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71. 发明申请

US20120294827A1 POLYMER GEL FORMULATION 审中-公开
标题翻译：聚合物凝胶配方
公开(公告)号：US20120294827A1
公开(公告)日：2012-11-22
申请号：US13575930
申请日：2011-01-28
申请人： Abraham J. Domb , Boris Vaisman , Lior Yankelson , Moran Yaniv
发明人： Abraham J. Domb , Boris Vaisman , Lior Yankelson , Moran Yaniv
IPC分类号： A61K31/765 , A61K8/85 , A61Q19/08 , A61P19/02 , A61P13/00 , A61P1/04 , A61P27/02 , A61K8/84 , A61P17/02
CPC分类号： A61L27/52 , A61L27/18
摘要： A polymer gel, in at least some embodiments, featuring both cross-linked castor oil and branched castor oil components, in which the castor oil is optionally replaced by ricinoleic acid.
摘要翻译：在至少一些实施方案中，聚合物凝胶具有交联的蓖麻油和支链蓖麻油组分，其中蓖麻油任选被蓖麻油酸取代。

72. 发明授权

US07919113B2 Dispersible concentrate lipospheres for delivery of active agents 有权
标题翻译：用于递送活性剂的可分散浓缩物脂质体
公开(公告)号：US07919113B2
公开(公告)日：2011-04-05
申请号：US10965551
申请日：2004-10-14
申请人： Abraham J. Domb
发明人： Abraham J. Domb
IPC分类号： A61K9/127
CPC分类号： A61K9/1075 , Y10S977/797 , Y10S977/799 , Y10S977/801
摘要： A formulation containing one or more lipophilic agents, methods of making and using the formulation are described herein. The formulation is formed by adding a pre-suspension concentrate composition to an aqueous medium. Upon contact with the aqueous medium, a solid nanoparticle suspension spontaneously forms. The resulting formulation is in the form of a microemulsion. The concentrate contains an amphiphilic solvent, a pharmaceutically acceptable solid carrier such as a solid fatty acid or ester, a surfactant, and an agent. Preferably the concentrate contains a combination of a surfactant with a high hydrophilic/lipophilic balance (HLB) of at least about 8 and a surfactant with a low HLB of less than about 5. The agent is preferably a lipophilic drug and other lipophilic ingredient, such as vitamins. The composition is suitable for use in medical and non-medical applications. The microemuslions described herein have increased stability was compared to the prior art.
摘要翻译：本文描述了含有一种或多种亲脂性试剂的制剂，制备和使用制剂的方法。该制剂通过将预悬浮浓缩组合物加入到水性介质中而形成。在与水性介质接触时，固体纳米颗粒悬浮液自发形成。所得制剂是微乳液的形式。浓缩物含有两亲溶剂，药学上可接受的固体载体如固体脂肪酸或酯，表面活性剂和试剂。优选地，浓缩物含有具有至少约8的高亲水/亲油平衡（HLB）的表面活性剂和低HLB小于约5的表面活性剂的组合。该试剂优选是亲脂性药物和其它亲脂性成分，例如作为维生素。该组合物适用于医疗和非医疗应用。与现有技术相比，本文所述的微型密封件具有增加的稳定性。

73. 发明申请

US20100159012A1 Conjugates of Therapeutically Active Compounds 审中-公开
标题翻译：治疗活性化合物的结合物
公开(公告)号：US20100159012A1
公开(公告)日：2010-06-24
申请号：US11992298
申请日：2006-09-26
申请人： Abraham J. Domb , Itzhack Polacheck , Marina Sokolsky , Jacob Golenser
发明人： Abraham J. Domb , Itzhack Polacheck , Marina Sokolsky , Jacob Golenser
IPC分类号： A61K9/14 , C07H3/00 , C07H3/02 , C08B37/02 , C07H1/00 , A61K31/715
CPC分类号： A61K47/61
摘要： The present invention discloses modified polymer conjugates of a polymer and a drug having reduced toxicity relative to the unmodified parent compound while retaining substantially the same degree of therapeutic activity as of the unmodified parent compound.
摘要翻译：本发明公开了相对于未修饰的母体化合物具有降低的毒性的聚合物和药物的改性聚合物缀合物，同时保留与未修饰的母体化合物基本上相同程度的治疗活性。

74. 发明申请

US20100084347A1 FLUID FILTER MONITORING DEVICE 有权
标题翻译：流体过滤器监控装置
公开(公告)号：US20100084347A1
公开(公告)日：2010-04-08
申请号：US12444635
申请日：2007-08-28
申请人： Haim Wilder , Abraham J. Domb
发明人： Haim Wilder , Abraham J. Domb
IPC分类号： B01D35/143
CPC分类号： B01D46/0086 , C02F1/003
摘要： An indicator for the status of the filter is provided. The indicator comprises at least one erodable member in contact with the source fluid and a visual indication arrangement that permits a viewer to gauge the appearance of the erodable member to thereby gauge the filter status. The erodable member is eroded by interaction with the fluid or with an element within the fluid. The indicator may be incorporated as an integral component of a filter or may be a stand-alone device to be incorporated into a filter or filtration system.
摘要翻译：提供过滤器状态指示。指示器包括与源流体接触的至少一个可侵蚀构件和允许观察者测量可侵蚀构件的外观从而测量过滤器状态的视觉指示装置。可侵蚀构件通过与流体或流体内的元素的相互作用而侵蚀。指示剂可以作为过滤器的整体部件结合，或者可以是要并入到过滤器或过滤系统中的独立装置。

75. 发明申请

US20090123514A1 Electropolymerizable Monomers and Polymeric Coatings on Implantable Devices Prepared Therefrom 审中-公开
标题翻译：在其上制备的可植入器件上的电聚合单体和聚合物涂层
公开(公告)号：US20090123514A1
公开(公告)日：2009-05-14
申请号：US11989221
申请日：2006-07-19
申请人： Abraham J. Domb
发明人： Abraham J. Domb
IPC分类号： C08F26/06 , A61F2/02 , C07D207/30 , C07D409/00 , C07D333/02 , B05D3/00 , B05D3/14 , B05C9/08
CPC分类号： C07D207/327 , A61L27/042 , A61L27/34 , A61L31/022 , A61L31/10 , A61L31/16 , A61L33/0088 , A61L2300/80 , A61L2400/12 , A61L2420/02 , C08F2/58 , C08F226/06 , C09D5/4476 , C08L39/06
摘要： Conductive surfaces of e.g., implantable devices, coated with electropolymerized polymers having active substances attached thereto are disclosed. Electropolymerizable monomers designed and used for obtaining such conductive surfaces and processes, devices and methods for attaching the electropolymerized polymers to conductive surfaces are also disclosed. The polymers, processes and devices presented herein can be beneficially used in the preparation of implantable medical devices.
摘要翻译：公开了涂覆有附着有活性物质的电聚合聚合物的可植入装置的导电表面。还公开了设计和用于获得这种导电表面的电聚合单体和用于将电聚合聚合物附着到导电表面的方法，装置和方法。本文提出的聚合物，方法和装置可有利地用于可植入医疗装置的制备。

76. 发明申请

US20090053309A1 ADHESIVE COMPOSITIONS FOR THE TREATMENT OF XEROSTOMIA 审中-公开
标题翻译：用于治疗XEROSTOMIA的粘合剂组合物
公开(公告)号：US20090053309A1
公开(公告)日：2009-02-26
申请号：US11959997
申请日：2007-12-19
申请人： Abraham J. Domb , Benny Brama
发明人： Abraham J. Domb , Benny Brama
IPC分类号： A61K9/20 , A61P1/00
CPC分类号： A61K9/006 , A61K9/2086 , A61K31/22
摘要： Compositions and methods for the treatment of xerostomia are disclosed herein. Methods for making the compositions are also disclosed herein. The compositions are designed for individuals having the physiologic ability to salivate but who do not salivate in sufficient quantity to satisfy their personal comfort level of oral hydration. The compositions are typically in the form of a film or tablet, preferably in the form of a sticker tablet, most preferably in the form of a double layer sticker tablet, where one layer contains a bioadhesive material and the second layer contains the sialogogic agent and the one or more lipids. The compositions adhere to a buccal surface or mucosal surface in the oral cavity for at least 15 minutes, preferably for at least 30 minutes. The compositions contain a therapeutically effective amount of one or more sialogogic agents and one or more lipids for treating xerostomia and a pharmaceutically acceptable bioadhesive carrier. The compositions optionally contain a non-lipid lubricant, a flavoring agent, and/or a buffering agent. The methods for treatment of xerostomia require placing the composition on the oral mucosa of a patient's mouth, preferably on the palate or the cheek. The composition will adhere to the mucosal surface and dissolve over a period of time. The composition is generally effective at treating or ameliorating the effects of xerostomia for a time period ranging from at least 30 minutes up to 8 hours following administration to the buccal or oral mucosa.
摘要翻译：本文公开了用于治疗口腔干燥症的组合物和方法。本文还公开了制备组合物的方法。该组合物被设计用于具有唾液的生理能力但没有足够量的唾液以满足其个人舒适水平的口服水合的个体。组合物通常为薄膜或片剂的形式，优选为贴片形式，最优选为双层贴片片剂的形式，其中一层包含生物粘附材料，第二层含有唾液酸剂，一种或多种脂质。组合物粘附在口腔中的口腔表面或粘膜表面至少15分钟，优选至少30分钟。组合物含有治疗有效量的一种或多种唾液酸化剂和一种或多种用于治疗口腔干燥症的脂质和药学上可接受的生物粘附性载体。组合物任选地含有非脂润滑剂，调味剂和/或缓冲剂。用于治疗口腔干燥症的方法需要将组合物置于患者口腔的口腔粘膜上，优选在口腔或面颊上。组合物将粘附到粘膜表面并溶解一段时间。该组合物在施用至颊或口腔粘膜后至少30分钟至8小时的时间段内通常有效地治疗或改善口腔干燥症的作用。

77. 发明申请

US20080226728A1 Antimicrobial Nanoparticulate Additives Forming Non-Leachable Sustained Antimicrobial Polymeric Compositions 有权
标题翻译：抗微生物纳米颗粒添加剂形成不可浸出的持续抗微生物聚合物组合物
公开(公告)号：US20080226728A1
公开(公告)日：2008-09-18
申请号：US11794492
申请日：2006-01-01
申请人： Abraham J. Domb , Ervin Weiss , Nurit Beyth , Ira Farber , Michael Perez Davidi
发明人： Abraham J. Domb , Ervin Weiss , Nurit Beyth , Ira Farber , Michael Perez Davidi
IPC分类号： A61K9/14
CPC分类号： A61K6/083 , A01N25/12 , A01N33/12 , A01N37/12 , A61K6/0008 , A61K6/0023 , A61K6/0032 , A61K6/0067 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/208 , A61L2300/404 , A61L2300/408 , A61L2300/624 , C08L39/02 , C08L33/08 , C08L5/08
摘要： The present invention provides a particle comprising at least one aliphatic polymer having anti-microbially active quaternary ammonium groups chemically bound thereto. The particle of the invention may be used to inhibit populations of microorganisms and biofilms. Also provided are methods for the preparation of such particles and uses thereof for the inhibition of microorganisms.
摘要翻译：本发明提供一种包含至少一种具有与其结合的抗微生物活性季铵基团的脂族聚合物的颗粒。本发明的颗粒可用于抑制微生物和生物膜的群体。还提供了制备这种颗粒的方法及其用于抑制微生物的用途。

78. 发明授权

US07001891B1 Biodegradable polycation composition for delivery of an anionic macromolecule 失效
标题翻译：用于递送阴离子大分子的可生物降解聚阳离子组合物
公开(公告)号：US07001891B1
公开(公告)日：2006-02-21
申请号：US10031728
申请日：2000-07-18
申请人： Abraham J. Domb
发明人： Abraham J. Domb
IPC分类号： C12N15/85 , C07H21/04 , C08B37/00 , C07K14/435
CPC分类号： C08B37/0018 , C08B37/0021 , C08B37/003
摘要： The present invention provides a biodegradable polycation composition for delivery of an anionic macromolecule, comprising a polysaccharide chain having an amount of saccharide units ranging from 2 to 2000 and at least one grafted oligoamine per 5 saccharide units, wherein said oligoamine is selected from the group consisting of a linear, branched and cyclic alkyl amine having at least two amino groups.
摘要翻译：本发明提供一种用于递送阴离子大分子的可生物降解的聚阳离子组合物，其包含每5个糖单元的糖单元量为2至2000的多糖链和至少一个接枝的寡胺，其中所述寡胺选自具有至少两个氨基的直链，支链和环状烷基胺。

79. 发明授权

US6011008A Conjugates of biologically active substances 失效
标题翻译：生物活性物质的结合物
公开(公告)号：US6011008A
公开(公告)日：2000-01-04
申请号：US90587
申请日：1998-06-04
申请人： Abraham J. Domb , Shimon Benita , Itzhack Polacheck , Galina Linden
发明人： Abraham J. Domb , Shimon Benita , Itzhack Polacheck , Galina Linden
IPC分类号： A61K47/48 , A61K37/02 , A61K37/36 , C07K13/00
CPC分类号： A61K47/4823
摘要： A method for producing a water-soluble polysaccharide conjugate of an oxidation-sensitive substance is described. The method comprises the following steps: (a) activating the polysaccharide to a dialdehyde by periodate oxidation; (b) purifying the dialdehyde from interfering anions and by-products; and (c) coupling the substance to the purified dialdehyde by Schiff base formation to form the conjugate. Optionally, the conjugate of step (c) is reduced to an amine conjugate by a reducing substance. The product conjugate may then be further purified from various reaction byproducts. The disclosed method results in the substance substantially retaining its biological activity. Also described are imine and amine polysaccaride conjugates of various drugs and polypeptides.
摘要翻译：对氧化敏感性物质的水溶性多糖缀合物的制造方法进行说明。该方法包括以下步骤：（a）通过高碘酸氧化活化多糖至二醛; （b）从干扰阴离子和副产物中纯化二醛; 和（c）通过席夫碱形成将物质与纯化的二醛偶合形成共轭物。任选地，步骤（c）的缀合物通过还原物质还原成胺缀合物。然后可以从各种反应副产物中进一步纯化产物缀合物。所公开的方法导致该物质基本上保留其生物活性。还描述了各种药物和多肽的亚胺和胺多糖偶联物。

80. 发明授权

US5919835A Biodegradable polymer blends for drug delivery 失效
标题翻译：用于药物递送的可生物降解聚合物共混物
公开(公告)号：US5919835A
公开(公告)日：1999-07-06
申请号：US995952
申请日：1992-12-23
申请人： Abraham J. Domb , Manoj Maniar , Andrew S. T. Haffer
发明人： Abraham J. Domb , Manoj Maniar , Andrew S. T. Haffer
IPC分类号： A61K47/34 , A61K9/20 , C08L67/00 , C08L67/02 , C08L67/04 , C08L73/00 , C08L73/02 , C08L101/16 , A61F2/02
CPC分类号： C08L67/04 , A61K9/2031 , A61K9/204 , C08L67/02 , C08L73/02
摘要： Blends of polymers having properties distinct from the individual polymer components and that are suitable for use as carriers of pharmaceutically active agents, are prepared from two or more polyanhydrides, polyesters or mixtures of polyanhydrides and polyesters. The blends have different properties than the polymers used to prepare the blends, providing a means for altering the characteristics of a polymeric matrix without altering the chemical structure of the component polymers. Blends of various polyanhydrides, polyesters, and polyanhydrides and polyesters, containing pharmaceutically active agents, are prepared using solvent mixing or melt mixing procedures. It has been discovered that the rate of release of the agent from the blends is different than the rate of release from the individual polyanhydride and polyester polymer components, being a function of the blend composition
摘要翻译：由两种或更多种聚酐，聚酯或聚酐和聚酯的混合物制备具有不同于各个聚合物组分并且适合用作药物活性剂载体的性质的聚合物的共混物。共混物具有与用于制备共混物的聚合物不同的性质，提供了改变聚合物基质的特性而不改变组分聚合物的化学结构的方法。使用溶剂混合或熔融混合程序制备含有药物活性剂的各种聚酐，聚酯和聚酐和聚酯的共混物。已经发现，试剂从共混物中的释放速率不同于单独的聚酐和聚酯聚合物组分的释放速率，作为共混组合物的函数

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