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    • 77. 发明授权
    • L-tartaric acid salt of a (1R) diastereomer of a
2-azadihydroxybicyclo�2.2.1!heptane compound and the preparation of
2-azabicyclo�2.2.1!heptane compounds
    • 2-氮杂双环[2.2.1]庚烷化合物的(1R)非对映异构体的L-酒石酸盐和2-氮杂双环[2.2.1]庚烷化合物的制备
    • US5684159A
    • 1997-11-04
    • US732024
    • 1996-10-16
    • Michael O'BrienPatrick LeonDenis LargeauMatthew PowersThierry Durand
    • Michael O'BrienPatrick LeonDenis LargeauMatthew PowersThierry Durand
    • C07D491/18C07D209/02C07D209/52
    • C07D209/52C07D209/02Y02P20/55
    • A method according to the invention is directed to the preparation of a 2-azadihydroxybicyclo�2.2.1!heptane compound of formula ##STR1## wherein * represents an R chirality, *' represents an S chirality, R is hydrogen or, respectively, a group of formula ##STR2## wherein R.sub.1 is alkyl and Ar is optionally substituted aryl, comprising bishydroxylating a bicyclo�2.2.1!heptene compound of formula ##STR3## wherein *, *' and R are as previously defined, in the presence of about 0.1 mol to about 5 mol % of a metal osmate compound or about 0.06 mol % to about 0.07 mol % osmium tetroxide, and an oxidizing agent capable of regenerating osmium tetroxide. The invention is also directed to the treatment of the (1R) diastereomer of the 2-azadihydroxybicyclo�2.2.1!heptane compound (I) wherein R is a group of formula II with L-tartaric acid, and the L-tartaric acid salt product thereof. Furthermore, the invention is directed to using the (1R) diastereomer of the 2-azadihydroxybicyclo�2.2.1!heptane compound in an acid facilitated acetalizing or ketalizing reaction that results in the protection of the dihydroxy moieties thereof in isopropanol. In addition, the invention is directed to oxidizing a bis O-protected derivative of the (1R) diastereomer of the 2-azadihydroxybicyclo�2.2.1!heptane compound to a corresponding lactam compound in the presence of about 0.01 mol % to about 1 mol % of RuO.sub.2 with about 3 equivalents of an oxidant to form the lactam compound with in an enantiomeric excess ("ee") of greater than or equal to about 95%.
    • 根据本发明的方法涉及式(I)的化合物(I)的2-氮杂二羟基双环[2.2.1]庚烷化合物,其中*表示R手性,*'表示S 手性,R分别为氢或分别为式(II)的基团,其中R 1为烷基,Ar为任选取代的芳基,其包含双羟基化双酚[2.2.1]庚烯化合物 (III)其中*,*'和R如前所定义,在约0.1mol至约5mol%的金属锇酸盐化合物或约0.06mol%至约0.07的存在下 mol%的四氧化锇和能够再生四氧化锇的氧化剂。 本发明还涉及其中R是式II的基团与L-酒石酸的2-氮杂二羟基双环[2.2.1]庚烷化合物(I)的(1R)非对映异构体的处理,并且L-酒石酸盐 其产品。 此外,本发明涉及使用2-氮杂二羟基双环[2.2.1]庚烷化合物的(1R)非对映体在酸促进缩醛或缩酮反应中,其导致保护其在异丙醇中的二羟基部分。 此外,本发明涉及在约0.01mol%至约1mol的存在下将2-氮杂二羟基双环[2.2.1]庚烷化合物的(1R)非对映异构体的双O保护的衍生物氧化成相应的内酰胺化合物 %的RuO 2与约3当量的氧化剂以形成具有大于或等于约95%的对映体过量(“ee”)的内酰胺化合物。
    • 80. 发明申请
    • MEMS Force Sensors Fabricated Using Paper Substrates
    • 使用纸基板制造的MEMS力传感器
    • US20140224018A1
    • 2014-08-14
    • US13557861
    • 2012-07-25
    • George WhitesidesXinyu LiuXiuJun LiMartin M. ThuoMichael O'BrienYu Sun
    • George WhitesidesXinyu LiuXiuJun LiMartin M. ThuoMichael O'BrienYu Sun
    • G01P15/12B81B7/02
    • B81B7/02B81C1/0015G01G3/13G01L1/18G01P15/0802G01P15/123G01P15/18G01P2015/0862
    • MEMS devices fabricated using inexpensive substrate materials such as paper or fabric, are provided. Using paper as a substrate, low cost, simple to prepare, lightweight, disposable piezoresistive sensors, including accelerometers are prepared. Signal-processing circuitry can also be patterned on the substrate material.The sensors can be utilized as two-dimensional sensors, or the paper substrate material can be folded to arrange the sensors in a three dimensional conformation. For example, three sensors can be patterned on a paper substrate and folded into a cube such that the three sensors are orthogonally positioned on the faces of a cube, permitting simultaneous measurement of accelerations along three orthogonal directions (x-y-z). These paper-based sensors can be mass produced by incorporating highly developed technologies for automatic paper cutting, folding, and screen-printing.Also provided are methods of modifying paper for use as a substrate material in MEMS devices.
    • 提供了使用诸如纸或织物之类的便宜的基底材料制造的MEMS器件。 使用纸作为基材,成本低,制备简单,重量轻,一次性压阻式传感器,包括加速度计。 信号处理电路也可以在衬底材料上图案化。 传感器可以用作二维传感器,或者可以将纸基材料折叠成三维构型。 例如,可以将三个传感器图案化在纸基底上并折叠成立方体,使得三个传感器正交地放置在立方体的表面上,允许沿着三个正交方向(x-y-z)同时测量加速度。 这些纸基传感器可以通过结合高度开发的自动切纸,折叠和丝网印刷技术进行批量生产。 还提供了修改用作MEMS器件中的基底材料的纸的方法。