A composition for delivering an active agent to a patient. The composition includes a polymer core encapsulating the active agent and a mucoadhesive coating disposed about the core. The polymer may include covalently linked poly(ethylene glycol) chains, and the mucoadhesive coating may be selected to facilitate transfer of the particle through the intestinal mucosa. A molecular weight and cross-link density of the polymer may be selected such that the polymer core will decompose in a predetermined time interval. The fraction of the dose of the drug entering the system at circulation during the predetermined time interval may be between about 0.25% and about 25%. The composition may be formulated as a plurality of nanoparticles or microparticles that are combined with a pharmaceutically acceptable carrier to produce an edible or inhalable drug product.
摘要翻译：用于将活性剂递送至患者的组合物。该组合物包括包封活性剂的聚合物芯和围绕该芯设置的粘膜粘附性涂层。聚合物可以包括共价连接的聚（乙二醇）链，并且可以选择粘膜粘附性涂层以促进颗粒通过肠粘膜的转移。可以选择聚合物的分子量和交联密度，使得聚合物芯将以预定的时间间隔分解。在预定时间间隔期间进入系统的药物剂量的分数可以在约0.25％至约25％之间。组合物可以配制成与药学上可接受的载体组合以产生可食用或可吸入的药物产品的多个纳米颗粒或微粒。

73. 发明授权

US09333163B2 Particles with multiple functionalized surface domains 有权
标题翻译：具有多个功能化表面结构域的颗粒
公开(公告)号：US09333163B2
公开(公告)日：2016-05-10
申请号：US13122654
申请日：2009-10-06
申请人： Omid C. Farokhzad , Carolina Salvador-Morales , Weiwei Gao , Liangfang Zhang , Juliana M. Chan , Robert S. Langer
发明人： Omid C. Farokhzad , Carolina Salvador-Morales , Weiwei Gao , Liangfang Zhang , Juliana M. Chan , Robert S. Langer
IPC分类号： A61K9/50 , A61K8/86 , A61K8/14 , A61K47/48 , A61K49/00 , A61Q19/00 , B82Y5/00 , A61K39/00
CPC分类号： A61K47/48915 , A61K8/14 , A61K8/86 , A61K31/7088 , A61K39/0005 , A61K39/39 , A61K47/6911 , A61K47/6923 , A61K47/6929 , A61K47/6937 , A61K49/0065 , A61K49/0067 , A61K49/0093 , A61K2039/55516 , A61K2039/55555 , A61K2039/6093 , A61Q19/00 , B82Y5/00 , C12N15/115 , C12N2310/16 , C12N2310/351 , C12N2320/32
摘要： This disclosure relates to particles (e.g., nanoparticles and microparticles) that display multiple functionalized surface domains in a controlled mosaic pattern. The disclosure also provides simple methods to create various particles that have multiple functionalized surface domains while allowing the use of a wide variety of diverse core structures. The multiple functionalized domains provide controllable particle binding and orientation, and controlled and sustained drug release profiles.
摘要翻译：本公开涉及以受控马赛克图案显示多个功能化表面结构域的颗粒（例如，纳米颗粒和微粒）。本公开还提供了简单的方法来产生具有多个功能化表面域的各种颗粒，同时允许使用各种不同的核心结构。多个功能化区域提供可控的颗粒结合和取向，以及受控和持续的药物释放特征。

74. 发明授权

US09198568B2 Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production 有权
标题翻译：将声音缺陷与可调粘膜植入物匹配的方法和系统，以恢复和增强个性化的人声和声音产生
公开(公告)号：US09198568B2
公开(公告)日：2015-12-01
申请号：US13579347
申请日：2011-03-04
申请人： Steven M. Zeitels , Robert E. Hillman , Sandeep Sidram Karajanagi , Robert S. Langer
发明人： Steven M. Zeitels , Robert E. Hillman , Sandeep Sidram Karajanagi , Robert S. Langer
IPC分类号： A61F2/00 , A61B1/267 , A61L27/26 , A61L27/50
CPC分类号： A61B1/2673 , A61L27/26 , A61L27/50 , C08L71/02
摘要： The disclosure relates to methods and systems for making customized treatments to a subject's vocal tissues to provide a desired level of vocal function.
摘要翻译：本公开涉及用于对受试者的声乐组织进行定制治疗以提供期望水平的声带功能的方法和系统。

75. 发明授权

US09193827B2 Poly(beta-amino alcohols), their preparation, and uses thereof 有权
标题翻译：聚（β-氨基醇），它们的制备及其用途
公开(公告)号：US09193827B2
公开(公告)日：2015-11-24
申请号：US13819280
申请日：2011-08-26
申请人： Minglin Ma , Wendy F. Liu , Robert S. Langer , Daniel Griffith Anderson
发明人： Minglin Ma , Wendy F. Liu , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： C08G73/02 , A61L31/10 , C09D5/16 , C08G59/22 , C08G59/30 , C08G59/50 , C09D179/02
CPC分类号： C08G73/0206 , A61K9/1273 , A61K31/7088 , A61K47/34 , A61K47/59 , A61L31/10 , C08G59/22 , C08G59/306 , C08G59/50 , C08G73/02 , C09D5/1637 , C09D179/02 , Y10T428/31725
摘要： A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.
摘要翻译：使用组合聚合制备了一类新的聚（β-氨基醇）（PBAAs）。本发明的PBAAs可用于生物技术和生物医学应用中，作为涂层（例如用于医疗装置或植入物的膜或多层膜的涂层），添加剂，材料，赋形剂，非生物污垢剂，微图案化剂和细胞包封剂。当用作表面涂层时，这些PBAAs根据其化学结构在体外和体内引起不同程度的炎症。这类材料的大化学多样性使我们能够鉴定体外抑制巨噬细胞活化的聚合物涂层。此外，在皮下植入羧化聚苯乙烯微粒之后，这些涂层减少了炎性细胞的募集，并减少了纤维化。这些聚合物可用于形成用于细胞包封的聚电解质复合物胶囊。本发明还可以具有许多其他生物学应用，例如抗微生物涂层，DNA或siRNA递送以及干细胞组织工程。

76. 发明授权

US09186640B2 Delivery and controlled release of encapsulated lipophilic nutrients 有权
标题翻译：包装的亲脂性营养物的交付和控制释放
公开(公告)号：US09186640B2
公开(公告)日：2015-11-17
申请号：US11846212
申请日：2007-08-28
申请人： Daniel S. Kohane , Yoon Yeo , Peter Given , Robert S. Langer
发明人： Daniel S. Kohane , Yoon Yeo , Peter Given , Robert S. Langer
IPC分类号： A23P1/08 , A23L1/00 , B01J13/10 , A23L1/0522 , A23L1/053 , A23L1/0562 , A23L1/30 , A23L1/48
CPC分类号： A61K9/1075 , A23L2/52 , A23L29/219 , A23L29/25 , A23L29/281 , A23L33/12 , A23P10/30 , A23V2002/00 , A61K9/0053 , A61K9/0095 , A61K31/202 , A61K35/60 , B01J13/10 , A23V2250/187 , A23V2250/1868 , A23V2200/254 , A23V2250/5432 , A23V2250/51 , A23V2200/224 , A23V2250/511 , A23V2250/5022 , A23V2250/54252
摘要： A complex coacervate delivery system is provided which encapsulates lipophilic nutrients such as, for example, fish oils high in omega-3 fatty acids. The complex coacervate delivery system protects the lipophilic nutrient from degradation, e.g., oxidation and hydrolysis, and also reduces or eliminates the unpleasant taste and odor of the lipophilic nutrient. The complex coacervate delivery system upon ingestion is operative to substantially release the lipophilic nutrient in the lower gastrointestinal tract in a pH-controlled manner. The complex coacervate delivery system may be included in a food or beverage product having a pH value within the range of about 1.5 to about 5.0.
摘要翻译：提供了一种复合凝聚物递送系统，其包封亲脂性营养物质，例如ω-3脂肪酸高的鱼油。复合凝聚物递送系统保护亲脂性营养物免受降解，例如氧化和水解，并且还减少或消除亲脂性营养物质的令人不快的味道和气味。摄入后的复合凝聚物递送系统可操作以基于pH控制的方式基本上释放下胃肠道中的亲脂性营养物质。复合凝聚物递送系统可以包含在pH值在约1.5至约5.0范围内的食品或饮料产品中。

77. 发明授权

US08912304B2 Polyol-based polymers 有权
标题翻译：多元醇类聚合物
公开(公告)号：US08912304B2
公开(公告)日：2014-12-16
申请号：US12600596
申请日：2008-05-16
申请人： Joost P. Bruggeman , Christiaan Nijst , Daniel S. Kohane , Robert S. Langer
发明人： Joost P. Bruggeman , Christiaan Nijst , Daniel S. Kohane , Robert S. Langer
IPC分类号： C08G63/02 , C08G63/668 , A61L27/54 , A61L27/52 , A61L27/58 , A61L27/38 , A61L27/16 , C08G63/21 , C08F283/00
CPC分类号： C08G63/668 , A61L27/16 , A61L27/38 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/604 , C08G63/21 , C08L33/02
摘要： The present invention provides inventive polyol-based polymers, materials, pharmaceutical compositions, and methods of making and using the inventive polymers and materials. In certain aspects of the invention, an inventive polymer corresponds to a polymer depicted below. Exemplary inventive polymers includes those prepared using polyol units (e.g., xylitol, mannitol, sorbitol, or maltitol) condensed with polycarboxylic acid units (e.g., citric acid, glutaric acid, or sebacic acid). The inventive polymers may be further derivatized or modified. For example, the polymer may be made photocrosslinkable by adding methacrylate moieties to the polymer.
摘要翻译：本发明提供本发明的多元醇基聚合物，材料，药物组合物以及制备和使用本发明的聚合物和材料的方法。在本发明的某些方面，本发明的聚合物对应于下面描述的聚合物。示例性的本发明聚合物包括使用与多元羧酸单元（例如柠檬酸，戊二酸或癸二酸）缩合的多元醇单元（例如木糖醇，甘露糖醇，山梨糖醇或麦芽糖醇）制备的那些聚合物。本发明的聚合物可进一步衍生或修饰。例如，可以通过向聚合物中加入甲基丙烯酸酯部分使聚合物可光交联。

78. 发明申请

US20130280334A1 Nanostructured Gels Capable of Controlled Release of Encapsulated Agents 审中-公开
标题翻译：纳米结构凝胶可以控制释放的封装剂
公开(公告)号：US20130280334A1
公开(公告)日：2013-10-24
申请号：US13825486
申请日：2011-09-23
申请人： Jeffrey M. Karp , Praveen Kumar Vemula , Nathaniel R. Campbell , Abdullah M. Syed , Sufeng Zhang , Omid C. Farokhzad , Robert S. Langer
发明人： Jeffrey M. Karp , Praveen Kumar Vemula , Nathaniel R. Campbell , Abdullah M. Syed , Sufeng Zhang , Omid C. Farokhzad , Robert S. Langer
IPC分类号： A61K47/14
CPC分类号： A61K47/22 , A61K9/0019 , A61K9/06 , A61K9/1075 , A61K31/166 , A61K31/405 , A61K31/4188 , A61K31/4745 , A61K31/573 , A61K31/58 , A61K31/713 , A61K38/28 , A61K47/14 , A61K47/26 , A61K47/28
摘要： Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.
摘要翻译：描述了包含胶凝剂，例如分子量为2500以下的可酶切割凝胶剂的自组装凝胶组合物。自组装凝胶组合物可以包封一种或多种试剂。还描述了使用自组装凝胶组合物制备自组装凝胶组合物的方法和药物递送方法。

79. 发明授权

US08562966B2 End-modified poly(beta-amino esters) and uses thereof 有权
标题翻译：末端改性的聚（β-氨基酯）及其用途
公开(公告)号：US08562966B2
公开(公告)日：2013-10-22
申请号：US13312224
申请日：2011-12-06
申请人： Gregory T. Zugates , Andreas Zumbuehl , Robert S. Langer , Daniel Griffith Anderson
发明人： Gregory T. Zugates , Andreas Zumbuehl , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： A61K31/765 , A61K9/14 , A61K38/00 , A61K48/00 , A61K47/00 , C08G63/91
CPC分类号： C12N15/87 , A61K9/5138 , A61K47/34 , C08G63/6856 , C08G73/02 , C08L79/02
摘要： Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.
摘要翻译：聚（β-氨基酯）被末端修饰以形成用于医疗和非医学领域的材料。使胺封端的聚（β-氨基酯）与亲电子试剂或丙烯酸酯封端的聚（β-氨基酯）与亲核试剂反应。本发明的末端改性聚合物可用于已经发现聚合物有用的任何领域，包括药物递送领域。末端修饰的聚合物特别可用于递送核酸如DNA或RNA。本发明还提供包含本发明的端基改性聚合物，制备本发明聚合物的方法和使用本发明聚合物的方法的组合物。

80. 发明授权

US08367113B2 Polymers for functional particles 有权
标题翻译：功能颗粒聚合物
公开(公告)号：US08367113B2
公开(公告)日：2013-02-05
申请号：US11803843
申请日：2007-05-15
申请人： Frank X. Gu , Benjamin A. Teply , Robert S. Langer , Omid C. Farokhzad
发明人： Frank X. Gu , Benjamin A. Teply , Robert S. Langer , Omid C. Farokhzad
IPC分类号： A61K9/14 , A61K9/51
CPC分类号： C08G63/912 , A61K9/5153 , A61K47/549 , A61K47/593 , A61K47/60 , A61K47/6935 , A61K47/6937 , A61K49/00 , A61K51/1244 , B82Y5/00 , Y10S977/773 , Y10S977/906 , Y10S977/915 , Y10T428/2982
摘要： The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other aspects of the invention are directed to methods using such libraries, methods of using or administering such polymeric conjugates, methods of promoting the use of such polymeric conjugates, kits involving such polymeric conjugates, or the like.
摘要翻译：本发明一般涉及聚合物和大分子，特别是阻止可用于颗粒如纳米颗粒的聚合物。本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。在一些情况下，纳米颗粒可以含有药物。在一些实施方案中，该部分可具有大于约1000Da的分子量; 例如，该部分可以包括多肽或多核苷酸，例如适体。该部分还可以是靶向部分，成像部分，螯合部分，带电部分或治疗部分。本发明的另一方面涉及制备这种聚合物缀合物的系统和方法。在一些实施方案中，将含有聚合物的溶液与诸如不混溶液体的液体接触以形成含有聚合物缀合物的纳米颗粒。本发明的其它方面涉及使用这种文库的方法，使用或施用这种聚合物缀合物的方法，促进使用这种聚合物缀合物的方法，涉及这种聚合物缀合物的试剂盒等。

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