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71. 发明申请

US20080193431A1 ACTIVATABLE PHOTODYNAMIC THERAPY AGENTS 有权
标题翻译：可激活的光电治疗剂
公开(公告)号：US20080193431A1
公开(公告)日：2008-08-14
申请号：US11383487
申请日：2006-05-15
申请人： Gang Zheng , Jerry D. Glickson , Britton Chance , Edward James Delikatny , Klara Stefflova , Juan Chen
发明人： Gang Zheng , Jerry D. Glickson , Britton Chance , Edward James Delikatny , Klara Stefflova , Juan Chen
IPC分类号： A61K38/43 , C12N9/00
CPC分类号： A61K41/0071 , A61K38/00 , A61K41/0057 , A61K41/0076 , A61K47/544 , A61K47/549 , A61K47/64 , A61K47/65 , C07K5/1008 , C07K5/101 , C07K5/1021 , C07K5/1024 , C07K7/06
摘要： The present invention relates to the field of conjugates comprising a substrate which is attached to at least one photoactivatable killing agent and at least one first quencher, and methods for their use. More particularly, the present invention relates to photodynamic therapy agents. The invention further relates to methods for decontaminating blood and methods for treating cancer or viral infection in a subject using the conjugates of the present invention.
摘要翻译：本发明涉及包含与至少一种可光活化杀伤剂和至少一种第一猝灭剂连接的底物的缀合物领域及其使用方法。更具体地说，本发明涉及光动力治疗剂。本发明还涉及使用本发明的缀合物来净化血液的方法和用于治疗受试者的癌症或病毒感染的方法。

72. 发明授权

US07139603B2 Optical techniques for examination of biological tissue 失效
标题翻译：用于检查生物组织的光学技术
公开(公告)号：US07139603B2
公开(公告)日：2006-11-21
申请号：US10403836
申请日：2003-03-31
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/0073 , A61B5/0091 , A61B5/1455 , A61B5/14551 , A61B5/4312 , A61B5/6814 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , A61B2562/146 , G01N21/3151 , G01N21/4795 , G01N21/6456 , G01N2021/1789 , G01N2021/3181 , G01N2021/6421 , G01N2021/6484 , G01N2201/0696
摘要： Methods and systems are described that examine tissue positioned between input ports and a detection port. At lease one source of a visible or infrared wavelength is provided that introduces electromagnetic radiation into the subject. The detection port is optically coupled to a detector that is connected to a detector circuit. Radiation intensities are selected for introduction at the input ports to define a null plane in the tissue. The detection port is positioned relative to the null plane. Radiation is introduced into the subject at the first input port and the radiation that migrates through the tissue is detected. The detector circuit stores a first detector signal corresponding to the first detected radiation. Radiation is introduced at the second input port and is detected. The first detector signal is subtracted from a second detector signal corresponding to the second detected radiation to obtain processed data.
摘要翻译：描述了检查位于输入端口和检测端口之间的组织的方法和系统。至少提供了将电磁辐射引入到受试者中的可见光或红外波长的一个源。检测端口光耦合到与检测器电路连接的检测器。选择辐射强度以在输入端口引入以在组织中定义零平面。检测端口相对于空平面定位。在第一输入端口将辐射引入受试者，检测通过组织迁移的辐射。检测器电路存储对应于第一检测到的辐射的第一检测器信号。在第二输入端口引入辐射并被检测。从与第二检测到的辐射相对应的第二检测器信号中减去第一检测器信号，以获得处理的数据。

73. 发明授权

US06708048B1 Phase modulation spectrophotometric apparatus 失效
标题翻译：相位调制分光光度仪
公开(公告)号：US06708048B1
公开(公告)日：2004-03-16
申请号：US09229284
申请日：1999-01-13
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B100
CPC分类号： G01N21/49 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/14551 , A61B5/14553 , A61B5/7228 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01J9/04 , G01N21/3151 , G01N21/47 , G01N21/4795 , G01N2021/1789 , G01N2021/1791 , G01N2021/3181 , G01N2201/06113 , G01N2201/0696
摘要： A pathlength corrected spectrophotometer for tissue examination includes an oscillator for generating a carrier waveform of a selected frequency, an LED light source for generating light of a selected wavelength that is intensity modulated at the selected frequency introduced to a subject, and a photodiode detector for detecting light that has migrated in the tissue of the subject. The spectrophotometer also includes a phase detector for measuring a phase shift between the introduced and detected light, a magnitude detector for determination of light attenuation in the examined tissue, and a processor adapted to calculate the photon migration pathlength and determine a physiological property of the examined tissue based on the pathlength and on the attenuation data.
摘要翻译：用于组织检查的路径长度校正分光光度计包括用于产生所选频率的载波波形的振荡器，用于产生被选择的波长的光的LED光源，所述光源以引入到被摄体的选定频率进行强度调制，以及光电二极管检测器，用于检测已经在受试者的组织中迁移的光。分光光度计还包括用于测量引入和检测到的光之间的相移的相位检测器，用于确定被检查组织中的光衰减的幅度检测器，以及适于计算光子迁移路径长度并确定检查的生理特性的处理器基于路径长度和衰减数据的组织。

74. 发明授权

US06542772B1 Examination and imaging of biological tissue 失效
标题翻译：生物组织的检查和成像
公开(公告)号：US06542772B1
公开(公告)日：2003-04-01
申请号：US09561656
申请日：2000-05-02
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B500
CPC分类号： A61B5/14553 , A61B5/0073 , A61B5/0091 , A61B5/1455 , A61B5/14551 , A61B5/4312 , A61B5/6814 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , A61B2562/146 , G01N21/3151 , G01N21/4795 , G01N21/6456 , G01N2021/1789 , G01N2021/3181 , G01N2021/6421 , G01N2021/6484 , G01N2201/0696
摘要： Methods and systems are described that examine tissue positioned between input ports and a detection port. At lease one source of a visible or infrared wavelength is provided that introduces electromagnetic radiation into the subject. The detection port is optically coupled to a detector that is connected to a detector circuit. Radiation intensities are selected for introduction at the input ports to define a null plane in the tissue. The detection port is positioned relative to the null plane. Radiation is introduced into the subject at the first input port and the radiation that migrates through the tissue is detected. The detector circuit stores a first detector signal corresponding to the first detected radiation. Radiation is introduced at the second input port and is detected. The first detector signal is subtracted from a second detector signal corresponding to the second detected radiation to obtain processed data.
摘要翻译：描述了检查位于输入端口和检测端口之间的组织的方法和系统。至少提供了将电磁辐射引入到受试者中的可见光或红外波长的一个源。检测端口光耦合到与检测器电路连接的检测器。选择辐射强度以在输入端口引入以在组织中定义零平面。检测端口相对于空平面定位。在第一输入端口将辐射引入受试者，检测通过组织迁移的辐射。检测器电路存储对应于第一检测到的辐射的第一检测器信号。在第二输入端口引入辐射并被检测。从与第二检测到的辐射相对应的第二检测器信号中减去第一检测器信号，以获得处理的数据。

75. 发明授权

US06526309B1 Transcranial in vivo examination of brain tissue 有权
标题翻译：经颅体内检查脑组织
公开(公告)号：US06526309B1
公开(公告)日：2003-02-25
申请号：US09440922
申请日：1999-11-16
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B600
CPC分类号： A61B5/6814 , A61B5/0035 , A61B5/0042 , A61B5/0077 , A61B5/0091 , A61B5/14532 , A61B5/1455 , A61B5/14551 , A61B5/14552 , A61B5/14553 , A61B5/1459 , A61B5/4312 , A61B5/6853 , A61B2562/0233 , A61B2562/046 , A61B2562/146
摘要： An optical system and method for transcranial in vivo examination of brain tissue includes a spectrophotometer coupled to an array of optical fibers and a processor. The array of optical fibers is constructed to transmit optical radiation of a visible to infra-red wavelength. The optical fibers have distal ends projected through the hair into contact with a surface of the scalp and arranged over a selected geometrical pattern. The spectrophotometer includes at least one light source constructed to emit optical radiation of the visible or infra-red wavelength and at least one light detector constructed to detect radiation that has migrated from a first of said distal ends within the brain tissue to a second of the distal ends. A sequencer is constructed to control introduction of radiation from a first distal end and constructed to control detection of radiation after arriving at a second distal end using a transmission/reception algorithm over the geometrical pattern. A processor is arranged to provide the transmission/reception algorithm and receive signals of the detected radiation from the detector, wherein the processor is arranged to produce a succession of optical data sets over time to monitor evolution of a tissue state of the examined brain tissue.
摘要翻译：用于脑组织经颅内体检的光学系统和方法包括耦合到光纤阵列和处理器的分光光度计。光学阵列被构造成透射可见到红外波长的光辐射。光纤具有通过毛发突出的远端与头皮的表面接触并布置在选定的几何图案上。分光光度计包括构造成发射可见光或红外波长的光辐射的至少一个光源，以及至少一个光检测器，被构造成检测已经从脑组织内的第一个远端迁移到第二个远端定序器被构造成控制来自第一远端的辐射的引入，并被构造成在使用几何图案上的发射/接收算法到达第二远端之后控制辐射的检测。处理器被布置成提供发射/接收算法并从检测器接收检测到的辐射的信号，其中处理器被布置成随着时间的推移产生一系列光学数据集，以监测所检查的脑组织的组织状态的进展。

76. 发明授权

US06493565B1 Examination of biological tissue by monitoring one or more solutes 失效
标题翻译：通过监测一个或多个溶质来检查生物组织
公开(公告)号：US06493565B1
公开(公告)日：2002-12-10
申请号：US08849203
申请日：1997-11-17
申请人： Britton Chance , Hanli Liu
发明人： Britton Chance , Hanli Liu
IPC分类号： A61B500
CPC分类号： A61B5/14546 , A61B5/14532 , A61B5/1455 , A61B5/6824
摘要： This invention is a scheme for monitoring a solute in a biological system comprising the steps of delivering light into a biological system (12) containing a solute, the light having a wavelength selected to be in a range wherein the solute is substantially non-absorbing; detecting at least first and second portions of the delivered light (16, 18, 20), the first portion having traveled through the biological system along one or more paths characterized by a first average path length, and the second portion having traveled through the biological system along one or more as characterized by a second average path length that is greater than the first average path length; and comparing the first and second portions of the delivered light to monitor concentration of the solute in the biological system. Also described are schemes for monitoring low molecular weight polyhydroxy solutes, generally sugars (mannitol, fructose, sucrose, glucose, sorbitol), alcohols (methanol, ethanol, propanediol), and electrolytes (sodium, potassium, magnesium, calcium, and chloride ions).
摘要翻译：本发明是用于监测生物系统中的溶质的方案，包括以下步骤：将光输送到包含溶质的生物系统（12）中，所述光的波长选择在一定范围内，其中溶质基本上不吸收; 检测所传送的光（16,18,20）的至少第一和第二部分，所述第一部分沿着一个或多个路径行进通过所述生物系统，其特征在于具有第一平均路径长度，并且所述第二部分已经穿过所述生物系统沿着一个或多个，其特征在于大于第一平均路径长度的第二平均路径长度; 以及比较所输送的光的第一和第二部分以监测生物系统中溶质的浓度。还描述了用于监测低分子量多羟基溶质，通常为糖（甘露醇，果糖，蔗糖，葡萄糖，山梨糖醇），醇（甲醇，乙醇，丙二醇）和电解质（钠，钾，镁，钙和氯离子）。

77. 发明授权

US06246892B1 Phase modulation spectroscopy 失效
标题翻译：相位调制光谱
公开(公告)号：US06246892B1
公开(公告)日：2001-06-12
申请号：US08799204
申请日：1997-02-13
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B500
CPC分类号： G01N21/49 , A61B5/0075 , A61B5/0084 , A61B5/14551 , A61B5/14553 , A61B5/7228 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01N21/3151 , G01N21/47 , G01N21/4795 , G01N2021/1789 , G01N2021/3181 , G01N2201/0696
摘要： A spectroscopic system for quantifying in vivo concentration of an absorptive pigment in biological tissue includes an oscillator for generating a first carrier waveform of a first frequency on the order of 108 Hz, a light source for generating light of at least two selected wavelengths modulated by the carrier waveform, and a detector for detecting radiation that has migrated over photon migration paths in the tissue from an input port to a detection port spaced several centimeters apart. At least one of the wavelengths is sensitive to concentration of an absorptive pigment present in the tissue, while the tissue exhibits similar scattering properties at the two wavelengths. A phase detector compares, at each wavelength, the detected radiation with the introduced radiation and determines therefrom the phase shift of the detected radiation at each wavelength. A processor quantifies the concentration of the absorptive pigment by employing the phase shifts measured at the two wavelengths and also employing a scattering property of the tissue.
摘要翻译：用于定量生物组织中吸收性颜料的体内浓度的光谱系统包括用于产生第一频率为108Hz的第一载流子波形的振荡器，用于产生至少两个选定波长的光的光源载波波形和检测器，用于检测已经从组织中的光子迁移路径迁移的辐射，该输入端口从输入端口到间隔几厘米的检测端口。至少一个波长对存在于组织中的吸收颜料的浓度敏感，而组织在两个波长处表现出相似的散射性质。相位检测器在每个波长处将检测到的辐射与引入的辐射进行比较，并由此确定每个波长处检测到的辐射的相移。处理器通过采用在两个波长处测量的相移并且还采用组织的散射特性来量化吸收性颜料的浓度。

78. 发明授权

US06192260B1 Methods and apparatus for examining tissue in vivo using the decay characteristics of scattered electromagnetic radiation 失效
标题翻译：使用散射电磁辐射的衰变特性检测体内组织的方法和装置
公开(公告)号：US06192260B1
公开(公告)日：2001-02-20
申请号：US07876364
申请日：1992-04-30
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B310
CPC分类号： G01J3/2889 , G01N21/49 , G01N21/59 , G01N2021/1791
摘要： Methods and apparatus using the principles of time-resolved spectroscopy are disclosed. The present invention employs incident light pulses of sufficiently short duration to permit the rate of the rise and decay of such pulses to be measured. Consequently, the rate of decay, u, permits a determination of the concentration of an absorptive pigment, such as hemoglobin. The present invention also allows the precise path length the photons travel to be determined. Using this path length information and by measuring changes in optical density using known continuous light (CW) spectrophotometry systems, the methods and apparatus disclosed allow changes in the concentration of an absorptive pigment to be correctly be measured. From these data, the oxygenation state of a tissue region, such as the brain, can be accurately determined in real time.
摘要翻译：公开了使用时间分辨光谱原理的方法和装置。本发明采用足够短持续时间的入射光脉冲，以允许测量这些脉冲的上升和下降的速率。因此，衰减速率u允许测定吸收性颜料如血红蛋白的浓度。本发明还允许确定光子行进的精确路径长度。使用该路径长度信息并通过使用已知的连续光（CW）分光光度法系统测量光密度的变化，所公开的方法和装置允许正确测量吸收性颜料的浓度的变化。从这些数据可以准确地确定脑组织区域的氧合状态。

79. 发明授权

US5917190A Object imaging using diffuse light 失效
标题翻译：对象成像使用漫射光
公开(公告)号：US5917190A
公开(公告)日：1999-06-29
申请号：US637645
申请日：1996-07-25
申请人： Arjun G. Yodh , Britton Chance , David A. Boas , Maureen O'Leary
发明人： Arjun G. Yodh , Britton Chance , David A. Boas , Maureen O'Leary
IPC分类号： A61B10/00 , G01N21/17 , G01N21/47 , G01N21/64 , G01S17/87 , G01S17/89
CPC分类号： G01N21/6428 , G01N21/4795 , G01S17/87 , G01S17/89 , A61B5/0091
摘要： Imaging tumors using diffuse light. An imaging system includes a source of diffuse light for generating oscillatory diffuse photon density waves to illuminate an object, a detector for detecting diffuse photon density waves interacting with the object, and a computer interfaced with the detector for processing data corresponding to the photon density waves detected to determine at least a position of the object. In one embodiment, the turbid medium and the object have associated therewith at least one diffusion coefficient and the diffuse photon density waves which illuminate the object refract around the object as a result of their interaction with it, thereby producing a distorted wavefront that allows the computer to construct an image of the object. In another embodiment, a fluorescent object produces re-radiated diffuse photon density waves which allow the object to be imaged.
摘要翻译： PCT No.PCT / US94 / 12486 Sec。 371日期：1996年7月25日 102（e）日期1996年7月25日PCT 1994年10月31日PCT PCT。出版物WO95 / 12132 日期1995年5月4日使用漫射光照射肿瘤。成像系统包括用于产生振荡漫射光子密度波以照射物体的漫射光源，用于检测与物体相互作用的漫射光子密度波的检测器和与检测器接口的计算机，用于处理对应于光子密度波的数据检测到以至少确定对象的位置。在一个实施例中，混浊介质和物体具有至少一个扩散系数，并且由于它们与其相互作用而照射物体折射物体的扩散光子密度波折射，从而产生允许计算机构建对象的图像。在另一个实施例中，荧光物体产生允许物体成像的再辐射漫射光子密度波。

80. 发明授权

US5820558A Optical techniques for examination of biological tissue 失效
标题翻译：用于检查生物组织的光学技术
公开(公告)号：US5820558A
公开(公告)日：1998-10-13
申请号：US849202
申请日：1997-06-02
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： G01N21/17 , A61B5/00 , A61B10/00 , G01N21/47 , G01N21/64
CPC分类号： A61B5/0091 , A61B5/0059 , A61B5/1455 , A61B5/14555 , A61B5/4312 , G01N21/4795 , G01N21/6428 , G01N21/6456
摘要： Methods and systems are described that examine a subject positioned between an input port and detection ports of a spectroscopic system applied to the subject. At least one source of a visible or infrared wavelength is provided that introduces electromagnetic radiation into the subject. The detection ports are optically connected to a detector circuit constructed to provide a detection signal of known sensitivity. The input and detection locations and the sensitivity define a null plane in the tissue. Radiation is introduced into the subject at the input port and the radiation that migrates through the tissue is detected at the detection ports. The detector circuit provides a first detection signal corresponding to a first detected radiation and a second detection signal corresponding to a second detected radiation. The first detection signal is subtracted from the second detection signal to obtain processed data.
摘要翻译： PCT No.PCT / US95 / 15694 Sec。 371日期：1997年6月2日 102（e）日期1997年6月2日PCT提交1995年12月4日PCT公布。公开号WO96 / 16596 日期1996年6月6日描述了检查位于应用于对象的光谱系统的输入端口和检测端口之间的被摄体的方法和系统。提供将电磁辐射引入到受试者中的至少一个可见光或红外波长的源。检测端口光学连接到检测器电路，检测器电路被构造成提供已知灵敏度的检测信号。输入和检测位置和灵敏度在组织中定义零平面。在输入端口将辐射引入受试者，并在检测端口检测到通过组织迁移的辐射。检测器电路提供对应于第一检测到的辐射的第一检测信号和对应于第二检测到的辐射的第二检测信号。从第二检测信号中减去第一检测信号以获得处理的数据。

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