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71. 发明申请

US20090130666A1 Cytometric system including nucleic acid sequence amplification, and method 审中-公开
标题翻译：细胞系统包括核酸序列扩增和方法
公开(公告)号：US20090130666A1
公开(公告)日：2009-05-21
申请号：US11921114
申请日：2006-05-30
申请人： Mark F. Oldham
发明人： Mark F. Oldham
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/34
CPC分类号： G01N35/1095 , B01L3/502761 , B01L3/502784 , B01L7/52 , G01N15/1056 , G01N15/1459 , G01N35/08 , G01N2015/0038
摘要： The invention relates to a cytometric system that can include a first station capable of selectively sorting a nucleic acid sequence-containing biological material from a biological sample, and a second station where nucleic acid of the sorted nucleic acid sequence-containing biological material, can undergo a nucleic acid amplification reaction. The system can include a conduit system adapted to facilitate transfer of a sorted biological material or processed biological material from one region or station, to another. All of the stations can be controlled by a central control system. Methods of sorting a biological material from a biological sample, and methods of amplifying nucleic acid of a sorted nucleic acid sequence-containing material, are also provided.
摘要翻译：本发明涉及一种细胞计数系统，其可以包括能够选择性地从生物样品中分选含有核酸序列的生物材料的第一站，以及包含分选的含有核酸序列的生物材料的核酸可以经历的第二站核酸扩增反应。该系统可以包括适于便于将分选的生物材料或加工的生物材料从一个区域或站转移到另一个区域或站的导管系统。所有车站均可由中央控制系统控制。还提供了从生物样品中分选生物材料的方法，以及扩增分选的含有核酸序列的材料的核酸的方法。

72. 发明申请

US20090021735A1 Time-delay integration in detection of labeled beads 有权
标题翻译：标记珠的检测时延整合
公开(公告)号：US20090021735A1
公开(公告)日：2009-01-22
申请号：US12283957
申请日：2008-09-17
申请人： Mark F. Oldham , Eric S. Nordman , Richard T. Reel , John S. Shigeura , Janice G. Shigeura
发明人： Mark F. Oldham , Eric S. Nordman , Richard T. Reel , John S. Shigeura , Janice G. Shigeura
IPC分类号： G01N21/62
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
摘要翻译：提供了一种用于检测标记珠粒的装置。该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

73. 发明授权

US07480042B1 Luminescence reference standards 有权
标题翻译：发光参考标准
公开(公告)号：US07480042B1
公开(公告)日：2009-01-20
申请号：US11173609
申请日：2005-06-30
申请人： J. Michael Phillips , Aldrich N. K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
发明人： J. Michael Phillips , Aldrich N. K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
IPC分类号： G01J1/10
CPC分类号： G01N21/278 , B82Y15/00 , G01J1/10 , G01N21/01 , G01N21/4785 , G01N21/6452 , G01N21/76 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/0691 , G01N2201/0697 , Y10S977/943 , Y10S977/949
摘要： Systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.
摘要翻译：系统及其组件，用于检测和/或分析光。样品分析之前，期间和/或之后，这些系统可以包括用于校准，验证和/或监测光检测系统的光学参考标准。

74. 发明申请

US20080316482A1 Optical scanning configurations, systems, and methods 有权
标题翻译：光学扫描配置，系统和方法
公开(公告)号：US20080316482A1
公开(公告)日：2008-12-25
申请号：US12222820
申请日：2008-08-18
申请人： Jon A. Hoshizaki , Howard Gregg King , Johannes P. Sluis , Steven J. Boege , Mark F. Oldham
发明人： Jon A. Hoshizaki , Howard Gregg King , Johannes P. Sluis , Steven J. Boege , Mark F. Oldham
IPC分类号： G01N21/64
CPC分类号： G01N21/645 , F21V29/54 , F21V29/677 , F21V29/763 , G01N21/6452 , G01N2021/6439 , G01N2201/062 , G01N2201/1211 , G05D23/1919 , G05D23/20
摘要： Methods and optical systems for scanning of a target sample, including methods and systems using a low mass scan head. The present invention also relates to methods and systems for performing sample assays, and for producing and measuring optical responses and signatures.
摘要翻译：用于扫描目标样品的方法和光学系统，包括使用低质量扫描头的方法和系统。本发明还涉及用于进行样品测定以及用于产生和测量光学响应和特征的方法和系统。

75. 发明申请

US20080308160A1 Device including inductively heatable fluid retainment region, and method 审中-公开
标题翻译：装置包括电感可加热流体保留区域和方法
公开(公告)号：US20080308160A1
公开(公告)日：2008-12-18
申请号：US12221604
申请日：2008-08-05
申请人： Steven J. Boege , Mark F. Oldham , Marc Haberstroh , Stephen J. Gunstream , Adrian Fawcett , Douglas W. Grunewald
发明人： Steven J. Boege , Mark F. Oldham , Marc Haberstroh , Stephen J. Gunstream , Adrian Fawcett , Douglas W. Grunewald
IPC分类号： F16L53/00
CPC分类号： H05B6/108 , B01F13/0818 , B01L3/50851 , B01L2300/0803 , B01L2300/0809 , B01L2300/1816 , H05B6/109 , H05B2214/04 , Y10T137/6606
摘要： A device is provided that comprises one or more fluid retainment regions each having at least one wall, and one or more loops in heat-transfer communication with the at least one wall. Each of the loops can comprise an electrical conductor that surrounds the same or a different fluid retainment region. A device is provided that comprises one or more fluid retainment regions each having particulates disposed therein. A system is provided that includes a platen adapted to hold a device including fluid retainment regions and one or more electrical conductors in heat-transfer communication with the fluid retainment regions. Methods of heating a sample are also provided.
摘要翻译：提供了一种装置，其包括一个或多个流体保持区域，每个流体保持区域各自具有至少一个壁，以及与所述至少一个壁热传递连通的一个或多个环路。每个环可以包括围绕相同或不同流体保持区域的电导体。提供了一种装置，其包括一个或多个流体保持区域，每个流体保持区域各自具有设置在其中的微粒。提供了一种系统，其包括适于保持包括流体保持区域的装置和与流体保持区域传热连通的一个或多个电导体的压板。还提供了加热样品的方法。

76. 发明申请

US20080240529A1 Methods for Improving the Perfomance of a Detector 有权
标题翻译：提高检测器性能的方法
公开(公告)号：US20080240529A1
公开(公告)日：2008-10-02
申请号：US12138151
申请日：2008-06-12
申请人： Mark F. Oldham
发明人： Mark F. Oldham
IPC分类号： G06K9/00
CPC分类号： H04N5/335
摘要： A system and method for allowing adjustments of various parameters associated with the operation of charge-coupled devices adapted for use in biological analysis devices. Gate voltage signal applied to the CCDs can be adjusted to advantageously affect the manner in which charge is transferred from pixels. The manner in which transferred charges from the pixels are processed in a readout process can also be adjusted to advantageously change the speed of the CCD based detector. Various methods of performing such adjustments are disclosed.
摘要翻译：一种用于允许调整与适于在生物分析装置中使用的电荷耦合装置的操作相关联的各种参数的系统和方法。可以调整施加到CCD的栅极电压信号以有利地影响从像素传送电荷的方式。在读出处理中处理来自像素的传送电荷的方式也可以被调整以有利地改变基于CCD的检测器的速度。公开了进行这种调整的各种方法。

77. 发明授权

US07410793B2 Optical instrument including excitation source 有权
标题翻译：光学仪器包括激发源
公开(公告)号：US07410793B2
公开(公告)日：2008-08-12
申请号：US10440920
申请日：2003-05-19
申请人： Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
发明人： Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
IPC分类号： C12M1/34 , C12M3/00 , C12M1/00 , G01N21/64 , G01N21/66
CPC分类号： G01N21/6486 , B01L7/52 , C12Q2545/101 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
摘要： An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.
摘要翻译：提供了一种光学仪器，用于同时用由光源产生的激发光束照射两个或更多个间隔开的反应区域。光源可以包括发光二极管的区域光阵列，一个或多个固态激光器，一个或多个微线激光器，或其组合。根据各种实施例，菲涅耳透镜可以沿着光源和反应区域之间的光束槽设置。还提供了使用光学仪器的分析方法。

78. 发明授权

US07388664B2 Methods for improving the performance of a detector 有权
标题翻译：提高检测器性能的方法
公开(公告)号：US07388664B2
公开(公告)日：2008-06-17
申请号：US11208970
申请日：2005-08-22
申请人： Mark F. Oldham
发明人： Mark F. Oldham
IPC分类号： G01J3/51 , C12M1/34
CPC分类号： H04N5/335
摘要： A system and method for allowing adjustments of various parameters associated with the operation of charge-coupled devices adapted for use in biological analysis devices. Gate voltage signal applied to the CCDs can be adjusted to advantageously affect the manner in which charge is transferred from pixels. The manner in which transferred charges from the pixels are processed in a readout process can also be adjusted to advantageously change the speed of the CCD based detector. Various methods of performing such adjustments are disclosed.
摘要翻译：一种用于允许调整与适于在生物分析装置中使用的电荷耦合装置的操作相关联的各种参数的系统和方法。可以调整施加到CCD的栅极电压信号以有利地影响从像素传送电荷的方式。在读出处理中处理来自像素的传送电荷的方式也可以被调整以有利地改变基于CCD的检测器的速度。公开了进行这种调整的各种方法。

79. 发明授权

US07382258B2 Sample carrier device incorporating radio frequency identification, and method 有权
标题翻译：采用射频识别的载波装置及方法
公开(公告)号：US07382258B2
公开(公告)日：2008-06-03
申请号：US11086069
申请日：2005-03-22
申请人： Mark F. Oldham , Richard D. Morris , Jerome A. Mack
发明人： Mark F. Oldham , Richard D. Morris , Jerome A. Mack
IPC分类号： G08B13/14
CPC分类号： B01L3/545 , B01L3/5027 , B01L3/5082 , B01L3/5085 , B01L9/06 , B01L2300/022 , G01N35/00732 , G01N35/00871 , G01N2001/021 , G01N2035/00782 , G01N2035/00801 , G01N2035/00821 , G06Q10/087
摘要： An apparatus for associating information with a carrier and/or at least one biological reagent is provided. The apparatus can include a carrier adapted to retain at least one biological reagent and at least one non-silicon Radio Frequency Identification Tag (RFID). The RFID tag can comprise information in the form of an information pointer that can be resolved by an information pointer resolution device. The information pointer and/or resolution device can be used to access a remote system. The carrier can be configured, for example, as a microfluidic processing device or a multi-well plate. Methods and systems using the apparatus are also provided.
摘要翻译：提供了一种用于将信息与载体和/或至少一种生物试剂相关联的装置。该装置可以包括适于保持至少一种生物试剂和至少一种非硅射频识别标签（RFID）的载体。 RFID标签可以包括可由信息指针分辨设备解析的信息指针形式的信息。信息指针和/或分辨率设备可用于访问远程系统。载体可以被配置为例如微流体处理装置或多孔板。还提供了使用该装置的方法和系统。

80. 发明申请

US20080105831A1 SYSTEMS, METHODS AND APPARATUS FOR SINGLE MOLECULE SEQUENCING 失效
标题翻译：用于单分子序列的系统，方法和装置
公开(公告)号：US20080105831A1
公开(公告)日：2008-05-08
申请号：US11749411
申请日：2007-05-16
申请人： Richard T. Reel , Mark F. Oldham , Eric S. Nordman , Steven J. Boege , Steven M. Menchen
发明人： Richard T. Reel , Mark F. Oldham , Eric S. Nordman , Steven J. Boege , Steven M. Menchen
IPC分类号： G01J1/58
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/648 , G01N2021/6432
摘要： An embodiment generally relates to a system for analysis of an analyte. The system can include a transparent substrate. The system also includes an excitation light source configured to induce an evanescent wave excitation of a fluorescently labeled molecule near the access to the transparent substrate and a detector for detecting the fluorescently labeled molecule.
摘要翻译：实施方案一般涉及用于分析分析物的系统。该系统可以包括透明基板。该系统还包括激发光源，其被配置为在靠近透明衬底的位置处诱导荧光标记分子的ev逝波激发和用于检测荧光标记分子的检测器。

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