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71. 发明申请

US20050205086A1 Retinoid immunomodulating kit and composition and uses thereof 审中-公开
标题翻译：类视黄醇免疫调节试剂盒及其组合物和用途
公开(公告)号：US20050205086A1
公开(公告)日：2005-09-22
申请号：US11078948
申请日：2005-03-11
申请人： Dov Tamarkin , Meir Eini , Doron Friedman
发明人： Dov Tamarkin , Meir Eini , Doron Friedman
IPC分类号： A61K8/04 , A61K8/67 , A61K31/07 , A61K31/203 , A61L9/04 , A61M11/00 , A61Q19/00
CPC分类号： A61Q19/00 , A61K8/046 , A61K8/671 , A61K9/0014 , A61K9/122 , A61K31/07 , A61K31/203
摘要： A composition and therapeutic kit including an aerosol packaging assembly including a container accommodating a pressurized product and an outlet capable of releasing a foamable composition, including a retinoid as a foam. The pressurized product includes a foamable composition including: a container accommodating a pressurized product; and an outlet capable of releasing the pressurized product as a foam; wherein the pressurized product comprises a foamable composition including: i. a retinoid; ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight; iii. a surface-active agent; iv. about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; v. water; and vi. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition. The composition further may include a therapeutically active foam adjuvant, selected from the group consisting of a fatty alcohol, a fatty acid, a hydroxyl fatty acid; and mixtures thereof.
摘要翻译：一种组合物和治疗试剂盒，其包括气溶胶包装组件，其包括容纳加压产品的容器和能够释放可发泡组合物的出口，其包含类视黄醇作为泡沫。加压产品包括可发泡组合物，其包括：容纳加压产品的容器; 以及能够释放作为泡沫的加压产品的出口; 其中所述加压产品包括可发泡组合物，其包含：i。类视黄醇 ii。选自浓度为约2％至约50％重量的至少一种选自疏水性有机载体，极性溶剂，软化剂及其混合物的有机载体; iii。表面活性剂; iv。约0.01重量％至约5重量％的至少一种选自生物粘附剂，胶凝剂，成膜剂和相变剂的聚合物添加剂; v。水和vi。液化或压缩气体推进剂的浓度为总组合物重量的约3％至约25％。组合物还可以包括治疗活性的泡沫佐剂，其选自脂肪醇，脂肪酸，羟基脂肪酸; 及其混合物。

72. 发明申请

US20050075407A1 Foam incorporating eutetic mixture 审中-公开
标题翻译：泡沫混合可溶性混合物
公开(公告)号：US20050075407A1
公开(公告)日：2005-04-07
申请号：US10922555
申请日：2004-08-20
申请人： Dov Tamarkin , Doron Friedman , Meir Eini
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K8/04 , A61K8/365 , A61K8/42 , A61K9/12 , A61K31/167 , A61K31/196 , A61K31/496 , A61Q19/00 , C08J9/00
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K8/342 , A61K8/37 , A61K8/39 , A61K8/731 , A61K9/0014 , A61K47/10 , A61K2800/91 , A61Q19/00 , A01N53/00
摘要： The invention relates to an alcohol-free cosmetic or pharmaceutical foam carrier comprising water, a surface-active agent a gelling agent and a combination of active agents, which creates, upon admixing, a eutectic mixture. The foam carrier further comprises active agents and excipients with therapeutic properties.
摘要翻译：本发明涉及一种无醇化妆品或药物泡沫载体，其包含水，表面活性剂，胶凝剂和活性剂的组合，其在混合时产生共晶混合物。泡沫载体还包含具有治疗性质的活性剂和赋形剂。

73. 发明授权

US08617100B2 Device for delivery of a foamable composition 有权
标题翻译：用于递送可发泡组合物的装置
公开(公告)号：US08617100B2
公开(公告)日：2013-12-31
申请号：US12204771
申请日：2008-09-04
申请人： Meir Eini , David Schuz , Helen Shifrin , Yohan Hazot , Dov Tamarkin
发明人： Meir Eini , David Schuz , Helen Shifrin , Yohan Hazot , Dov Tamarkin
IPC分类号： A61M1/06 , A61M31/00
CPC分类号： A61M31/00
摘要： A device for delivery of a foamable composition to a body cavity includes a pressurized composition reservoir; a hollow body having a longitudinally extending wall and having at least one aperture provided through a wall of said body, the proximal end in fluid communication with the reservoir for receiving a foamable composition from said composition reservoir; and an actuator operatively connected to the composition reservoir for effecting release of a foamable composition from said composition reservoir into a body cavity through said hollow body; wherein said body has a length less than about 125 mm and internal diameter in the range of about 1.5 mm to about 3.5 mm, wherein said length and internal diameter are selected to provide a delivery of at least about 70% of the foamable composition during operation. The foam delivery device can have multiple apertures.
摘要翻译：用于将可发泡组合物递送到体腔的装置包括加压组合物储存器; 具有纵向延伸的壁并具有通过所述主体的壁设置的至少一个孔的空心体，所述近端与所述储存器流体连通以从所述组合物储存器接收可发泡组合物; 以及致动器，其可操作地连接到所述组合物储存器，用于通过所述中空体从所述组合物储存器中释放可发泡组合物到体腔中; 其中所述主体具有小于约125mm的长度，并且内径在约1.5mm至约3.5mm的范围内，其中所述长度和内径被选择为在操作期间提供至少约70％的可发泡组合物的输送。泡沫输送装置可以具有多个孔。

74. 发明申请

US20060275221A1 Saccharide foamable compositions 有权
标题翻译：糖类可发泡组合物
公开(公告)号：US20060275221A1
公开(公告)日：2006-12-07
申请号：US11430437
申请日：2006-05-09
申请人： Dov Tamarkin , Doron Friedman , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Alex Besonov
IPC分类号： A61K8/00 , A61K9/00
CPC分类号： A61K9/122 , A61K8/046 , A61K8/39 , A61K8/60 , A61K8/988 , A61K9/0014 , A61K9/7015 , A61K47/26 , A61K47/38 , A61Q19/00 , Y10S514/945
摘要： A foamable composition, containing a saccharide for use in the treatment of various disorders including: water, a saccharide, about 0.2% to about 5% by weight of a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric agent selected from a bio-adhesive agent, a gelling agent, a film forming agent and a phase change agent, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：一种可发泡组合物，其含有用于治疗各种疾病的糖类，包括水，糖类，约0.2％至约5％重量的表面活性剂，至少约0.01％至约5％一种选自生物粘合剂，胶凝剂，成膜剂和相变剂的聚合物，以及以总组合物重量计约3％至约25％浓度的液化或压缩气体推进剂。

75. 发明授权

US07645803B2 Saccharide foamable compositions 有权
标题翻译：糖类可发泡组合物
公开(公告)号：US07645803B2
公开(公告)日：2010-01-12
申请号：US11430437
申请日：2006-05-09
申请人： Dov Tamarkin , Doron Friedman , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Alex Besonov
IPC分类号： A61K9/12 , A61K8/02 , A61K31/70 , A61K31/715 , A01N25/02 , A01N43/04
CPC分类号： A61K9/122 , A61K8/046 , A61K8/39 , A61K8/60 , A61K8/988 , A61K9/0014 , A61K9/7015 , A61K47/26 , A61K47/38 , A61Q19/00 , Y10S514/945
摘要： A foamable composition, containing a saccharide for use in the treatment of various disorders including: water, a saccharide, about 0.2% to about 5% by weight of a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric agent selected from a bio-adhesive agent, a gelling agent, a film forming agent and a phase change agent, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：一种可发泡组合物，其含有用于治疗各种疾病的糖类，包括水，糖类，约0.2％至约5％重量的表面活性剂，至少约0.01％至约5％一种选自生物粘合剂，胶凝剂，成膜剂和相变剂的聚合物，以及以总组合物重量计约3％至约25％浓度的液化或压缩气体推进剂。

76. 发明授权

US08636982B2 Wax foamable vehicle and pharmaceutical compositions thereof 有权
标题翻译：蜡可发泡车辆及其药物组合物
公开(公告)号：US08636982B2
公开(公告)日：2014-01-28
申请号：US12187840
申请日：2008-08-07
申请人： Dov Tamarkin , Rita Keynan , David Schuz , Tal Berman
发明人： Dov Tamarkin , Rita Keynan , David Schuz , Tal Berman
IPC分类号： A61K9/12
CPC分类号： A61K9/124 , A61K8/046 , A61K8/31 , A61K8/342 , A61K8/361 , A61K8/4993 , A61K8/86 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0046 , A61K9/1075 , A61K9/122 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/44 , A61Q5/006 , A61Q7/00 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： Unique foamable vehicles or carriers comprising at least one wax, waxy substance, counterpart or derivative, a stabilizer, water, and a propellant are provided. In some embodiments, the wax is a liquid wax. In some embodiments, the wax includes a solid wax and a liquid wax. The compositions are substantially free of crystals. The components are selected to provide a composition that is substantially resistant to aging and to phase separation, and/or can substantially solubilize and or stabilize active ingredients. Pharmaceutical and cosmetic compositions with potentially enhanced skin delivery and their uses are also provided.
摘要翻译：提供了包含至少一种蜡，蜡质物质，对应物或衍生物，稳定剂，水和推进剂的独特的可发泡车辆或载体。在一些实施方案中，蜡是液体蜡。在一些实施方案中，蜡包括固体蜡和液体蜡。组合物基本上不含晶体。选择组分以提供基本上耐老化和相分离的组合物和/或可以基本上溶解和/或稳定活性成分。还提供了具有潜在增强的皮肤递送及其用途的药物和化妆品组合物。

77. 发明申请

US20120087872A1 Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof 审中-公开
标题翻译：可泡沫车辆和包含非质子极性溶剂的药物组合物及其用途
公开(公告)号：US20120087872A1
公开(公告)日：2012-04-12
申请号：US13263201
申请日：2010-04-28
申请人： Dov Tamarkin , David Schuz , Tal Berman , Yohan Hazot
发明人： Dov Tamarkin , David Schuz , Tal Berman , Yohan Hazot
IPC分类号： A61K9/12 , A61P17/00 , A61P29/00
CPC分类号： A61K9/122 , A61K8/046 , A61K8/46 , A61K9/0014 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/38 , A61K2800/31 , A61Q19/00
摘要： The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.
摘要翻译：本发明教导了包含非质子极性溶剂的可发泡药物和化妆品组合物; 泡沫组合物及其用途。

78. 发明授权

US08900553B2 Oil and liquid silicone foamable carriers and formulations 有权
标题翻译：油和液体硅胶可发泡载体和配方
公开(公告)号：US08900553B2
公开(公告)日：2014-12-02
申请号：US12795213
申请日：2010-06-07
申请人： Dov Tamarkin , Helena Shifrin , Rita Keynan , Enbal Ziv , Tal Berman , David Schuz , Elana Gazal
发明人： Dov Tamarkin , Helena Shifrin , Rita Keynan , Enbal Ziv , Tal Berman , David Schuz , Elana Gazal
IPC分类号： A61K9/12 , A61K8/04 , A61K9/00 , A61K31/65 , A61K47/06 , A61K47/14 , A61K47/24
CPC分类号： A61K9/12 , A61K8/046 , A61K9/0014 , A61K9/122 , A61K31/20 , A61K31/355 , A61K31/522 , A61K31/59 , A61K31/65 , A61K31/7056 , A61K45/06 , A61K47/06 , A61K47/14 , A61K47/24 , A61K47/34 , A61K47/44 , Y10S514/871 , Y10S514/945
摘要： A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01% to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.
摘要翻译：公开了一种适用于外用的无水可发泡药物组合物。组合物包括可发泡载体至少一种液化或压缩气体推进剂。可发泡载体包括至少一种液体油; 至少一种硅氧烷和至少一种至少一种稳定剂; 其中所述稳定剂选自约0.01％至约25％重量的至少一种表面活性剂单独或与泡沫佐剂组合; 和约0％至约5％重量的至少一种聚合物单体或与泡沫佐剂组合; 及其混合物。进一步描述包含活性剂的药物组合物，其制备方法，适用于载体的推进剂及其用途。

79. 发明授权

US06967023B1 Pharmaceutical and cosmetic carrier or composition for topical application 有权
标题翻译：用于局部应用的药物和化妆品载体或组合物
公开(公告)号：US06967023B1
公开(公告)日：2005-11-22
申请号：US09653267
申请日：2000-08-31
申请人： Meir Eini , Dov Tamarkin
发明人： Meir Eini , Dov Tamarkin
IPC分类号： A21D2/14 , A21D2/16 , A21D13/08 , A23C9/13 , A23C11/04 , A23C13/12 , A23C15/16 , A23C19/055 , A23C19/093 , A23D7/00 , A23D7/005 , A23D7/01 , A23D9/007 , A23D9/02 , A23G1/00 , A23G1/30 , A23G1/36 , A23G1/38 , A23G3/34 , A23G9/32 , A23G9/44 , A23G9/52 , A23J3/22 , A23L1/00 , A23L1/16 , A23L1/164 , A23L1/18 , A23L1/19 , A23L1/217 , A23L1/30 , A23L1/314 , A23L1/40 , A61K20060101 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/18 , A61K8/34 , A61K8/36 , A61K8/365 , A61K8/92 , A61K8/97 , A61K8/98 , A61K9/00 , A61K9/06 , A61K31/07 , A61K31/197 , A61K31/225 , A61K31/351 , A61K31/355 , A61K31/357 , A61K31/4188 , A61K31/43 , A61K31/4415 , A61K31/455 , A61K31/496 , A61K31/51 , A61K31/525 , A61K31/545 , A61K31/57 , A61K31/59 , A61K31/65 , A61K31/714 , A61K33/04 , A61K33/06 , A61K33/14 , A61K33/18 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/34 , A61K35/60 , A61K36/00 , A61K36/738 , A61K36/899 , A61K45/00 , A61K45/06 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/44 , A61P1/10 , A61P1/14 , A61P3/02 , A61P3/06 , A61P3/10 , A61P7/02 , A61P7/04 , A61P9/10 , A61P9/12 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P17/08 , A61P17/10 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/02 , A61Q19/00 , A61K7/00 , A61K7/48 , A61K31/74
CPC分类号： A21D2/14 , A21D2/16 , A23C9/1315 , A23C11/04 , A23C13/12 , A23C15/16 , A23C19/055 , A23C19/093 , A23D7/0053 , A23D7/0056 , A23D7/011 , A23D7/013 , A23D9/007 , A23G1/305 , A23G1/36 , A23G1/38 , A23G3/346 , A23G2200/08 , A23J3/227 , A23L7/109 , A23L7/122 , A23L7/183 , A23L13/43 , A23L19/18 , A23L23/10 , A23L33/115 , A23P20/11 , A61K8/342 , A61K8/922 , A61K9/0014 , A61K9/0048 , A61K31/225 , A61K31/351 , A61K31/43 , A61K31/496 , A61K31/545 , A61K31/573 , A61K31/65 , A61K36/738 , A61K36/899 , A61K45/06 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/44 , A61Q19/00 , Y10S514/863 , Y10S514/864 , A61K2300/00
摘要： A pharmaceutical or cosmetic carrier or composition for topical application characterized by rheological properties which render the carrier or composition semi-solid at rest and a liquid upon application of shear forces thereto. The composition or carrier are prepared by mixing 1–25 percent of a solidifying agent and 75–99 percent of a hydrophobic solvent, by weight, wherein at least one of them has therapeutic or cosmetic benefits, in the presence or absence of a biologically active substance.
摘要翻译：用于局部施用的药物或化妆品载体或组合物，其特征在于使得载体或组合物半固体静止时具有流变性质，并且在施加剪切力时使液体成为液体。组合物或载体通过混合1-25％的固化剂和75-99％的疏水性溶剂（按重量计），其中至少一种在存在或不存在生物活性的情况下具有治疗或美容益处物质。

80. 发明授权

US06432037B1 Intravaginal device for electrically stimulating and/or for sensing electrical activity of muscles and/or nerves defining and surrounding the intravaginal cavity 有权
标题翻译：用于电刺激和/或感测限定和围绕阴道内腔的肌肉和/或神经的电活动的阴道内装置
公开(公告)号：US06432037B1
公开(公告)日：2002-08-13
申请号：US09653263
申请日：2000-08-31
申请人： Meir Eini , Dov Tamarkin
发明人： Meir Eini , Dov Tamarkin
IPC分类号： A61F200
CPC分类号： A61B5/07 , A61B5/0031 , A61B5/04882 , A61B5/227 , A61B5/486 , A61B2562/164 , A61N1/0524
摘要： A device for stimulating muscles and nerves defining and surrounding an intravaginal cavity of an individual and/or for sensing electrical activity of muscles defining and surrounding an intravaginal cavity is provided. The device includes (a) a body having memory properties such that when the body is contracted and positioned within an intravaginal cavity of the individual the body self expands to conform to a contour of the intravaginal cavity; and (b) at least one pair of electrodes being attached to an exterior surface of the body such that when the body is positioned within the intravaginal cavity, each electrode of the at least one pair of electrodes is biased against a wall of the intravaginal cavity.
摘要翻译：提供了一种用于刺激限定和围绕个体的阴道内腔和/或用于感测限定和围绕阴道腔的肌肉的电活动的肌肉和神经的装置。该装置包括（a）具有记忆特性的身体，使得当身体收缩并定位在个体的阴道腔内时，身体自身膨胀以符合阴道腔的轮廓; 和（b）至少一对电极附接到身体的外表面，使得当身体位于阴道腔内时，至少一对电极的每个电极被偏压到阴道内腔的壁。

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