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71. 发明授权

US07312299B2 Bioabsorbabl, biobeneficial polyester polymers for stent coatings 有权
标题翻译： Bioabsorbabl，用于支架涂层的生物有益聚酯聚合物
公开(公告)号：US07312299B2
公开(公告)日：2007-12-25
申请号：US11643330
申请日：2006-12-20
申请人： Syed F. A. Hossainy , Stephen D. Pacetti
发明人： Syed F. A. Hossainy , Stephen D. Pacetti
IPC分类号： C08G63/02
CPC分类号： A61L31/06 , A61L27/18 , C08G63/20 , C08G63/668 , C08G63/6854 , C08G63/6886 , C08L67/02 , C08L67/025 , C08L67/04 , C08L69/00 , C08L73/02 , C08L2666/20 , C08L2666/18
摘要： This disclosure covers polymers, some of which are useful in medical device applications. Some of these medical devices are implantable within a mammalian body, such as in a body lumen. The copolymers comprise at least one alcoholic moiety derived from a diol, triol, or polyol. Additionally, the copolymers comprise an acidic moiety, derived from a polycarboxylic acid, and a biobeneficial moiety. Some of these copolymers are biodegradable or bioerodable. Medical devices comprising these polymers and methods of making these polymers are within the scope of this disclosure.
摘要翻译：本公开内容涵盖聚合物，其中一些在医疗器械应用中是有用的。这些医疗装置中的一些可植入哺乳动物体内，例如在体腔中。共聚物包含至少一种衍生自二醇，三醇或多元醇的醇部分。另外，共聚物包含衍生自多元羧酸的酸性部分和生物有益部分。这些共聚物中的一些是可生物降解的或可生物侵蚀的。包含这些聚合物的医疗装置和制备这些聚合物的方法在本公开的范围内。

72. 发明授权

US07301001B2 Bioabsorbable, biobeneficial polyester polymers for stent coatings 有权
公开(公告)号：US07301001B2
公开(公告)日：2007-11-27
申请号：US11643331
申请日：2006-12-20
申请人： Syed F. A. Hossainy , Stephen D. Pacetti
发明人： Syed F. A. Hossainy , Stephen D. Pacetti
IPC分类号： C08G63/02
CPC分类号： A61L31/06 , A61L27/18 , C08G63/20 , C08G63/668 , C08G63/6854 , C08G63/6886 , C08L67/02 , C08L67/025 , C08L67/04 , C08L69/00 , C08L73/02 , C08L2666/20 , C08L2666/18
摘要： This disclosure covers polymers, some of which are useful in medical device applications. Some of these medical devices are implantable within a mammalian body, such as in a body lumen. The copolymers comprise at least one alcoholic moiety derived from a diol, triol, or polyol. Additionally, the copolymers comprise an acidic moiety, derived from a polycarboxylic acid, and a biobeneficial moiety. Some of these copolymers are biodegradable or bioerodable. Medical devices comprising these polymers and methods of making these polymers are within the scope of this disclosure.

73. 发明授权

US07247364B2 Coating for implantable medical devices 有权
标题翻译：可植入医疗器械的涂层
公开(公告)号：US07247364B2
公开(公告)日：2007-07-24
申请号：US11067375
申请日：2005-02-25
申请人： Syed F. A. Hossainy , Yiwen Tang , Andrew C. Tung , Stephen D. Pacetti
发明人： Syed F. A. Hossainy , Yiwen Tang , Andrew C. Tung , Stephen D. Pacetti
IPC分类号： B32B7/02 , A61L27/00 , A61L27/26 , A61L27/52 , A61L27/54
CPC分类号： A61F2/06 , A61F2/0077 , A61F2250/0067 , Y10T428/13 , Y10T428/24942 , Y10T428/3154 , Y10T428/31786 , Y10T428/31855 , Y10T428/31935
摘要： An implantable medical device, such as a stent, is disclosed having a coating. The coating includes a poly(butylene terephthalate-co-ethylene glycol)polymer. The coating can also include a drug.
摘要翻译：公开了一种具有涂层的可植入医疗装置，例如支架。涂层包括聚（对苯二甲酸丁二醇酯 - 共 - 乙二醇）聚合物。涂层还可以包括药物。

74. 发明授权

US07186789B2 Bioabsorbable, biobeneficial polyester polymers for use in drug eluting stent coatings 有权
标题翻译：用于药物洗脱支架涂层的生物可吸收的生物有益的聚酯聚合物
公开(公告)号：US07186789B2
公开(公告)日：2007-03-06
申请号：US10460016
申请日：2003-06-11
申请人： Syed F. A. Hossainy , Stephen D. Pacetti
发明人： Syed F. A. Hossainy , Stephen D. Pacetti
IPC分类号： C08G63/00
CPC分类号： A61L31/06 , A61L27/18 , C08G63/20 , C08G63/668 , C08G63/6854 , C08G63/6886 , C08L67/02 , C08L67/025 , C08L67/04 , C08L69/00 , C08L73/02 , C08L2666/20 , C08L2666/18
摘要： This disclosure covers polymers, some of which are useful in medical device applications. Some of these medical devices are implantable within a mammalian body, such as in a body lumen. The copolymers comprise at least one alcoholic moiety derived from a diol, triol, or polyol. Additionally, the copolymers comprise an acidic moiety, derived from a polycarboxylic acid, and a biobeneficial moiety. Some of these copolymers are biodegradable or bioerodable. Medical devices comprising these polymers and methods of making these polymers are within the scope of this disclosure.
摘要翻译：本公开内容涵盖聚合物，其中一些在医疗器械应用中是有用的。这些医疗装置中的一些可植入哺乳动物体内，例如在体腔中。共聚物包含至少一种衍生自二醇，三醇或多元醇的醇部分。另外，共聚物包含衍生自多元羧酸的酸性部分和生物有益部分。这些共聚物中的一些是可生物降解的或可生物侵蚀的。包含这些聚合物的医疗装置和制备这些聚合物的方法在本公开的范围内。

75. 发明授权

US07005137B1 Coating for implantable medical devices 失效
标题翻译：可植入医疗器械的涂层
公开(公告)号：US07005137B1
公开(公告)日：2006-02-28
申请号：US10176510
申请日：2002-06-21
申请人： Syed F. A. Hossainy , Stephen D. Pacetti
发明人： Syed F. A. Hossainy , Stephen D. Pacetti
IPC分类号： A61F2/02
CPC分类号： A61L31/10
摘要： A coating for an implantable medical device, such as a stent, is disclosed. The coating comprising a block copolymer obtained by a polymerization reaction of at least two reagents. A method for forming the coating is also disclosed.
摘要翻译：公开了用于可植入医疗装置（例如支架）的涂层。所述涂层包含通过至少两种试剂的聚合反应获得的嵌段共聚物。还公开了一种形成涂层的方法。

76. 发明授权

US06908624B2 Coating for implantable devices and a method of forming the same 有权
标题翻译：用于可植入装置的涂层及其形成方法
公开(公告)号：US06908624B2
公开(公告)日：2005-06-21
申请号：US10320935
申请日：2002-12-16
申请人： Syed F. A. Hossainy , Steven Z. Wu , Manish Gada , Anthony Andreacchi
发明人： Syed F. A. Hossainy , Steven Z. Wu , Manish Gada , Anthony Andreacchi
IPC分类号： A61F2/82 , A61L27/34 , A61L29/08 , A61L31/10 , A61L31/16 , A61L33/00 , A61F2/00
CPC分类号： A61L33/0011 , A61F2/82 , A61F2250/0067 , A61L27/34 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/606 , A61L2420/02 , Y10S514/822 , C08L29/04 , C08L33/10
摘要： Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
摘要翻译：提供用于可植入装置或腔内假体（例如支架）的涂层，包括形成涂层的方法。涂层可用于递送活性成分或活性成分的组合。

77. 发明授权

US06395326B1 Apparatus and method for depositing a coating onto a surface of a prosthesis 有权
标题翻译：用于将涂层沉积到假体表面上的装置和方法
公开(公告)号：US06395326B1
公开(公告)日：2002-05-28
申请号：US09583371
申请日：2000-05-31
申请人： Daniel Castro , Steven Wu , Kevin L. Woolbright , Kurt W. Scheinpflug , Syed F. A. Hossainy , Li Chen
发明人： Daniel Castro , Steven Wu , Kevin L. Woolbright , Kurt W. Scheinpflug , Syed F. A. Hossainy , Li Chen
IPC分类号： A61L2700
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0068 , A61L31/10 , A61L2300/606 , B05D1/002 , B05D1/26 , B05D1/40 , B05D3/107
摘要： A patterned coating on a prosthesis, for example a stent, and a method for forming the coating are disclosed. Additionally, an apparatus for forming the patterned coating is disclosed.
摘要翻译：公开了假体上的图案化涂层，例如支架，以及形成涂层的方法。另外，公开了一种用于形成图案化涂层的装置。

78. 发明授权

US06287628B1 Porous prosthesis and a method of depositing substances into the pores 有权
标题翻译：多孔假体和将物质沉积到孔中的方法
公开(公告)号：US06287628B1
公开(公告)日：2001-09-11
申请号：US09390855
申请日：1999-09-03
申请人： Syed F. A. Hossainy , Li Chen
发明人： Syed F. A. Hossainy , Li Chen
IPC分类号： A61L2900
CPC分类号： A61L31/16 , A61F2/91 , A61L31/146
摘要： A porous implantable prosthesis is loaded with a substance for subsequent application to biological tissues. A method according to loading the substance to the porous prosthesis is provided. A first fluid in combination with an added substance is applied to the porous prosthesis. During the application, the first fluid containing the substance is capable of penetrating into prosthesis pores. The first fluid is removed and a second fluid is applied to the prosthesis. The second fluid is not capable of significantly penetrating into the pores. Prior to the application of the second fluid, the prosthesis can be immersed in a third fluid and agitated via mechanical perturbation techniques so that any of the substance gathered on the surface of the body, after the application of the first fluid, is removed. The third fluid should not be capable of dissolving the substance.
摘要翻译：多孔可植入假体装载有用于随后应用于生物组织的物质。提供了将物质装载到多孔假体的方法。将与添加物质组合的第一流体施加到多孔假体。在施用期间，含有该物质的第一流体能够渗透到假体孔中。移除第一流体，将第二流体施加到假体。第二种流体不能显着渗透到孔中。在施加第二流体之前，可以将假体浸入第三流体中并通过机械扰动技术进行搅拌，使得在施加第一流体之后聚集在身体表面上的任何物质被去除。第三种液体不能溶解物质。

79. 发明授权

US5834274A Gels for encapsulation of biological materials 失效
公开(公告)号：US5834274A
公开(公告)日：1998-11-10
申请号：US467693
申请日：1995-06-06
申请人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Jennifer L. Hill , Syed F. A. Hossainy
发明人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Jennifer L. Hill , Syed F. A. Hossainy
IPC分类号： A61K9/16 , A61K9/50 , A61K35/12 , A61K38/42 , A61K38/44 , A61L24/00 , A61L24/04 , A61L26/00 , A61L27/34 , A61L27/38 , A61L27/52 , A61L29/08 , A61L31/10 , A61L31/14 , C08B37/08 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/08 , C08F290/10 , C08F291/00 , C09D153/00 , C12N5/00 , C12N5/071 , C12N5/077 , C12N11/04 , C12N11/02 , C08J7/16 , A61K47/32
CPC分类号： C12N11/04 , A61K38/42 , A61K38/44 , A61K47/48315 , A61K47/48784 , A61K47/48876 , A61K9/1635 , A61K9/1647 , A61K9/5026 , A61K9/5031 , A61K9/5073 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L27/34 , A61L27/3683 , A61L27/38 , A61L27/52 , A61L29/085 , A61L31/10 , A61L31/145 , A61L31/148 , B82Y5/00 , C08B37/003 , C08B37/0072 , C08B37/0084 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/062 , C08F290/08 , C08F290/10 , C08F291/00 , C09D153/00 , C12N5/0012 , C12N5/0677 , A61K2035/128 , C12N2533/30 , C12N2533/32 , C12N2533/40 , C12N2533/74 , Y10S514/801 , Y10S530/812 , Y10S530/813 , Y10S530/815 , Y10S530/817 , Y10T428/2987 , Y10T428/2989
摘要： Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particularly useful as tissue adhesives, coatings for tissue lumens including blood vessels, coatings for cells such as islets of Langerhans, coatings, plugs, supports or substrates for contact with biological materials such as the body, and as drug delivery devices for biologically active molecules.

80. 发明授权

US09572692B2 Bioabsorbable stent that modulates plaque geometric morphology and chemical composition 有权
标题翻译：生物可吸收支架，调节斑块几何形态和化学成分
公开(公告)号：US09572692B2
公开(公告)日：2017-02-21
申请号：US12510076
申请日：2009-07-27
申请人： Richard Rapoza , Yunbing Wang , James P. Oberhauser , Syed F. A. Hossainy
发明人： Richard Rapoza , Yunbing Wang , James P. Oberhauser , Syed F. A. Hossainy
IPC分类号： A61F2/82 , A61F2/91 , A61L31/16 , A61L31/06 , A61L31/14
CPC分类号： A61F2/915 , A61F2/06 , A61F2/82 , A61F2/91 , A61F2/958 , A61F2002/825 , A61F2002/91566 , A61F2002/91583 , A61F2210/0004 , A61F2210/0076 , A61F2230/0054 , A61F2250/0067 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/412 , C08L67/04
摘要： Methods of treating a diseased blood vessel exhibiting stenosis with a bioabsorable stent are disclosed. The implanted stent supports the section of the vessel at an increased diameter for a period of time to allow the vessel to heal. The stent loses radial strength sufficient to support the section of the vessel in less than 6 months after implantation, loses mechanical integrity, and then erodes away from the section. The biodegradable stent results in changes in properties of plaque with time as the stent degrades. The time-dependent properties include the luminal area of the plaque and plaque geometric morphology parameters.
摘要翻译：公开了用生物可吸收支架治疗显示狭窄的患病血管的方法。植入的支架在增加的直径的一段时间内支撑血管的部分，以允许血管愈合。支架在植入后6个月内失去足以支撑血管的部分的径向强度，丧失机械完整性，然后从该部分脱落。生物降解支架随着支架退化而导致斑块的性质随时间的变化。时间依赖性质包括斑块和斑块几何形态参数的腔面积。

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